Detailed information for compound 2070134

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 317.406 | Formula: C16H19N3O2S
  • H donors: 1 H acceptors: 2 LogP: 1.98 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ncccc1CNC(=O)N1CCCC1c1cscc1
  • InChi: 1S/C16H19N3O2S/c1-21-15-12(4-2-7-17-15)10-18-16(20)19-8-3-5-14(19)13-6-9-22-11-13/h2,4,6-7,9,11,14H,3,5,8,10H2,1H3,(H,18,20)
  • InChiKey: OFQCOOACFVGJRL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0007 0.0069 0.0073
Mycobacterium ulcerans aldehyde dehydrogenase 0.0027 0.1429 1
Schistosoma mansoni cell adhesion molecule 0.0007 0.0029 0.0048
Echinococcus multilocularis ecdysone induced protein 78C 0.0027 0.1424 0.1424
Loa Loa (eye worm) hypothetical protein 0.0027 0.1424 0.149
Echinococcus multilocularis netrin receptor unc 5 0.0008 0.0113 0.0113
Trypanosoma cruzi cysteine peptidase, putative 0.0028 0.1524 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0027 0.1424 0.2674
Brugia malayi Steroid receptor seven-up type 2 0.0027 0.1424 0.1428
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.0541 0.0497
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0013 0.0435 0.0385
Brugia malayi orphan nuclear receptor NR2E1 0.0013 0.0435 0.0385
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0007 0.0029 0.0029
Brugia malayi Immunoglobulin I-set domain containing protein 0.0008 0.0113 0.0046
Brugia malayi follicle stimulating hormone receptor 0.0103 0.6787 0.7082
Brugia malayi hypothetical protein 0.0013 0.0435 0.0385
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0027 0.1424 0.1428
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.1524 0.5
Schistosoma mansoni coup transcription factor 0.0027 0.1424 0.2674
Loa Loa (eye worm) hypothetical protein 0.0143 0.9555 1
Onchocerca volvulus Bile acid receptor homolog 0.0027 0.1424 0.276
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0013 0.0435 0.0745
Brugia malayi Nuclear hormone receptor E75 0.0013 0.0435 0.0385
Loa Loa (eye worm) hypothetical protein 0.0013 0.0435 0.0455
Onchocerca volvulus 0.0076 0.4886 0.9813
Schistosoma mansoni jun-related protein 0.003 0.1662 0.3122
Plasmodium falciparum cysteine proteinase falcipain 3 0.0007 0.0069 0.5
Echinococcus multilocularis FTZ F1 alpha 0.0027 0.1424 0.1424
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0007 0.0069 0.5
Echinococcus granulosus cathepsin L cysteine proteinase 0.0007 0.0069 0.0069
Loa Loa (eye worm) DR-78 0.0013 0.0435 0.0455
Schistosoma mansoni steroid hormone receptor ad4bp 0.0027 0.1424 0.2674
Leishmania major cathepsin L-like protease 0.0028 0.1524 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0069 0.5
Echinococcus multilocularis neuroglian 0.0006 0.0003 0.0003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.1524 0.5
Brugia malayi Nuclear hormone receptor E75 0.0013 0.0435 0.0385
Onchocerca volvulus Protein ultraspiracle homolog 0.0027 0.1424 0.276
Loa Loa (eye worm) hypothetical protein 0.0008 0.012 0.0126
Loa Loa (eye worm) hypothetical protein 0.0013 0.0435 0.0455
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0027 0.1424 0.149
Onchocerca volvulus 0.0029 0.1591 0.3099
Echinococcus multilocularis cathepsin L cysteine protease 0.0007 0.0069 0.0069
Schistosoma mansoni netrin receptor unc5 0.0008 0.0113 0.0208
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.1524 0.5
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0055 0.3444 0.3444
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0007 0.0069 0.5
Brugia malayi ecdysteroid receptor 0.0027 0.1424 0.1428
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0014 0.0541 0.0541
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0013 0.0435 0.0455
Schistosoma mansoni RAR-like nuclear receptor 0.0027 0.1424 0.2674
Loa Loa (eye worm) hypothetical protein 0.0014 0.0541 0.0566
Onchocerca volvulus 0.0027 0.1424 0.276
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.1524 0.5
Schistosoma mansoni aldehyde dehydrogenase 0.0027 0.1429 0.2684
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0027 0.1429 0.1429
Brugia malayi bHLH-PAS transcription factor 0.0016 0.0665 0.0628
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.1524 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0028 0.1524 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0007 0.0069 0.0069
Onchocerca volvulus 0.0013 0.0435 0.0745
Leishmania major cathepsin L-like protease 0.0028 0.1524 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0007 0.0069 0.0073
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0069 0.5
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.1424 0.1428
Loa Loa (eye worm) hypothetical protein 0.0027 0.1424 0.149
Plasmodium vivax vivapain-2 0.0007 0.0069 0.5
Schistosoma mansoni hypothetical protein 0.0016 0.0664 0.1244
Mycobacterium ulcerans aldehyde dehydrogenase 0.0027 0.1429 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.1424 0.149
Brugia malayi hypothetical protein 0.0029 0.1591 0.1604
Loa Loa (eye worm) hypothetical protein 0.0027 0.1424 0.149
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0027 0.1424 0.2674
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0013 0.0435 0.0435
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.1524 0.5
Echinococcus multilocularis nuclear receptor nhr 48 0.0013 0.0435 0.0435
Echinococcus granulosus netrin receptor unc 5 0.0008 0.0113 0.0113
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0007 0.0069 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0007 0.0069 0.5
Brugia malayi nuclear receptor NHR-88 0.0027 0.1424 0.1428
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0016 0.0664 0.0664
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0027 0.1424 0.1428
Echinococcus multilocularis tumor protein p63 0.0149 1 1
Trypanosoma cruzi cruzipain precursor, putative 0.0028 0.1524 1
Brugia malayi hypothetical protein 0.0072 0.4598 0.4775
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.1424 0.1428
Loa Loa (eye worm) hypothetical protein 0.0013 0.0435 0.0455
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0027 0.1424 0.1428
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0027 0.1424 0.1424
Brugia malayi tailless protein 0.0013 0.0435 0.0385
Schistosoma mansoni aldehyde dehydrogenase 0.0027 0.1429 0.2684
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0014 0.0541 0.1012
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0027 0.1424 0.1424
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.1424 0.2674
Brugia malayi nuclear hormone receptor family member nhr-6 0.0013 0.0435 0.0385
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0007 0.0069 0.5
Brugia malayi photoreceptor-specific nuclear receptor 0.0027 0.1424 0.1428
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0069 0.5
Loa Loa (eye worm) hypothetical protein 0.0013 0.0435 0.0455
Schistosoma mansoni nuclear receptor nhr-48 0.0013 0.0435 0.0813
Loa Loa (eye worm) hypoxia-induced factor 1 0.0066 0.4207 0.4403
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0027 0.1424 0.276
Brugia malayi hypothetical protein 0.0013 0.0435 0.0385
Schistosoma mansoni nuclear hormone receptor 0.0013 0.0435 0.0813
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0069 0.5
Schistosoma mansoni nuclear hormone receptor 0.0027 0.1424 0.2674
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0069 0.5
Schistosoma mansoni single-minded 0.0021 0.1056 0.1981
Echinococcus granulosus FTZ F1 alpha 0.0027 0.1424 0.1424
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0027 0.1424 0.149
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0007 0.0069 0.0069
Loa Loa (eye worm) nuclear hormone receptor 0.0013 0.0435 0.0455
Giardia lamblia Hypothetical protein 0.0143 0.9555 0.5
Schistosoma mansoni nuclear receptor 0.0013 0.0435 0.0813
Brugia malayi hypothetical protein 0.0016 0.0664 0.0627
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0069 0.5
Brugia malayi bZIP transcription factor family protein 0.0037 0.2148 0.2192
Loa Loa (eye worm) ctsf protein 0.0007 0.0069 0.0073
Loa Loa (eye worm) hypothetical protein 0.0007 0.0029 0.003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0069 0.5
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0103 0.6787 0.7103
Brugia malayi nuclear receptor RXR 0.0013 0.0435 0.0385
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0013 0.0435 0.0435
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0007 0.0069 0.5
Loa Loa (eye worm) cysteine protease 0.0007 0.0069 0.0073
Loa Loa (eye worm) hypothetical protein 0.0022 0.1081 0.1131
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.1524 0.5
Loa Loa (eye worm) hypothetical protein 0.0014 0.0541 0.0566
Brugia malayi ecdysone receptor 0.0013 0.0435 0.0385
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0007 0.0069 0.5
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0014 0.0541 0.1012
Onchocerca volvulus Netrin receptor homolog 0.0008 0.0088 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0069 0.5
Brugia malayi nuclear receptor NHR-88 0.0013 0.0435 0.0385
Echinococcus granulosus nuclear receptor nhr 48 0.0013 0.0435 0.0435
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0069 0.5
Schistosoma mansoni zinc finger protein 0.0013 0.0435 0.0813
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0007 0.0069 0.5
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0014 0.0541 0.0541
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.1424 0.1428
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0007 0.0069 0.0069
Schistosoma mansoni cathepsin F (C01 family) 0.0007 0.0069 0.0125
Loa Loa (eye worm) hypothetical protein 0.0013 0.0435 0.0455
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0027 0.1424 0.149
Echinococcus granulosus Nuclear hormone receptor HR96 0.0013 0.0435 0.0435
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0027 0.1424 0.1424
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0027 0.1424 0.149
Schistosoma mansoni hypothetical protein 0.003 0.1662 0.3122
Loa Loa (eye worm) hypothetical protein 0.0027 0.1424 0.149
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.1424 0.1424
Echinococcus multilocularis roundabout 2 0.0008 0.012 0.012
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0083 0.5363 0.5613
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0013 0.0435 0.0435
Entamoeba histolytica hypothetical protein 0.0016 0.0664 1
Toxoplasma gondii aldehyde dehydrogenase 0.0027 0.1429 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0069 0.5
Echinococcus granulosus nuclear factor of activated T cells 5 0.0032 0.1829 0.1829
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0013 0.0435 0.0745
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.1424 0.1428
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0013 0.0435 0.0435
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.1424 0.1424
Echinococcus multilocularis jun protein 0.0037 0.2148 0.2148
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0013 0.0435 0.0813
Echinococcus multilocularis cysteine protease 0.0007 0.0069 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.1424 0.1428
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0027 0.1424 0.1424
Schistosoma mansoni transcription factor LCR-F1 0.0016 0.0664 0.1244
Loa Loa (eye worm) hypothetical protein 0.0014 0.0541 0.0566
Leishmania major cathepsin L-like protease 0.0028 0.1524 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0022 0.1102 0.7098
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0027 0.1429 0.1429
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.1424 0.1428
Echinococcus granulosus single minded 2 0.0016 0.0665 0.0665
Echinococcus granulosus cathepsin l cysteine peptidase 0.0007 0.0069 0.0069
Loa Loa (eye worm) fibroinase 0.0007 0.0069 0.0073
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.1524 0.5
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0027 0.1429 0.5
Echinococcus granulosus thyroid hormone receptor alpha 0.0013 0.0435 0.0435
Entamoeba histolytica hypothetical protein 0.0016 0.0664 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.1424 0.1424
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0037 0.2148 0.2148
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0027 0.1424 0.1424
Brugia malayi steroid hormone receptor 0.0027 0.1424 0.1428
Loa Loa (eye worm) hypothetical protein 0.0013 0.0435 0.0455
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0016 0.0664 0.0664
Brugia malayi conserved hypotetical protein 0.0013 0.0435 0.0385
Loa Loa (eye worm) hypothetical protein 0.0027 0.1424 0.149
Echinococcus multilocularis transfer RNA-Lys 0.0016 0.0665 0.0665
Schistosoma mansoni thyroid hormone receptor 0.0082 0.5317 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0435 0.0455
Entamoeba histolytica hypothetical protein 0.0016 0.0664 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0013 0.0435 0.0435
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0013 0.0435 0.0435
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.1524 0.5
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0027 0.1424 0.1428
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0027 0.1424 0.1428
Echinococcus granulosus jun protein 0.0037 0.2148 0.2148
Schistosoma mansoni cathepsin F (C01 family) 0.0007 0.0069 0.0125
Echinococcus multilocularis cysteine protease 0.0007 0.0069 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.1424 0.1428
Brugia malayi Fibroblast growth factor family protein 0.0143 0.9555 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0013 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.0013 0.0435 0.0455
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0032 0.1829 0.1829
Brugia malayi hypothetical protein 0.0014 0.0541 0.0497
Loa Loa (eye worm) hypothetical protein 0.0014 0.0541 0.0566
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0014 0.0541 0.0566
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0027 0.1424 0.1424
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0027 0.1424 0.149
Echinococcus granulosus cathepsin l1 0.0007 0.0069 0.0069
Schistosoma mansoni hypothetical protein 0.0055 0.3444 0.6476
Loa Loa (eye worm) hypothetical protein 0.0013 0.0435 0.0455
Brugia malayi nuclear hormone receptor 0.0027 0.1424 0.1428
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0013 0.0435 0.0813
Onchocerca volvulus 0.0016 0.0665 0.1213
Schistosoma mansoni aryl hydrocarbon receptor 0.0021 0.1056 0.1981
Brugia malayi nuclear hormone receptor 0.0013 0.0435 0.0385
Schistosoma mansoni cellular tumor antigen P53 0.0022 0.1081 0.2028
Brugia malayi PAS domain containing protein 0.0021 0.1056 0.104
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.1424 0.1424
Loa Loa (eye worm) hypothetical protein 0.0013 0.0435 0.0455
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0027 0.1424 0.1424
Mycobacterium ulcerans aldehyde dehydrogenase 0.0027 0.1429 1
Schistosoma mansoni nuclear receptor 0.0013 0.0435 0.0813
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0037 0.2148 0.2148
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0069 0.5
Brugia malayi hypoxia-induced factor 1 0.0066 0.4207 0.4362
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0027 0.1424 0.1424
Onchocerca volvulus 0.0022 0.1081 0.2061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0069 0.5
Brugia malayi nuclear receptor RXR 0.0014 0.0541 0.0497
Loa Loa (eye worm) hypothetical protein 0.0072 0.4598 0.4813
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0027 0.1424 0.1424
Loa Loa (eye worm) hypothetical protein 0.0027 0.1424 0.149
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0026 0.1353 0.8824
Schistosoma mansoni thyroid hormone receptor 0.0082 0.5317 1
Entamoeba histolytica hypothetical protein 0.0016 0.0664 1
Brugia malayi nuclear receptor NHR-67 0.0013 0.0435 0.0385
Loa Loa (eye worm) hypothetical protein 0.0013 0.0435 0.0455
Echinococcus multilocularis thyroid hormone receptor alpha 0.0082 0.5317 0.5317
Echinococcus granulosus ecdysone induced protein 78C 0.0027 0.1424 0.1424
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0027 0.1424 0.2674
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.1524 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.1524 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0013 0.0435 0.0435
Brugia malayi hypothetical protein 0.0014 0.0541 0.0497
Brugia malayi Fibroblast growth factor family protein 0.0143 0.9555 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0541 0.0566
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0027 0.1424 0.1428
Onchocerca volvulus 0.0013 0.0435 0.0745
Loa Loa (eye worm) hypothetical protein 0.0036 0.2077 0.2174
Loa Loa (eye worm) hypothetical protein 0.0013 0.0435 0.0455
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0007 0.0069 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0069 0.5
Echinococcus granulosus roundabout 2 0.0008 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0013 0.0435 0.0455
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0027 0.1424 0.1428
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0027 0.1429 0.9347
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0007 0.0069 0.5
Loa Loa (eye worm) hypothetical protein 0.0027 0.1424 0.149
Onchocerca volvulus Tyrosine kinase homolog 0.0077 0.4978 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0007 0.0069 0.5
Loa Loa (eye worm) hypothetical protein 0.0008 0.012 0.0126
Plasmodium vivax vivapain-2 0.0007 0.0069 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0007 0.0069 0.5
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0055 0.3444 0.3444
Loa Loa (eye worm) hypothetical protein 0.0143 0.9555 1
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.0541 0.0497
Brugia malayi nuclear hormone receptor family member odr-7 0.0013 0.0435 0.0385
Brugia malayi Immunoglobulin I-set domain containing protein 0.0083 0.5363 0.5581
Schistosoma mansoni retinoic acid receptor RXR 0.0027 0.1424 0.2674
Loa Loa (eye worm) hypothetical protein 0.0007 0.0069 0.0073
Echinococcus granulosus twitchin 0.0006 0.0003 0.0003
Loa Loa (eye worm) nuclear receptor NHR-67 0.0013 0.0435 0.0455
Echinococcus granulosus neuroglian 0.0006 0.0003 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0027 0.1424 0.149
Loa Loa (eye worm) steroid hormone receptor 0.0027 0.1424 0.149
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0069 0.5
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0027 0.1424 0.2674
Schistosoma mansoni nuclear hormone receptor 0.0013 0.0435 0.0813
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0027 0.1424 0.149
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0027 0.1424 0.2674
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0007 0.0069 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0028 0.1524 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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