TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 361.308 | Formula: C20H22Cl2N2
H donors: 1 H acceptors: 0 LogP: 4.7 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Clc1cccc(c1)[C@@H]1N2CCC([C@@H]1NCc1ccccc1Cl)CC2
InChi: 1S/C20H22Cl2N2/c21-17-6-3-5-15(12-17)20-19(14-8-10-24(20)11-9-14)23-13-16-4-1-2-7-18(16)22/h1-7,12,14,19-20,23H,8-11,13H2/t19-,20-/m0/s1
InChiKey: UIAXBDBJUGFIIR-PMACEKPBSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	tachykinin receptor 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K04224 tachykinin receptor 3, putative	Get druggable targets OG5_137770	All targets in OG5_137770

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	BRM protein	0.0034	0.0278	0.0482
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0263	0.0457
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0169	0.0232
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0037	0.0312	0.0929
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0435	0.0755
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0544	0.576	1
Entamoeba histolytica	DNA repair and recombination protein RAD52, putative	0.0336	0.3527	0.6124
Plasmodium falciparum	methionine aminopeptidase 1a, putative	0.0056	0.0518	0.1098
Echinococcus multilocularis	BRK domain containing protein	0.0011	0.0038	0.0038
Plasmodium vivax	DEAD/DEAH helicase, putative	0.001	0.0026	0.0055
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0032	0.0263	0.077
Trypanosoma cruzi	hexose transporter	0.0033	0.0268	0.1558
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0032	0.0263	0.0559
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0026	0.0192	0.0192
Schistosoma mansoni	glucose transport protein	0.0105	0.1048	1
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0076	0.0132
Echinococcus granulosus	lysyl tRNA synthetase	0.0023	0.0169	0.1617
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0081	0.014
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0076	0.0056
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0081	0.0081
Echinococcus multilocularis	calcium dependent protein kinase	0.003	0.0242	0.0242
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0105	0.1048	0.1048
Plasmodium falciparum	protein kinase 7	0.0297	0.3111	0.6598
Trypanosoma brucei	glucose transporter 1E	0.0033	0.0268	0.1558
Brugia malayi	Associated with TFs and helicases family protein	0.0011	0.0038	0.0066
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0011	0.0034	0.0322
Echinococcus granulosus	glutamate receptor 2	0.0011	0.0034	0.0322
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0263	0.2513
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0076	0.0056
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0032	0.0256	0.0445
Trypanosoma brucei	sugar transporter, putative	0.0015	0.0076	0.0442
Brugia malayi	Cytochrome P450 family protein	0.0014	0.007	0.0122
Schistosoma mansoni	serine/threonine protein kinase	0.0032	0.0263	0.2513
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0268	0.0391
Schistosoma mansoni	protein kinase	0.0032	0.0263	0.2513
Plasmodium vivax	sugar transporter, putative	0.0015	0.0076	0.0161
Mycobacterium leprae	PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M)	0.0056	0.0518	1
Loa Loa (eye worm)	sugar transporter	0.0105	0.1048	0.1819
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0256	0.2446
Toxoplasma gondii	methionine aminopeptidase, type i, putative	0.0056	0.0518	0.1595
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0076	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0076	0.0132
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0076	0.0056
Toxoplasma gondii	lysine-tRNA ligase	0.0023	0.0169	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0076	0.0132
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0032	0.0263	0.0559
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0037	0.0312	0.1818
Leishmania major	myo-inositol/proton symporter (MIT)	0.0015	0.0076	0.0442
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0032	0.0263	0.0559
Echinococcus granulosus	methionyl aminopeptidase 1 M24 family	0.0088	0.0865	0.826
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0013	0.0056	0.0098
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.017	0.1744	0.5569
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0023	0.0169	0.0984
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0076	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0193	0.0334
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0256	0.2446
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0169	0.1617
Trichomonas vaginalis	myo-inositol transporter, putative	0.0015	0.0076	0.0056
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0015	0.0076	0.0076
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0081	0.0772
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0076	0.0132
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0179	0.1041
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0268	0.1558
Mycobacterium ulcerans	sugar transporter	0.0015	0.0076	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0179	0.031
Plasmodium vivax	hexose transporter	0.0105	0.1048	0.2222
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0544	0.576	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0435	0.0755
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0015	0.0076	0.0726
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0021	0.0138	0.0165
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0081	0.0081
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0081	0.014
Leishmania major	protein kinase, putative	0.0032	0.0263	0.1532
Trypanosoma cruzi	hypothetical protein, conserved	0.0168	0.1718	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0076	0.0056
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0081	0.0772
Entamoeba histolytica	Rad52/22 family double-strand break repair protein, putative	0.0096	0.0944	0.1639
Loa Loa (eye worm)	hypothetical protein	0.001	0.0026	0.0045
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.0544	0.576	1
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0023	0.0169	0.0986
Toxoplasma gondii	hypothetical protein	0.0032	0.0264	0.0774
Mycobacterium tuberculosis	Methionine aminopeptidase MapB (map) (peptidase M)	0.0056	0.0518	0.1138
Trypanosoma cruzi	hypothetical protein, conserved	0.0032	0.0264	0.1539
Toxoplasma gondii	LsmAD domain-containing protein	0.0024	0.0179	0.0496
Leishmania major	glucose transporter, lmgt1	0.0033	0.0268	0.1558
Echinococcus granulosus	nmda type glutamate receptor	0.0026	0.0192	0.1832
Plasmodium falciparum	DEAD/DEAH box helicase, putative	0.001	0.0026	0.0055
Loa Loa (eye worm)	cytochrome P450 family protein	0.0014	0.007	0.0122
Brugia malayi	Sugar transporter family protein	0.0105	0.1048	0.1819
Plasmodium vivax	lysine--tRNA ligase, putative	0.0023	0.0169	0.0359
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0076	0.0132
Mycobacterium ulcerans	integral membrane transport protein	0.0015	0.0076	0.0068
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0268	0.1558
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0268	0.1558
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0032	0.0256	0.0445
Leishmania major	hypothetical protein, conserved	0.0168	0.1718	1
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0076	0.0056
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0263	0.2513
Brugia malayi	major facilitator superfamily protein	0.0015	0.0076	0.0132
Schistosoma mansoni	glutamate receptor NMDA	0.0011	0.0034	0.0322
Trypanosoma cruzi	hexose transporter, putative	0.0018	0.0109	0.0633
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0076	0.0132
Entamoeba histolytica	protein kinase, putative	0.0032	0.0263	0.0457
Echinococcus granulosus	BRK domain containing protein	0.0011	0.0038	0.0361
Trypanosoma cruzi	sugar transporter, putative	0.0015	0.0076	0.0442
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0169	0.0294
Leishmania major	glucose transporter, lmgt2	0.0033	0.0268	0.1558
Loa Loa (eye worm)	BRM protein	0.0041	0.0363	0.0629
Brugia malayi	Cam kinase protein 1	0.0032	0.0263	0.0457
Plasmodium vivax	proline--tRNA ligase, putative	0.0037	0.0312	0.0663
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0268	0.0391
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.0544	0.576	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0105	0.1048	0.1048
Trichomonas vaginalis	sugar transport protein, putative	0.0015	0.0076	0.0056
Schistosoma mansoni	glucose transport protein	0.0105	0.1048	1
Schistosoma mansoni	sugar transporter	0.0015	0.0076	0.0726
Echinococcus multilocularis	global transcription activator snf2l2	0.0065	0.0615	0.0615
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0169	0.1617
Echinococcus multilocularis	BRK domain containing protein	0.0011	0.0038	0.0038
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0037	0.0312	0.1818
Echinococcus multilocularis	lysyl tRNA synthetase	0.0023	0.0169	0.0169
Echinococcus multilocularis	Chromo domain	0.0011	0.0038	0.0038
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0011	0.0034	0.0034
Loa Loa (eye worm)	methionine aminopeptidase type I	0.0088	0.0865	0.1502
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0076	0.0056
Echinococcus multilocularis	BRK domain containing protein	0.0011	0.0038	0.0038
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0312	0.1818
Mycobacterium tuberculosis	Probable glutamine-binding lipoprotein GlnH (GLNBP)	0.0018	0.0115	0.01
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0081	0.0081
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0312	0.1818
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.002	0.0131	0.0143
Brugia malayi	Cytochrome P450 family protein	0.0014	0.007	0.0122
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0076	0.0056
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.0169	0.0219
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein	0.0018	0.0115	0.1619
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0076	0.0056
Echinococcus multilocularis	BRK domain containing protein	0.0011	0.0038	0.0038
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0076	0.0132
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0015	0.0076	0.0068
Schistosoma mansoni	hypothetical protein	0.0011	0.0038	0.0361
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0105	0.1048	1
Entamoeba histolytica	hypothetical protein	0.0096	0.0944	0.1639
Echinococcus multilocularis	methionyl aminopeptidase 1 (M24 family)	0.0088	0.0865	0.0865
Loa Loa (eye worm)	sugar transporter	0.0015	0.0076	0.0132
Toxoplasma gondii	sugar transporter ST1	0.0015	0.0076	0.0163
Echinococcus granulosus	Chromo domain	0.0011	0.0038	0.0362
Loa Loa (eye worm)	CYP4Cod1	0.0014	0.007	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0081	0.014
Onchocerca volvulus		0.0544	0.576	1
Giardia lamblia	Lysyl-tRNA synthetase	0.0023	0.0169	0.0164
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0076	0.0056
Schistosoma mansoni	hypothetical protein	0.0105	0.1048	1
Echinococcus multilocularis	chromodomain helicase DNA binding protein 7	0.0011	0.0038	0.0038
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0081	0.014
Trypanosoma brucei	methionine aminopeptidase, putative	0.0088	0.0865	0.5036
Plasmodium vivax	methionine aminopeptidase 1b, putative	0.0088	0.0865	0.1835
Trypanosoma brucei	PAB1-binding protein , putative	0.0024	0.0179	0.1041
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0271	0.047
Giardia lamblia	DNA repair protein RAD52	0.0336	0.3527	0.6072
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0268	0.0391
Trichomonas vaginalis	conserved hypothetical protein	0.0105	0.1048	0.1755
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0076	0.0132
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0268	0.1558
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0076	0.0056
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0446	0.4715	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0032	0.0264	0.1539
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0268	0.1558
Schistosoma mansoni	protein kinase	0.0032	0.0263	0.2513
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0268	0.1558
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0076	0.0056
Echinococcus multilocularis	BRK domain containing protein	0.0011	0.0038	0.0038
Echinococcus granulosus	GPCR family 2	0.0015	0.0081	0.0772
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0263	0.0263
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0076	0.0056
Trypanosoma brucei	metallo- peptidase, Clan MG, Family M24	0.0088	0.0865	0.5036
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0076	0.0132
Toxoplasma gondii	methionine aminopeptidase	0.0056	0.0518	0.1595
Brugia malayi	hypothetical protein	0.0015	0.0076	0.0132
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0076	0.0132
Echinococcus granulosus	General substrate transporter	0.009	0.0889	0.8483
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0011	0.0034	0.0322
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.0544	0.576	1
Schistosoma mansoni	methionyl aminopeptidase 1 (M24 family)	0.0056	0.0518	0.4944
Brugia malayi	hypothetical protein	0.0024	0.0179	0.031
Chlamydia trachomatis	lysine--tRNA ligase	0.0023	0.0169	0.2755
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0312	0.1818
Brugia malayi	hypothetical protein	0.0016	0.0086	0.0149
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0076	0.0056
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0544	0.576	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0076	0.0056
Trypanosoma cruzi	cytochrome P450, putative	0.0014	0.007	0.0408
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0256	0.2446
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.002	0.0131	0.0143
Brugia malayi	hypothetical protein	0.0015	0.0076	0.0132
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0032	0.0263	0.0559
Schistosoma mansoni	sugar transporter	0.0015	0.0076	0.0726
Plasmodium falciparum	protein kinase 6	0.0446	0.4715	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0076	0.0056
Echinococcus granulosus	solute carrier family 22	0.0015	0.0076	0.0726
Toxoplasma gondii	facilitative glucose transporter GT1	0.0105	0.1048	0.3312
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0076	0.0076
Plasmodium falciparum	hexose transporter	0.0105	0.1048	0.2222
Giardia lamblia	Prolyl-tRNA synthetase	0.0032	0.0256	0.0317
Echinococcus multilocularis	General substrate transporter	0.009	0.0889	0.0889
Brugia malayi	Sugar transporter family protein	0.0015	0.0076	0.0132
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0032	0.0263	0.0559
Brugia malayi	Methionine aminopeptidase protein type I	0.0088	0.0865	0.1502
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0011	0.0034	0.0322
Schistosoma mansoni	helicase	0.0065	0.0615	0.5867
Leishmania major	cytochrome p450-like protein	0.0014	0.007	0.0408
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0076	0.0056
Brugia malayi	lysyl-tRNA synthetase	0.0023	0.0169	0.0294
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0179	0.0379
Trypanosoma cruzi	hexose transporter, putative	0.0015	0.0076	0.0442
Toxoplasma gondii	sugar transporter ST3	0.0015	0.0076	0.0163
Entamoeba histolytica	protein kinase, putative	0.0032	0.0263	0.0457
Chlamydia trachomatis	arginine ABC transporter substrate-binding protein ArtJ	0.0018	0.0115	0.1619
Schistosoma mansoni	protein kinase	0.0032	0.0263	0.2513
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0435	0.0755
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0263	0.0263
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0011	0.0034	0.0034
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0169	0.0232
Echinococcus multilocularis	methionyl aminopeptidase 1 (M24 family)	0.0056	0.0518	0.0518
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0023	0.0169	0.0986
Schistosoma mansoni	sugar transporter	0.0015	0.0076	0.0726
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.0376	0.3959	1
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0032	0.0263	0.077
Plasmodium vivax	methionine aminopeptidase 1a, putative	0.0056	0.0518	0.1098
Trypanosoma cruzi	hypothetical protein, conserved	0.0168	0.1718	1
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0076	0.0076
Schistosoma mansoni	hypothetical protein	0.0015	0.0081	0.0772
Brugia malayi	Sugar transporter family protein	0.0015	0.0076	0.0132
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0168	0.1718	0.2929
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0015	0.0076	0.0068
Brugia malayi	BRM protein	0.0065	0.0615	0.1067
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0263	0.2513
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0263	0.0263
Schistosoma mansoni	hypothetical protein	0.0015	0.0081	0.0772
Loa Loa (eye worm)	helicase DNA-binding protein	0.0011	0.0038	0.0066
Trypanosoma brucei	cytochrome P450, putative	0.0014	0.007	0.0408
Leishmania major	methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24	0.0088	0.0865	0.5036
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0076	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0271	0.047
Toxoplasma gondii	protein kinase, putative	0.0297	0.3111	1
Echinococcus granulosus	global transcription activator snf2l2	0.0065	0.0615	0.5867
Leishmania major	lysyl-tRNA synthetase, putative	0.0023	0.0169	0.0986
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.017	0.1744	0.3698
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0268	0.1558
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0015	0.0076	0.0726
Schistosoma mansoni	hypothetical protein	0.0033	0.0271	0.2587
Entamoeba histolytica	hypothetical protein	0.0023	0.0169	0.0294
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0168	0.1718	0.2929
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0032	0.0263	0.0457
Trichomonas vaginalis	CAMK family protein kinase	0.0032	0.0263	0.0383
Plasmodium vivax	hypothetical protein, conserved	0.0032	0.0264	0.0561
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0032	0.0263	0.1532
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0076	0.0056
Loa Loa (eye worm)	cytochrome P450 family protein	0.0014	0.007	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0076	0.0132
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0011	0.0034	0.0034
Echinococcus granulosus	solute carrier family 22	0.0015	0.0076	0.0726
Trypanosoma cruzi	glucose transporter, putative	0.0015	0.0076	0.0442
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0076	0.0056
Schistosoma mansoni	glucose transport protein	0.0105	0.1048	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0076	0.0056
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0076	0.0056
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0033	0.0268	0.1558
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0076	0.0056
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0076	0.0056
Leishmania major	hypothetical protein, conserved	0.0032	0.0264	0.1539
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.0544	0.576	1
Mycobacterium ulcerans	glutamine-binding lipoprotein GlnH	0.0018	0.0115	0.0136
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0544	0.576	1
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0011	0.0034	0.0322
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0076	0.0056
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0076	0.0056
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0544	0.576	1
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein (hisJ)	0.0018	0.0115	0.1619
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0105	0.1048	1
Trypanosoma cruzi	metallo- peptidase, Clan MG, Family M24	0.0088	0.0865	0.5036
Trypanosoma cruzi	cytochrome P450, putative	0.0014	0.007	0.0408
Schistosoma mansoni	glucose transporter	0.0015	0.0076	0.0726
Trichomonas vaginalis	glucose transporter, putative	0.0033	0.0268	0.0391
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0076	0.0132
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0032	0.0263	0.077
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0263	0.0263
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0011	0.0034	0.0034
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0011	0.0034	0.0034
Echinococcus granulosus	synaptic vesicle 2 protein	0.0015	0.0076	0.0726
Schistosoma mansoni	hypothetical protein	0.0011	0.0038	0.0362
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0014	0.007	0.0058
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0032	0.0263	0.2513
Plasmodium falciparum	methionine aminopeptidase 1b, putative	0.0088	0.0865	0.1835
Toxoplasma gondii	methionine aminopeptidase	0.0088	0.0865	0.2721
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0268	0.1558
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0179	0.1041
Plasmodium falciparum	proline--tRNA ligase	0.0037	0.0312	0.0663
Echinococcus granulosus	solute carrier family 22	0.0015	0.0076	0.0726
Trichomonas vaginalis	glucose transporter, putative	0.0033	0.0268	0.0391
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0032	0.0263	0.0559
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0076	0.0056
Plasmodium falciparum	HP12 protein homolog, putative	0.0032	0.0264	0.0561
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0032	0.0256	0.323
Echinococcus multilocularis	glutamate receptor 2	0.0011	0.0034	0.0034
Toxoplasma gondii	sugar transporter ST2	0.0015	0.0076	0.0163
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0256	0.0256
Toxoplasma gondii	SWI2/SNF2 Brahma-like putative	0.0012	0.0044	0.006
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.0168	0.1718	1
Echinococcus multilocularis	BRK domain containing protein	0.0011	0.0038	0.0038
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0105	0.1048	1
Schistosoma mansoni	hypothetical protein	0.0015	0.0081	0.0772
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0032	0.0263	0.0559
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0032	0.0256	0.0445
Leishmania major	hypothetical protein, conserved	0.0024	0.0179	0.1041
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0544	0.576	1
Treponema pallidum	methionine aminopeptidase (map)	0.0056	0.0518	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0076	0.0056
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0076	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0256	0.0445
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0015	0.0076	0.0076
Trypanosoma brucei	glucose transporter 2A	0.0033	0.0268	0.1558
Toxoplasma gondii	transporter, major facilitator family protein	0.0015	0.0076	0.0163
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0076	0.0056
Plasmodium falciparum	lysine--tRNA ligase	0.0023	0.0169	0.0359
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0076	0.0132
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0032	0.0263	0.0559
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0544	0.576	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0076	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0256	0.0445
Echinococcus granulosus	calcium dependent protein kinase	0.003	0.0242	0.2308
Trypanosoma brucei	hypothetical protein, conserved	0.0032	0.0264	0.1539
Schistosoma mansoni	sugar transporter	0.0015	0.0076	0.0726
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0076	0.0132
Brugia malayi	hypothetical protein	0.0015	0.0076	0.0132
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0011	0.0034	0.0329
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0076	0.0056
Echinococcus granulosus	solute carrier family 22	0.0015	0.0076	0.0726
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0268	0.0391
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0076	0.0076
Leishmania major	hypothetical protein, conserved	0.0015	0.0076	0.0442
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0268	0.1558
Plasmodium vivax	ataxin-2 like protein, putative	0.0024	0.0179	0.0379
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0076	0.0056
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0015	0.0076	0.0442
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0076	0.0132
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0032	0.0263	0.0457
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0268	0.1558
Echinococcus multilocularis	nmda type glutamate receptor	0.0026	0.0192	0.0192
Mycobacterium leprae	PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP)	0.0056	0.0518	1
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0032	0.0263	0.0559
Brugia malayi	major facilitator superfamily protein	0.0015	0.0076	0.0132
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0076	0.0056
Chlamydia trachomatis	methionine aminopeptidase	0.0056	0.0518	1
Schistosoma mansoni	hypothetical protein	0.0015	0.0081	0.0772
Wolbachia endosymbiont of Brugia malayi	methionine aminopeptidase	0.0056	0.0518	1
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0015	0.0076	0.0161
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0076	0.0076
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0268	0.1558
Trypanosoma brucei	methionine aminopeptidase, type I, putative	0.0088	0.0865	0.5036
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0544	0.576	1
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0105	0.1048	0.1048
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0076	0.0056
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0268	0.0391
Plasmodium falciparum	mitogen-activated protein kinase 2	0.017	0.1744	0.3698
Mycobacterium ulcerans	methionine aminopeptidase MapB	0.0056	0.0518	0.0841
Mycobacterium tuberculosis	Methionine aminopeptidase MapA (map) (peptidase M) (MetAP)	0.0056	0.0518	0.1138
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0268	0.1558
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0105	0.1048	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0268	0.1558
Chlamydia trachomatis	glutamine binding protein	0.0018	0.0115	0.1619
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0076	0.0056
Leishmania major	glucose transporter, lmgt3	0.0033	0.0268	0.1558
Schistosoma mansoni	hypothetical protein	0.0011	0.0034	0.0329
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0076	0.0056
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0179	0.0379
Echinococcus multilocularis	BRK domain	0.0011	0.0038	0.0038
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0105	0.1048	0.1048
Schistosoma mansoni	methionyl aminopeptidase 1 (M24 family)	0.0056	0.0518	0.4944
Trichomonas vaginalis	glucose transporter, putative	0.0015	0.0076	0.0056
Mycobacterium ulcerans	methionine aminopeptidase	0.0056	0.0518	0.0841
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0076	0.0056
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0076	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0076	0.0132
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0435	0.0755
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0032	0.0256	0.0371
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0076	0.0132
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0032	0.0263	0.0457
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0076	0.0132
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0076	0.0056
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0268	0.1558
Trypanosoma cruzi	metallo- peptidase, Clan MG, Family M24	0.0088	0.0865	0.5036
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0076	0.0056

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 6.64	Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]-SP as ligand.	ChEMBL.	9733486
IC50 (binding)	= 230 nM	Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells	ChEMBL.	No reference
IC50 (binding)	= 230 nM	Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells	ChEMBL.	No reference
Log IC50 (binding)	= 6.64 M	Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]-SP as ligand.	ChEMBL.	9733486

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL332140

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 210464