TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 273.334 | Formula: C14H19N5O
H donors: 1 H acceptors: 3 LogP: 1.3 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Cc1nn(c(c1)C)CC1CCCN1C(=O)c1n[nH]cc1
InChi: 1S/C14H19N5O/c1-10-8-11(2)19(17-10)9-12-4-3-7-18(12)14(20)13-5-6-15-16-13/h5-6,8,12H,3-4,7,9H2,1-2H3,(H,15,16)
InChiKey: WLYJLSAWVMCZEK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.001	0.0024	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0421	0.0645
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.001	0.0024	0.0011
Schistosoma mansoni	voltage-gated potassium channel	0.001	0.0024	0.0013
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.001	0.0024	0.0011
Echinococcus granulosus	sodium channel protein	0.001	0.0024	0.0011
Loa Loa (eye worm)	hypothetical protein	0.001	0.0024	0.0017
Toxoplasma gondii	AGC kinase	0.0016	0.0074	0.1129
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0099	0.103
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.001	0.0024	0.0011
Schistosoma mansoni	transient receptor potential channel 4	0.001	0.0024	0.0013
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.001	0.0024	0.0011
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0011	0.0026	0.0016
Trypanosoma cruzi	cdc2-related kinase 1	0.003	0.0208	0.0338
Loa Loa (eye worm)	voltage-gated potassium channel	0.001	0.0024	0.0017
Loa Loa (eye worm)	cytohesin 3	0.015	0.1334	0.2086
Brugia malayi	Variant SH3 domain containing protein	0.0029	0.0203	0.0191
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0034	0.0246	0.0233
Entamoeba histolytica	MIR domain protein	0.011	0.0958	1
Echinococcus multilocularis	rac serine:threonine kinase	0.0017	0.0084	0.0142
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0132	0.1376
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0011	0.0026	0.0016
Trichomonas vaginalis	AGC family protein kinase	0.0037	0.0277	0.2891
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.001	0.0024	0.0011
Loa Loa (eye worm)	hypothetical protein	0.001	0.0024	0.0017
Echinococcus granulosus	voltage gated potassium channel	0.001	0.0024	0.0011
Trypanosoma cruzi	cdc2-related kinase 3	0.003	0.0208	0.0338
Brugia malayi	Cytohesin 3	0.015	0.1334	0.1322
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.001	0.0024	0.0013
Echinococcus granulosus	potassium voltage gated channel protein	0.001	0.0024	0.0011
Trypanosoma cruzi	target of rapamycin kinase 3	0.0027	0.0181	0.0288
Brugia malayi	Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog	0.001	0.0024	0.0011
Entamoeba histolytica	protein kinase, putative	0.0037	0.0277	0.2691
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0117	0.1223
Echinococcus multilocularis	potassium voltage gated channel protein	0.001	0.0024	0.0011
Onchocerca volvulus		0.0072	0.0604	0.6254
Echinococcus granulosus	TRP transient receptor potential channel	0.001	0.0024	0.0011
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.001	0.0024	0.002
Schistosoma mansoni	transient receptor potential channel	0.001	0.0024	0.0013
Trypanosoma brucei	inositol 1,4,5-trisphosphate receptor	0.059	0.5483	1
Echinococcus multilocularis	shaker cognate	0.001	0.0024	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0681	0.6343	1
Echinococcus multilocularis	potassium voltage gated channel subfamily C	0.001	0.0024	0.0011
Echinococcus granulosus	transient receptor potential cation channel	0.001	0.0024	0.0011
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0132	0.1376
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit	0.001	0.0024	0.0011
Brugia malayi	Cyclic-nucleotide gated cation channel	0.001	0.0024	0.0011
Echinococcus multilocularis	ryanodine receptor 44f	0.05	0.4638	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0164	0.1711
Giardia lamblia	Kinase, CMGC CDK	0.003	0.0208	0.8278
Plasmodium vivax	phospholipase C-like, putative	0.0022	0.0133	0.5854
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.001	0.0024	0.0011
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0098	0.1027
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0011	0.0033	0.0037
Loa Loa (eye worm)	hypothetical protein	0.001	0.0024	0.0017
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0034	0.0246	0.0492
Brugia malayi	Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog	0.001	0.0024	0.0011
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.001	0.0024	0.0011
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0011	0.0033	0.0025
Echinococcus multilocularis	transient receptor potential cation channel	0.001	0.0024	0.0011
Loa Loa (eye worm)	hypothetical protein	0.001	0.0024	0.0017
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0132	0.0119
Echinococcus multilocularis	voltage gated hydrogen channel 1	0.001	0.0024	0.0011
Echinococcus granulosus	voltage dependent calcium channel	0.001	0.0024	0.0011
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0132	0.1376
Onchocerca volvulus		0.011	0.0958	1
Leishmania major	phospholipase c-like protein	0.0043	0.0328	0.0854
Schistosoma mansoni	voltage-gated potassium channel	0.001	0.0024	0.0013
Loa Loa (eye worm)	voltage-gated calcium channel	0.001	0.0024	0.0017
Echinococcus multilocularis	3 phosphoinositide dependent protein kinase 1	0.0037	0.0277	0.0559
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.001	0.0024	0.0248
Schistosoma mansoni	serine/threonine protein kinase	0.0037	0.0277	0.0326
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.001	0.0024	0.0017
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0117	0.1223
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0034	0.0246	0.0288
Echinococcus granulosus	sodium leak channel non selective protein	0.001	0.0024	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0133	0.0189
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0115	0.1203
Echinococcus multilocularis	stromal cell derived factor 2	0.011	0.0958	0.2033
Echinococcus multilocularis	sodium channel protein	0.001	0.0024	0.0011
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.001	0.0024	0.0011
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0034	0.0246	0.2359
Loa Loa (eye worm)	hypothetical protein	0.001	0.0024	0.0017
Trichomonas vaginalis	mannosyltransferase 1, putative	0.011	0.0958	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0024	0.0017
Loa Loa (eye worm)	hypothetical protein	0.001	0.0024	0.0017
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0011	0.0033	0.0055
Loa Loa (eye worm)	ryanodine receptor	0.0189	0.1705	0.2673
Plasmodium falciparum	cyclin, putative	0.0018	0.0093	0.3693
Echinococcus multilocularis	cyclin dependent kinase	0.003	0.0208	0.041
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.0039	0.0403
Echinococcus multilocularis	potassium voltage gated channel protein	0.001	0.0024	0.0011
Brugia malayi	olfactory channel protein osm-9	0.001	0.0024	0.0011
Leishmania major	CYC2-like cyclin, putative	0.0018	0.0093	0.0218
Loa Loa (eye worm)	hypothetical protein	0.001	0.0024	0.0017
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0011	0.0033	0.0037
Plasmodium vivax	protein kinase Crk2	0.003	0.0208	1
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.001	0.0024	0.0011
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.003	0.0208	0.0309
Trypanosoma cruzi	CYC2-like cyclin 4, putative	0.0018	0.0093	0.0128
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.001	0.0024	0.0011
Echinococcus multilocularis	voltage gated potassium channel	0.001	0.0024	0.0011
Schistosoma mansoni	voltage-gated potassium channel	0.001	0.0024	0.0013
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0164	0.1711
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0027	0.0181	0.0307
Loa Loa (eye worm)	hypothetical protein	0.001	0.0024	0.0017
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.001	0.0024	0.0013
Echinococcus multilocularis	transient receptor potential gamma protein	0.001	0.0024	0.0011
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.001	0.0024	0.0011
Echinococcus multilocularis	two pore calcium channel protein 2	0.001	0.0024	0.0011
Schistosoma mansoni	voltage-gated potassium channel	0.001	0.0024	0.0013
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0016	0.0077	0.0118
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.001	0.0024	0.0013
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0098	0.1027
Entamoeba histolytica	protein kinase, putative	0.0016	0.0074	0.051
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0017	0.0084	0.0623
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.003	0.0208	0.0309
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0132	0.1376
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.001	0.0024	0.0115
Brugia malayi	Protein kinase domain containing protein	0.0037	0.0277	0.0264
Schistosoma mansoni	calcium-activated potassium channel	0.001	0.0024	0.0013
Loa Loa (eye worm)	ryanodine receptor	0.001	0.0024	0.0017
Schistosoma mansoni	voltage-gated ion channel	0.001	0.0024	0.0013
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0181	0.1884
Schistosoma mansoni	transient receptor potential channel	0.001	0.0024	0.0013
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.001	0.0024	0.0013
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.001	0.0024	0.0011
Echinococcus granulosus	potassium voltage gated channel protein	0.001	0.0024	0.0011
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0011	0.0033	0.0017
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0181	0.1884
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.001	0.0024	0.0115
Schistosoma mansoni	voltage-gated potassium channel	0.001	0.0024	0.0013
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.001	0.0024	0.0013
Trypanosoma brucei	phosphoinositide-specific phospholipase C	0.0043	0.0328	0.0576
Echinococcus granulosus	cyclin dependent kinase 1	0.003	0.0208	0.041
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.001	0.0024	0.0013
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.003	0.0208	0.0309
Schistosoma mansoni	stromal cell-derived factor 2 precursor-like protein	0.011	0.0958	0.1166
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0164	0.1711
Entamoeba histolytica	cell division protein kinase 2, putative	0.003	0.0208	0.1953
Echinococcus multilocularis	sodium leak channel non selective protein	0.001	0.0024	0.0011
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0027	0.0181	0.0455
Schistosoma mansoni	calcium channel voltage-dependent p/q type alpha 1a-related	0.001	0.0024	0.0013
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.003	0.0208	0.4168
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0034	0.0246	0.2359
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0421	0.0645
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0034	0.0246	0.0426
Trichomonas vaginalis	CMGC family protein kinase	0.003	0.0208	0.2173
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog	0.001	0.0024	0.0011
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0164	0.1711
Echinococcus granulosus	potassium voltage gated channel protein	0.001	0.0024	0.0011
Echinococcus multilocularis	potassium voltage gated channel subfamily KQT	0.001	0.0024	0.0011
Toxoplasma gondii	phosphoinositide phospholipase PIPLC	0.0057	0.0466	1
Echinococcus granulosus	ryanodine receptor 44f	0.05	0.4638	1
Echinococcus granulosus	3-phosphoinositide-dependent protein kinase 1	0.0037	0.0277	0.0559
Schistosoma mansoni	voltage-gated potassium channel	0.001	0.0024	0.0013
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.001	0.0024	0.0011
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0099	0.103
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0018	0.0093	0.0128
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.001	0.0024	0.0011
Toxoplasma gondii	cyclin, N-terminal domain-containing protein	0.0018	0.0093	0.1574
Schistosoma mansoni	voltage-gated potassium channel	0.001	0.0024	0.0013
Echinococcus granulosus	transient receptor potential cation channel	0.001	0.0024	0.0011
Loa Loa (eye worm)	MIR domain-containing protein	0.011	0.0958	0.1493
Echinococcus granulosus	potassium channel KvQLT family member kqt 1	0.001	0.0024	0.0011
Trypanosoma cruzi	cdc2-related kinase 3	0.003	0.0208	0.0338
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0011	0.0033	0.0031
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.001	0.0024	0.0013
Trypanosoma brucei	cyclin 2	0.0018	0.0093	0.0147
Leishmania major	hypothetical protein, unknown function	0.001	0.0024	0.0029
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0009	0.0012	0.0122
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0164	0.1711
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0132	0.1376
Trichomonas vaginalis	AGC family protein kinase	0.0037	0.0277	0.2891
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0034	0.0246	0.0407
Echinococcus multilocularis	cyclin dependent kinase 1	0.003	0.0208	0.041
Trypanosoma cruzi	CYC2-like cyclin 6, putative	0.0018	0.0093	0.0128
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.001	0.0024	0.0013
Echinococcus granulosus	potassium voltage gated channel subfamily C	0.001	0.0024	0.0011
Schistosoma mansoni	voltage-gated potassium channel	0.001	0.0024	0.0013
Schistosoma mansoni	voltage-dependent calcium channel	0.001	0.0024	0.0013
Schistosoma mansoni	voltage-gated potassium channel KCNQ	0.001	0.0024	0.0013
Leishmania major	hypothetical protein, conserved	0.0401	0.3704	1
Schistosoma mansoni	voltage-gated potassium channel	0.001	0.0024	0.0013
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0132	0.1376
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0011	0.0033	0.0031
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog	0.001	0.0024	0.0011
Echinococcus multilocularis	transient receptor potential cation channel	0.001	0.0024	0.0011
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.0033	0.0346
Schistosoma mansoni	hypothetical protein	0.001	0.0024	0.0013
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0017	0.0084	0.0623
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0181	0.1884
Loa Loa (eye worm)	hypothetical protein	0.001	0.0024	0.0017
Echinococcus granulosus	potassium voltage gated channel protein	0.001	0.0024	0.0011
Loa Loa (eye worm)	hypothetical protein	0.001	0.0024	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0669	0.6222	0.9808
Brugia malayi	Transient-receptor-potential like protein	0.001	0.0024	0.0011
Echinococcus granulosus	cyclin dependent kinase 5	0.003	0.0208	0.041
Onchocerca volvulus		0.0106	0.0925	0.9651
Echinococcus granulosus	voltage gated potassium channel	0.001	0.0024	0.0011
Trypanosoma brucei	CYC2-like cyclin, putative	0.0018	0.0093	0.0147
Toxoplasma gondii	cyclin2 related protein	0.0018	0.0093	0.1574
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.001	0.0024	0.0011
Echinococcus multilocularis	voltage dependent calcium channel	0.001	0.0024	0.0011
Schistosoma mansoni	60S ribosomal protein L21	0.001	0.0024	0.0013
Echinococcus granulosus	stromal cell derived factor 2	0.011	0.0958	0.2033
Plasmodium falciparum	phosphoinositide-specific phospholipase C	0.0022	0.0133	0.5854
Schistosoma mansoni	vesicular amine transporter	0.001	0.0024	0.0013
Entamoeba histolytica	cell division protein kinase 2, putative	0.003	0.0208	0.1953
Schistosoma mansoni	voltage-gated potassium channel	0.001	0.0024	0.0013
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.001	0.0024	0.0011
Schistosoma mansoni	inositol 145-trisphosphate receptor	0.0569	0.5288	0.6504
Schistosoma mansoni	phospholipase C beta	0.0051	0.0409	0.0488
Loa Loa (eye worm)	hypothetical protein	0.001	0.0024	0.0017
Loa Loa (eye worm)	hypothetical protein	0.001	0.0024	0.0017
Schistosoma mansoni	voltage-gated potassium channel	0.001	0.0024	0.0013
Echinococcus multilocularis	short transient receptor potential channel 6	0.001	0.0024	0.0011
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.0033	0.0346
Echinococcus multilocularis	voltage gated potassium channel	0.001	0.0024	0.0011
Plasmodium falciparum	protein kinase 5	0.003	0.0208	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0024	0.0017
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.0033	0.0346
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0023	0.0141	0.1467
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.001	0.0024	0.0011
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.001	0.0024	0.0011
Loa Loa (eye worm)	calcium channel	0.001	0.0024	0.0017
Echinococcus multilocularis	transient receptor potential cation channel	0.001	0.0024	0.0011
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0022	0.0132	0.0217
Echinococcus granulosus	hypothetical protein	0.001	0.0024	0.0011
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0132	0.1376
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.001	0.0024	0.0011
Echinococcus granulosus	voltage gated hydrogen channel 1	0.001	0.0024	0.0011
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.001	0.0024	0.0013
Echinococcus granulosus	calcium activated potassium channel	0.0011	0.0031	0.0026
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.001	0.0024	0.0017
Echinococcus multilocularis	hyperpolarization activated cyclic	0.001	0.0024	0.0011
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0029	0.0203	0.0301
Brugia malayi	MIR domain containing protein	0.011	0.0958	0.0946
Loa Loa (eye worm)	voltage-dependent calcium channel	0.001	0.0024	0.0017
Entamoeba histolytica	protein kinase, putative	0.0022	0.0132	0.1133
Trypanosoma brucei	cdc2-related kinase 1	0.003	0.0208	0.0357
Echinococcus granulosus	two pore calcium channel protein 1	0.001	0.0024	0.0011
Echinococcus granulosus	two pore calcium channel protein 2	0.001	0.0024	0.0011
Brugia malayi	phospholipase C homolog	0.0039	0.0289	0.0276
Echinococcus multilocularis	transient receptor potential cation channel	0.001	0.0024	0.0011
Schistosoma mansoni	inositol 145-trisphosphate receptor	0.087	0.8123	1
Plasmodium vivax	cyclin, putative	0.0018	0.0093	0.3693
Echinococcus multilocularis	transient receptor potential cation channel	0.001	0.0024	0.0011
Schistosoma mansoni	phospholipase C-like protein 2 plc-L2	0.0039	0.0289	0.034
Schistosoma mansoni	two-pore calcium channel	0.001	0.0024	0.0013
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0022	0.0132	0.0188
Echinococcus granulosus	voltage dependent calcium channel	0.001	0.0024	0.0011
Echinococcus granulosus	serine threonine protein kinase nrc	0.0011	0.0026	0.0016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0164	0.1711
Brugia malayi	phospholipase C homolog	0.0014	0.0058	0.0045
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.001	0.0024	0.0011
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0034	0.0246	0.0407
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.001	0.0024	0.0011
Echinococcus granulosus	potassium large conductance calcium activated	0.001	0.0024	0.0011
Echinococcus granulosus	short transient receptor potential channel 6	0.001	0.0024	0.0011
Leishmania major	phosphatidylinositol-specific phospholipase-like protein	0.0022	0.0133	0.0325
Echinococcus multilocularis	1 phosphatidylinositol 4,5 bisphosphate	0.0053	0.0421	0.0871
Echinococcus multilocularis	cytohesin 1	0.015	0.1334	0.2846
Trypanosoma brucei	cdc2-related kinase 3	0.003	0.0208	0.0357
Brugia malayi	ion channel NompC	0.001	0.0024	0.0011
Trichomonas vaginalis	1-phosphatidylinositol phosphodiesterase, putative	0.0009	0.0013	0.0135
Schistosoma mansoni	phospholipase C-like protein 2 plc-L2	0.0014	0.0058	0.0056
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0025	0.0164	0.3169
Brugia malayi	p70 ribosomal S6 kinase beta	0.0016	0.0074	0.0061
Brugia malayi	Voltage-gated calcium channel, alpha subunit	0.001	0.0024	0.0011
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0016	0.0074	0.0096
Loa Loa (eye worm)	ion channel NompC	0.001	0.0024	0.0017
Echinococcus multilocularis	potassium voltage gated channel protein	0.001	0.0024	0.0011
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.001	0.0024	0.0011
Brugia malayi	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4	0.0051	0.0409	0.0396
Schistosoma mansoni	voltage-gated cation channel	0.001	0.0024	0.0013
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.003	0.0208	0.0529
Schistosoma mansoni	voltage-gated potassium channel	0.001	0.0024	0.0013
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0099	0.103
Schistosoma mansoni	voltage-gated potassium channel	0.001	0.0024	0.0013
Schistosoma mansoni	serine/threonine-protein kinase	0.0017	0.0084	0.0088
Trichomonas vaginalis	CMGC family protein kinase	0.003	0.0208	0.2173
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0011	0.0033	0.0017
Schistosoma mansoni	serine/threonine protein kinase	0.003	0.0208	0.0241
Schistosoma mansoni	ryanodine receptor 1 skeletal muscle	0.0189	0.1705	0.2087
Loa Loa (eye worm)	hypothetical protein	0.0569	0.5288	0.8332
Echinococcus multilocularis	cyclin dependent kinase 5	0.003	0.0208	0.041
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0115	0.1203
Schistosoma mansoni	voltage-gated potassium channel	0.001	0.0024	0.0013
Echinococcus granulosus	cyclin dependent kinase	0.003	0.0208	0.041
Echinococcus multilocularis	two pore calcium channel protein 1	0.001	0.0024	0.0011
Echinococcus multilocularis	transient receptor potential cation channel	0.001	0.0024	0.0011
Echinococcus multilocularis	transfer RNA-Gly	0.001	0.0024	0.0011
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.001	0.0024	0.0029
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0011	0.0033	0.0055
Loa Loa (eye worm)	hypothetical protein	0.001	0.0024	0.0017
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0014	0.0059	0.0084
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0098	0.1027
Loa Loa (eye worm)	phosphatidylinositol 3	0.0034	0.0246	0.0368
Echinococcus granulosus	transient receptor potential cation channel	0.001	0.0024	0.0011
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.015	0.1334	0.1629
Entamoeba histolytica	protein kinase, putative	0.0022	0.0132	0.1133
Loa Loa (eye worm)	Plcb4 protein	0.0051	0.0409	0.0625
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0246	0.2568
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0034	0.0246	0.0632
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.001	0.0024	0.0011
Trypanosoma cruzi	Protein kinase B	0.0017	0.0084	0.0111
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0199	0.2079
Onchocerca volvulus		0.001	0.0024	0.0115
Echinococcus granulosus	shaker cognate	0.001	0.0024	0.0011
Echinococcus multilocularis	potassium voltage gated channel protein	0.001	0.0024	0.0011
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0099	0.103
Schistosoma mansoni	serine/threonine-protein kinase	0.0017	0.0084	0.0088
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.001	0.0024	0.0011
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.001	0.0024	0.0011
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.001	0.0024	0.0013
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0246	0.2568
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.001	0.0024	0.0013
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0093	0.0975
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.001	0.0024	0.0011
Brugia malayi	Protein kinase domain containing protein	0.003	0.0208	0.0196
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0181	0.1884
Brugia malayi	Phosphatidylinositol-specific phospholipase C, X domain containing protein	0.0022	0.0133	0.012
Leishmania major	phosphoinositide-specific phospholipase C, putative	0.0041	0.0316	0.082
Loa Loa (eye worm)	hypothetical protein	0.001	0.0024	0.0017
Trypanosoma cruzi	cdc2-related kinase 1	0.003	0.0208	0.0338
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0134	0.1395
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.001	0.0024	0.0013
Echinococcus granulosus	ryanodine receptor 44f	0.0388	0.3582	0.7715
Trichomonas vaginalis	AGC family protein kinase	0.0037	0.0277	0.2891
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.0037	0.0277	0.0417
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.0033	0.0346
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.001	0.0024	0.0248
Loa Loa (eye worm)	hypothetical protein	0.001	0.0024	0.0017
Echinococcus granulosus	cytohesin 1	0.015	0.1334	0.2846
Brugia malayi	cell division control protein 2 homolog	0.003	0.0208	0.0196
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0181	0.1884
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.001	0.0024	0.0011
Echinococcus multilocularis	ryanodine receptor 44f	0.0388	0.3582	0.7715
Echinococcus granulosus	transient receptor potential cation channel	0.001	0.0024	0.0011
Loa Loa (eye worm)	hypothetical protein	0.001	0.0024	0.0017
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0017	0.0084	0.0111
Echinococcus granulosus	serine/threonine protein kinase	0.0017	0.0084	0.0142
Loa Loa (eye worm)	hypothetical protein	0.001	0.0024	0.0017
Schistosoma mansoni	voltage-gated potassium channel	0.001	0.0024	0.0013
Trichomonas vaginalis	1-phosphatidylinositol phosphodiesterase, putative	0.0009	0.0013	0.0135
Schistosoma mansoni	serine/threonine protein kinase	0.003	0.0208	0.0241
Echinococcus multilocularis	conserved hypothetical protein	0.001	0.0024	0.0011
Brugia malayi	Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog	0.001	0.0024	0.0011
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.001	0.0024	0.0011
Trypanosoma cruzi	inositol 1,4,5-trisphosphate receptor, putative	0.059	0.5483	1
Brugia malayi	Ryanodine Receptor TM 4-6 family protein	0.07	0.6515	0.6511
Echinococcus granulosus	transient receptor potential cation channel	0.001	0.0024	0.0011
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.0037	0.0277	0.0417
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.0033	0.0346
Loa Loa (eye worm)	phosphatidylinositol 3	0.0011	0.0033	0.0032
Giardia lamblia	GTOR	0.0034	0.0246	1
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.001	0.0024	0.0011
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0246	0.2568
Loa Loa (eye worm)	hypothetical protein	0.001	0.0024	0.0017
Echinococcus multilocularis	short transient receptor potential channel 6	0.001	0.0024	0.0011
Echinococcus granulosus	Potassium voltage gated channel protein Shaw	0.001	0.0024	0.0011
Brugia malayi	hypothetical protein	0.001	0.0024	0.0011
Schistosoma mansoni	voltage-gated potassium channel	0.001	0.0024	0.0013
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0034	0.0246	0.0426
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.001	0.0024	0.0011
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.003	0.0208	0.0529
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0011	0.0033	0.002
Echinococcus granulosus	hyperpolarization activated cyclic	0.001	0.0024	0.0011
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.001	0.0024	0.0011
Brugia malayi	cation channel family protein	0.001	0.0024	0.0011
Trypanosoma cruzi	phosphoinositide-specific phospholipase C, putative	0.0043	0.0328	0.0557
Brugia malayi	voltage-dependent calcium channel	0.001	0.0024	0.0011
Loa Loa (eye worm)	hypothetical protein	0.05	0.4638	0.7306
Brugia malayi	Phosphatidylinositol-specific phospholipase C, X domain containing protein	0.0077	0.0649	0.0637
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0034	0.0246	0.0492
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.001	0.0024	0.0011
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0164	0.1711
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.003	0.0208	0.041
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0201	0.0297
Trichomonas vaginalis	CMGC family protein kinase	0.003	0.0208	0.2173
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0117	0.1223
Echinococcus granulosus	potassium voltage gated channel protein	0.001	0.0024	0.0011
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0034	0.0246	0.0632
Echinococcus multilocularis	voltage dependent calcium channel	0.001	0.0024	0.0011
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.001	0.0024	0.0011
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0011	0.0026	0.0004
Schistosoma mansoni	ryanodine receptor related	0.07	0.6515	0.8018
Loa Loa (eye worm)	phosphatidylinositol-specific phospholipase C	0.0077	0.0649	0.1005
Schistosoma mansoni	voltage-gated potassium channel	0.001	0.0024	0.0013
Echinococcus granulosus	transient receptor potential gamma protein	0.001	0.0024	0.0011
Loa Loa (eye worm)	voltage-gated potassium channel	0.001	0.0024	0.0017
Schistosoma mansoni	voltage-gated potassium channel	0.001	0.0024	0.0013
Echinococcus granulosus	short transient receptor potential channel 6	0.001	0.0024	0.0011
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.001	0.0024	0.0011
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.001	0.0024	0.0011
Echinococcus granulosus	1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4	0.0053	0.0421	0.0871
Echinococcus granulosus	transient receptor potential cation channel	0.001	0.0024	0.0011
Brugia malayi	phosphoinositide-dependent protein kinase I	0.0037	0.0277	0.0264
Loa Loa (eye worm)	hypothetical protein	0.001	0.0024	0.0017
Giardia lamblia	Kinase, CMGC CDK	0.003	0.0208	0.8278
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.001	0.0024	0.0017
Echinococcus multilocularis	hyperpolarization activated cyclic	0.001	0.0024	0.0011
Echinococcus granulosus	hyperpolarization activated cyclic	0.001	0.0024	0.0011
Schistosoma mansoni	transient receptor potential channel	0.001	0.0024	0.0013
Echinococcus multilocularis	calcium activated potassium channel	0.0011	0.0031	0.0026
Echinococcus multilocularis	potassium large conductance calcium activated	0.001	0.0024	0.0011
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.001	0.0024	0.0013
Echinococcus multilocularis	cyclin dependent kinase 1	0.003	0.0208	0.041

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3496292

Bibliographic References

No literature references available for this target.

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Detailed information for compound 2069268