Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Integrin alpha pat-2 precursor | 0.0154 | 0.0581 | 0.1301 |
Schistosoma mansoni | neuropilin (nrp) and tolloid (tll)-like | 0.0071 | 0.0014 | 0.0014 |
Loa Loa (eye worm) | integrin beta-2 | 0.0315 | 0.1686 | 0.3181 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0707 | 0.4371 | 0.8298 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0382 | 0.2149 | 0.408 |
Schistosoma mansoni | integrin alpha | 0.0154 | 0.0581 | 0.0581 |
Brugia malayi | Kelch motif family protein | 0.0119 | 0.0342 | 0.0753 |
Loa Loa (eye worm) | DPY-31 protein | 0.0105 | 0.0248 | 0.0444 |
Echinococcus multilocularis | integrin beta 2 | 0.0233 | 0.1126 | 0.2138 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.0278 | 0.1432 | 0.1432 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0071 | 0.0014 | 0.0014 |
Echinococcus multilocularis | cubilin | 0.0071 | 0.0014 | 0.0027 |
Echinococcus granulosus | integrin beta 2 | 0.0233 | 0.1126 | 0.2138 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.1192 | 0.2242 |
Echinococcus multilocularis | neuropilin (nrp) and tolloid (tll) | 0.0071 | 0.0014 | 0.0027 |
Loa Loa (eye worm) | zinc metalloproteinase toh-2 | 0.0105 | 0.0248 | 0.0444 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0382 | 0.2149 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0071 | 0.0014 | 0.5 |
Brugia malayi | dihydrofolate reductase family protein | 0.0382 | 0.2149 | 0.49 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0014 | 0.0014 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0279 | 0.144 | 0.5 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0707 | 0.4371 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0106 | 0.0254 | 0.0483 |
Echinococcus multilocularis | laminin | 0.027 | 0.1379 | 0.2618 |
Echinococcus granulosus | CUB | 0.0071 | 0.0014 | 0.0027 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0071 | 0.0014 | 0.0014 |
Onchocerca volvulus | Arrow homolog | 0.0243 | 0.1192 | 0.2704 |
Loa Loa (eye worm) | hypothetical protein | 0.0803 | 0.5034 | 0.9556 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 0.1379 | 0.2597 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.1192 | 0.2242 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0201 | 0.0355 |
Echinococcus granulosus | Tolloid protein 1 | 0.0837 | 0.5268 | 1 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0315 | 0.1686 | 0.3836 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0014 | 0.0014 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.027 | 0.1379 | 0.2597 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0279 | 0.144 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0014 | 0.0014 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.0116 | 0.0325 | 0.0712 |
Brugia malayi | Zinc metalloproteinase toh-2 precursor | 0.0105 | 0.0248 | 0.0536 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0248 | 0.0444 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0837 | 0.5268 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0106 | 0.0254 | 0.0254 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0707 | 0.4371 | 1 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0119 | 0.0342 | 0.0624 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0837 | 0.5268 | 0.5268 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0279 | 0.144 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0382 | 0.2149 | 0.5 |
Schistosoma mansoni | integrin beta subunit | 0.0185 | 0.0798 | 0.0798 |
Brugia malayi | Dihydrofolate reductase | 0.0382 | 0.2149 | 0.49 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0707 | 0.4371 | 0.8293 |
Echinococcus granulosus | neuropilin nrp and tolloid tll | 0.0071 | 0.0014 | 0.0027 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0382 | 0.2149 | 1 |
Echinococcus multilocularis | fibrillin 1 | 0.028 | 0.1448 | 0.275 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0279 | 0.144 | 1 |
Brugia malayi | astacin protease protein 30 | 0.0105 | 0.0248 | 0.0536 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0098 | 0.0201 | 0.0428 |
Onchocerca volvulus | 0.0106 | 0.0254 | 0.0551 | |
Echinococcus granulosus | laminin | 0.027 | 0.1379 | 0.2618 |
Echinococcus granulosus | cubilin | 0.0071 | 0.0014 | 0.0027 |
Loa Loa (eye worm) | AStacin protease | 0.0524 | 0.3116 | 0.5905 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0014 | 0.0014 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0014 | 0.0014 |
Echinococcus granulosus | cubilin | 0.0071 | 0.0014 | 0.0027 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0279 | 0.144 | 0.5 |
Onchocerca volvulus | Putative cubilin | 0.0098 | 0.0201 | 0.0428 |
Echinococcus multilocularis | integrin alpha 3 | 0.0118 | 0.0335 | 0.0637 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0243 | 0.1192 | 0.2704 |
Brugia malayi | Nematode astacin protease protein 30 | 0.0105 | 0.0248 | 0.0536 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0239 | 0.1168 | 0.4822 |
Schistosoma mansoni | dihydrofolate reductase | 0.0382 | 0.2149 | 0.2149 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0707 | 0.4371 | 0.8298 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0237 | 0.1152 | 0.2165 |
Onchocerca volvulus | 0.0105 | 0.0248 | 0.0536 | |
Loa Loa (eye worm) | hypothetical protein | 0.0341 | 0.1866 | 0.3524 |
Loa Loa (eye worm) | thymidylate synthase | 0.0106 | 0.0254 | 0.0457 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0279 | 0.144 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0382 | 0.2149 | 1 |
Schistosoma mansoni | egf-like domain protein | 0.0243 | 0.1192 | 0.1192 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0109 | 0.018 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0382 | 0.2149 | 0.4063 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.027 | 0.1379 | 0.3132 |
Brugia malayi | Nematode astacin protease protein 30 | 0.0105 | 0.0248 | 0.0536 |
Echinococcus multilocularis | CUB | 0.0071 | 0.0014 | 0.0027 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.0355 | 0.0648 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0837 | 0.5268 | 1 |
Brugia malayi | Fibulin-1 precursor | 0.027 | 0.1379 | 0.3132 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.0325 | 0.0591 |
Schistosoma mansoni | neuropilin (nrp) and tolloid (tll)-like | 0.0071 | 0.0014 | 0.0014 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0707 | 0.4371 | 0.4371 |
Echinococcus granulosus | integrin alpha 3 | 0.0118 | 0.0335 | 0.0637 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0243 | 0.1192 | 0.2242 |
Echinococcus multilocularis | cubilin | 0.0071 | 0.0014 | 0.0027 |
Brugia malayi | thymidylate synthase | 0.0106 | 0.0254 | 0.0551 |
Echinococcus granulosus | thymidylate synthase | 0.0106 | 0.0254 | 0.0483 |
Brugia malayi | zinc metalloproteinase toh-2 precursor | 0.0105 | 0.0248 | 0.0536 |
Echinococcus granulosus | dihydrofolate reductase | 0.0382 | 0.2149 | 0.408 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.