Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | transfer RNA-Ile | 0.0281 | 0.4726 | 0.9178 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0032 | 0.0028 | 0.0033 |
Brugia malayi | hypothetical protein | 0.0032 | 0.0028 | 0.0019 |
Onchocerca volvulus | 0.0511 | 0.9066 | 1 | |
Onchocerca volvulus | 0.0032 | 0.0028 | 0.0019 | |
Echinococcus multilocularis | thymidine kinase | 0.0281 | 0.4726 | 0.9178 |
Brugia malayi | TAR-binding protein | 0.0073 | 0.0803 | 0.0875 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0028 | 0.0031 |
Loa Loa (eye worm) | thymidylate synthase | 0.0303 | 0.5148 | 0.5678 |
Brugia malayi | Carboxylesterase family protein | 0.0032 | 0.0028 | 0.0019 |
Trypanosoma brucei | thymidine kinase | 0.056 | 1 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0032 | 0.0028 | 0.0033 |
Echinococcus granulosus | Thymidine kinase 2 mitochondrial | 0.0281 | 0.4726 | 0.9178 |
Echinococcus multilocularis | acetylcholinesterase | 0.0189 | 0.2998 | 0.5815 |
Loa Loa (eye worm) | TAR-binding protein | 0.0073 | 0.0803 | 0.0885 |
Onchocerca volvulus | 0.0056 | 0.0474 | 0.0511 | |
Loa Loa (eye worm) | RNA binding protein | 0.0073 | 0.0803 | 0.0885 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.0803 | 0.1542 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0032 | 0.0028 | 0.0033 |
Echinococcus multilocularis | thymidine kinase | 0.0281 | 0.4726 | 0.9178 |
Trypanosoma cruzi | thymidine kinase, putative | 0.056 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0073 | 0.0803 | 0.0885 |
Echinococcus multilocularis | geminin | 0.0195 | 0.3112 | 0.6038 |
Loa Loa (eye worm) | hypothetical protein | 0.0511 | 0.9066 | 1 |
Giardia lamblia | Thymidine kinase | 0.056 | 1 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0056 | 0.0474 | 0.0901 |
Echinococcus granulosus | thymidine kinase | 0.0281 | 0.4726 | 0.9178 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0189 | 0.2998 | 0.3307 |
Brugia malayi | hypothetical protein | 0.0273 | 0.4571 | 0.5037 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0032 | 0.0028 | 0.0033 |
Loa Loa (eye worm) | carboxylesterase | 0.0032 | 0.0028 | 0.0031 |
Loa Loa (eye worm) | carboxylesterase | 0.0032 | 0.0028 | 0.0031 |
Onchocerca volvulus | 0.0032 | 0.0028 | 0.0019 | |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0032 | 0.0028 | 0.0033 |
Echinococcus multilocularis | neuroligin | 0.0032 | 0.0028 | 0.0033 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0032 | 0.0028 | 0.0033 |
Echinococcus multilocularis | acetylcholinesterase | 0.0189 | 0.2998 | 0.5815 |
Brugia malayi | Carboxylesterase family protein | 0.0189 | 0.2998 | 0.3299 |
Echinococcus granulosus | acetylcholinesterase | 0.0189 | 0.2998 | 0.5815 |
Brugia malayi | thymidylate synthase | 0.0303 | 0.5148 | 0.5673 |
Trichomonas vaginalis | thymidine kinase, putative | 0.056 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0195 | 0.3112 | 0.6038 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0028 | 0.0031 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.0011 | 0.0012 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.0803 | 0.1542 |
Echinococcus granulosus | thymidine kinase | 0.0281 | 0.4726 | 0.9178 |
Mycobacterium ulcerans | thymidylate synthase | 0.0303 | 0.5148 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0144 | 0.2147 | 0.2125 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.0474 | 0.0901 |
Schistosoma mansoni | acetylcholinesterase | 0.0032 | 0.0028 | 0.0033 |
Brugia malayi | Carboxylesterase family protein | 0.0032 | 0.0028 | 0.0019 |
Schistosoma mansoni | hypothetical protein | 0.0195 | 0.3112 | 0.6038 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.0803 | 0.1542 |
Brugia malayi | hypothetical protein | 0.0144 | 0.2147 | 0.2359 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0032 | 0.0028 | 0.0033 |
Trypanosoma cruzi | thymidine kinase, putative | 0.056 | 1 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.056 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.0011 | 0.0012 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0028 | 0.0031 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0144 | 0.2147 | 0.4139 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0073 | 0.0803 | 0.0875 |
Brugia malayi | Carboxylesterase family protein | 0.0032 | 0.0028 | 0.0019 |
Onchocerca volvulus | 0.0032 | 0.0028 | 0.0019 | |
Loa Loa (eye worm) | runx1 | 0.0064 | 0.0633 | 0.0698 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0303 | 0.5148 | 0.5 |
Onchocerca volvulus | 0.0032 | 0.0028 | 0.0019 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0189 | 0.2998 | 0.5815 |
Echinococcus granulosus | carboxylesterase 5A | 0.0189 | 0.2998 | 0.5815 |
Echinococcus multilocularis | Protein lozenge | 0.0064 | 0.0633 | 0.1212 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0028 | 0.0031 |
Schistosoma mansoni | thymidine kinase | 0.0281 | 0.4726 | 0.9178 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0303 | 0.5148 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.4571 | 0.5042 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0011 | 0.0012 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0273 | 0.4571 | 0.8878 |
Echinococcus granulosus | acetylcholinesterase | 0.0189 | 0.2998 | 0.5815 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0032 | 0.0028 | 0.0033 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.0803 | 0.1542 |
Loa Loa (eye worm) | carboxylesterase | 0.0189 | 0.2998 | 0.3307 |
Echinococcus granulosus | tar DNA binding protein | 0.0073 | 0.0803 | 0.1542 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0303 | 0.5148 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0511 | 0.9066 | 1 |
Onchocerca volvulus | 0.0303 | 0.5148 | 0.5673 | |
Trichomonas vaginalis | thymidine kinase, putative | 0.056 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0303 | 0.5148 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.006 | 0.055 | 0.1049 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0189 | 0.2998 | 0.5815 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0032 | 0.0028 | 0.0033 |
Brugia malayi | Carboxylesterase family protein | 0.0189 | 0.2998 | 0.3299 |
Brugia malayi | Carboxylesterase family protein | 0.0032 | 0.0028 | 0.0019 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.2998 | 0.3307 |
Brugia malayi | hypothetical protein | 0.0511 | 0.9066 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.2998 | 0.3307 |
Echinococcus granulosus | thymidylate synthase | 0.0303 | 0.5148 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0032 | 0.0028 | 0.0033 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0032 | 0.0028 | 0.0033 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0273 | 0.4571 | 0.8878 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0028 | 0.0031 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0056 | 0.0474 | 0.0511 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0028 | 0.0031 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0303 | 0.5148 | 0.3822 |
Echinococcus multilocularis | thymidylate synthase | 0.0303 | 0.5148 | 1 |
Onchocerca volvulus | 0.0032 | 0.0028 | 0.0019 | |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0303 | 0.5148 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.0803 | 0.1542 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0028 | 0.0031 |
Echinococcus multilocularis | tar DNA binding protein | 0.0073 | 0.0803 | 0.1542 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0303 | 0.5148 | 0.5 |
Echinococcus granulosus | neuroligin | 0.0032 | 0.0028 | 0.0033 |
Brugia malayi | RNA binding protein | 0.0073 | 0.0803 | 0.0875 |
Schistosoma mansoni | gliotactin | 0.0032 | 0.0028 | 0.0033 |
Leishmania major | thymidine kinase, putative | 0.056 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0195 | 0.3112 | 0.6038 |
Schistosoma mansoni | lozenge | 0.0064 | 0.0633 | 0.1212 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.