Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.3663 | 0.6308 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0201 | 0.0191 |
Brugia malayi | Trehalase family protein | 0.0153 | 0.0201 | 0.0191 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.5284 | 0.9128 | 0.9121 |
Loa Loa (eye worm) | alpha-L-fucosidase | 0.3498 | 0.6021 | 0.6586 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0589 | 0.0961 | 0.3551 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0105 | 0.0118 | 0.0245 |
Onchocerca volvulus | 0.0153 | 0.0201 | 0.0234 | |
Loa Loa (eye worm) | trehalase | 0.0153 | 0.0201 | 0.0191 |
Trypanosoma brucei | glycosyl hydrolase-like protein | 0.0523 | 0.0846 | 0.8724 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0523 | 0.0846 | 0.3102 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0589 | 0.0961 | 0.3551 |
Echinococcus granulosus | beta galactosidase | 0.077 | 0.1275 | 0.12 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0589 | 0.0961 | 0.0884 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.5284 | 0.9128 | 0.9121 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0589 | 0.0961 | 0.3551 |
Echinococcus multilocularis | beta galactosidase | 0.077 | 0.1275 | 0.12 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0105 | 0.0118 | 0.0245 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0523 | 0.0846 | 0.3102 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0589 | 0.0961 | 0.5 |
Brugia malayi | carbohydrate phosphorylase | 0.0085 | 0.0084 | 0.0062 |
Onchocerca volvulus | 0.0153 | 0.0201 | 0.0234 | |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0085 | 0.0084 | 0.0062 |
Loa Loa (eye worm) | hypothetical protein | 0.0523 | 0.0846 | 0.0899 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0105 | 0.0118 | 0.0245 |
Schistosoma mansoni | alpha-l-fucosidase | 0.3498 | 0.6021 | 0.668 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0105 | 0.0118 | 0.0245 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0589 | 0.0961 | 1 |
Leishmania major | glycosyl hydrolase-like protein | 0.0523 | 0.0846 | 0.8724 |
Mycobacterium leprae | Possible hydrolase | 0.0074 | 0.0065 | 0.5 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0589 | 0.0961 | 0.3551 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.1534 | 0.2605 | 1 |
Mycobacterium ulcerans | alpha-L-fucosidase | 0.5785 | 1 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0085 | 0.0084 | 0.0094 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0523 | 0.0846 | 0.3102 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0105 | 0.0118 | 0.0099 |
Loa Loa (eye worm) | TRE-1 protein | 0.0153 | 0.0201 | 0.0191 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0105 | 0.0118 | 0.0245 |
Trypanosoma brucei | glucosidase, putative | 0.0589 | 0.0961 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0085 | 0.0084 | 0.0094 |
Loa Loa (eye worm) | trehalase | 0.0153 | 0.0201 | 0.0191 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0085 | 0.0084 | 0.0877 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.1534 | 0.2605 | 1 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0523 | 0.0846 | 0.8724 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0589 | 0.0961 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0153 | 0.0201 | 0.0573 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0589 | 0.0961 | 0.0884 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0523 | 0.0846 | 0.3102 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.5284 | 0.9128 | 1 |
Brugia malayi | Alpha-L-fucosidase family protein | 0.3498 | 0.6021 | 0.6586 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0589 | 0.0961 | 0.3551 |
Schistosoma mansoni | beta-galactosidase | 0.077 | 0.1275 | 0.1414 |
Loa Loa (eye worm) | hypothetical protein | 0.077 | 0.1275 | 0.137 |
Mycobacterium tuberculosis | Conserved protein | 0.0074 | 0.0065 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0235 | 0.0345 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0105 | 0.0118 | 0.0245 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0523 | 0.0846 | 0.8809 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0523 | 0.0846 | 0.8724 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0589 | 0.0961 | 0.3551 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0072 | 0.0062 | 0.0025 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0589 | 0.0961 | 0.3551 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0201 | 0.0191 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0085 | 0.0084 | 0.0877 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0589 | 0.0961 | 0.3551 |
Giardia lamblia | Glycogen phosphorylase | 0.0085 | 0.0084 | 0.5 |
Onchocerca volvulus | Trehalase homolog | 0.0153 | 0.0201 | 0.0234 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0085 | 0.0084 | 0.0047 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0085 | 0.0084 | 0.0114 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0201 | 0.0191 |
Schistosoma mansoni | alpha-glucosidase | 0.5218 | 0.9014 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0523 | 0.0846 | 0.3102 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0523 | 0.0846 | 0.3102 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0201 | 0.0191 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0523 | 0.0846 | 0.3102 |
Schistosoma mansoni | alpha glucosidase | 0.0589 | 0.0961 | 0.1066 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0105 | 0.0118 | 0.0099 |
Brugia malayi | hypothetical protein | 0.0153 | 0.0201 | 0.0191 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0589 | 0.0961 | 0.1025 |
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 0.5785 | 1 | 1 |
Trichomonas vaginalis | trehalase, putative | 0.0153 | 0.0201 | 0.0573 |
Onchocerca volvulus | 0.0153 | 0.0201 | 0.0234 | |
Onchocerca volvulus | 0.0153 | 0.0201 | 0.0234 | |
Schistosoma mansoni | alpha-glucosidase | 0.5218 | 0.9014 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0201 | 0.0191 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0589 | 0.0961 | 1 |
Brugia malayi | Trehalase family protein | 0.0153 | 0.0201 | 0.0191 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.5284 | 0.9128 | 0.9121 |
Treponema pallidum | hypothetical protein | 0.0053 | 0.0028 | 0.5 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0085 | 0.0084 | 0.5 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0589 | 0.0961 | 0.1025 |
Loa Loa (eye worm) | hypothetical protein | 0.077 | 0.1275 | 0.137 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0523 | 0.0846 | 0.3102 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.5284 | 0.9128 | 1 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0589 | 0.0961 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0085 | 0.0084 | 0.0114 |
Loa Loa (eye worm) | trehalase | 0.0153 | 0.0201 | 0.0191 |
Plasmodium vivax | hypothetical protein, conserved | 0.0235 | 0.0345 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0072 | 0.0062 | 0.0025 |
Onchocerca volvulus | Uncharacterized family 31 glucosidase KIAA1161 homolog | 0.0523 | 0.0846 | 0.1265 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0589 | 0.0961 | 0.3551 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0589 | 0.0961 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0523 | 0.0846 | 0.0899 |
Onchocerca volvulus | 0.0153 | 0.0201 | 0.0234 | |
Mycobacterium ulcerans | glycosyl hydrolase | 0.0074 | 0.0065 | 0.0065 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.0109 | 0.009 |
Loa Loa (eye worm) | TRE-2 protein | 0.0153 | 0.0201 | 0.0191 |
Brugia malayi | Trehalase family protein | 0.0153 | 0.0201 | 0.0191 |
Brugia malayi | Trehalase family protein | 0.0153 | 0.0201 | 0.0191 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.