TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 565.707 | Formula: C30H43N7O4
H donors: 3 H acceptors: 3 LogP: 4.87 Rotable bonds: 12
Rule of 5 violations (Lipinski): 2
SMILES: N#CN/C(=N\CCCN1CCC(CC1)C(C)(C)C)/Nc1cccc(c1)n1c(C(=O)OC)c(C)nc(/c/1=C(\OC)/O)C
InChi: 1S/C30H43N7O4/c1-20-25(27(38)40-6)37(26(21(2)34-20)28(39)41-7)24-11-8-10-23(18-24)35-29(33-19-31)32-14-9-15-36-16-12-22(13-17-36)30(3,4)5/h8,10-11,18,22,38H,9,12-17H2,1-7H3,(H2,32,33,35)/b27-25+
InChiKey: WTYWVIVDIVDHPV-IMVLJIQESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	neuropeptide Y receptor Y1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	follicle stimulating hormone receptor	neuropeptide Y receptor Y1	384 aa	345 aa	22.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	lipoxygenase	0.0128	0.2697	0.2971
Echinococcus granulosus	g protein coupled receptor	0.013	0.2754	0.3007
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.013	0.2754	0.3035
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.1359	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0197	0.6429
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Brugia malayi	Lipocalin / cytosolic fatty-acid binding protein family protein	0.0405	0.902	1
Echinococcus granulosus	neuropeptide Y receptor	0.013	0.2754	0.3007
Brugia malayi	sulfakinin receptor protein	0.013	0.2754	0.3007
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0197	0.6429
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.013	0.2754	0.3007
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.013	0.2754	0.3035
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.013	0.2754	0.3007
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0197	0.6429
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0197	0.0153
Echinococcus granulosus	Polycystic kidney disease protein	0.0021	0.0271	0.0235
Echinococcus multilocularis	fatty acid binding protein FABP2	0.0405	0.902	1
Onchocerca volvulus		0.0021	0.0271	0.0211
Brugia malayi	hypothetical protein	0.013	0.2754	0.3007
Brugia malayi	AKH receptor	0.013	0.2754	0.3007
Schistosoma mansoni	DNA helicase recq5	0.0021	0.0273	0.0277
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.013	0.2754	0.2898
Leishmania major	cathepsin L-like protease	0.0069	0.1359	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.013	0.2754	0.3035
Onchocerca volvulus	Adenylate cyclase type 2 homolog	0.0162	0.347	0.343
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0197	0.6429
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.1283	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0197	0.6429
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.013	0.2754	0.3035
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.013	0.2754	0.3007
Echinococcus granulosus	neuropeptide s receptor	0.013	0.2754	0.3007
Schistosoma mansoni	neuropeptide f receptor 76f	0.013	0.2754	0.3035
Echinococcus multilocularis	neuropeptide receptor A26	0.013	0.2754	0.2898
Loa Loa (eye worm)	hypothetical protein	0.0162	0.347	0.3525
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.013	0.2754	0.2898
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.013	0.2754	0.3035
Echinococcus multilocularis	neuropeptide Y receptor	0.013	0.2754	0.2898
Brugia malayi	hypothetical protein	0.0021	0.0271	0.0235
Loa Loa (eye worm)	adenylyl cyclase 3	0.0162	0.347	0.3525
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Trypanosoma cruzi	cytochrome P450, putative	0.0017	0.0175	0.1069
Echinococcus multilocularis	rhodopsin orphan GPCR	0.013	0.2754	0.2898
Onchocerca volvulus		0.013	0.2754	0.271
Onchocerca volvulus		0.013	0.2754	0.271
Schistosoma mansoni	rab6-interacting	0.0021	0.0271	0.0275
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0197	0.6429
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.1359	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.013	0.2754	0.2898
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0021	0.0271	0.0083
Echinococcus granulosus	biogenic amine 5HT receptor	0.013	0.2754	0.3007
Brugia malayi	Cytochrome P450 family protein	0.0017	0.0175	0.0128
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Brugia malayi	Melatonin receptor type 1A	0.013	0.2754	0.3007
Loa Loa (eye worm)	cysteine protease	0.0018	0.0197	0.02
Echinococcus granulosus	neuropeptides capa receptor	0.013	0.2754	0.3007
Trypanosoma cruzi	cysteine peptidase, putative	0.0069	0.1359	1
Brugia malayi	hypothetical protein	0.013	0.2754	0.3007
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0271	0.0275
Echinococcus multilocularis	Polycystic kidney disease protein	0.0021	0.0271	0.0083
Brugia malayi	hypothetical protein	0.013	0.2754	0.3007
Brugia malayi	neuropeptide F receptor	0.013	0.2754	0.3007
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0066	0.1283	0.1231
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0018	0.0197	0.0153
Schistosoma mansoni	histamine h1 receptor	0.013	0.2754	0.3035
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.1359	1
Onchocerca volvulus		0.0018	0.0197	0.0138
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Echinococcus granulosus	orexin receptor type 2	0.013	0.2754	0.3007
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0128	0.2697	0.2943
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.1359	1
Echinococcus granulosus	cathepsin l1	0.0018	0.0197	0.0153
Schistosoma mansoni	lipoxygenase	0.0089	0.182	0.1997
Loa Loa (eye worm)	RecQ helicase	0.0021	0.0273	0.0277
Brugia malayi	hypothetical protein	0.013	0.2754	0.3007
Loa Loa (eye worm)	lipocalin/cytosolic fatty-acid binding protein family protein	0.0405	0.902	0.9164
Echinococcus granulosus	lipoxygenase domain containing protein	0.0021	0.0271	0.0235
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Onchocerca volvulus	Neuropeptide F receptor homolog	0.013	0.2754	0.271
Echinococcus granulosus	neuropeptide receptor	0.013	0.2754	0.3007
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Echinococcus granulosus	tm gpcr rhodopsin	0.013	0.2754	0.3007
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.013	0.2754	0.2898
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.038	0.8436	0.8571
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0197	0.02
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Trichomonas vaginalis	DNA helicase recq1, putative	0.0021	0.0273	1
Plasmodium vivax	vivapain-2	0.0018	0.0197	0.7027
Brugia malayi	Doublecortin family protein	0.0021	0.0271	0.0235
Echinococcus granulosus	7TM GPCR rhodopsin	0.013	0.2754	0.3007
Brugia malayi	GnHR receptor homolog	0.013	0.2754	0.3007
Echinococcus multilocularis	neuropeptide s receptor	0.013	0.2754	0.2898
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0197	0.6429
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.013	0.2754	0.3007
Onchocerca volvulus		0.0018	0.0197	0.0138
Onchocerca volvulus		0.0018	0.0197	0.0138
Echinococcus granulosus	tachykinin peptides receptor 99D	0.013	0.2754	0.3007
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0018	0.0197	0.02
Echinococcus granulosus	bloom syndrome protein	0.0021	0.0273	0.0237
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0197	0.6429
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0197	0.6429
Loa Loa (eye worm)	hypothetical protein	0.0441	0.9843	1
Brugia malayi	Dopamine receptor protein 1	0.013	0.2754	0.3007
Echinococcus multilocularis	allatostatin A receptor	0.013	0.2754	0.2898
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.013	0.2754	0.3007
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0197	0.6429
Onchocerca volvulus		0.013	0.2754	0.271
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.013	0.2754	0.3035
Onchocerca volvulus		0.013	0.2754	0.271
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0197	0.6429
Schistosoma mansoni	alpha-1 adrenergic receptor	0.013	0.2754	0.3035
Entamoeba histolytica	cysteine proteinase, putative	0.0018	0.0197	0.6956
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0197	0.0153
Brugia malayi	hypothetical protein	0.013	0.2754	0.3007
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.013	0.2754	0.3035
Echinococcus multilocularis	rhodopsin orphan GPCR	0.013	0.2754	0.2898
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.1359	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.013	0.2754	0.2898
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Onchocerca volvulus		0.013	0.2754	0.271
Schistosoma mansoni	neuropeptide receptor	0.013	0.2754	0.3035
Echinococcus multilocularis	fmrfamide receptor	0.013	0.2754	0.2898
Brugia malayi	larval opioid receptor	0.013	0.2754	0.3007
Onchocerca volvulus		0.0018	0.0197	0.0138
Schistosoma mansoni	amine GPCR	0.013	0.2754	0.3035
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.013	0.2754	0.3035
Echinococcus multilocularis	rhodopsin orphan GPCR	0.013	0.2754	0.2898
Onchocerca volvulus	Cathepsin L homolog	0.0018	0.0197	0.0138
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0021	0.0273	0.0237
Brugia malayi	Serotonin receptor	0.013	0.2754	0.3007
Onchocerca volvulus		0.013	0.2754	0.271
Brugia malayi	Dopamine receptor	0.013	0.2754	0.3007
Schistosoma mansoni	hypothetical protein	0.0021	0.0271	0.0275
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0128	0.2697	0.2833
Echinococcus multilocularis	RUN	0.0021	0.0271	0.0083
Schistosoma mansoni	neuropeptide F-like receptor	0.013	0.2754	0.3035
Brugia malayi	G protein-coupled receptor F59B2.13	0.013	0.2754	0.3007
Echinococcus multilocularis	g-protein coupled receptor	0.013	0.2754	0.2898
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.1359	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.013	0.2754	0.3007
Echinococcus granulosus	fatty acid binding protein FABP2	0.0405	0.902	1
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Echinococcus granulosus	somatostatin receptor	0.013	0.2754	0.3007
Loa Loa (eye worm)	doublecortin family protein	0.0021	0.0271	0.0275
Brugia malayi	G protein-coupled receptor	0.013	0.2754	0.3007
Schistosoma mansoni	neuropeptide receptor	0.013	0.2754	0.3035
Schistosoma mansoni	biogenic amine receptor	0.013	0.2754	0.3035
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0066	0.1283	0.5
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Plasmodium falciparum	LCCL domain-containing protein	0.0021	0.0271	0.9667
Echinococcus multilocularis	rhodopsin orphan GPCR	0.013	0.2754	0.2898
Schistosoma mansoni	opsin-like receptor	0.013	0.2754	0.3035
Entamoeba histolytica	cysteine proteinase, putative	0.0018	0.0197	0.6956
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.013	0.2754	0.2898
Echinococcus multilocularis	neuropeptides capa receptor	0.013	0.2754	0.2898
Echinococcus multilocularis	G protein coupled receptor 139	0.013	0.2754	0.2898
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0197	0.6429
Brugia malayi	hypothetical protein	0.013	0.2754	0.3007
Loa Loa (eye worm)	G-protein coupled receptor	0.013	0.2754	0.2798
Echinococcus granulosus	rhodopsin orphan GPCR	0.013	0.2754	0.3007
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.013	0.2754	0.3007
Echinococcus granulosus	7tm_1 domain containing protein	0.013	0.2754	0.3007
Plasmodium vivax	multidomain scavenger receptor, putative	0.0021	0.0271	1
Schistosoma mansoni	amine GPCR	0.013	0.2754	0.3035
Schistosoma mansoni	growth hormone secretagogue receptor	0.013	0.2754	0.3035
Schistosoma mansoni	biogenic amine receptor	0.013	0.2754	0.3035
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0063	0.1223	0.8969
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.013	0.2754	0.2798
Echinococcus granulosus	tm gpcr rhodopsin	0.013	0.2754	0.3007
Leishmania major	cathepsin L-like protease	0.0018	0.0197	0.0189
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Echinococcus multilocularis	serotonin receptor	0.013	0.2754	0.2898
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.013	0.2754	0.3035
Schistosoma mansoni	blooms syndrome DNA helicase	0.0011	0.0033	0.0011
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.013	0.2754	0.3035
Schistosoma mansoni	biogenic amine (5HT) receptor	0.013	0.2754	0.3035
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.013	0.2754	0.2898
Echinococcus multilocularis	sex peptide receptor	0.013	0.2754	0.2898
Brugia malayi	G-protein coupled receptor	0.013	0.2754	0.3007
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0033	0.0034
Echinococcus granulosus	g protein coupled receptor	0.013	0.2754	0.3007
Echinococcus granulosus	rhodopsin orphan GPCR	0.013	0.2754	0.3007
Echinococcus granulosus	fatty acid binding protein FABP2	0.0405	0.902	1
Onchocerca volvulus		0.0162	0.347	0.343
Echinococcus granulosus	neuropeptide Y receptor	0.013	0.2754	0.3007
Leishmania major	cathepsin L-like protease	0.0018	0.0197	0.0189
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0197	0.6429
Echinococcus multilocularis	neuropeptide Y receptor	0.013	0.2754	0.2898
Onchocerca volvulus		0.013	0.2754	0.271
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.013	0.2754	0.3035
Schistosoma mansoni	biogenic amine receptor	0.013	0.2754	0.3035
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Leishmania major	cathepsin L-like protease	0.0069	0.1359	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.013	0.2754	0.3035
Brugia malayi	Dopamine receptor protein 2	0.013	0.2754	0.3007
Echinococcus multilocularis	bloom syndrome protein	0.0021	0.0273	0.0086
Trypanosoma cruzi	cysteine peptidase, putative	0.0069	0.1359	1
Schistosoma mansoni	hypothetical protein	0.013	0.2754	0.3035
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.013	0.2754	0.2898
Loa Loa (eye worm)	neuropeptide F receptor	0.013	0.2754	0.2798
Onchocerca volvulus	Cathepsin F homolog	0.0018	0.0197	0.0138
Onchocerca volvulus		0.0018	0.0197	0.0138
Trypanosoma cruzi	cysteine peptidase, putative	0.0018	0.0197	0.1237
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.013	0.2754	0.271
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0197	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0273	0.0277
Echinococcus granulosus	neuropeptide receptor A26	0.013	0.2754	0.3007
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0021	0.0273	0.1981
Echinococcus granulosus	allatostatin A receptor	0.013	0.2754	0.3007
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.013	0.2754	0.3035
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0197	0.6429
Onchocerca volvulus		0.013	0.2754	0.271
Schistosoma mansoni	amine GPCR	0.013	0.2754	0.3035
Echinococcus multilocularis	adenylate cyclase 9	0.0162	0.347	0.371
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.013	0.2754	0.2798
Trichomonas vaginalis	DNA helicase recq, putative	0.0021	0.0273	1
Onchocerca volvulus		0.013	0.2754	0.271
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Echinococcus granulosus	rhodopsin orphan GPCR	0.013	0.2754	0.3007
Echinococcus multilocularis	orexin receptor type 2	0.013	0.2754	0.2898
Echinococcus granulosus	biogenic amine 5HT receptor	0.013	0.2754	0.3007
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.013	0.2754	0.2798
Onchocerca volvulus		0.013	0.2754	0.271
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.013	0.2754	0.3035
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0066	0.1283	0.9359
Onchocerca volvulus		0.013	0.2754	0.271
Onchocerca volvulus		0.0018	0.0197	0.0138
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0021	0.0273	0.083
Loa Loa (eye worm)	fibroinase	0.0018	0.0197	0.02
Schistosoma mansoni	cathepsin F (C01 family)	0.0018	0.0197	0.0193
Brugia malayi	hypothetical protein	0.013	0.2754	0.3007
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Schistosoma mansoni	aldehyde dehydrogenase	0.0066	0.1283	0.14
Echinococcus granulosus	hypothetical protein	0.013	0.2754	0.3007
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.1359	1
Brugia malayi	hypothetical protein	0.013	0.2754	0.3007
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.1359	1
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Echinococcus granulosus	rhodopsin orphan GPCR	0.013	0.2754	0.3007
Schistosoma mansoni	biogenic amine (5HT) receptor	0.013	0.2754	0.3035
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.013	0.2754	0.2898
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.0061
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.013	0.2754	0.3007
Onchocerca volvulus		0.0021	0.0271	0.0211
Onchocerca volvulus		0.013	0.2754	0.271
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.1283	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.013	0.2754	0.2898
Schistosoma mansoni	neuropeptide F-like receptor	0.013	0.2754	0.3035
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.013	0.2754	0.3035
Toxoplasma gondii	aldehyde dehydrogenase	0.0066	0.1283	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.013	0.2754	0.3007
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0197	0.6429
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.013	0.2754	0.3035
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.1283	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.013	0.2754	0.3035
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0021	0.0273	0.0086
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.013	0.2754	0.2898
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0018	0.0197	0.6429
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.0021	0.0273	1
Onchocerca volvulus		0.013	0.2754	0.271
Brugia malayi	ORL1-like opioid receptor	0.013	0.2754	0.3007
Brugia malayi	RE15519p	0.013	0.2754	0.3007
Echinococcus granulosus	g protein coupled receptor	0.013	0.2754	0.3007
Loa Loa (eye worm)	cytochrome P450 family protein	0.0017	0.0175	0.0178
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0021	0.0273	0.083
Echinococcus multilocularis	neuropeptides capa receptor	0.013	0.2754	0.2898
Echinococcus multilocularis	rhodopsin orphan GPCR	0.013	0.2754	0.2898
Schistosoma mansoni	myosin xvIII	0.013	0.2754	0.3035
Echinococcus granulosus	G protein coupled receptor 139	0.013	0.2754	0.3007
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.013	0.2754	0.2898
Trypanosoma cruzi	cytochrome P450, putative	0.0017	0.0175	0.1069
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.013	0.2754	0.3035
Treponema pallidum	ATP-dependent DNA helicase	0.0011	0.0033	0.5
Giardia lamblia	Sgs1 DNA helicase, putative	0.0021	0.0273	0.5
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0197	0.0153
Plasmodium vivax	vivapain-2	0.0018	0.0197	0.7027
Toxoplasma gondii	cathepsin CPL	0.0018	0.0197	0.1378
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0033	0.0034
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Schistosoma mansoni	neuropeptide receptor	0.013	0.2754	0.3035
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0197	0.0153
Echinococcus multilocularis	g protein coupled receptor	0.013	0.2754	0.2898
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.013	0.2754	0.2898
Schistosoma mansoni	hypothetical protein	0.013	0.2754	0.3035
Schistosoma mansoni	fatty acid binding protein	0.0405	0.902	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.013	0.2754	0.3007
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0021	0.0273	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.0061
Echinococcus multilocularis	somatostatin receptor	0.013	0.2754	0.2898
Schistosoma mansoni	polycystin 1-related	0.0021	0.0271	0.0275
Echinococcus granulosus	g-protein coupled receptor	0.013	0.2754	0.3007
Onchocerca volvulus		0.013	0.2754	0.271
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.013	0.2754	0.3035
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0018	0.0197	0.02
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0021	0.0273	0.181
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0197	0.6429
Brugia malayi	putative neuropeptide receptor	0.013	0.2754	0.3007
Brugia malayi	putative neuropeptide receptor NPR1	0.013	0.2754	0.3007
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Brugia malayi	Adenylyl cyclase protein	0.0162	0.347	0.3806
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0066	0.1283	0.1365
Echinococcus multilocularis	g protein coupled receptor	0.013	0.2754	0.2898
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0197	0.0153
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0021	0.0273	0.0086
Leishmania major	cysteine peptidase A (CPA)	0.0018	0.0197	0.0189
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0197	0.6429
Echinococcus granulosus	lipoxygenase domain containing protein	0.0021	0.0271	0.0235
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Echinococcus granulosus	rhodopsin orphan GPCR	0.013	0.2754	0.3007
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0197	0.6429
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.013	0.2754	0.2898
Echinococcus granulosus	dro:myosuppressin receptor	0.013	0.2754	0.3007
Brugia malayi	G-protein coupled receptor	0.013	0.2754	0.3007
Echinococcus multilocularis	rhodopsin orphan GPCR	0.013	0.2754	0.2898
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0021	0.0271	0.0083
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0197	0.6429
Onchocerca volvulus		0.013	0.2754	0.271
Echinococcus multilocularis	rhodopsin orphan GPCR	0.013	0.2754	0.2898
Brugia malayi	Cytochrome P450 family protein	0.0017	0.0175	0.0128
Schistosoma mansoni	loxhd1	0.0021	0.0271	0.0275
Echinococcus multilocularis	rhodopsin orphan GPCR	0.013	0.2754	0.2898
Echinococcus multilocularis	dro:myosuppressin receptor	0.013	0.2754	0.2898
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Entamoeba histolytica	recQ family DNA helicase	0.0011	0.0033	0.0381
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0018	0.0197	0.0153
Trypanosoma cruzi	cruzipain precursor, putative	0.0069	0.1359	1
Entamoeba histolytica	cysteine protease, putative	0.0018	0.0197	0.6956
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.013	0.2754	0.3035
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0018	0.0197	0.6429
Brugia malayi	Papain family cysteine protease containing protein	0.0018	0.0197	0.0153
Onchocerca volvulus		0.013	0.2754	0.271
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0011	0.0033	0.0385
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0021	0.0273	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0271	0.0275
Onchocerca volvulus		0.013	0.2754	0.271
Brugia malayi	follicle stimulating hormone receptor	0.038	0.8436	0.9348
Schistosoma mansoni	fatty acid binding protein	0.0405	0.902	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0066	0.1283	0.14
Brugia malayi	Serotonin receptor	0.013	0.2754	0.3007
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0021	0.0273	0.1981
Schistosoma mansoni	cathepsin F (C01 family)	0.0018	0.0197	0.0193
Loa Loa (eye worm)	cytochrome P450 family protein	0.0017	0.0175	0.0178
Brugia malayi	hypothetical protein	0.013	0.2754	0.3007
Echinococcus multilocularis	fatty acid binding protein FABP2	0.0405	0.902	1
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Entamoeba histolytica	cysteine proteinase, putative	0.0012	0.006	0.1476
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0197	0.6429
Echinococcus granulosus	peptide allatostatin:somatostatin	0.013	0.2754	0.3007
Leishmania major	cathepsin L-like protease	0.0018	0.0197	0.0189
Brugia malayi	Bloom's syndrome protein homolog	0.0021	0.0273	0.0237
Echinococcus multilocularis	neuropeptide receptor	0.013	0.2754	0.2898
Loa Loa (eye worm)	CYP4Cod1	0.0017	0.0175	0.0178
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.1359	1
Loa Loa (eye worm)	TYRA-2 protein	0.013	0.2754	0.2798
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.013	0.2754	0.3035
Onchocerca volvulus		0.0018	0.0197	0.0138
Schistosoma mansoni	DNA helicase recq1	0.0021	0.0273	0.0277
Echinococcus granulosus	tm gpcr rhodopsin	0.013	0.2754	0.3007
Onchocerca volvulus		0.0155	0.3313	0.3273
Trypanosoma cruzi	cysteine peptidase, putative	0.0069	0.1359	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.013	0.2754	0.2898
Echinococcus granulosus	rhodopsin orphan GPCR	0.013	0.2754	0.3007
Brugia malayi	hypothetical protein	0.013	0.2754	0.3007
Echinococcus multilocularis	G-protein coupled receptor, putative	0.013	0.2754	0.2898
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.1359	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.013	0.2754	0.2798
Echinococcus multilocularis	g protein coupled receptor	0.013	0.2754	0.2898
Brugia malayi	neuropeptide F receptor	0.013	0.2754	0.3007
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Echinococcus multilocularis	fmrfamide receptor	0.013	0.2754	0.2898
Schistosoma mansoni	neuropeptide receptor	0.013	0.2754	0.3035
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Echinococcus granulosus	RUN	0.0021	0.0271	0.0235
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0021	0.0273	0.0277
Schistosoma mansoni	hypothetical protein	0.013	0.2754	0.3035
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0021	0.0273	1
Leishmania major	cathepsin L-like protease	0.0018	0.0197	0.0189
Entamoeba histolytica	recQ family helicase, putative	0.0021	0.0273	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.0061
Schistosoma mansoni	rab6-interacting	0.0021	0.0271	0.0275
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0021	0.0273	0.0237
Trypanosoma cruzi	major cysteine proteinase, putative	0.0054	0.1022	0.7457
Echinococcus granulosus	rhodopsin orphan GPCR	0.013	0.2754	0.3007
Echinococcus granulosus	sex peptide receptor	0.013	0.2754	0.3007
Echinococcus multilocularis	serotonin receptor	0.013	0.2754	0.2898
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Echinococcus granulosus	adenylate cyclase 9	0.0162	0.347	0.3806
Echinococcus granulosus	fmrfamide receptor	0.013	0.2754	0.3007
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Schistosoma mansoni	opsin-like receptor	0.013	0.2754	0.3035
Schistosoma mansoni	adenoreceptor	0.013	0.2754	0.3035
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Leishmania major	cathepsin L-like protease	0.0069	0.1359	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.1359	1
Echinococcus granulosus	neuropeptide receptor	0.013	0.2754	0.3007
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Loa Loa (eye worm)	ctsf protein	0.0018	0.0197	0.02
Schistosoma mansoni	opsin-like receptor	0.013	0.2754	0.3035
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Brugia malayi	hypothetical protein	0.0021	0.0271	0.0235
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.013	0.2754	0.2798
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Loa Loa (eye worm)	hypothetical protein	0.013	0.2754	0.2798
Echinococcus granulosus	neuropeptides capa receptor	0.013	0.2754	0.3007
Echinococcus granulosus	serotonin receptor	0.013	0.2754	0.3007
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0197	0.6429
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0197	0.6429
Schistosoma mansoni	cathepsin F (C01 family)	0.0012	0.006	0.0041
Trichomonas vaginalis	DNA helicase recq, putative	0.0021	0.0273	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.013	0.2754	0.3007
Leishmania major	cathepsin L-like protease	0.0018	0.0197	0.0189
Brugia malayi	Tachykinin-like peptides receptor 99D	0.013	0.2754	0.3007
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.013	0.2754	0.3007
Schistosoma mansoni	amine GPCR	0.013	0.2754	0.3035
Schistosoma mansoni	hypothetical protein	0.013	0.2754	0.3035
Loa Loa (eye worm)	neuropeptide F receptor	0.013	0.2754	0.2798
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.013	0.2754	0.3035
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0197	0.6429
Loa Loa (eye worm)	G-protein coupled receptor	0.013	0.2754	0.2798
Echinococcus granulosus	neuropeptide FF receptor 2	0.013	0.2754	0.3007
Onchocerca volvulus	Cathepsin L homolog	0.0018	0.0197	0.0138
Echinococcus multilocularis	neuropeptide receptor	0.013	0.2754	0.2898
Schistosoma mansoni	amine GPCR	0.013	0.2754	0.3035
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0011	0.0033	0.0075

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 231 nM	Inhibition of I-PYY binding to Nueopeptide Y1 receptor expressed in human neuroblastoma SK-N-MC cells	ChEMBL.	11814791
IC50 (binding)	= 231 nM	Inhibition of I-PYY binding to Nueopeptide Y1 receptor expressed in human neuroblastoma SK-N-MC cells	ChEMBL.	11814791

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 201417