TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 288.345 | Formula: C15H20N4O2
H donors: 0 H acceptors: 3 LogP: 1.86 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Cc1noc(c1)C(=O)N1CCCC1Cn1nc(cc1C)C
InChi: 1S/C15H20N4O2/c1-10-7-12(3)19(16-10)9-13-5-4-6-18(13)15(20)14-8-11(2)17-21-14/h7-8,13H,4-6,9H2,1-3H3
InChiKey: XIVXLPOTYXCYSR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0058	0.0515	0.1067
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0058	0.0515	0.1067
Echinococcus multilocularis	neuropeptide receptor A26	0.0558	1	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0058	0.0515	0.0965
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0064	0.0638	0.132
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0058	0.0515	0.1067
Loa Loa (eye worm)	TAR-binding protein	0.0074	0.0828	0.1713
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0035	0.0085	0.0085
Schistosoma mansoni	lamin	0.0064	0.0638	0.0904
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0031	0.0009	0.0009
Entamoeba histolytica	hypothetical protein	0.0086	0.1044	0.5
Echinococcus granulosus	geminin	0.0403	0.7057	0.7057
Brugia malayi	TAR-binding protein	0.0074	0.0828	0.1713
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0515	0.1067
Echinococcus granulosus	FTZ F1 alpha	0.0058	0.0515	0.0515
Brugia malayi	Pre-SET motif family protein	0.0035	0.0085	0.0176
Onchocerca volvulus	Protein ultraspiracle homolog	0.0058	0.0515	0.0965
Echinococcus granulosus	tar DNA binding protein	0.0074	0.0828	0.0828
Entamoeba histolytica	hypothetical protein	0.0086	0.1044	0.5
Echinococcus multilocularis	ecdysone induced protein 78C	0.0058	0.0515	0.0515
Brugia malayi	hypothetical protein	0.0086	0.1044	0.216
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0058	0.0515	0.1067
Echinococcus granulosus	intermediate filament protein	0.0064	0.0638	0.0638
Schistosoma mansoni	intermediate filament proteins	0.0064	0.0638	0.0904
Schistosoma mansoni	hypothetical protein	0.0058	0.0526	0.0745
Echinococcus multilocularis	survival motor neuron protein 1	0.0286	0.4832	0.4832
Brugia malayi	photoreceptor-specific nuclear receptor	0.0058	0.0515	0.1067
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0058	0.0515	0.0515
Plasmodium vivax	SET domain protein, putative	0.0035	0.0085	0.5
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0009	0.0019
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0035	0.0085	0.5
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0085	0.012
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0058	0.0515	0.1067
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0058	0.0515	0.073
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0175	0.2741	0.2741
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0058	0.0515	0.0515
Loa Loa (eye worm)	hypothetical protein	0.0286	0.4832	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0086	0.1044	0.1044
Schistosoma mansoni	ankyrin 23/unc44	0.0034	0.007	0.01
Mycobacterium tuberculosis	Probable aminotransferase	0.0184	0.29	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0034	0.007	0.0146
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0058	0.0515	0.1067
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0034	0.006	0.006
Brugia malayi	Nuclear hormone receptor-like 1	0.0058	0.0515	0.1067
Echinococcus multilocularis	tar DNA binding protein	0.0074	0.0828	0.0828
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.0828	0.1173
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.0828	0.1173
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0085	0.0176
Entamoeba histolytica	hypothetical protein	0.0086	0.1044	0.5
Schistosoma mansoni	hypothetical protein	0.0034	0.007	0.01
Schistosoma mansoni	hypothetical protein	0.0403	0.7057	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0058	0.0515	0.073
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0058	0.0515	0.0515
Brugia malayi	Death domain containing protein	0.0034	0.007	0.0146
Schistosoma mansoni	netrin receptor unc5	0.0034	0.007	0.01
Mycobacterium leprae	PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA	0.0184	0.29	0.5
Schistosoma mansoni	transcription factor LCR-F1	0.0086	0.1044	0.1479
Echinococcus multilocularis	lamin dm0	0.0064	0.0638	0.0638
Trichomonas vaginalis	set domain proteins, putative	0.0277	0.4677	1
Onchocerca volvulus	Bile acid receptor homolog	0.0058	0.0515	0.0965
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0058	0.0515	0.1067
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0058	0.0515	0.1067
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0058	0.0515	0.0515
Echinococcus multilocularis	neuropeptide s receptor	0.0558	1	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0074	0.0828	0.1713
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.0828	0.1173
Brugia malayi	cytoplasmic intermediate filament protein	0.0034	0.0074	0.0152
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0058	0.0515	0.1067
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0058	0.0515	0.0515
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0515	0.1067
Echinococcus granulosus	Ankyrin	0.0034	0.0076	0.0076
Echinococcus granulosus	histone lysine methyltransferase setb	0.0035	0.0085	0.0085
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0058	0.0515	0.1067
Loa Loa (eye worm)	hypothetical protein	0.0034	0.007	0.0146
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0035	0.0085	0.0085
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0034	0.007	0.007
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0058	0.0515	0.073
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0058	0.0526	0.1089
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0244	0.4039	0.836
Schistosoma mansoni	thyroid hormone receptor	0.0058	0.0515	0.073
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0058	0.0515	0.0515
Brugia malayi	bHLH-PAS transcription factor	0.0043	0.0246	0.051
Schistosoma mansoni	single-minded	0.0059	0.0535	0.0759
Echinococcus granulosus	death domain containing protein	0.0034	0.007	0.007
Brugia malayi	Steroid receptor seven-up type 2	0.0058	0.0515	0.1067
Echinococcus multilocularis	geminin	0.0403	0.7057	0.7057
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0615	0.1274
Echinococcus granulosus	survival motor neuron protein 1	0.0286	0.4832	0.4832
Schistosoma mansoni	nuclear hormone receptor	0.0058	0.0515	0.073
Echinococcus multilocularis	musashi	0.0064	0.0638	0.0638
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0058	0.0515	0.073
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0034	0.0074	0.0152
Echinococcus granulosus	neuropeptide receptor A26	0.0558	1	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0058	0.0515	0.0515
Schistosoma mansoni	thyroid hormone receptor	0.0058	0.0515	0.073
Echinococcus granulosus	lamin	0.0064	0.0638	0.0638
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0638	0.132
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0058	0.0515	0.073
Mycobacterium ulcerans	hypothetical protein	0.0184	0.29	1
Onchocerca volvulus		0.0058	0.0515	0.0965
Brugia malayi	RNA recognition motif domain containing protein	0.0074	0.0828	0.1713
Loa Loa (eye worm)	intermediate filament protein	0.0064	0.0638	0.132
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0086	0.1044	0.1044
Brugia malayi	hypothetical protein	0.0197	0.3156	0.6532
Loa Loa (eye worm)	steroid hormone receptor	0.0058	0.0515	0.1067
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0058	0.0515	0.073
Loa Loa (eye worm)	hypothetical protein	0.0197	0.3156	0.6532
Echinococcus granulosus	netrin receptor unc 5	0.0034	0.007	0.007
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0058	0.0515	0.1067
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0058	0.0515	0.0515
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0515	0.1067
Schistosoma mansoni	hypothetical protein	0.0086	0.1044	0.1479
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0058	0.0515	0.0515
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0515	0.1067
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0515	0.1067
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0058	0.0515	0.1067
Brugia malayi	hypoxia-induced factor 1	0.0182	0.2867	0.5933
Onchocerca volvulus		0.0278	0.4682	1
Brugia malayi	steroid hormone receptor	0.0058	0.0515	0.1067
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0515	0.1067
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0034	0.007	0.0146
Echinococcus multilocularis	transfer RNA-Lys	0.0043	0.0246	0.0246
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0058	0.0515	0.0515
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0058	0.0515	0.073
Onchocerca volvulus		0.0043	0.0246	0.0381
Schistosoma mansoni	RAR-like nuclear receptor	0.0058	0.0515	0.073
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0058	0.0515	0.1067
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0058	0.0515	0.1067
Schistosoma mansoni	lamin	0.0064	0.0638	0.0904
Brugia malayi	ecdysteroid receptor	0.0058	0.0515	0.1067
Echinococcus granulosus	ecdysone induced protein 78C	0.0058	0.0515	0.0515
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0058	0.0515	0.073
Brugia malayi	nuclear receptor NHR-88	0.0058	0.0515	0.1067
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0515	0.1067
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0035	0.0085	0.012
Entamoeba histolytica	hypothetical protein	0.0086	0.1044	0.5
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0515	0.1067
Echinococcus multilocularis	lamin	0.0064	0.0638	0.0638
Mycobacterium tuberculosis	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA	0.0184	0.29	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.0828	0.1173
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0058	0.0515	0.1067
Brugia malayi	Protein kinase domain containing protein	0.0034	0.007	0.0146
Onchocerca volvulus		0.0058	0.0526	0.0988
Schistosoma mansoni	aryl hydrocarbon receptor	0.0059	0.0535	0.0759
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.0828	0.1173
Echinococcus multilocularis	Ankyrin	0.0034	0.0076	0.0076
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0058	0.0515	0.1067
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0058	0.0515	0.1067
Onchocerca volvulus		0.0035	0.0085	0.0031
Schistosoma mansoni	coup transcription factor	0.0058	0.0515	0.073
Schistosoma mansoni	hypothetical protein	0.0403	0.7057	1
Echinococcus granulosus	single minded 2	0.0043	0.0246	0.0246
Onchocerca volvulus		0.0064	0.0638	0.123
Brugia malayi	Pre-SET motif family protein	0.0244	0.4039	0.836
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0058	0.0515	0.0515
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0058	0.0515	0.0515
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0031	0.0009	0.0009
Echinococcus multilocularis	FTZ F1 alpha	0.0058	0.0515	0.0515
Brugia malayi	hypothetical protein	0.0286	0.4832	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0058	0.0515	0.1067
Onchocerca volvulus		0.0064	0.0638	0.123
Brugia malayi	Uncoordinated protein 44	0.0034	0.007	0.0146
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0058	0.0515	0.1067
Brugia malayi	PAS domain containing protein	0.0059	0.0535	0.1108
Brugia malayi	intermediate filament protein	0.0064	0.0638	0.132
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0076	0.0157
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0085	0.012
Brugia malayi	Intermediate filament tail domain containing protein	0.0064	0.0638	0.132
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0034	0.007	0.007
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0034	0.0076	0.0108
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0175	0.2741	0.2741
Echinococcus granulosus	lamin dm0	0.0064	0.0638	0.0638
Mycobacterium ulcerans	adenosylmethionine-8-amino-7-oxononanoate aminotransferase	0.0184	0.29	1
Schistosoma mansoni	survival motor neuron protein	0.0058	0.0526	0.0745
Brugia malayi	nuclear hormone receptor	0.0058	0.0515	0.1067
Brugia malayi	RNA binding protein	0.0074	0.0828	0.1713
Echinococcus multilocularis	netrin receptor unc 5	0.0034	0.007	0.007
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0085	0.012
Loa Loa (eye worm)	RNA binding protein	0.0074	0.0828	0.1713
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0058	0.0515	0.1067
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0058	0.0515	0.0515
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0058	0.0515	0.0515
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0182	0.2867	0.5933

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3496538

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 2069891