Detailed information for compound 202146

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 162.253 | Formula: C6H14N2OS
  • H donors: 2 H acceptors: 1 LogP: -0.8 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: SCC[C@H](CCC(=O)N)N
  • InChi: 1S/C6H14N2OS/c7-5(3-4-10)1-2-6(8)9/h5,10H,1-4,7H2,(H2,8,9)/t5-/m0/s1
  • InChiKey: WLJXEIBRTVWAOP-YFKPBYRVSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0049 0.0527 0.1035
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0054 0.0642 0.1261
Brugia malayi Protein kinase domain containing protein 0.0172 0.3217 0.3217
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0049 0.0527 0.5553
Onchocerca volvulus 0.0154 0.2813 0.8742
Brugia malayi latrophilin 2 splice variant baaae 0.0029 0.0075 0.0075
Echinococcus multilocularis cyclin dependent kinase 1 0.0049 0.0527 0.1035
Onchocerca volvulus 0.0054 0.0642 0.1995
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0461 0.0905
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0258 0.5092 0.5092
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0027 0.0031 0.0051
Onchocerca volvulus 0.0054 0.0642 0.1995
Echinococcus multilocularis snurportin 1 0.0258 0.5092 1
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0042 0.0372 0.073
Loa Loa (eye worm) hypothetical protein 0.0027 0.0031 0.0031
Echinococcus multilocularis rho associated protein kinase 0.0158 0.2902 0.5698
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0054 0.0642 0.1261
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0054 0.0641 0.6813
Onchocerca volvulus 0.0054 0.0642 0.1995
Loa Loa (eye worm) hypothetical protein 0.0027 0.0031 0.0031
Echinococcus granulosus glycine receptor subunit alpha 1 0.0054 0.0642 0.1261
Entamoeba histolytica hypothetical protein 0.003 0.011 0.0052
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0928 0.1823
Schistosoma mansoni protein kinase 0.0094 0.1503 0.2952
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0928 0.1823
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0527 0.1423
Brugia malayi Protein kinase domain containing protein 0.0064 0.0847 0.0847
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0527 0.1423
Echinococcus granulosus protein kinase 0.0067 0.0922 0.1811
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0054 0.0642 0.0642
Brugia malayi hypothetical protein 0.003 0.011 0.011
Schistosoma mansoni hypothetical protein 0.0027 0.0031 0.0061
Loa Loa (eye worm) hypothetical protein 0.0026 0.0027 0.0027
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0054 0.0642 0.0642
Plasmodium vivax glycogen synthase kinase 3, putative 0.0054 0.0641 0.6813
Loa Loa (eye worm) ACC-1 protein 0.0054 0.0642 0.0642
Loa Loa (eye worm) hypothetical protein 0.0042 0.0364 0.0364
Loa Loa (eye worm) hypothetical protein 0.0054 0.0642 0.0642
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0029 0.0092 0.0181
Loa Loa (eye worm) hypothetical protein 0.0054 0.0642 0.0642
Schistosoma mansoni nAChR subunit 0.0054 0.0642 0.1261
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0027 0.0031 0.0061
Brugia malayi Protein kinase domain containing protein 0.0067 0.0928 0.0928
Entamoeba histolytica hypothetical protein 0.003 0.011 0.0052
Loa Loa (eye worm) hypothetical protein 0.0054 0.0642 0.0642
Schistosoma mansoni nAChR subunit 0.0054 0.0642 0.1261
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0054 0.0642 0.0642
Echinococcus granulosus serine:threonine protein kinase mig 15 0.009 0.1414 0.2777
Trypanosoma cruzi cdc2-related kinase 1 0.0049 0.0527 0.5553
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0027 0.0031 0.0061
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0046 0.0461 0.0905
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0029 0.0092 0.0181
Leishmania major protein kinase A catalytic subunit isoform 1 0.0046 0.0461 0.4816
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0067 0.0928 1
Loa Loa (eye worm) ACC-1 protein 0.0054 0.0642 0.0642
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0054 0.0641 0.0641
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0054 0.0642 0.1261
Plasmodium vivax protein kinase Crk2 0.0049 0.0527 0.5553
Onchocerca volvulus 0.0027 0.0031 0.0097
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0067 0.0922 0.0922
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0172 0.3217 0.3217
Echinococcus multilocularis cyclin dependent kinase 1 0.0049 0.0527 0.1035
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0046 0.0461 0.0905
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0027 0.0031 0.0061
Echinococcus granulosus nAChR subunit 0.0054 0.0642 0.1261
Brugia malayi cell division control protein 2 homolog 0.0049 0.0527 0.0527
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0049 0.0527 0.0527
Schistosoma mansoni nAChR subunit 0.0054 0.0642 0.1261
Loa Loa (eye worm) hypothetical protein 0.0045 0.0438 0.0438
Loa Loa (eye worm) hypothetical protein 0.0054 0.0642 0.0642
Leishmania major protein kinase, putative 0.0067 0.0928 1
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0054 0.0642 0.1261
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0031 0.012 0.012
Echinococcus granulosus CDC7 cell division cycle 7 0.0064 0.0847 0.1663
Loa Loa (eye worm) hypothetical protein 0.0046 0.0461 0.0461
Loa Loa (eye worm) hypothetical protein 0.0029 0.0092 0.0092
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0054 0.0642 0.1261
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0067 0.0928 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0042 0.0364 0.0364
Brugia malayi hypothetical protein 0.0026 0.0027 0.0027
Schistosoma mansoni hypothetical protein 0.0258 0.5092 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0642 0.0642
Loa Loa (eye worm) hypothetical protein 0.0054 0.0642 0.0642
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0067 0.0928 1
Onchocerca volvulus 0.0054 0.0642 0.1995
Loa Loa (eye worm) hypothetical protein 0.0054 0.0642 0.0642
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0027 0.0031 0.0051
Trypanosoma cruzi cdc2-related kinase 3 0.0049 0.0527 0.5553
Echinococcus granulosus glycine receptor subunit beta 0.0054 0.0642 0.1261
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0054 0.0642 0.1261
Echinococcus granulosus cyclin dependent kinase 0.0049 0.0527 0.1035
Loa Loa (eye worm) hypothetical protein 0.0029 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0029 0.0092 0.0092
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0067 0.0928 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0031 0.0031
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0029 0.0092 0.0092
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0042 0.0364 0.0364
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0027 0.0031 0.0061
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.012 0.0236
Echinococcus granulosus cyclin dependent kinase 5 0.0049 0.0527 0.1035
Brugia malayi Protein kinase domain containing protein 0.0031 0.012 0.012
Brugia malayi Calcitonin receptor-like protein seb-1 0.0042 0.0364 0.0364
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0527 0.1035
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0054 0.0642 0.0642
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0054 0.0641 0.1258
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0054 0.0642 0.1261
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0054 0.0642 0.0642
Schistosoma mansoni hypothetical protein 0.0029 0.0075 0.0147
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0031 0.012 0.0236
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0049 0.0527 0.0527
Trypanosoma brucei cdc2-related kinase 1 0.0049 0.0527 0.5553
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0054 0.0642 0.1261
Schistosoma mansoni rap gtpase-activating protein 0.0027 0.0031 0.0061
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0054 0.0642 0.0642
Brugia malayi Cation transporter family protein 0.0054 0.0642 0.0642
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0046 0.0461 0.4816
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0641 0.3852
Loa Loa (eye worm) hypothetical protein 0.0054 0.0642 0.0642
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0172 0.3217 0.3217
Onchocerca volvulus 0.0054 0.0641 0.1992
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.0928 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0054 0.0642 0.1261
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0067 0.0928 0.0928
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0054 0.0642 0.0642
Entamoeba histolytica hypothetical protein 0.003 0.011 0.0052
Brugia malayi probable protein kinase 0.0094 0.1503 0.1503
Toxoplasma gondii AGC kinase 0.0046 0.0461 0.4816
Entamoeba histolytica protein kinase domain containing protein 0.0054 0.0641 0.1636
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0182 0.3444 0.3444
Trypanosoma cruzi cdc2-related kinase 3 0.0049 0.0527 0.5553
Schistosoma mansoni protein kinase 0.0031 0.012 0.0236
Brugia malayi Cation transporter family protein 0.0054 0.0642 0.0642
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0029 0.0092 0.0092
Onchocerca volvulus 0.0158 0.2902 0.9019
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0054 0.0642 0.1261
Onchocerca volvulus 0.0054 0.0642 0.1995
Echinococcus granulosus hypothetical protein 0.0063 0.0839 0.1648
Echinococcus granulosus cyclin dependent kinase 1 0.0049 0.0527 0.1035
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0054 0.0642 0.1261
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0054 0.0642 0.0642
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0054 0.0642 0.0642
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0046 0.0461 0.0905
Echinococcus granulosus nAChR subunit 0.0029 0.0092 0.0181
Echinococcus granulosus snurportin 1 0.0258 0.5092 1
Entamoeba histolytica protein kinase, putative 0.0054 0.0641 0.1636
Giardia lamblia Kinase, CMGC GSK 0.0054 0.0641 0.3852
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0482 1 1
Leishmania major protein kinase A catalytic subunit 0.0046 0.0461 0.4816
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0031 0.012 0.0236
Onchocerca volvulus 0.0054 0.0642 0.1995
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0054 0.0641 0.1258
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0054 0.0642 0.1261
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0046 0.0461 0.4816
Onchocerca volvulus 0.0029 0.0092 0.0287
Loa Loa (eye worm) hypothetical protein 0.0029 0.0092 0.0092
Echinococcus multilocularis glycine receptor subunit beta 0.0054 0.0642 0.1261
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0054 0.0642 0.0642
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0054 0.0642 0.0642
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0172 0.3217 0.3217
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0527 0.1423
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0054 0.0642 0.1261
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0054 0.0641 0.6813
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0046 0.0461 0.4816
Echinococcus multilocularis CDC7 cell division cycle 7 0.0064 0.0847 0.1663
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0641 0.3852
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0049 0.0527 0.5553
Schistosoma mansoni vam6/vps39 related 0.0027 0.0031 0.0061
Loa Loa (eye worm) hypothetical protein 0.009 0.1414 0.1414
Schistosoma mansoni nAChR subunit 0.0054 0.0642 0.1261
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0046 0.0461 0.4816
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0029 0.0092 0.0092
Brugia malayi Temporarily assigned gene name protein 59 0.0027 0.0031 0.0031
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.003 0.011 0.0216
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0054 0.0642 0.0642
Echinococcus granulosus dual specificity protein kinase clk2 0.0067 0.0928 0.1823
Schistosoma mansoni transcription factor LCR-F1 0.003 0.011 0.0216
Brugia malayi Protein kinase domain containing protein 0.0049 0.0527 0.0527
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0461 0.0905
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0054 0.0642 0.0642
Loa Loa (eye worm) hypothetical protein 0.0029 0.0092 0.0092
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0054 0.0642 0.1261
Loa Loa (eye worm) hypothetical protein 0.0054 0.0642 0.0642
Entamoeba histolytica PH domain containing protein kinase, putative 0.0046 0.0461 0.1099
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0046 0.0461 0.4816
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0054 0.0641 0.1258
Leishmania major protein kinase, putative 0.0067 0.0928 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0642 0.0642
Entamoeba histolytica protein kinase domain containing protein 0.0054 0.0641 0.1636
Echinococcus granulosus protein kinase shaggy 0.0054 0.0641 0.1258
Loa Loa (eye worm) hypothetical protein 0.0054 0.0642 0.0642
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.003 0.011 0.0216
Loa Loa (eye worm) hypothetical protein 0.0063 0.0839 0.0839
Entamoeba histolytica cell division protein kinase 2, putative 0.0049 0.0527 0.1297
Loa Loa (eye worm) hypothetical protein 0.0054 0.0642 0.0642
Plasmodium falciparum protein kinase 5 0.0049 0.0527 0.5553
Trichomonas vaginalis CMGC family protein kinase 0.0064 0.0847 0.8259
Echinococcus multilocularis 0.0067 0.0922 0.1811
Echinococcus multilocularis cyclin dependent kinase 0.0049 0.0527 0.1035
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0031 0.012 0.0236
Echinococcus multilocularis dual specificity protein kinase clk2 0.0067 0.0928 0.1823
Entamoeba histolytica hypothetical protein 0.003 0.011 0.0052
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0046 0.0461 0.0905
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0046 0.0461 0.4816
Loa Loa (eye worm) hypothetical protein 0.0054 0.0642 0.0642
Loa Loa (eye worm) hypothetical protein 0.0054 0.0642 0.0642
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0054 0.0642 0.1261
Schistosoma mansoni nAChR subunit 0.0054 0.0642 0.1261
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0054 0.0642 0.0642
Giardia lamblia Kinase, CMGC CLK 0.0067 0.0928 1
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0172 0.3217 0.6318
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.0847 0.1663
Loa Loa (eye worm) hypothetical protein 0.0029 0.0092 0.0092
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0054 0.0642 0.0642
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0054 0.0642 0.0642
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0054 0.0642 0.1261
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0046 0.0461 0.4816
Schistosoma mansoni protein kinase 0.0067 0.0922 0.1811
Loa Loa (eye worm) hypothetical protein 0.0054 0.0642 0.0642
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0031 0.012 0.0236
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0049 0.0527 0.5553
Schistosoma mansoni serine/threonine protein kinase 0.0158 0.2902 0.5698
Onchocerca volvulus 0.0064 0.0847 0.2632
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0046 0.0461 0.0905
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0054 0.0641 0.6813
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0029 0.0092 0.0092
Brugia malayi excitatory GABA receptor EXP-1A 0.0054 0.0642 0.0642
Leishmania major protein kinase A catalytic subunit isoform 2 0.0046 0.0461 0.4816
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0054 0.0642 0.0642
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0046 0.0461 0.0905
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0182 0.3444 0.6764
Plasmodium falciparum glycogen synthase kinase 3 0.0054 0.0641 0.6813
Echinococcus multilocularis glycine receptor subunit beta 0.0054 0.0642 0.1261
Trichomonas vaginalis CMGC family protein kinase 0.0064 0.0847 0.8259
Brugia malayi hypothetical protein 0.0027 0.0031 0.0031
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0054 0.0642 0.1261
Echinococcus multilocularis nAChR subunit 0.0029 0.0092 0.0181
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0054 0.0642 0.1261
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0182 0.3444 0.6764
Trypanosoma brucei protein kinase, putative 0.0054 0.0641 0.6813
Echinococcus granulosus Vam6:Vps39 protein 0.0027 0.0031 0.0061
Toxoplasma gondii AGC kinase 0.0046 0.0461 0.4816
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0049 0.0527 0.0527
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0054 0.0642 0.1261
Loa Loa (eye worm) AGC/PKA protein kinase 0.0046 0.0461 0.0461
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0054 0.0642 0.0642
Entamoeba histolytica protein kinase domain containing protein 0.0182 0.3444 1
Trichomonas vaginalis CMGC family protein kinase 0.0064 0.0847 0.8259
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0046 0.0461 0.0905
Echinococcus multilocularis cyclin dependent kinase 5 0.0049 0.0527 0.1035
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0461 0.0905
Trypanosoma brucei cdc2-related kinase 3 0.0049 0.0527 0.5553
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0172 0.3217 0.6318
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0027 0.0031 0.0051
Echinococcus multilocularis 0.0063 0.0839 0.1648
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0046 0.0461 0.4816
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0031 0.012 0.0236
Onchocerca volvulus Putative nachr subunit 0.0054 0.0642 0.1995
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0067 0.0928 1
Schistosoma mansoni nAChR subunit 0.0054 0.0642 0.1261
Loa Loa (eye worm) LGC-31 protein 0.0054 0.0642 0.0642
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0046 0.0461 0.0461
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0054 0.0642 0.1261
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0054 0.0642 0.0642
Giardia lamblia Kinase, CMGC CDK 0.0049 0.0527 0.1423
Brugia malayi RNA, U transporter 1 0.0069 0.0953 0.0953
Echinococcus multilocularis protein kinase shaggy 0.0054 0.0641 0.1258
Loa Loa (eye worm) hypothetical protein 0.0054 0.0642 0.0642
Echinococcus granulosus glycine receptor subunit beta 0.0054 0.0642 0.1261
Schistosoma mansoni serine/threonine protein kinase 0.0182 0.3444 0.6764
Loa Loa (eye worm) hypothetical protein 0.0029 0.0092 0.0092
Loa Loa (eye worm) CDC7 protein kinase 0.0064 0.0847 0.0847
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.012 0.0236
Plasmodium vivax serine/threonine kinase-1, putative 0.0067 0.0928 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0642 0.0642
Schistosoma mansoni neurotransmitter gated ion channel 0.0029 0.0092 0.0181
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0054 0.0641 0.0641
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0527 0.1035
Echinococcus granulosus rho-associated protein kinase 1 0.0158 0.2902 0.5698
Schistosoma mansoni serine/threonine protein kinase 0.0172 0.3217 0.6318
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0054 0.0642 0.1261
Schistosoma mansoni nAChR subunit 0.0054 0.0642 0.1261
Entamoeba histolytica PH domain containing protein kinase, putative 0.0046 0.0461 0.1099
Loa Loa (eye worm) hypothetical protein 0.0029 0.0092 0.0092
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0054 0.0642 0.1261
Brugia malayi intracellular kinase 0.0054 0.0641 0.0641
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0046 0.0461 0.4816
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0054 0.0642 0.1261
Loa Loa (eye worm) AGC/PKA protein kinase 0.0046 0.0461 0.0461
Loa Loa (eye worm) hypothetical protein 0.0029 0.0092 0.0092
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0054 0.0642 0.1261
Entamoeba histolytica cell division protein kinase 2, putative 0.0049 0.0527 0.1297
Echinococcus multilocularis nAChR subunit 0.0054 0.0642 0.1261
Onchocerca volvulus 0.0029 0.0092 0.0287
Loa Loa (eye worm) hypothetical protein 0.0054 0.0642 0.0642
Loa Loa (eye worm) hypothetical protein 0.0054 0.0642 0.0642
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0042 0.0372 0.073
Loa Loa (eye worm) GABA receptor subunit 0.0029 0.0092 0.0092
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0054 0.0642 0.0642
Giardia lamblia Kinase, CMGC CDK 0.0049 0.0527 0.1423
Giardia lamblia Kinase, CDC7 0.0064 0.0847 0.8259
Brugia malayi Cation transporter family protein 0.0054 0.0642 0.0642
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0054 0.0642 0.0642
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0172 0.3217 1
Schistosoma mansoni hypothetical protein 0.003 0.011 0.0216
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0182 0.3444 0.3444
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0067 0.0928 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0092 0.0092
Plasmodium falciparum protein serine/threonine kinase-1 0.0067 0.0928 1
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0054 0.0642 0.1261
Trypanosoma cruzi cdc2-related kinase 1 0.0049 0.0527 0.5553
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0067 0.0928 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0054 0.0642 0.0642
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0031 0.012 0.0236
Onchocerca volvulus 0.0064 0.0847 0.2632
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0046 0.0461 0.4816
Echinococcus granulosus glycine receptor subunit alpha 1 0.0054 0.0642 0.1261
Giardia lamblia Kinase, CMGC GSK 0.0054 0.0641 0.3852

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 0 % Inhibitory activity against Tetanus neurotoxin (TeNt) light chain by using fluorescent synaptobrevin derivative [Pya88]S 39-88 as substrate at 10e-3 M. ChEMBL. 9719598
Inhibition (binding) = 0 % Inhibitory activity against Tetanus neurotoxin (TeNt) light chain by using fluorescent synaptobrevin derivative [Pya88]S 39-88 as substrate at 10e-3 M. ChEMBL. 9719598

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.