Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Arrow homolog | 0.0243 | 0.1192 | 0.2704 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.0116 | 0.0325 | 0.0712 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0119 | 0.0342 | 0.0624 |
Onchocerca volvulus | 0.0105 | 0.0248 | 0.0536 | |
Echinococcus multilocularis | cubilin | 0.0071 | 0.0014 | 0.0027 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.027 | 0.1379 | 0.2597 |
Echinococcus granulosus | integrin alpha 3 | 0.0118 | 0.0335 | 0.0637 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0707 | 0.4371 | 0.8298 |
Echinococcus multilocularis | CUB | 0.0071 | 0.0014 | 0.0027 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0071 | 0.0014 | 0.0014 |
Schistosoma mansoni | neuropilin (nrp) and tolloid (tll)-like | 0.0071 | 0.0014 | 0.0014 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.0355 | 0.0648 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 0.1379 | 0.2597 |
Loa Loa (eye worm) | zinc metalloproteinase toh-2 | 0.0105 | 0.0248 | 0.0444 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0154 | 0.0581 | 0.1301 |
Schistosoma mansoni | integrin alpha | 0.0154 | 0.0581 | 0.0581 |
Schistosoma mansoni | integrin beta subunit | 0.0185 | 0.0798 | 0.0798 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0279 | 0.144 | 0.5 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0707 | 0.4371 | 0.4371 |
Brugia malayi | Kelch motif family protein | 0.0119 | 0.0342 | 0.0753 |
Echinococcus multilocularis | thymidylate synthase | 0.0106 | 0.0254 | 0.0483 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0707 | 0.4371 | 0.8293 |
Schistosoma mansoni | neuropilin (nrp) and tolloid (tll)-like | 0.0071 | 0.0014 | 0.0014 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0109 | 0.018 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0279 | 0.144 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0279 | 0.144 | 0.5 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0707 | 0.4371 | 1 |
Echinococcus granulosus | integrin beta 2 | 0.0233 | 0.1126 | 0.2138 |
Echinococcus multilocularis | neuropilin (nrp) and tolloid (tll) | 0.0071 | 0.0014 | 0.0027 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0382 | 0.2149 | 0.4063 |
Echinococcus granulosus | thymidylate synthase | 0.0106 | 0.0254 | 0.0483 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0071 | 0.0014 | 0.5 |
Echinococcus multilocularis | fibrillin 1 | 0.028 | 0.1448 | 0.275 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0382 | 0.2149 | 0.408 |
Brugia malayi | dihydrofolate reductase family protein | 0.0382 | 0.2149 | 0.49 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0106 | 0.0254 | 0.0254 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0201 | 0.0355 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0707 | 0.4371 | 0.8298 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0243 | 0.1192 | 0.2242 |
Brugia malayi | Zinc metalloproteinase toh-2 precursor | 0.0105 | 0.0248 | 0.0536 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.1192 | 0.2242 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.1192 | 0.2242 |
Schistosoma mansoni | dihydrofolate reductase | 0.0382 | 0.2149 | 0.2149 |
Brugia malayi | astacin protease protein 30 | 0.0105 | 0.0248 | 0.0536 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0071 | 0.0014 | 0.0014 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.0325 | 0.0591 |
Brugia malayi | Fibulin-1 precursor | 0.027 | 0.1379 | 0.3132 |
Echinococcus granulosus | neuropilin nrp and tolloid tll | 0.0071 | 0.0014 | 0.0027 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0382 | 0.2149 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0239 | 0.1168 | 0.4822 |
Brugia malayi | Dihydrofolate reductase | 0.0382 | 0.2149 | 0.49 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.027 | 0.1379 | 0.3132 |
Echinococcus granulosus | dihydrofolate reductase | 0.0382 | 0.2149 | 0.408 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0315 | 0.1686 | 0.3836 |
Loa Loa (eye worm) | hypothetical protein | 0.0341 | 0.1866 | 0.3524 |
Echinococcus granulosus | laminin | 0.027 | 0.1379 | 0.2618 |
Schistosoma mansoni | egf-like domain protein | 0.0243 | 0.1192 | 0.1192 |
Echinococcus multilocularis | integrin alpha 3 | 0.0118 | 0.0335 | 0.0637 |
Echinococcus multilocularis | cubilin | 0.0071 | 0.0014 | 0.0027 |
Brugia malayi | thymidylate synthase | 0.0106 | 0.0254 | 0.0551 |
Brugia malayi | Nematode astacin protease protein 30 | 0.0105 | 0.0248 | 0.0536 |
Echinococcus granulosus | cubilin | 0.0071 | 0.0014 | 0.0027 |
Onchocerca volvulus | 0.0106 | 0.0254 | 0.0551 | |
Loa Loa (eye worm) | integrin beta-2 | 0.0315 | 0.1686 | 0.3181 |
Brugia malayi | zinc metalloproteinase toh-2 precursor | 0.0105 | 0.0248 | 0.0536 |
Echinococcus granulosus | CUB | 0.0071 | 0.0014 | 0.0027 |
Echinococcus granulosus | Tolloid protein 1 | 0.0837 | 0.5268 | 1 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0837 | 0.5268 | 0.5268 |
Loa Loa (eye worm) | AStacin protease | 0.0524 | 0.3116 | 0.5905 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0243 | 0.1192 | 0.2704 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0382 | 0.2149 | 0.5 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0237 | 0.1152 | 0.2165 |
Onchocerca volvulus | Putative cubilin | 0.0098 | 0.0201 | 0.0428 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0279 | 0.144 | 1 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0837 | 0.5268 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0106 | 0.0254 | 0.0457 |
Loa Loa (eye worm) | DPY-31 protein | 0.0105 | 0.0248 | 0.0444 |
Brugia malayi | Nematode astacin protease protein 30 | 0.0105 | 0.0248 | 0.0536 |
Echinococcus multilocularis | laminin | 0.027 | 0.1379 | 0.2618 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0707 | 0.4371 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0014 | 0.0014 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0279 | 0.144 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0382 | 0.2149 | 1 |
Echinococcus multilocularis | integrin beta 2 | 0.0233 | 0.1126 | 0.2138 |
Echinococcus granulosus | cubilin | 0.0071 | 0.0014 | 0.0027 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0248 | 0.0444 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.0278 | 0.1432 | 0.1432 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0014 | 0.0014 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0098 | 0.0201 | 0.0428 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0014 | 0.0014 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0837 | 0.5268 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0014 | 0.0014 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0279 | 0.144 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0803 | 0.5034 | 0.9556 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0382 | 0.2149 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0014 | 0.0014 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.