Detailed information for compound 2092282

Basic information

Technical information
  • TDR Targets ID: 2092282
  • Name: (6S,7S)-7-[[2-(difluoromethylsulfanyl)acetyl] amino]-3-[[1-(2-hydroxyethyl)tetrazol-5-yl]su lfanylmethyl]-7-methoxy-8-oxo-5-oxa-1-azabicy clo[4.2.0]oct-2-ene-2-carboxylic acid
  • MW: 496.466 | Formula: C15H18F2N6O7S2
  • H donors: 3 H acceptors: 8 LogP: -1.18 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCn1nnnc1SCC1=C(C(=O)O)N2[C@@H](OC1)[C@@](C2=O)(OC)NC(=O)CSC(F)F
  • InChi: 1S/C15H18F2N6O7S2/c1-29-15(18-8(25)6-31-13(16)17)11(28)23-9(10(26)27)7(4-30-12(15)23)5-32-14-19-20-21-22(14)2-3-24/h12-13,24H,2-6H2,1H3,(H,18,25)(H,26,27)/t12-,15+/m0/s1
  • InChiKey: UHRBTBZOWWGKMK-SWLSCSKDSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (6S,7S)-7-[[2-(difluoromethylthio)-1-oxoethyl]amino]-3-[[[1-(2-hydroxyethyl)-5-tetrazolyl]thio]methyl]-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • (6S,7S)-7-[[2-(difluoromethylthio)acetyl]amino]-3-[[[1-(2-hydroxyethyl)tetrazol-5-yl]thio]methyl]-8-keto-7-methoxy-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • (6S,7S)-7-[2-(difluoromethylsulfanyl)ethanoylamino]-3-[[1-(2-hydroxyethyl)-1,2,3,4-tetrazol-5-yl]sulfanylmethyl]-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus fmrfamide receptor 0.0085 0.1678 0.1663
Echinococcus multilocularis adenylate cyclase 9 0.0156 0.3383 0.3371
Echinococcus granulosus adenylate cyclase 9 0.0156 0.3383 0.3371
Loa Loa (eye worm) hypothetical protein 0.0027 0.0293 0.0293
Brugia malayi hypothetical protein 0.0085 0.1678 0.1678
Trichomonas vaginalis adenosine deaminase, putative 0.0433 1 1
Brugia malayi G-protein coupled receptor 0.0085 0.1678 0.1678
Brugia malayi RNA binding protein 0.0062 0.1129 0.1129
Echinococcus multilocularis rhodopsin orphan GPCR 0.0085 0.1678 0.1663
Loa Loa (eye worm) G-protein coupled receptor 0.0085 0.1678 0.1678
Trypanosoma cruzi adenosine monophosphate deaminase-like protein, putative 0.0141 0.3021 1
Schistosoma mansoni neuropeptide receptor 0.0085 0.1678 0.1663
Echinococcus granulosus AMP deaminase 2 0.0141 0.3021 0.3008
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Echinococcus granulosus neuropeptide Y receptor 0.0085 0.1678 0.1663
Echinococcus multilocularis fmrfamide receptor 0.0085 0.1678 0.1663
Echinococcus granulosus somatostatin receptor 0.0085 0.1678 0.1663
Onchocerca volvulus 0.0085 0.1678 0.1416
Brugia malayi RE15519p 0.0085 0.1678 0.1678
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0085 0.1678 0.1663
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0524 0.0524
Trypanosoma cruzi AMP deaminase, putative 0.0141 0.3021 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Entamoeba histolytica adenosine deaminase, putative 0.0433 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0085 0.1678 0.1663
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0524 0.1687
Echinococcus granulosus L aminoadipate semialdehyde 0.0085 0.1671 0.1656
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0085 0.1678 0.1663
Plasmodium vivax adenosine/AMP deaminase, putative 0.0141 0.3021 0.3008
Schistosoma mansoni biogenic amine receptor 0.0085 0.1678 0.1663
Schistosoma mansoni opsin-like receptor 0.0085 0.1678 0.1663
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0085 0.1678 0.1663
Echinococcus granulosus neuropeptide s receptor 0.0085 0.1678 0.1663
Onchocerca volvulus 0.0085 0.1678 0.1416
Brugia malayi neuropeptide F receptor 0.0085 0.1678 0.1678
Echinococcus granulosus g protein coupled receptor 0.0085 0.1678 0.1663
Mycobacterium leprae Probable lipase LipE 0.0037 0.0524 0.0314
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Echinococcus granulosus rhodopsin orphan GPCR 0.0085 0.1678 0.1663
Schistosoma mansoni biogenic amine (5HT) receptor 0.0085 0.1678 0.1663
Mycobacterium tuberculosis Conserved protein 0.0037 0.0524 0.0507
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0085 0.1678 0.1678
Leishmania major AMP deaminase, putative,adenosine monophosphate deaminase-like protein 0.0141 0.3021 0.3008
Loa Loa (eye worm) hypothetical protein 0.0085 0.1671 0.1671
Echinococcus granulosus adenosine deaminase 0.0433 1 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Echinococcus multilocularis neuropeptide Y receptor 0.0085 0.1678 0.1663
Schistosoma mansoni amine GPCR 0.0085 0.1678 0.1663
Loa Loa (eye worm) hypothetical protein 0.0427 0.9839 0.9839
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0085 0.1678 0.1663
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Brugia malayi intermediate filament protein 0.0027 0.0305 0.0305
Echinococcus multilocularis rhodopsin orphan GPCR 0.0085 0.1678 0.1663
Echinococcus multilocularis geminin 0.0166 0.3608 0.3597
Echinococcus granulosus biogenic amine 5HT receptor 0.0085 0.1678 0.1663
Onchocerca volvulus 0.0085 0.1678 0.1416
Echinococcus multilocularis tar DNA binding protein 0.0062 0.1129 0.1113
Schistosoma mansoni amine GPCR 0.0085 0.1678 0.1663
Echinococcus granulosus serotonin receptor 0.0085 0.1678 0.1663
Trypanosoma brucei AMP deaminase, putative 0.0141 0.3021 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0524 0.0524
Echinococcus granulosus neuropeptide receptor A26 0.0085 0.1678 0.1663
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Echinococcus granulosus neuropeptide Y receptor 0.0085 0.1678 0.1663
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0433 1 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0085 0.1678 0.1663
Loa Loa (eye worm) hypothetical protein 0.0037 0.0524 0.0524
Echinococcus granulosus neuropeptides capa receptor 0.0085 0.1678 0.1663
Onchocerca volvulus 0.0141 0.3021 0.2801
Brugia malayi hypothetical protein 0.0085 0.1678 0.1678
Echinococcus multilocularis g protein coupled receptor 0.0085 0.1678 0.1663
Schistosoma mansoni neuropeptide receptor 0.0085 0.1678 0.1663
Onchocerca volvulus 0.0037 0.0524 0.0227
Schistosoma mansoni hypothetical protein 0.0085 0.1678 0.1663
Loa Loa (eye worm) TYRA-2 protein 0.0085 0.1678 0.1678
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0217 0.02
Leishmania major adenine aminohydrolase 0.0433 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0085 0.1678 0.1663
Schistosoma mansoni biogenic amine receptor 0.0085 0.1678 0.1663
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0489 0.0472
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0085 0.1678 0.1663
Onchocerca volvulus 0.0085 0.1678 0.1416
Leishmania major hypothetical protein, conserved 0.0037 0.0524 0.0507
Leishmania major AMP deaminase, putative 0.0141 0.3021 0.3008
Plasmodium vivax adenosine deaminase, putative 0.0433 1 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0085 0.1678 0.1663
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Schistosoma mansoni intermediate filament proteins 0.0027 0.0305 0.0287
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0085 0.1678 0.1663
Schistosoma mansoni neuropeptide receptor 0.0085 0.1678 0.1663
Echinococcus granulosus neuropeptide receptor 0.0085 0.1678 0.1663
Brugia malayi hypothetical protein 0.0085 0.1678 0.1678
Onchocerca volvulus 0.0085 0.1678 0.1416
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0085 0.1671 0.1656
Echinococcus multilocularis AMP deaminase 2 0.0141 0.3021 0.3008
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1129 0.1113
Onchocerca volvulus 0.0037 0.0524 0.0227
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.1678 0.1663
Echinococcus multilocularis sex peptide receptor 0.0085 0.1678 0.1663
Schistosoma mansoni neuropeptide F-like receptor 0.0085 0.1678 0.1663
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Mycobacterium ulcerans adenosine deaminase 0.0433 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.1678 0.1663
Schistosoma mansoni hypothetical protein 0.0085 0.1678 0.1663
Onchocerca volvulus 0.0085 0.1678 0.1416
Loa Loa (eye worm) TAR-binding protein 0.0062 0.1129 0.1129
Schistosoma mansoni neuropeptide f receptor 76f 0.0085 0.1678 0.1663
Loa Loa (eye worm) follicle stimulating hormone receptor 0.031 0.7053 0.7053
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0085 0.1678 0.1663
Brugia malayi Serotonin receptor 0.0085 0.1678 0.1678
Brugia malayi adenosine monophosphate deaminase 0.0141 0.3021 0.3021
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0524 0.0507
Echinococcus multilocularis g protein coupled receptor 0.0085 0.1678 0.1663
Loa Loa (eye worm) AMP deaminase 0.0141 0.3021 0.3021
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Schistosoma mansoni alpha-1 adrenergic receptor 0.0085 0.1678 0.1663
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0433 1 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0085 0.1678 0.1678
Trichomonas vaginalis adenosine deaminase, putative 0.0433 1 1
Loa Loa (eye worm) hypothetical protein 0.0156 0.3383 0.3383
Leishmania major hypothetical protein, conserved 0.0141 0.3021 0.3008
Echinococcus granulosus hypothetical protein 0.0085 0.1678 0.1663
Trypanosoma brucei adenosine monophosphate deaminase, putative 0.0141 0.3021 1
Trypanosoma cruzi AMP deaminase, putative 0.0141 0.3021 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0524 0.0507
Echinococcus granulosus neuropeptide FF receptor 2 0.0085 0.1678 0.1663
Brugia malayi sulfakinin receptor protein 0.0085 0.1678 0.1678
Onchocerca volvulus 0.0085 0.1671 0.1409
Entamoeba histolytica hypothetical protein 0.0035 0.0489 0.0278
Onchocerca volvulus Neuropeptide F receptor homolog 0.0085 0.1678 0.1416
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0085 0.1678 0.1678
Schistosoma mansoni opsin-like receptor 0.0085 0.1678 0.1663
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Echinococcus granulosus lamin dm0 0.0027 0.0305 0.0287
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.1678 0.1663
Schistosoma mansoni growth hormone secretagogue receptor 0.0085 0.1678 0.1663
Brugia malayi putative neuropeptide receptor 0.0085 0.1678 0.1678
Brugia malayi hypothetical protein 0.0085 0.1678 0.1678
Loa Loa (eye worm) hypothetical protein 0.0037 0.0524 0.0524
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0085 0.1678 0.1663
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0085 0.1678 0.1416
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.1129 0.1129
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Echinococcus granulosus rhodopsin orphan GPCR 0.0085 0.1678 0.1663
Onchocerca volvulus 0.0085 0.1678 0.1416
Trypanosoma brucei AMP deaminase, putative 0.0141 0.3021 1
Brugia malayi Dopamine receptor 0.0085 0.1678 0.1678
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Entamoeba histolytica AMP deaminase, putative 0.0141 0.3021 0.2866
Onchocerca volvulus 0.0085 0.1678 0.1416
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Onchocerca volvulus 0.0156 0.3383 0.3175
Brugia malayi ORL1-like opioid receptor 0.0085 0.1678 0.1678
Trypanosoma cruzi AMP deaminase, putative 0.0141 0.3021 1
Onchocerca volvulus 0.015 0.3224 0.3012
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0085 0.1678 0.1663
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Loa Loa (eye worm) G-protein coupled receptor 0.0085 0.1678 0.1678
Echinococcus granulosus geminin 0.0166 0.3608 0.3597
Echinococcus granulosus rhodopsin orphan GPCR 0.0085 0.1678 0.1663
Brugia malayi GnHR receptor homolog 0.0085 0.1678 0.1678
Brugia malayi putative neuropeptide receptor NPR1 0.0085 0.1678 0.1678
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0085 0.1678 0.1663
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0524 0.0507
Echinococcus granulosus g protein coupled receptor 0.0085 0.1678 0.1663
Brugia malayi Serotonin receptor 0.0085 0.1678 0.1678
Plasmodium falciparum AMP deaminase, putative 0.0141 0.3021 0.3008
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0704 0.0704
Loa Loa (eye worm) neuropeptide F receptor 0.0085 0.1678 0.1678
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0085 0.1678 0.1663
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0524 0.0507
Schistosoma mansoni biogenic amine receptor 0.0085 0.1678 0.1663
Echinococcus granulosus G protein coupled receptor 139 0.0085 0.1678 0.1663
Schistosoma mansoni neuropeptide receptor 0.0085 0.1678 0.1663
Loa Loa (eye worm) hypothetical protein 0.0037 0.0524 0.0524
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0217 0.02
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Brugia malayi beta-lactamase family protein 0.0037 0.0524 0.0524
Echinococcus granulosus tachykinin peptides receptor 99D 0.0085 0.1678 0.1663
Loa Loa (eye worm) melatonin receptor type 1A 0.0085 0.1678 0.1678
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0217 0.02
Trypanosoma brucei AMP deaminase, putative 0.0141 0.3021 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Schistosoma mansoni neuropeptide F-like receptor 0.0085 0.1678 0.1663
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0524 0.0314
Echinococcus granulosus allatostatin A receptor 0.0085 0.1678 0.1663
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0234 0.5243 0.5235
Echinococcus granulosus tar DNA binding protein 0.0062 0.1129 0.1113
Echinococcus multilocularis L aminoadipate semialdehyde 0.0085 0.1671 0.1656
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0305 0.0305
Echinococcus multilocularis neuropeptide receptor 0.0085 0.1678 0.1663
Echinococcus multilocularis rhodopsin orphan GPCR 0.0085 0.1678 0.1663
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0085 0.1678 0.1663
Plasmodium falciparum adenosine deaminase 0.0433 1 1
Loa Loa (eye worm) RNA binding protein 0.0062 0.1129 0.1129
Brugia malayi hypothetical protein 0.0085 0.1678 0.1678
Onchocerca volvulus 0.0085 0.1678 0.1416
Brugia malayi hypothetical protein 0.0035 0.0489 0.0489
Brugia malayi hypothetical protein 0.0085 0.1678 0.1678
Echinococcus granulosus intermediate filament protein 0.0027 0.0305 0.0287
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Echinococcus multilocularis neuropeptide s receptor 0.0085 0.1678 0.1663
Mycobacterium ulcerans hypothetical protein 0.0037 0.0524 0.0314
Echinococcus multilocularis rhodopsin orphan GPCR 0.0085 0.1678 0.1663
Echinococcus multilocularis G protein coupled receptor 139 0.0085 0.1678 0.1663
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.1678 0.1663
Brugia malayi Dopamine receptor protein 2 0.0085 0.1678 0.1678
Schistosoma mansoni hypothetical protein 0.0085 0.1678 0.1663
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Echinococcus multilocularis g protein coupled receptor 0.0085 0.1678 0.1663
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0217 0.02
Treponema pallidum adenosine deaminase 0.0433 1 1
Onchocerca volvulus 0.0085 0.1678 0.1416
Echinococcus multilocularis neuropeptide Y receptor 0.0085 0.1678 0.1663
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.1678 0.1663
Echinococcus multilocularis adenosine deaminase 0.0433 1 1
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0524 0.0314
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1129 0.1113
Schistosoma mansoni adenoreceptor 0.0085 0.1678 0.1663
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0524 0.0314
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0524 0.1687
Echinococcus multilocularis rhodopsin orphan GPCR 0.0085 0.1678 0.1663
Loa Loa (eye worm) hypothetical protein 0.0037 0.0524 0.0524
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0085 0.1678 0.1663
Mycobacterium tuberculosis Conserved protein 0.0037 0.0524 0.0507
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1129 0.1113
Echinococcus multilocularis musashi 0.0027 0.0305 0.0287
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0524 0.0507
Echinococcus granulosus lamin 0.0027 0.0305 0.0287
Trypanosoma cruzi AMP deaminase 2, putative 0.0141 0.3021 1
Onchocerca volvulus 0.0085 0.1678 0.1416
Schistosoma mansoni myosin xvIII 0.0085 0.1678 0.1663
Loa Loa (eye worm) hypothetical protein 0.0292 0.6628 0.6628
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Brugia malayi AKH receptor 0.0085 0.1678 0.1678
Entamoeba histolytica hypothetical protein 0.0035 0.0489 0.0278
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0524 0.0507
Loa Loa (eye worm) hypothetical protein 0.0433 1 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Leishmania major AMP deaminase, putative,amp deaminase-like protein 0.0141 0.3021 0.3008
Echinococcus granulosus neuropeptide receptor 0.0085 0.1678 0.1663
Schistosoma mansoni AMP deaminase 0.0141 0.3021 0.3008
Schistosoma mansoni hypothetical protein 0.0035 0.0489 0.0472
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0524 0.0507
Echinococcus granulosus sex peptide receptor 0.0085 0.1678 0.1663
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0704 0.0688
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0524 0.0507
Brugia malayi follicle stimulating hormone receptor 0.031 0.7053 0.7053
Schistosoma mansoni histamine h1 receptor 0.0085 0.1678 0.1663
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0085 0.1678 0.1663
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0085 0.1678 0.1663
Brugia malayi G-protein coupled receptor 0.0085 0.1678 0.1678
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0524 0.0507
Mycobacterium ulcerans beta-lactamase 0.0037 0.0524 0.0314
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0217 0.02
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0018 0.0018
Echinococcus granulosus peptide allatostatin:somatostatin 0.0085 0.1678 0.1663
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Schistosoma mansoni adenosine deaminase 0.0433 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0704 0.0688
Echinococcus multilocularis serotonin receptor 0.0085 0.1678 0.1663
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.1678 0.1663
Echinococcus multilocularis allatostatin A receptor 0.0085 0.1678 0.1663
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0085 0.1678 0.1678
Echinococcus granulosus rhodopsin orphan GPCR 0.0085 0.1678 0.1663
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0085 0.1678 0.1663
Echinococcus granulosus 7tm_1 domain containing protein 0.0085 0.1678 0.1663
Echinococcus multilocularis g-protein coupled receptor 0.0085 0.1678 0.1663
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0085 0.1678 0.1663
Echinococcus multilocularis neuropeptide receptor A26 0.0085 0.1678 0.1663
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Echinococcus multilocularis lamin dm0 0.0027 0.0305 0.0287
Mycobacterium tuberculosis Conserved protein 0.0037 0.0524 0.0507
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0085 0.1678 0.1663
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0085 0.1678 0.1678
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0217 0.0665
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0085 0.1678 0.1678
Echinococcus multilocularis somatostatin receptor 0.0085 0.1678 0.1663
Schistosoma mansoni amine GPCR 0.0085 0.1678 0.1663
Brugia malayi hypothetical protein 0.0085 0.1678 0.1678
Echinococcus multilocularis fmrfamide receptor 0.0085 0.1678 0.1663
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0305 0.0305
Brugia malayi G protein-coupled receptor F59B2.13 0.0085 0.1678 0.1678
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0524 0.0507
Echinococcus granulosus g-protein coupled receptor 0.0085 0.1678 0.1663
Onchocerca volvulus 0.0037 0.0524 0.0227
Echinococcus granulosus rhodopsin orphan GPCR 0.0085 0.1678 0.1663
Echinococcus granulosus neuropeptides capa receptor 0.0085 0.1678 0.1663
Echinococcus multilocularis lamin 0.0027 0.0305 0.0287
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Schistosoma mansoni lamin 0.0027 0.0305 0.0287
Onchocerca volvulus 0.0085 0.1678 0.1416
Echinococcus multilocularis rhodopsin orphan GPCR 0.0085 0.1678 0.1663
Trypanosoma cruzi AMP deaminase, putative 0.0141 0.3021 1
Schistosoma mansoni opsin-like receptor 0.0085 0.1678 0.1663
Loa Loa (eye worm) hypothetical protein 0.0141 0.3021 0.3021
Brugia malayi Tachykinin-like peptides receptor 99D 0.0085 0.1678 0.1678
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0085 0.1678 0.1663
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0489 0.0472
Echinococcus granulosus tm gpcr rhodopsin 0.0085 0.1678 0.1663
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0085 0.1671 0.1671
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0085 0.1678 0.1663
Brugia malayi hypothetical protein 0.0085 0.1678 0.1678
Loa Loa (eye worm) hypothetical protein 0.0037 0.0524 0.0524
Mycobacterium tuberculosis Probable adenosine deaminase Add (adenosine aminohydrolase) 0.0433 1 1
Brugia malayi TAR-binding protein 0.0062 0.1129 0.1129
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0704 0.0688
Schistosoma mansoni lamin 0.0027 0.0305 0.0287
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.1129 0.1129
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0489 0.0472
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0217 0.5
Onchocerca volvulus 0.0085 0.1678 0.1416
Echinococcus granulosus alpha 1A adrenergic receptor 0.0085 0.1678 0.1663
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1129 0.1113
Echinococcus granulosus orexin receptor type 2 0.0085 0.1678 0.1663
Brugia malayi Adenylyl cyclase protein 0.0156 0.3383 0.3383
Brugia malayi hypothetical protein 0.0085 0.1678 0.1678
Mycobacterium ulcerans lipase LipD 0.0037 0.0524 0.0314
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0085 0.1678 0.1678
Brugia malayi isocitrate dehydrogenase 0.0015 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Schistosoma mansoni amine GPCR 0.0085 0.1678 0.1663
Trypanosoma cruzi adenosine monophosphate deaminase, putative 0.0141 0.3021 1
Schistosoma mansoni hypothetical protein 0.0166 0.3608 0.3597
Trypanosoma cruzi AMP deaminase, putative 0.0141 0.3021 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0085 0.1678 0.1663
Echinococcus multilocularis neuropeptides capa receptor 0.0085 0.1678 0.1663
Schistosoma mansoni biogenic amine (5HT) receptor 0.0085 0.1678 0.1663
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0704 0.0688
Entamoeba histolytica hypothetical protein 0.0035 0.0489 0.0278
Loa Loa (eye worm) neuropeptide F receptor 0.0085 0.1678 0.1678
Schistosoma mansoni adenosine deaminase-related 0.0433 1 1
Toxoplasma gondii AMP deaminase 0.0141 0.3021 0.3008
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0085 0.1678 0.1663
Echinococcus granulosus biogenic amine 5HT receptor 0.0085 0.1678 0.1663
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Echinococcus multilocularis neuropeptide receptor 0.0085 0.1678 0.1663
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0085 0.1678 0.1678
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0524 0.1687
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0704 0.0688
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Echinococcus multilocularis dro:myosuppressin receptor 0.0085 0.1678 0.1663
Brugia malayi beta-lactamase 0.0037 0.0524 0.0524
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0085 0.1678 0.1678
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0085 0.1678 0.1663
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Brugia malayi beta-lactamase family protein 0.0037 0.0524 0.0524
Onchocerca volvulus 0.0085 0.1678 0.1416
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0085 0.1678 0.1663
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0217 0.5
Loa Loa (eye worm) beta-lactamase 0.0037 0.0524 0.0524
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0704 0.0704
Loa Loa (eye worm) hypothetical protein 0.0037 0.0524 0.0524
Echinococcus multilocularis serotonin receptor 0.0085 0.1678 0.1663
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.1678 0.1663
Loa Loa (eye worm) hypothetical protein 0.0292 0.6628 0.6628
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0524 0.0507
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0085 0.1678 0.1663
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1129 0.1113
Schistosoma mansoni hypothetical protein 0.0166 0.3608 0.3597
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0085 0.1678 0.1663
Entamoeba histolytica hypothetical protein 0.0035 0.0489 0.0278
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0704 0.0688
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0305 0.0305
Echinococcus granulosus g protein coupled receptor 0.0085 0.1678 0.1663
Echinococcus granulosus tm gpcr rhodopsin 0.0085 0.1678 0.1663
Onchocerca volvulus 0.0085 0.1678 0.1416
Brugia malayi neuropeptide F receptor 0.0085 0.1678 0.1678
Echinococcus granulosus rhodopsin orphan GPCR 0.0085 0.1678 0.1663
Echinococcus multilocularis orexin receptor type 2 0.0085 0.1678 0.1663
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0018 0.0018
Onchocerca volvulus 0.0085 0.1678 0.1416
Echinococcus granulosus dro:myosuppressin receptor 0.0085 0.1678 0.1663
Echinococcus multilocularis neuropeptide FF receptor 2 0.0085 0.1678 0.1663
Brugia malayi Melatonin receptor type 1A 0.0085 0.1678 0.1678
Loa Loa (eye worm) adenylyl cyclase 3 0.0156 0.3383 0.3383
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0524 0.0507
Leishmania major adenosine monophosphate deaminase, putative,AMP deaminase, putative 0.0141 0.3021 0.3008
Brugia malayi G protein-coupled receptor 0.0085 0.1678 0.1678
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Echinococcus granulosus rhodopsin orphan GPCR 0.0085 0.1678 0.1663
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Onchocerca volvulus AMP deaminase 2 homolog 0.0141 0.3021 0.2801
Onchocerca volvulus 0.0085 0.1678 0.1416
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Schistosoma mansoni hypothetical protein 0.0085 0.1678 0.1663
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.1678 0.1663
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Loa Loa (eye worm) hypothetical protein 0.0027 0.0305 0.0305
Brugia malayi hypothetical protein 0.0085 0.1678 0.1678
Echinococcus multilocularis neuropeptides capa receptor 0.0085 0.1678 0.1663
Onchocerca volvulus Adenosine deaminase homolog 0.0433 1 1
Mycobacterium leprae Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) 0.0433 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.1678 0.1663
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0217 0.02
Echinococcus granulosus 7TM GPCR rhodopsin 0.0085 0.1678 0.1663
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0085 0.1678 0.1663
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Onchocerca volvulus Adenylate cyclase type 2 homolog 0.0156 0.3383 0.3175
Loa Loa (eye worm) hypothetical protein 0.0292 0.6628 0.6628
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Entamoeba histolytica AMP deaminase, putative 0.0141 0.3021 0.2866
Brugia malayi Dopamine receptor protein 1 0.0085 0.1678 0.1678
Echinococcus granulosus tm gpcr rhodopsin 0.0085 0.1678 0.1663
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0085 0.1678 0.1663
Toxoplasma gondii ABC1 family protein 0.0037 0.0524 0.0507
Onchocerca volvulus Adenylate cyclase type 3 homolog 0.0433 0.9998 0.9998
Entamoeba histolytica adenosine deaminase, putative 0.0433 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0704 0.0688
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0085 0.1678 0.1663
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0085 0.1678 0.1663
Brugia malayi larval opioid receptor 0.0085 0.1678 0.1678
Loa Loa (eye worm) hypothetical protein 0.0085 0.1678 0.1678
Echinococcus multilocularis G-protein coupled receptor, putative 0.0085 0.1678 0.1663
Schistosoma mansoni amine GPCR 0.0085 0.1678 0.1663
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0085 0.1678 0.1663
Loa Loa (eye worm) hypothetical protein 0.0292 0.6628 0.6628

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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