Detailed information for compound 210354

Basic information

Technical information
  • TDR Targets ID: 210354
  • Name: 1-(4-nitrophenyl)-2-quinolin-2-ylethanol
  • MW: 294.305 | Formula: C17H14N2O3
  • H donors: 1 H acceptors: 4 LogP: 3.16 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(c1ccc(cc1)[N+](=O)[O-])Cc1ccc2c(n1)cccc2
  • InChi: 1S/C17H14N2O3/c20-17(13-6-9-15(10-7-13)19(21)22)11-14-8-5-12-3-1-2-4-16(12)18-14/h1-10,17,20H,11H2
  • InChiKey: KDEMWCFSSHWZFE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(4-nitrophenyl)-2-(2-quinolyl)ethanol
  • 1-(4-nitrophenyl)-2-quinolin-2-yl-ethanol
  • 38101-97-2
  • NSC34890

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0118 0.0874 1
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0061 0.0351 1
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0355748 0.5 0.5
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0043 0.0183 0.0178
Trypanosoma cruzi C-8 sterol isomerase, putative 0.111 1 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.007 0.0429 0.1644
Echinococcus multilocularis nmda type glutamate receptor 0.0164 0.1298 0.5016
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0061 0.0351 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0498 0.0493
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0043 0.0183 0.0178
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0046 0.0212 0.0801
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.0617 0.0613
Leishmania major C-8 sterol isomerase-like protein 0.111 1 1
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.028 0.2368 0.9166
Plasmodium falciparum transporter, putative 0.0043 0.0183 0.3362
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0498 0.4551
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0046 0.0212 0.0801
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0032 0.0173
Echinococcus multilocularis sodium and chloride dependent glycine 0.0043 0.0183 0.0692
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0617 0.2375
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0061 0.0351 1
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0061 0.0351 1
Schistosoma mansoni ATP-binding cassette transporter 0.0046 0.0212 0.0814
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0046 0.0212 0.0801
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0253 0.0963
Trichomonas vaginalis lysosomal pro-X carboxypeptidase, putative 0.0061 0.0351 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0617 0.2386
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0024 0.0074
Trypanosoma cruzi putative prolyl carboxypeptidase, putative 0.0061 0.0351 0.0351
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0046 0.0212 0.0801
Schistosoma mansoni protein kinase 0.0024 0.0005 0.0014
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0061 0.0351 1
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0024 0.0024
Entamoeba histolytica hypothetical protein 0.0024 0.0005 0.0143
Trypanosoma cruzi extracellular receptor, putative 0.0024 0.0005 0.0005
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0118 0.0874 1
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0061 0.0351 1
Toxoplasma gondii serine carboxypeptidase s28 protein 0.0061 0.0351 0.69
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0061 0.0351 0.0351
Schistosoma mansoni sodium/chloride dependent transporter 0.0043 0.0183 0.0705
Loa Loa (eye worm) hypothetical protein 0.0061 0.0351 0.0346
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.005 0.0025
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0617 0.2375
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0024 0.0024
Schistosoma mansoni glutamate receptor kainate 0.0046 0.0212 0.0814
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0498 1
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.0498 0.1912
Loa Loa (eye worm) hypothetical protein 0.0043 0.0183 0.0178
Echinococcus multilocularis serotonin receptor 0.0138 0.1057 0.4081
Brugia malayi Flap endonuclease-1 0.0026 0.0024 0.0019
Echinococcus multilocularis glutamate receptor 2 0.0046 0.0212 0.0801
Echinococcus multilocularis snurportin 1 0.0304 0.2583 1
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0351 1
Echinococcus granulosus nmda type glutamate receptor 0.0164 0.1298 0.5016
Echinococcus granulosus serotonin transporter 0.0253 0.2119 0.82
Echinococcus multilocularis serotonin transporter 0.0253 0.2119 0.82
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0061 0.0351 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0043 0.0183 0.0692
Plasmodium vivax amine transporter, putative 0.0043 0.0183 0.3362
Echinococcus granulosus geminin 0.0167 0.1326 0.5126
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0118 0.0874 0.4035
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.007 0.0429 0.1644
Loa Loa (eye worm) hypothetical protein 0.0028 0.005 0.0045
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0024 0.0019
Loa Loa (eye worm) hypothetical protein 0.028 0.2368 0.2364
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0498 1
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0061 0.0351 1
Loa Loa (eye worm) hypothetical protein 0.0355748 0.5 0.5
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0043 0.0183 0.0178
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0043 0.0183 0.0705
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0043 0.0183 0.0705
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0081 0.053 0.2036
Brugia malayi Glutamate receptor 2 precursor 0.0046 0.0212 0.0207
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0617 0.2375
Loa Loa (eye worm) hypothetical protein 0.0138 0.1057 0.1053
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0043 0.0183 0.3362
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0061 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.0253 0.2119 0.2115
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0043 0.0183 0.0692
Loa Loa (eye worm) hypothetical protein 0.0355748 0.5 0.5
Echinococcus granulosus glutamate receptor 2 0.007 0.0429 0.1644
Schistosoma mansoni metabotropic glutamate receptor 0.0024 0.0005 0.0014
Brugia malayi Serine carboxypeptidase S28 family protein 0.028 0.2368 0.2364
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.0355748 0.5 0.5
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0061 0.0351 1
Loa Loa (eye worm) glutamate receptor 2 0.0046 0.0212 0.0207
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0617 0.2386
Schistosoma mansoni sodium/chloride dependent transporter 0.0043 0.0183 0.0705
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0061 0.0351 0.1354
Echinococcus multilocularis serotonin receptor 0.0138 0.1057 0.4081
Onchocerca volvulus 0.0043 0.0183 0.0844
Loa Loa (eye worm) hypothetical protein 0.0081 0.053 0.0525
Onchocerca volvulus 0.0061 0.0351 0.1637
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0043 0.0183 0.0705
Echinococcus granulosus flap endonuclease 1 0.0026 0.0024 0.0074
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.028 0.2368 0.9166
Loa Loa (eye worm) hypothetical protein 0.0043 0.0183 0.0178
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0253 0.2119 0.2115
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0253 0.0963
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0043 0.0183 0.0705
Schistosoma mansoni metabotropic glutamate receptor 0.0024 0.0005 0.0014
Giardia lamblia Thymus-specific serine protease precursor 0.0061 0.0351 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0043 0.0183 0.0705
Brugia malayi Serine protease Z688.6 precursor 0.0061 0.0351 0.0346
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0351 1
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0355748 0.5 0.5
Brugia malayi Serine protease Z688.6 precursor 0.0061 0.0351 0.0346
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0081 0.053 0.2036
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.007 0.0429 0.1644
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0061 0.0351 1
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0043 0.0183 0.0692
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0043 0.0183 0.0692
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0498 0.4551
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0024 0.0688
Brugia malayi RNA, U transporter 1 0.0081 0.0532 0.0528
Onchocerca volvulus 0.0253 0.2119 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0183 0.0178
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0046 0.0212 0.0801
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0061 0.0351 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.0498 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0183 0.0178
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.028 0.2368 0.9167
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0253 0.4744
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0061 0.0351 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0032 0.0173
Onchocerca volvulus 0.0043 0.0183 0.0844
Loa Loa (eye worm) hypothetical protein 0.0043 0.0183 0.0178
Loa Loa (eye worm) hypothetical protein 0.0355748 0.5 0.5
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0118 0.0874 0.4035
Treponema pallidum sodium- and chloride- dependent transporter 0.0253 0.2119 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0043 0.0183 0.0705
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0081 0.053 0.2036
Giardia lamblia Serine peptidase, putative 0.0061 0.0351 1
Echinococcus multilocularis glutamate receptor 2 0.007 0.0429 0.1644
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0043 0.0183 0.0178
Plasmodium vivax importin-beta 2, putative 0.0028 0.005 0.0535
Loa Loa (eye worm) hypothetical protein 0.0043 0.0183 0.0178
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0304 0.2583 0.2579
Chlamydia trachomatis glutamine binding protein 0.0118 0.0874 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0164 0.1298 0.5016
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0061 0.0351 0.1342
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0043 0.0183 0.0705
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.007 0.0429 0.1644
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0081 0.053 0.0525
Brugia malayi hypothetical protein 0.0043 0.0183 0.0178
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0043 0.0183 0.0692
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0024 0.0688
Echinococcus granulosus biogenic amine 5HT receptor 0.0138 0.1057 0.4081
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0061 0.0351 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.007 0.0429 0.1644
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0061 0.0351 1
Loa Loa (eye worm) solute carrier family 6 member 4 0.0253 0.2119 0.2115
Onchocerca volvulus Putative nachr subunit 0.0081 0.053 0.2483
Brugia malayi Probable ClpP-like protease 0.0077 0.0498 0.0493
Echinococcus multilocularis geminin 0.0167 0.1326 0.5126
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0077 0.0498 0.5
Loa Loa (eye worm) hypothetical protein 0.0043 0.0183 0.0178
Loa Loa (eye worm) hypothetical protein 0.0253 0.2119 0.2115
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0617 0.2386
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0183 0.3362
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0498 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.0617 0.0613
Schistosoma mansoni hypothetical protein 0.0304 0.2583 1
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0081 0.053 0.2036
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.007 0.0429 0.1644
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.005 0.0025
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0061 0.0351 1
Plasmodium falciparum importin beta, putative 0.0028 0.005 0.0535
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0046 0.0212 0.0801
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0081 0.053 0.2036
Loa Loa (eye worm) hypothetical protein 0.0567 0.5007 0.5005
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0081 0.053 0.2036
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0043 0.0183 0.0178
Echinococcus granulosus importin subunit beta 1 0.0028 0.005 0.0173
Echinococcus granulosus glutamate receptor subunit protein glur 0.0046 0.0212 0.0801
Echinococcus granulosus sodium and chloride dependent glycine 0.0043 0.0183 0.0692
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0043 0.0183 0.0178
Loa Loa (eye worm) hypothetical protein 0.0138 0.1057 0.1053
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0043 0.0183 0.0692
Echinococcus granulosus snurportin 1 0.0304 0.2583 1
Schistosoma mansoni glutamate receptor kainate 0.0046 0.0212 0.0814
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.007 0.0429 0.1644
Loa Loa (eye worm) norepinephrine transporter 0.0253 0.2119 0.2115
Schistosoma mansoni sodium/chloride dependent transporter 0.0253 0.2119 0.8202
Toxoplasma gondii hypothetical protein 0.0027 0.0032 0.0173
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0498 0.2231
Schistosoma mansoni glutamate receptor AMPA 0.0046 0.0212 0.0814
Loa Loa (eye worm) serotonin transporter b 0.0253 0.2119 0.2115
Echinococcus multilocularis importin subunit beta 1 0.0028 0.005 0.0173
Loa Loa (eye worm) hypothetical protein 0.111 1 1
Schistosoma mansoni sodium-dependent amino acid transporter 0.0043 0.0183 0.0705
Schistosoma mansoni tyrosine kinase 0.0024 0.0005 0.0014
Loa Loa (eye worm) glutamate receptor 1 0.0046 0.0212 0.0207
Schistosoma mansoni hypothetical protein 0.0167 0.1326 0.5133
Schistosoma mansoni importin beta-1 0.0028 0.005 0.0186
Brugia malayi Glutamate receptor 1 precursor 0.0046 0.0212 0.0207
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.007 0.0429 0.1644
Echinococcus granulosus sodium and chloride dependent glycine 0.0043 0.0183 0.0692
Schistosoma mansoni glutamate receptor AMPA 0.0046 0.0212 0.0814
Brugia malayi Importin beta-1 subunit 0.0028 0.005 0.0045
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0043 0.0183 0.3362
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0046 0.0212 0.0801
Echinococcus multilocularis NMDA receptor 0.0046 0.0212 0.0801
Loa Loa (eye worm) hypothetical protein 0.0253 0.2119 0.2115
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.005 0.0535
Leishmania major extracellular receptor, putative 0.0024 0.0005 0.0005
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.0498 0.1912
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0043 0.0183 0.0705
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0081 0.053 0.0525
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.0498 0.1923
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0617 0.2375
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0043 0.0183 0.0692
Toxoplasma gondii hypothetical protein 0.0043 0.0183 0.3362
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0043 0.0183 0.3362
Loa Loa (eye worm) hypothetical protein 0.028 0.2368 0.2364
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0253 0.2119 0.8202
Schistosoma mansoni glutamate receptor NMDA 0.0046 0.0212 0.0814
Echinococcus granulosus glutamate NMDA receptor subunit 0.0046 0.0212 0.0801
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.0498 1
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0061 0.0351 0.1342
Schistosoma mansoni hypothetical protein 0.0167 0.1326 0.5133
Schistosoma mansoni hypothetical protein 0.0046 0.0212 0.0814
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0061 0.0351 1
Toxoplasma gondii hypothetical protein 0.0043 0.0183 0.3362
Onchocerca volvulus 0.0043 0.0183 0.0844
Schistosoma mansoni biogenic amine (5HT) receptor 0.0138 0.1057 0.4089
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0061 0.0351 1
Schistosoma mansoni tyrosine kinase 0.0024 0.0005 0.0014
Plasmodium falciparum amino acid transporter, putative 0.0043 0.0183 0.3362
Schistosoma mansoni glutamate receptor NMDA 0.007 0.0429 0.1656
Brugia malayi Serine carboxypeptidase S28 family protein 0.0355748 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.028 0.2368 0.2364
Schistosoma mansoni glutamate receptor kainate 0.0046 0.0212 0.0814
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0118 0.0874 1
Echinococcus multilocularis sodium and chloride dependent glycine 0.0043 0.0183 0.0692
Trypanosoma brucei C-8 sterol isomerase, putative 0.111 1 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 6 uM In vitro anti protozoal activity against Plasmodium falciparum sensitive strain W2 was determined ChEMBL. 15203133
IC50 (functional) = 6 uM In vitro anti protozoal activity against Plasmodium falciparum sensitive strain W2 was determined ChEMBL. 15203133
IC50 (functional) = 15 uM In vitro anti protozoal activity of the compound against Plasmodium falciparum resistant strain Ghana was determined ChEMBL. 15203133
IC50 (functional) = 15 uM In vitro anti protozoal activity of the compound against Plasmodium falciparum resistant strain Ghana was determined ChEMBL. 15203133
IC50 (functional) > 32 uM In vitro anti protozoal activity against Trypanosoma brucei strain S427 was determined ChEMBL. 15203133
IC50 (functional) > 32 uM In vitro anti protozoal activity against Trypanosoma cruzi strain Tulahuen CL2 was determined ChEMBL. 15203133
IC50 (functional) > 32 uM In vitro anti protozoal activity against Leishmania infantum strain MHOM-ET-67/L82 was determined ChEMBL. 15203133
IC50 (functional) > 32 uM In vitro anti protozoal activity against Leishmania amazonensis strain MHOM/ET/L82/LV9 was determined ChEMBL. 15203133
IC50 (functional) > 32 uM Cytotoxicity of the compound was determined in macrophages ChEMBL. 15203133
IC50 (functional) > 32 uM Cytotoxicity of the compound was determined in MRC-5 cells ChEMBL. 15203133
IC50 (functional) > 32 uM In vitro anti protozoal activity against Trypanosoma brucei strain S427 was determined ChEMBL. 15203133
IC50 (functional) > 32 uM In vitro anti protozoal activity against Trypanosoma cruzi strain Tulahuen CL2 was determined ChEMBL. 15203133
IC50 (functional) > 32 uM In vitro anti protozoal activity against Leishmania infantum strain MHOM-ET-67/L82 was determined ChEMBL. 15203133
IC50 (functional) > 32 uM Cytotoxicity of the compound was determined in macrophages ChEMBL. 15203133
IC50 (functional) > 32 uM Cytotoxicity of the compound was determined in MRC-5 cells ChEMBL. 15203133
Inhibition (functional) = 10 % Inhibitory activity against proliferationof HTLV-1 transformed cell lines (HUT-102) at 10 microM ChEMBL. 15203133

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 15203133

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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