TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 390.455 | Formula: C22H18N2O3S
H donors: 2 H acceptors: 3 LogP: 4.02 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: N#C/C(=C\c1cc(CSc2ccc3c(c2)cccc3)c(c(c1)OC)O)/C(=O)N
InChi: 1S/C22H18N2O3S/c1-27-20-10-14(8-17(12-23)22(24)26)9-18(21(20)25)13-28-19-7-6-15-4-2-3-5-16(15)11-19/h2-11,25H,13H2,1H3,(H2,24,26)/b17-8+
InChiKey: PWAFUGMDLMAVBQ-CAOOACKPSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	erb-b2 receptor tyrosine kinase 2	Starlite/ChEMBL	References
Homo sapiens	epidermal growth factor receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Brugia malayi	Furin-like cysteine rich region family protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	IPR000494,EGF receptor, L domain,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis		Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Tyrosine-protein kinase transforming protein erbB, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-2 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-4 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Loa Loa (eye worm)	TK/EGFR protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	ko:K05085 receptor tyrosine-protein kinase erbB-4, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0009	0.0062	0.0071
Echinococcus granulosus	epidermal growth factor receptor	0.0194	0.3826	0.3826
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0009	0.0062	0.0071
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0009	0.0062	0.0202
Loa Loa (eye worm)	cysteine protease	0.0009	0.0062	0.0086
Echinococcus multilocularis	cathepsin L cysteine protease	0.0009	0.0062	0.0062
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0011	0.0104	0.0104
Echinococcus multilocularis	calpain 5	0.0021	0.0303	0.0303
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0062	0.0202
Schistosoma mansoni	tyrosine kinase	0.0194	0.3826	0.4332
Brugia malayi	Cathepsin L-like precursor	0.0009	0.0062	0.0086
Schistosoma mansoni	calpain C (C02 family)	0.0021	0.0303	0.0343
Echinococcus granulosus	epidermal growth factor receptor	0.036	0.7221	0.7221
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0073	0.1365	0.1365
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0021	0.0303	0.0414
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0097	0.1855	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0062	0.0202
Schistosoma mansoni	cpg binding protein	0.0031	0.0511	0.0579
Echinococcus multilocularis	calpain family protein 1, d	0.0049	0.0873	0.0873
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0062	0.0086
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0011	0.0104	0.0104
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0011	0.0104	0.0104
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0104	0.0144
Echinococcus granulosus	cysteine protease	0.0009	0.0062	0.0062
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0011	0.0104	0.0104
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0011	0.0104	0.0144
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0009	0.0062	0.0071
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0011	0.0104	0.0118
Echinococcus multilocularis	FTZ F1 alpha	0.0011	0.0104	0.0104
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0009	0.0062	0.0202
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0021	0.0303	0.134
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0104	0.0144
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0293	0.5858	1
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.0039	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0104	0.0144
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0011	0.0104	0.0104
Brugia malayi	Papain family cysteine protease containing protein	0.0009	0.0062	0.0086
Schistosoma mansoni	cpg binding protein	0.0033	0.0547	0.062
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0021	0.0303	0.134
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0062	0.0202
Brugia malayi	nuclear hormone receptor	0.0011	0.0104	0.0144
Echinococcus granulosus	cathepsin l1	0.0009	0.0062	0.0062
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0009	0.0062	0.0202
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0097	0.1855	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0009	0.0062	0.0062
Loa Loa (eye worm)	ctsf protein	0.0009	0.0062	0.0086
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0011	0.0104	0.0104
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0062	0.0202
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0021	0.0303	0.0414
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0009	0.0062	0.0062
Schistosoma mansoni	retinoic acid receptor RXR	0.0011	0.0104	0.0118
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0021	0.0303	0.0414
Entamoeba histolytica	hypothetical protein	0.0039	0.067	1
Echinococcus granulosus	FTZ F1 alpha	0.0011	0.0104	0.0104
Loa Loa (eye worm)	cathepsin B	0.0097	0.1855	0.2569
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0009	0.0062	0.0071
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0078	0.0078
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0009	0.0062	0.0086
Plasmodium falciparum	serine repeat antigen 6	0.0009	0.0062	0.5
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0011	0.0104	0.0118
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0009	0.0062	0.0202
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0062	0.0202
Brugia malayi	Cathepsin L-like precursor	0.0009	0.0062	0.0086
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0115	0.2228	0.2228
Loa Loa (eye worm)	fibroinase	0.0009	0.0062	0.0086
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0062	0.0202
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0011	0.0104	0.0144
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0021	0.0303	0.0414
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0009	0.0062	0.0202
Echinococcus granulosus	dnaJ subfamily B	0.0439	0.8832	0.8832
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0062	0.0202
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0039	0.0044
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0011	0.0104	0.0144
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0039	0.0039
Plasmodium falciparum	serine repeat antigen 3	0.0009	0.0062	0.5
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0011	0.0104	0.0118
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0011	0.0104	0.0104
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0073	0.1365	0.1365
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0104	0.0118
Echinococcus granulosus	cathepsin b	0.0293	0.5858	0.5858
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.0021	0.0303	0.134
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0062	0.0202
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0009	0.0062	0.0086
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0069	0.1293	0.1464
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0009	0.0062	0.5
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0009	0.0062	0.0071
Schistosoma mansoni	RAR-like nuclear receptor	0.0011	0.0104	0.0118
Plasmodium falciparum	serine repeat antigen 5	0.0009	0.0062	0.5
Entamoeba histolytica	calpain large subunit domain III containing protein	0.0021	0.0303	0.395
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0062	0.0202
Brugia malayi	hypothetical protein	0.0039	0.067	0.0928
Echinococcus granulosus	insulin receptor	0.0115	0.2228	0.2228
Plasmodium falciparum	serine repeat antigen 9	0.0009	0.0062	0.5
Echinococcus multilocularis	insulin receptor	0.0115	0.2228	0.2228
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0062	0.0202
Plasmodium falciparum	serine repeat antigen 1	0.0009	0.0062	0.5
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0009	0.0062	0.0071
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0039	0.0039
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0062	0.0202
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0078	0.0078
Brugia malayi	calpain 7	0.0021	0.0303	0.0419
Schistosoma mansoni	tyrosine kinase	0.0194	0.3826	0.4332
Brugia malayi	Cathepsin L-like precursor	0.0009	0.0062	0.0086
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0009	0.0062	0.0202
Trypanosoma brucei	calpain-like protein, putative	0.0021	0.0303	0.134
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0078	0.0107
Echinococcus granulosus	calpain 7 C02 family	0.0021	0.0303	0.0303
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0011	0.0104	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0104	0.0144
Schistosoma mansoni	calpain-7 (C02 family)	0.0021	0.0303	0.0343
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0009	0.0062	0.0202
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0062	0.0086
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0021	0.0303	0.134
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0097	0.1855	0.21
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0009	0.0062	0.0202
Echinococcus granulosus	calpain 5	0.0021	0.0303	0.0303
Plasmodium falciparum	serine repeat antigen 8	0.0009	0.0062	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0011	0.0104	0.0144
Loa Loa (eye worm)	calpain family protein 1	0.0069	0.1293	0.179
Brugia malayi	steroid hormone receptor	0.0011	0.0104	0.0144
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0104	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0104	0.0144
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0104	0.0104
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0062	0.0202
Schistosoma mansoni	tyrosine kinase	0.0115	0.2228	0.2523
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0062	0.0202
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0021	0.0303	0.0414
Brugia malayi	Papain family cysteine protease containing protein	0.0009	0.0062	0.0086
Entamoeba histolytica	protein kinase, putative	0.0021	0.0303	0.395
Schistosoma mansoni	cathepsin S (C01 family)	0.0009	0.0062	0.0071
Onchocerca volvulus		0.0011	0.0104	0.0516
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0011	0.0104	0.0118
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0062	0.0202
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0009	0.0062	0.0086
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0009	0.0062	0.0086
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0194	0.3826	0.3826
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0293	0.5858	0.6633
Brugia malayi	Cathepsin L-like precursor	0.0009	0.0062	0.0086
Trypanosoma cruzi	kinesin, putative	0.0021	0.0303	0.0414
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0104	0.0144
Trypanosoma brucei	kinesin, putative	0.0021	0.0303	0.134
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0009	0.0062	0.0062
Echinococcus multilocularis	epidermal growth factor receptor	0.0194	0.3826	0.3826
Trypanosoma brucei	calpain-like protein, putative	0.0021	0.0303	0.134
Toxoplasma gondii	cathepsin B	0.0097	0.1855	1
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0009	0.0062	0.5
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0115	0.2228	0.2228
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0009	0.0062	0.0202
Brugia malayi	cathepsin B-like cysteine proteinase	0.0293	0.5858	0.8113
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0021	0.0303	0.0414
Echinococcus multilocularis	neuropeptide s receptor	0.0497	1	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0011	0.0104	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0062	0.0086
Echinococcus multilocularis	dnaJ subfamily B	0.0439	0.8832	0.8832
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0062	0.0202
Leishmania major	kinesin, putative	0.0021	0.0303	0.134
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0065	0.1216	0.1377
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0104	0.0144
Echinococcus multilocularis	cathepsin b	0.0293	0.5858	0.5858
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0062	0.0086
Trypanosoma brucei	calpain-like protein, putative	0.0021	0.0303	0.134
Brugia malayi	Papain family cysteine protease containing protein	0.0009	0.0062	0.0086
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0104	0.0104
Echinococcus granulosus	cathepsin L	0.0009	0.0062	0.0062
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0097	0.1855	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1293	0.179
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0021	0.0303	0.0343
Plasmodium falciparum	serine repeat antigen 4	0.0009	0.0062	0.5
Brugia malayi	cathepsin L-like precursor	0.0009	0.0062	0.0086
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0104	0.0118
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0009	0.0062	0.0202
Brugia malayi	CXXC zinc finger family protein	0.0031	0.0511	0.0708
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0021	0.0303	0.0414
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0062	0.0086
Loa Loa (eye worm)	TK/INSR protein kinase	0.0115	0.2228	0.3085
Schistosoma mansoni	cathepsin B (C01 family)	0.0009	0.0062	0.0071
Schistosoma mansoni	tyrosine kinase	0.0115	0.2228	0.2523
Schistosoma mansoni	cathepsin F (C01 family)	0.0009	0.0062	0.0071
Echinococcus multilocularis	epidermal growth factor receptor	0.036	0.7221	0.7221
Loa Loa (eye worm)	calpain	0.0021	0.0303	0.0419
Echinococcus granulosus	cathepsin b	0.0293	0.5858	0.5858
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0011	0.0104	0.0144
Schistosoma mansoni	cathepsin C	0.0009	0.0062	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0062	0.0086
Onchocerca volvulus		0.0031	0.0511	0.5539
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0293	0.5858	0.6633
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0097	0.1855	0.3093
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0009	0.0062	0.5
Brugia malayi	Steroid receptor seven-up type 2	0.0011	0.0104	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0104	0.0144
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0009	0.0062	0.0202
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0021	0.0303	0.0414
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0009	0.0062	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0062	0.0086
Schistosoma mansoni	hypothetical protein	0.0039	0.067	0.0759
Echinococcus multilocularis	calpain	0.0021	0.0303	0.0303
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0062	0.0086
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0104	0.0118
Echinococcus multilocularis	cysteine protease	0.0009	0.0062	0.0062
Entamoeba histolytica	hypothetical protein	0.0039	0.067	1
Plasmodium falciparum	serine repeat antigen 2	0.0009	0.0062	0.5
Echinococcus multilocularis	cysteine protease	0.0009	0.0062	0.0062
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0009	0.0062	0.0071
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.067	0.0759
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0009	0.0062	0.5
Schistosoma mansoni	cpg binding protein	0.0033	0.0547	0.062
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0073	0.1365	0.1545
Brugia malayi	photoreceptor-specific nuclear receptor	0.0011	0.0104	0.0144
Schistosoma mansoni	cathepsin F (C01 family)	0.0009	0.0062	0.0071
Onchocerca volvulus		0.0049	0.0873	1
Plasmodium falciparum	serine repeat antigen 7	0.0009	0.0062	0.5
Onchocerca volvulus	Protein ultraspiracle homolog	0.0011	0.0104	0.0516
Echinococcus multilocularis	cathepsin L	0.0009	0.0062	0.0062
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0104	0.0144
Brugia malayi	Papain family cysteine protease containing protein	0.0009	0.0062	0.0086
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0009	0.0062	0.0086
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0293	0.5858	0.6633
Echinococcus multilocularis	calpain A	0.0073	0.1365	0.1365
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0009	0.0062	0.0202
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0009	0.0062	0.0071
Entamoeba histolytica	hypothetical protein	0.0039	0.067	1
Trypanosoma cruzi	kinesin, putative	0.0021	0.0303	0.0414
Schistosoma mansoni	cathepsin F (C01 family)	0.0009	0.0062	0.0071
Schistosoma mansoni	hypothetical protein	0.0439	0.8832	1
Schistosoma mansoni	tyrosine kinase	0.0191	0.3784	0.4285
Echinococcus multilocularis	ecdysone induced protein 78C	0.0011	0.0104	0.0104
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0062	0.0202
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0062	0.0202
Schistosoma mansoni	calpain (C02 family)	0.0021	0.0303	0.0343
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0075	0.0104
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0104	0.0104
Echinococcus granulosus	ecdysone induced protein 78C	0.0011	0.0104	0.0104
Brugia malayi	calpain family protein 1	0.0069	0.1293	0.179
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0011	0.0104	0.0118
Loa Loa (eye worm)	TK/EGFR protein kinase	0.036	0.7221	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0009	0.0062	0.0086
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0009	0.0062	0.0202
Trypanosoma brucei	calpain-like protein, putative	0.0021	0.0303	0.134
Echinococcus granulosus	cathepsin l1	0.0009	0.0062	0.0062
Brugia malayi	Cathepsin L-like precursor	0.0009	0.0062	0.0086
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0293	0.5858	0.6633
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0058	0.1074	0.5641
Echinococcus multilocularis	cathepsin L cysteine protease	0.0009	0.0062	0.0062
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0011	0.0104	0.0516
Brugia malayi	calpain family protein 1	0.0069	0.1293	0.179
Brugia malayi	Cathepsin L-like precursor	0.0009	0.0062	0.0086
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0062	0.0202
Brugia malayi	Cathepsin L-like precursor	0.0009	0.0062	0.0086
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0104	0.0144
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0009	0.0062	0.0202
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0104	0.0144
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0009	0.0062	0.5
Brugia malayi	nuclear receptor NHR-88	0.0011	0.0104	0.0144
Schistosoma mansoni	tyrosine kinase	0.036	0.7221	0.8176
Echinococcus granulosus	calpain	0.0021	0.0303	0.0303
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0011	0.0104	0.0104
Brugia malayi	Furin-like cysteine rich region family protein	0.036	0.7221	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0062	0.0202
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0062	0.0202
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0062	0.0202
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0011	0.0104	0.0104
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0062	0.0202
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0011	0.0104	0.0144
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0104	0.0144
Trypanosoma brucei	antigen, putative	0.0021	0.0303	0.134
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0009	0.0062	0.0202
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0009	0.0062	0.0086
Brugia malayi	Papain family cysteine protease containing protein	0.0009	0.0062	0.0086
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0009	0.0062	0.0202
Echinococcus multilocularis	calpain 7 (C02 family)	0.0021	0.0303	0.0303
Giardia lamblia	Cathepsin B precursor	0.0097	0.1855	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0104	0.0104
Brugia malayi	Cathepsin L-like precursor	0.0009	0.0062	0.0086
Echinococcus granulosus	cathepsin L	0.0009	0.0062	0.0062
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0011	0.0104	0.0144
Plasmodium vivax	calpain, putative	0.0021	0.0303	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0062	0.0086
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0011	0.0104	0.0118
Brugia malayi	Protein kinase domain containing protein	0.0115	0.2228	0.3085
Echinococcus multilocularis	cathepsin b	0.0293	0.5858	0.5858
Echinococcus granulosus	calpain A	0.0073	0.1365	0.1365
Loa Loa (eye worm)	calpain family protein 1	0.0049	0.0873	0.1209
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0021	0.0303	0.0414
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0009	0.0062	0.0086
Echinococcus granulosus	cpg binding protein	0.0033	0.0547	0.0547
Brugia malayi	calpain 5	0.0021	0.0303	0.0419
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0009	0.0062	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0062	0.0086
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0021	0.0303	0.134
Loa Loa (eye worm)	calpain 5	0.0021	0.0303	0.0419
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0009	0.0062	0.0071
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0009	0.0062	0.0202
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0062	0.0202
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0104	0.0118
Schistosoma mansoni	tyrosine kinase	0.0191	0.3784	0.4285
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0062	0.0202
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0009	0.0062	0.5
Brugia malayi	cathepsin F-like cysteine proteinase	0.0009	0.0062	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0873	0.1209
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0009	0.0062	0.0071
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.0039	0.0039
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0073	0.1365	0.1545
Echinococcus multilocularis		0.0111	0.2154	0.2154
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0011	0.0104	0.0144
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0009	0.0062	0.0062
Giardia lamblia	Cathepsin B precursor	0.0097	0.1855	1
Echinococcus granulosus	calpain A	0.0021	0.0303	0.0303
Brugia malayi	ecdysteroid receptor	0.0011	0.0104	0.0144
Entamoeba histolytica	hypothetical protein	0.0039	0.067	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0021	0.0303	0.0414
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0873	0.1209
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0009	0.0062	0.0202
Brugia malayi	cathepsin L-like cysteine proteinase	0.0009	0.0062	0.0086
Schistosoma mansoni	calpain-7 (C02 family)	0.0021	0.0303	0.0343
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.067	0.067
Giardia lamblia	Cathepsin B precursor	0.0097	0.1855	1
Schistosoma mansoni	coup transcription factor	0.0011	0.0104	0.0118
Loa Loa (eye worm)	steroid hormone receptor	0.0011	0.0104	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0104	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0293	0.5858	0.8113
Echinococcus multilocularis	hypothetical protein	0.0021	0.0303	0.0303
Schistosoma mansoni	tyrosine kinase	0.0191	0.3784	0.4285
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0009	0.0062	0.0202
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0009	0.0062	0.0202
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0009	0.0062	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1293	0.179
Echinococcus multilocularis	cpg binding protein	0.0033	0.0547	0.0547
Brugia malayi	cathepsin L precursor	0.0009	0.0062	0.0086
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.067	0.067
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.0511	0.0708
Echinococcus granulosus	neuropeptide receptor A26	0.0497	1	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0009	0.0062	0.5
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0009	0.0062	0.0071
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0009	0.0062	0.0202
Echinococcus multilocularis	neuropeptide receptor A26	0.0497	1	1
Brugia malayi	fibroinase precursor	0.0009	0.0062	0.0086
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0011	0.0104	0.0144
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0011	0.0104	0.0144
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0062	0.0202
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0011	0.0104	0.0144
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0011	0.0104	0.0144
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0011	0.0104	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0104	0.0144
Brugia malayi	Papain family cysteine protease containing protein	0.0009	0.0062	0.0086
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0062	0.0202
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0009	0.0062	0.0202
Echinococcus multilocularis	cathepsin L	0.0009	0.0062	0.0062
Onchocerca volvulus	Bile acid receptor homolog	0.0011	0.0104	0.0516

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.7 uM	Inhibitiory concentration against EGF receptor by autophosphorylation	ChEMBL.	7902440
IC50 (binding)	= 1.7 uM	Inhibitiory concentration against EGF receptor by autophosphorylation	ChEMBL.	7902440
IC50 (functional)	= 4.6 uM	Inhibitiory concentration against ErbB2/neu (HER-2) by autophosphorylation	ChEMBL.	7902440
IC50 (functional)	= 4.6 uM	Inhibitiory concentration against ErbB2/neu (HER-2) by autophosphorylation	ChEMBL.	7902440
IC50 (binding)	= 6.6 uM	Inhibitiory concentration against EGF receptor by polyGAT phosphorylation	ChEMBL.	7902440
IC50 (binding)	= 6.6 uM	Inhibitiory concentration against EGF receptor by polyGAT phosphorylation	ChEMBL.	7902440
IC50 (functional)	= 10 uM	Inhibition of HER-14 (human EGFR over-expressing NIH3T3) cell proliferation	ChEMBL.	7902440
IC50 (functional)	= 10 uM	Inhibition of HER-14 (human EGFR over-expressing NIH3T3) cell proliferation	ChEMBL.	7902440

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL330879

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 207308