Detailed information for compound 20910

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 329.44 | Formula: C18H27N5O
  • H donors: 1 H acceptors: 2 LogP: 3.21 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC(c1nc2c([nH]1)n1[C@H]3CCC[C@H]3N=c1n(c2=O)C)CCC
  • InChi: 1S/C18H27N5O/c1-4-7-11(8-5-2)15-20-14-16(21-15)23-13-10-6-9-12(13)19-18(23)22(3)17(14)24/h11-13H,4-10H2,1-3H3,(H,20,21)/t12-,13+/m1/s1
  • InChiKey: CSRSQFSFDXYRFV-OLZOCXBDSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bos taurus Phosphodiesterase 5A Starlite/ChEMBL References
Bos taurus Phosphodiesterase 1A Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Neospora caninum hypothetical protein Get druggable targets OG5_128202 All targets in OG5_128202
Neospora caninum 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP phosphodiesterase A, putative Get druggable targets OG5_128202 All targets in OG5_128202
Leishmania mexicana cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Toxoplasma gondii hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein Get druggable targets OG5_128202 All targets in OG5_128202
Leishmania mexicana phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Candida albicans similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania braziliensis cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase Get druggable targets OG5_128202 All targets in OG5_128202
Schistosoma japonicum Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma congolense cAMP-specific phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP phosphodiesterase A, putative Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei gambiense cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic Get druggable targets OG5_128202 All targets in OG5_128202
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein Get druggable targets OG5_128202 All targets in OG5_128202
Cryptosporidium parvum cGMP phosphodiesterase A4 Get druggable targets OG5_128202 All targets in OG5_128202
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania braziliensis cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma congolense 3', 5'-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania infantum cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei cAMP-specific phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania donovani cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum expressed protein Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei cAMP phosphodiesterase A, putative Get druggable targets OG5_128202 All targets in OG5_128202
Leishmania infantum cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania infantum cAMP phosphodiesterase A Get druggable targets OG5_128202 All targets in OG5_128202
Loa Loa (eye worm) PDE1B protein Get druggable targets OG5_128202 All targets in OG5_128202
Trypanosoma brucei gambiense 3, 5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania braziliensis cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei cAMP-specific phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic Get druggable targets OG5_128202 All targets in OG5_128202
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative Get druggable targets OG5_128202 All targets in OG5_128202
Neospora caninum hypothetical protein Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania mexicana cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Cryptosporidium hominis cGMP phosphodiesterase A4 Get druggable targets OG5_128202 All targets in OG5_128202
Schistosoma japonicum Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Trypanosoma brucei gambiense cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Candida albicans similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128202 All targets in OG5_128202
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic Get druggable targets OG5_128202 All targets in OG5_128202
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania donovani phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma congolense cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0166 0.0753 0.831
Schistosoma mansoni ATPase 0.0166 0.0753 0.0696
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0239 0.1361 0.3802
Trichomonas vaginalis cation-transporting ATPase, putative 0.0166 0.0753 0.831
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.0183 0.0894 0.0838
Trypanosoma brucei calcium-translocating P-type ATPase 0.0183 0.0894 1
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0183 0.0894 1
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.1278 1 1
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.0398 0.2681 0.5
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0083 0.0061 0.0683
Trypanosoma brucei calcium-transporting ATPase, putative 0.0116 0.0341 0.3358
Trichomonas vaginalis cation-transporting ATPase, putative 0.0091 0.0126 0.0779
Schistosoma mansoni na+/k+ atpase alpha subunit 0.0481 0.3374 0.3334
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0166 0.0753 0.831
Trypanosoma brucei P-type H+-ATPase, putative 0.0091 0.0126 0.0779
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0986 0.7572 0.7557
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0166 0.0753 0.831
Loa Loa (eye worm) hypothetical protein 0.0322 0.2054 0.1952
Brugia malayi Membrane calcium atpase protein 3 0.0183 0.0894 0.2364
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0183 0.0894 1
Echinococcus multilocularis nervana 2 0.0986 0.7572 0.7557
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.1278 1 1
Echinococcus multilocularis nervana 2 0.0986 0.7572 0.7557
Plasmodium falciparum calcium-transporting ATPase 0.0183 0.0894 0.5
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0166 0.0753 0.831
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0088 0.0101 0.0481
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0088 0.0101 0.004
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0183 0.0894 0.5
Trypanosoma cruzi plasma-membrane proton-efflux P-type ATPase, putative 0.0091 0.0126 0.1409
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0091 0.0126 0.1409
Brugia malayi Na,K-ATPase alpha subunit 0.0481 0.3374 1
Echinococcus granulosus nervana 2 0.1278 1 1
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.1278 1 1
Leishmania major P-type H -ATPase, putative 0.0091 0.0126 0.0779
Schistosoma mansoni transmemberane protein 0.1278 1 1
Loa Loa (eye worm) hypothetical protein 0.1278 1 1
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0183 0.0894 0.0838
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0166 0.0753 0.8425
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0166 0.0753 0.0696
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.1278 1 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0239 0.1361 0.1308
Echinococcus multilocularis calcium transporting atpase 0.0183 0.0894 0.0838
Brugia malayi E1-E2 ATPase family protein 0.0107 0.0267 0.0433
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0166 0.0753 0.8425
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0183 0.0894 0.2287
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0183 0.0894 0.0838
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0166 0.0753 0.831
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0166 0.0753 0.831
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0083 0.0061 0.0683
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0166 0.0753 0.8224
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.0183 0.0894 0.0838
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0107 0.0267 0.2984
Echinococcus granulosus nervana 2 0.1278 1 1
Leishmania major calcium motive p-type ATPase, putative 0.0183 0.0894 1
Leishmania major P-type H -ATPase, putative 0.0091 0.0126 0.0779
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0183 0.0894 0.0838
Loa Loa (eye worm) calcium ATPase 0.0092 0.0141 0.0015
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0239 0.1361 0.1308
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0239 0.1361 0.1308
Plasmodium vivax calcium-transporting ATPase, putative 0.0183 0.0894 1
Brugia malayi Probable calcium-transporting ATPase KIAA0703 0.0116 0.0341 0.0661
Echinococcus granulosus nervana 2 0.0986 0.7572 0.7557
Onchocerca volvulus 0.0986 0.7572 0.6411
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.1278 1 1
Toxoplasma gondii P-type ATPase4, putative 0.0183 0.0894 1
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0088 0.0101 0.0481
Leishmania major calcium-transporting ATPase, putative 0.0183 0.0894 1
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.1278 1 1
Loa Loa (eye worm) PDE1B protein 0.0239 0.1361 0.1251
Loa Loa (eye worm) hypothetical protein 0.0116 0.0341 0.0218
Echinococcus multilocularis nervana 2 0.1278 1 1
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0481 0.3374 0.329
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0415 0.2821 0.8297
Trypanosoma cruzi P-type H+-ATPase, putative 0.0091 0.0126 0.1409
Leishmania major P-type ATPase, putative 0.0183 0.0894 1
Trypanosoma brucei P-type H+-ATPase, putative 0.0091 0.0126 0.0779
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0183 0.0894 1
Loa Loa (eye worm) hypothetical protein 0.0166 0.0753 0.0635
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0183 0.0894 0.0838
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0166 0.0753 0.831
Trypanosoma cruzi P-type H+-ATPase, putative 0.0091 0.0126 0.1409
Trypanosoma brucei calcium motive p-type ATPase, putative 0.0183 0.0894 1
Schistosoma mansoni ATPase 0.0166 0.0753 0.0696
Trichomonas vaginalis cation-transporting ATPase, putative 0.0166 0.0753 0.831
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0166 0.0753 0.8425
Trichomonas vaginalis cation-transporting ATPase, putative 0.0166 0.0753 0.831
Loa Loa (eye worm) hypothetical protein 0.1278 1 1
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0415 0.2821 0.273
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0183 0.0894 0.0838
Toxoplasma gondii P-type ATPase PMA1 0.0091 0.0126 0.0313
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.0183 0.0894 0.0838
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0481 0.3374 0.3334
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0166 0.0753 0.831
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0116 0.0341 0.0218
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0083 0.0061 0.0683
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0183 0.0894 1
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0166 0.0753 0.8425
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0166 0.0753 0.0696
Trypanosoma cruzi P-type H+-ATPase, putative 0.0091 0.0126 0.1409
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0088 0.0101 0.004
Loa Loa (eye worm) hypothetical protein 0.0374 0.2481 0.2385
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0986 0.7572 0.7557
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0464 0.3234 1
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0166 0.0753 0.8425
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.0481 0.3374 0.3334
Plasmodium vivax P-type ATPase4, putative 0.0183 0.0894 1
Mycobacterium tuberculosis Possible metal cation transporting P-type ATPase CtpH 0.0099 0.02 0.5
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0183 0.0894 1
Echinococcus granulosus calcium transporting atpase 0.0183 0.0894 0.0838
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0183 0.0894 0.2364
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.0183 0.0894 0.0838
Loa Loa (eye worm) hypothetical protein 0.0298 0.1854 0.175
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0092 0.0141 0.0046
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0166 0.0753 0.831
Leishmania major calcium-translocating P-type ATPase 0.0166 0.0753 0.831
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0166 0.0753 0.831
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0092 0.0141 0.1575
Toxoplasma gondii E1-E2 ATPase subfamily protein 0.0091 0.0126 0.0313
Echinococcus multilocularis nervana 2 0.1278 1 1
Echinococcus granulosus nervana 2 0.0986 0.7572 0.7557
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0166 0.0753 0.8425
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0183 0.0894 0.0838
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0183 0.0894 0.0838
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0088 0.0101 0.1131
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0986 0.7572 0.7557
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0183 0.0894 0.0838
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0183 0.0894 1
Giardia lamblia Potassium-transporting ATPase alpha chain 1 0.0481 0.3374 1
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0183 0.0894 1
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.1278 1 1
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0183 0.0894 0.0838
Brugia malayi calcium ATPase 0.0092 0.0141 0.0046
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0088 0.0101 0.1131
Trypanosoma cruzi calcium-transporting ATPase, putative 0.0116 0.0341 0.3812
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0986 0.7572 0.7557
Onchocerca volvulus 0.1278 1 1
Loa Loa (eye worm) hypothetical protein 0.0481 0.3374 0.329
Echinococcus granulosus Na:K ATPase alpha subunit 0.0481 0.3374 0.3334

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 60 nM Optimum inhibitory concentration required to inhibit c-GMP specific phosphodiesterase 1 (PDE1) of bovine aorta ChEMBL. 9990447
IC50 (binding) = 60 nM Optimum inhibitory concentration required to inhibit c-GMP specific phosphodiesterase 1 (PDE1) of bovine aorta ChEMBL. 9990447
IC50 (binding) = 150 nM Optimum inhibitory concentration required to inhibit c-GMP specific Phosphodiesterase 5 (PDE5) of bovine lung ChEMBL. 9990447
IC50 (binding) = 150 nM Optimum inhibitory concentration required to inhibit c-GMP specific Phosphodiesterase 5 (PDE5) of bovine lung ChEMBL. 9990447
IC50 (binding) = 80000 nM Optimum inhibitory concentration required to inhibit cGMP specific phosphodiesterase 3 (PDE3) ChEMBL. 9990447
IC50 (binding) = 80000 nM Optimum inhibitory concentration required to inhibit cGMP specific phosphodiesterase 3 (PDE3) ChEMBL. 9990447

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.