Detailed information for compound 2076243

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 544.445 | Formula: C21H26F6N4O6
  • H donors: 2 H acceptors: 7 LogP: -1.19 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CC(=O)N1CCN(CC2(C1)CC(=O)N(C2)C)Cc1ccncc1
  • InChi: 1S/C17H24N4O2.2C2HF3O2/c1-14(22)21-8-7-20(10-15-3-5-18-6-4-15)12-17(13-21)9-16(23)19(2)11-17;2*3-2(4,5)1(6)7/h3-6H,7-13H2,1-2H3;2*(H,6,7)
  • InChiKey: ZGYFFVCGMLUIQM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0734 0.6435 0.6435
Echinococcus multilocularis protein kinase c eta type 0.0204 0.1545 0.1545
Schistosoma mansoni serine/threonine protein kinase 0.0217 0.1664 0.1595
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0217 0.1664 0.1664
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.027 0.2153 0.2153
Echinococcus multilocularis expressed protein 0.0131 0.0873 0.0873
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0571 0.4933 0.4933
Schistosoma mansoni regulator of G protein signaling 0.0131 0.0873 0.0797
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0295 0.2383 0.2383
Loa Loa (eye worm) AGC/PKA protein kinase 0.0295 0.2383 0.2383
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.1121 1 1
Entamoeba histolytica protein kinase, putative 0.0041 0.0042 0.0076
Giardia lamblia Kinase, AGC PKA 0.0295 0.2383 0.5
Schistosoma mansoni serine/threonine protein kinase 0.1121 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0295 0.2383 0.232
Brugia malayi Regulator of G protein signaling domain containing protein 0.0131 0.0873 0.0835
Schistosoma mansoni protein kinase C mu 0.0204 0.1545 0.1474
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0204 0.1545 0.1545
Brugia malayi hypothetical protein 0.0131 0.0873 0.0835
Echinococcus multilocularis raf serine:threonine protein kinase 0.0205 0.1557 0.1557
Brugia malayi Protein kinase domain containing protein 0.0217 0.1664 0.1629
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.0083 0.0083
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0131 0.0873 0.0797
Brugia malayi Variant SH3 domain containing protein 0.0043 0.0056 0.0014
Schistosoma mansoni serine/threonine protein kinase 0.027 0.2153 0.2088
Schistosoma mansoni serine/threonine protein kinase 0.0217 0.1664 0.1595
Echinococcus granulosus cGMP dependent protein kinase 0.0058 0.0194 0.0194
Schistosoma mansoni unc-13 (munc13) 0.0232 0.1804 0.1736
Loa Loa (eye worm) hypothetical protein 0.0204 0.1545 0.1545
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0209 0.1587 0.1587
Trichomonas vaginalis AGC family protein kinase 0.028 0.2245 0.9083
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.0083 0.0083
Brugia malayi regulator of G-protein signaling rgs-7 0.0131 0.0873 0.0835
Brugia malayi Regulator of G protein signaling domain containing protein 0.0131 0.0873 0.0835
Echinococcus multilocularis serine:threonine protein kinase 38 0.027 0.2153 0.2153
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0257 0.2034 0.7688
Loa Loa (eye worm) TK protein kinase 0.0041 0.0042 0.0042
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0131 0.0873 0.0797
Brugia malayi RhoGAP domain containing protein 0.0204 0.1545 0.1509
Brugia malayi C1-like domain containing protein 0.0364 0.302 0.2991
Brugia malayi p70 ribosomal S6 kinase beta 0.027 0.2153 0.212
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0083 0.0083
Echinococcus multilocularis regulator of G protein signaling 3 0.0131 0.0873 0.0873
Trichomonas vaginalis AGC family protein kinase 0.027 0.2153 0.8477
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0295 0.2383 0.2383
Loa Loa (eye worm) hypothetical protein 0.0785 0.6906 0.6906
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0568 0.4907 0.4907
Entamoeba histolytica PH domain containing protein kinase, putative 0.0305 0.2475 0.4435
Schistosoma mansoni axis inhibition protein axin 0.0131 0.0873 0.0797
Echinococcus multilocularis serine:threonine protein kinase N2 0.027 0.2153 0.2153
Brugia malayi Hr1 repeat family protein 0.027 0.2153 0.212
Echinococcus multilocularis tyrosine protein kinase Blk 0.0041 0.0042 0.0042
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0295 0.2383 1
Loa Loa (eye worm) hypothetical protein 0.0131 0.0873 0.0873
Trichomonas vaginalis AGC family protein kinase 0.028 0.2245 0.9083
Loa Loa (eye worm) RGS-3 protein 0.0131 0.0873 0.0873
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0131 0.0873 0.0797
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0295 0.2383 0.2383
Schistosoma mansoni diacylglycerol kinase theta 0.0204 0.1545 0.1474
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0568 0.4907 0.4886
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0045 0.0083 0.0083
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0083 0.0083
Echinococcus granulosus axis inhibition protein axin 0.0131 0.0873 0.0873
Loa Loa (eye worm) hypothetical protein 0.0131 0.0873 0.0873
Entamoeba histolytica protein kinase, putative 0.028 0.2245 0.4023
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0364 0.302 0.302
Entamoeba histolytica diacylglycerol kinase, putative 0.0204 0.1545 0.2769
Loa Loa (eye worm) AGC/PKG protein kinase 0.0058 0.0194 0.0194
Brugia malayi protein kinase C3,putative 0.0316 0.2583 0.2551
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0364 0.302 0.2991
Loa Loa (eye worm) hypothetical protein 0.0361 0.2993 0.2993
Trichomonas vaginalis AGC family protein kinase 0.028 0.2245 0.9083
Trichomonas vaginalis AGC family protein kinase 0.0295 0.2383 1
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.027 0.2153 0.2153
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0295 0.2383 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0131 0.0873 0.0873
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0045 0.0083 0.0083
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0295 0.2383 0.2383
Schistosoma mansoni serine/threonine protein kinase 0.0205 0.1557 0.1486
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0344 0.2837 0.2837
Loa Loa (eye worm) hypothetical protein 0.0131 0.0873 0.0873
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0295 0.2383 0.2383
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0295 0.2383 1
Echinococcus granulosus axis inhibition protein axin 0.0131 0.0873 0.0873
Echinococcus granulosus Diacylglycerol kinase theta 0.0204 0.1545 0.1545
Onchocerca volvulus 0.0785 0.6906 1
Echinococcus multilocularis regulator of G protein signaling 0.0131 0.0873 0.0873
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0295 0.2383 0.5
Onchocerca volvulus 0.0232 0.1804 0.1333
Echinococcus granulosus tyrosine protein kinase Lyn 0.0058 0.0202 0.0202
Brugia malayi hypothetical protein 0.0131 0.0873 0.0835
Echinococcus granulosus serine:threonine protein kinase N2 0.027 0.2153 0.2153
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0295 0.2383 1
Echinococcus granulosus Protein kinase C brain isozyme 0.1032 0.9185 0.9185
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0041 0.0042 0.0042
Entamoeba histolytica PH domain containing protein kinase, putative 0.0305 0.2475 0.4435
Trichomonas vaginalis AGC family protein kinase 0.028 0.2245 0.9083
Echinococcus granulosus regulator of G protein signaling 3 0.0131 0.0873 0.0873
Brugia malayi Pleckstrin Homology Domain 0.0214 0.1636 0.1601
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0568 0.4907 0.4907
Echinococcus multilocularis Protein kinase C, brain isozyme 0.1032 0.9185 0.9185
Toxoplasma gondii diacylglycerol kinase, putative 0.0204 0.1545 0.617
Schistosoma mansoni regulator of G protein signaling 0.0131 0.0873 0.0797
Echinococcus multilocularis myotubularin protein 13 0.0214 0.1636 0.1636
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0295 0.2383 1
Schistosoma mansoni protein kinase C 0.0232 0.1804 0.1736
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.07 0.6117 0.6101
Entamoeba histolytica hypothetical protein 0.0131 0.0873 0.1565
Schistosoma mansoni vav2 0.0218 0.1678 0.1609
Toxoplasma gondii AGC kinase 0.0295 0.2383 1
Loa Loa (eye worm) AGC/NDR protein kinase 0.027 0.2153 0.2153
Echinococcus granulosus regulator of G protein signaling 7 0.0131 0.0873 0.0873
Brugia malayi diacylglycerol kinase 0.0204 0.1545 0.1509
Echinococcus granulosus protein kinase c eta type 0.0204 0.1545 0.1545
Schistosoma mansoni regulator of G protein signaling 0.0131 0.0873 0.0797
Loa Loa (eye worm) hypothetical protein 0.0204 0.1545 0.1545
Loa Loa (eye worm) hypothetical protein 0.0989 0.8788 0.8788
Echinococcus granulosus regulator of G protein signaling 3 0.0131 0.0873 0.0873
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0295 0.2383 0.5
Schistosoma mansoni axis inhibition protein axin 0.0131 0.0873 0.0797
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0043 0.0056 0.0056
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0209 0.1587 0.1587
Echinococcus granulosus unc 13 munc13 0.0232 0.1804 0.1804
Schistosoma mansoni serine/threonine protein kinase 0.1032 0.9185 0.9178
Loa Loa (eye worm) AGC/AKT protein kinase 0.028 0.2245 0.2245
Brugia malayi PXA domain containing protein 0.0131 0.0873 0.0835
Schistosoma mansoni serine/threonine protein kinase 0.0295 0.2383 0.232
Trichomonas vaginalis AGC family protein kinase 0.027 0.2153 0.8477
Loa Loa (eye worm) hypothetical protein 0.0785 0.6906 0.6906
Echinococcus granulosus G protein coupled receptor kinase 1 0.0213 0.1627 0.1627
Brugia malayi Variant SH3 domain containing protein 0.0209 0.1587 0.1551
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0058 0.0194 0.0194
Entamoeba histolytica protein kinase, putative 0.0041 0.0042 0.0076
Brugia malayi Protein kinase domain containing protein 0.027 0.2153 0.212
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.027 0.2153 0.2153
Echinococcus multilocularis axis inhibition protein axin 0.0131 0.0873 0.0873
Brugia malayi Protein kinase domain containing protein 0.028 0.2245 0.2212
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0131 0.0873 0.0873
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0083 0.0083
Brugia malayi Ras association domain family 1 isoform A 0.0204 0.1545 0.1509
Leishmania major protein kinase A catalytic subunit isoform 1 0.0295 0.2383 0.5
Echinococcus multilocularis beta adrenergic receptor kinase 0.0344 0.2837 0.2837
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0295 0.2383 0.5
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0045 0.0083 0.0083
Schistosoma mansoni serine/threonine protein kinase 0.1032 0.9185 0.9178
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0041 0.0042 0.0042
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.053 0.4554 0.4554
Echinococcus granulosus RNA directed DNA polymerase 0.053 0.4554 0.4554
Echinococcus granulosus tyrosine kinase 0.0041 0.0042 0.0042
Schistosoma mansoni serine/threonine protein kinase 0.07 0.6117 0.6085
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0131 0.0873 0.0873
Schistosoma mansoni serine/threonine protein kinase 0.0295 0.2383 0.232
Trichomonas vaginalis AGC family protein kinase 0.028 0.2245 0.9083
Echinococcus granulosus protein kinase C gamma type 0.0828 0.7303 0.7303
Loa Loa (eye worm) RasGEF domain-containing protein 0.0204 0.1545 0.1545
Echinococcus granulosus beta-adrenergic receptor kinase 0.0344 0.2837 0.2837
Brugia malayi Egg laying defective protein 4 0.0058 0.0194 0.0153
Schistosoma mansoni diacylglycerol kinase theta 0.0204 0.1545 0.1474
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0295 0.2383 0.5
Echinococcus multilocularis Regulator of G protein signaling 20 0.0131 0.0873 0.0873
Echinococcus granulosus tyrosine protein kinase Src42A 0.004 0.003 0.003
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0232 0.1804 0.1804
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0045 0.0083 0.0083
Entamoeba histolytica protein kinase, putative 0.027 0.2153 0.386
Loa Loa (eye worm) PXA domain-containing protein 0.0131 0.0873 0.0873
Schistosoma mansoni hypothetical protein 0.0204 0.1545 0.1474
Schistosoma mansoni serine/threonine protein kinase 0.027 0.2153 0.2088
Schistosoma mansoni regulator of G protein signaling 0.0131 0.0873 0.0797
Leishmania major protein kinase A catalytic subunit 0.0295 0.2383 0.5
Echinococcus granulosus expressed protein 0.0131 0.0873 0.0873
Schistosoma mansoni serine/threonine protein kinase 0.027 0.2153 0.2088
Brugia malayi RhoGAP domain containing protein 0.0209 0.1587 0.1551
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0282 0.2264 0.2264
Echinococcus granulosus Rac GTPase activating protein 1 0.0204 0.1545 0.1545
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0295 0.2383 0.2383
Entamoeba histolytica diacylglycerol kinase, putative 0.0204 0.1545 0.2769
Loa Loa (eye worm) hypothetical protein 0.0351 0.2901 0.2901
Loa Loa (eye worm) SRC-1 0.0045 0.0083 0.0083
Trichomonas vaginalis AGC family protein kinase 0.028 0.2245 0.9083
Echinococcus granulosus raf serine:threonine protein kinase 0.0205 0.1557 0.1557
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0045 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.053 0.4554 0.4554
Echinococcus multilocularis Rac GTPase activating protein 1 0.0204 0.1545 0.1545
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0209 0.1587 0.1587
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0295 0.2383 0.2351
Echinococcus multilocularis expressed conserved protein 0.0058 0.0194 0.0194
Trichomonas vaginalis AGC family protein kinase 0.027 0.2153 0.8477
Echinococcus multilocularis regulator of G protein signaling 7 0.0131 0.0873 0.0873
Echinococcus granulosus serine:threonine protein kinase N2 0.0631 0.5488 0.5488
Schistosoma mansoni rac gtpase activating protein 0.0204 0.1545 0.1474
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0217 0.1664 0.1664
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0045 0.0083 0.0083
Echinococcus granulosus Regulator of G protein signaling 20 0.0131 0.0873 0.0873
Loa Loa (eye worm) AGC/PKN protein kinase 0.027 0.2153 0.2153
Brugia malayi PXA domain containing protein 0.0131 0.0873 0.0835
Loa Loa (eye worm) hypothetical protein 0.0785 0.6906 0.6906
Echinococcus granulosus NDR protein kinase 0.027 0.2153 0.2153
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.07 0.6117 0.6117
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.027 0.2153 0.2153
Echinococcus multilocularis Diacylglycerol kinase theta 0.0204 0.1545 0.1545
Entamoeba histolytica hypothetical protein 0.0456 0.3874 0.6943
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0045 0.0083 0.0083
Onchocerca volvulus 0.0351 0.2901 0.3196
Entamoeba histolytica protein kinase, putative 0.028 0.2245 0.4023
Echinococcus granulosus protein kinase c iota type 0.0573 0.4953 0.4953
Loa Loa (eye worm) hypothetical protein 0.1055 0.9396 0.9396
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0232 0.1804 0.1804
Echinococcus granulosus cGMP dependent protein kinase 1 0.0058 0.0194 0.0194
Echinococcus multilocularis protein kinase c epsilon type 0.1121 1 1
Loa Loa (eye worm) hypothetical protein 0.0204 0.1545 0.1545
Brugia malayi RhoGEF domain containing protein 0.0204 0.1545 0.1509
Echinococcus multilocularis N chimaerin 0.0209 0.1587 0.1587
Loa Loa (eye worm) hypothetical protein 0.0131 0.0873 0.0873
Brugia malayi Protein kinase c protein 2 0.0775 0.6814 0.6801
Brugia malayi diacylglycerol kinase 0.0204 0.1545 0.1509
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0324 0.265 0.265
Schistosoma mansoni serine/threonine protein kinase 0.027 0.2153 0.2088
Entamoeba histolytica hypothetical protein 0.0131 0.0873 0.1565
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0295 0.2383 0.5
Loa Loa (eye worm) hypothetical protein 0.0204 0.1545 0.1545
Brugia malayi regulator of G-protein signaling egl-10 0.0131 0.0873 0.0835
Loa Loa (eye worm) AGC/PKA protein kinase 0.0295 0.2383 0.2383
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0568 0.4907 0.4907
Trichomonas vaginalis AGC family protein kinase 0.028 0.2245 0.9083
Echinococcus granulosus tyrosine protein kinase Src42A 0.0045 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0131 0.0873 0.0873
Echinococcus multilocularis tyrosine protein kinase Srms 0.0041 0.0042 0.0042
Schistosoma mansoni regulator of G protein signaling 0.0131 0.0873 0.0797
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0568 0.4907 0.4907
Echinococcus multilocularis protein kinase c iota type 0.0573 0.4953 0.4953
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.027 0.2153 0.2153
Echinococcus multilocularis regulator of G protein signaling 3 0.0131 0.0873 0.0873
Trichomonas vaginalis AGC family protein kinase 0.028 0.2245 0.9083
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0209 0.1587 0.1517
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.027 0.2153 0.2153
Echinococcus multilocularis axis inhibition protein axin 0.0131 0.0873 0.0873
Loa Loa (eye worm) hypothetical protein 0.0147 0.102 0.102
Echinococcus granulosus tyrosine protein kinase Src64B 0.0045 0.0083 0.0083
Brugia malayi SRC-1 0.0045 0.0083 0.0041
Schistosoma mansoni serine/threonine protein kinase 0.0344 0.2837 0.2778
Echinococcus multilocularis tyrosine protein kinase Src42A 0.004 0.003 0.003
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0194 0.0112
Schistosoma mansoni unc-13 (munc13) 0.0232 0.1804 0.1736
Onchocerca volvulus 0.0361 0.2993 0.3352
Brugia malayi Protein kinase domain containing protein 0.027 0.2153 0.212
Entamoeba histolytica protein kinase, putative 0.027 0.2153 0.386
Loa Loa (eye worm) hypothetical protein 0.0295 0.2383 0.2383
Loa Loa (eye worm) hypothetical protein 0.0147 0.102 0.102
Loa Loa (eye worm) hypothetical protein 0.0131 0.0873 0.0873
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0131 0.0873 0.0873
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.0083 0.0083
Entamoeba histolytica hypothetical protein 0.0204 0.1545 0.2769
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0058 0.0194 0.0194
Echinococcus multilocularis RNA directed DNA polymerase 0.053 0.4554 0.4554
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0194 0.0112
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.027 0.2153 0.2153
Echinococcus granulosus N chimaerin 0.0209 0.1587 0.1587
Echinococcus granulosus protein kinase c epsilon type 0.1121 1 1
Schistosoma mansoni z-protein (S1r protein) 0.0131 0.0873 0.0797
Echinococcus granulosus myotubularin protein 13 0.0214 0.1636 0.1636
Echinococcus granulosus cGMP dependent protein kinase 1 0.0058 0.0194 0.0194
Entamoeba histolytica PH domain containing protein kinase, putative 0.0641 0.558 1
Toxoplasma gondii AGC kinase 0.027 0.2153 0.895
Schistosoma mansoni serine/threonine protein kinase 0.0344 0.2837 0.2778
Schistosoma mansoni protein kinase C mu 0.0364 0.302 0.2962
Schistosoma mansoni atypical protein kinase C 0.0581 0.5021 0.4979
Entamoeba histolytica hypothetical protein 0.0131 0.0873 0.1565
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.027 0.2153 0.2153
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0045 0.0083 0.0083
Echinococcus multilocularis serine:threonine protein kinase N2 0.0888 0.7859 0.7859
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0282 0.2264 0.2264
Leishmania major protein kinase A catalytic subunit isoform 2 0.0295 0.2383 0.5
Brugia malayi A-kinase anchor protein 10, precursor 0.0131 0.0873 0.0835
Toxoplasma gondii AGC kinase 0.0295 0.2383 1
Loa Loa (eye worm) hypothetical protein 0.0214 0.1636 0.1636
Echinococcus multilocularis unc 13 (munc13) 0.0232 0.1804 0.1804
Loa Loa (eye worm) raf kinase 0.0204 0.1545 0.1545
Loa Loa (eye worm) CAMK/PKD protein kinase 0.016 0.1139 0.1139
Mycobacterium ulcerans hypothetical protein 0.0045 0.0075 0.5
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0204 0.1545 0.1545
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0209 0.1587 0.1517
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.027 0.2153 0.2153
Echinococcus granulosus tyrosine protein kinase Blk 0.0041 0.0042 0.0042
Echinococcus multilocularis G protein coupled receptor kinase 1 0.0213 0.1627 0.1627
Loa Loa (eye worm) hypothetical protein 0.0204 0.1545 0.1545
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.027 0.2153 0.2153
Echinococcus granulosus regulator of G protein signaling 7 0.0131 0.0873 0.0873
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0295 0.2383 0.2383
Schistosoma mansoni serine/threonine kinase 0.027 0.2153 0.2088
Echinococcus multilocularis serine threonine protein kinase 0.0828 0.7303 0.7303
Loa Loa (eye worm) hypothetical protein 0.0232 0.1804 0.1804
Loa Loa (eye worm) hypothetical protein 0.0204 0.1545 0.1545

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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