Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.019 | 0.2267 | 1 |
Trypanosoma brucei | Emopamil binding protein, putative | 0.0147 | 0.1575 | 0.69 |
Schistosoma mansoni | Lamin B receptor (ERG24) | 0.005 | 0.0036 | 0.0036 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.2267 | 0.3198 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.1092 | 0.4801 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.019 | 0.2267 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.019 | 0.2267 | 0.5 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.019 | 0.2267 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0006 | 0.0009 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.019 | 0.2267 | 0.5 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0673 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0147 | 0.1575 | 0.69 |
Brugia malayi | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 0.019 | 0.2267 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.033 | 0.4502 | 0.4483 |
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 0.7089 | 1 |
Trypanosoma cruzi | Emopamil binding protein, putative | 0.0147 | 0.1575 | 0.69 |
Leishmania major | 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative | 0.0147 | 0.1575 | 0.69 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.1092 | 0.154 |
Trypanosoma cruzi | 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative | 0.0147 | 0.1575 | 0.69 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0006 | 0.0009 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.019 | 0.2267 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0673 | 1 | 1 |
Trypanosoma cruzi | Emopamil binding protein, putative | 0.0147 | 0.1575 | 0.69 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.019 | 0.2267 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.019 | 0.2267 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.1092 | 0.154 |
Onchocerca volvulus | 0.0147 | 0.1575 | 1 | |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.019 | 0.2267 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.033 | 0.4502 | 0.4483 |
Trypanosoma cruzi | 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative | 0.0147 | 0.1575 | 0.69 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.019 | 0.2267 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.