TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 358.431 | Formula: C20H26N2O4
H donors: 2 H acceptors: 3 LogP: 5.33 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)CNc1cccn2c1c(C(=O)O)c(c2CC1CCCCC1)C
InChi: 1S/C20H26N2O4/c1-13-16(11-14-7-4-3-5-8-14)22-10-6-9-15(21-12-17(23)26-2)19(22)18(13)20(24)25/h6,9-10,14,21H,3-5,7-8,11-12H2,1-2H3,(H,24,25)
InChiKey: KQGRGIHJVPTCEH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.0382	0.039
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0042	0.0463	0.0463
Schistosoma mansoni	nAChR subunit	0.0036	0.0286	0.0292
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0077	0.1518	0.1518
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0036	0.0286	0.0286
Brugia malayi	hypothetical protein	0.0036	0.0286	0.0286
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0077	0.1518	0.155
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1518	0.1518
Plasmodium falciparum	hexose transporter	0.0026	0	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0026	0	0.5
Echinococcus multilocularis	sodium:myo inositol cotransporter	0.0039	0.0396	0.0405
Schistosoma mansoni	hypothetical protein	0.0039	0.0382	0.039
Onchocerca volvulus		0.0077	0.1518	0.423
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0077	0.1518	0.1518
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0026	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0286	0.0286
Trypanosoma cruzi	lanosterol synthase, putative	0.0145	0.3537	0.3537
Brugia malayi	hypothetical protein	0.0036	0.0286	0.0286
Loa Loa (eye worm)	LGC-31 protein	0.0077	0.1518	0.1518
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0077	0.1518	0.1518
Onchocerca volvulus		0.0077	0.1518	0.423
Loa Loa (eye worm)	ACC-1 protein	0.0077	0.1518	0.1518
Mycobacterium ulcerans	integral membrane transport protein	0.0026	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0286	0.0286
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0077	0.1518	0.155
Schistosoma mansoni	nAChR subunit	0.0077	0.1518	0.155
Trichomonas vaginalis	sugar transporter, putative	0.0026	0	0.5
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0077	0.1518	0.155
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0	0.5
Onchocerca volvulus		0.0042	0.0463	0.1291
Trichomonas vaginalis	sugar transporter, putative	0.0026	0	0.5
Onchocerca volvulus		0.0039	0.0396	0.1105
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0286	0.0286
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0077	0.1518	0.155
Loa Loa (eye worm)	acetylcholine receptor protein	0.0036	0.0286	0.0286
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0286	0.0286
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0036	0.0286	0.0292
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0	0.5
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0036	0.0286	0.0292
Brugia malayi	Cation transporter family protein	0.0077	0.1518	0.1518
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0	0.5
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0077	0.1518	0.155
Onchocerca volvulus	Putative nachr subunit	0.0147	0.3587	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0036	0.0286	0.0286
Onchocerca volvulus		0.0036	0.0286	0.0798
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0077	0.1518	0.155
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0147	0.3587	0.3664
Loa Loa (eye worm)	hypothetical protein	0.0147	0.3587	0.3587
Schistosoma mansoni	nAChR subunit	0.0077	0.1518	0.155
Trypanosoma cruzi	Emopamil binding protein, putative	0.0136	0.3254	0.3254
Schistosoma mansoni	nAChR subunit	0.0077	0.1518	0.155
Loa Loa (eye worm)	hypothetical protein	0.0112	0.2533	0.2533
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0286	0.0286
Onchocerca volvulus		0.0036	0.0286	0.0798
Onchocerca volvulus		0.0147	0.3587	1
Onchocerca volvulus		0.0042	0.0463	0.1291
Schistosoma mansoni	neurotransmitter gated ion channel	0.0036	0.0286	0.0292
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0077	0.1518	0.1518
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0286	0.0286
Echinococcus multilocularis	solute carrier family 5	0.0039	0.0396	0.0405
Trypanosoma brucei	Emopamil binding protein, putative	0.0136	0.3254	0.3254
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0077	0.1518	0.1518
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0463	0.0463
Echinococcus multilocularis	sodium coupled monocarboxylate transporter 1	0.0039	0.0396	0.0405
Trichomonas vaginalis	sugar transporter, putative	0.0026	0	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0026	0	0.5
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0147	0.3587	0.3664
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0463	0.0463
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0036	0.0286	0.0286
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0077	0.1518	0.155
Loa Loa (eye worm)	hypothetical protein	0.0147	0.3587	0.3587
Trichomonas vaginalis	sugar transporter, putative	0.0026	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0186	0.4735	0.4735
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0286	0.0286
Echinococcus multilocularis	nAChR subunit	0.0042	0.0463	0.0473
Echinococcus granulosus	nAChR subunit	0.0042	0.0463	0.0473
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0077	0.1518	0.155
Loa Loa (eye worm)	hypothetical protein	0.0147	0.3587	0.3587
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0286	0.0286
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0286	0.0286
Trichomonas vaginalis	glucose transporter, putative	0.0026	0	0.5
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0077	0.1518	0.155
Schistosoma mansoni	nAChR subunit	0.0036	0.0286	0.0292
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0147	0.3587	0.3664
Echinococcus granulosus	sodium:myo inositol cotransporter	0.0039	0.0396	0.0405
Brugia malayi	Sodium:solute symporter family protein	0.0039	0.0396	0.0396
Trichomonas vaginalis	sugar transporter, putative	0.0026	0	0.5
Onchocerca volvulus		0.0077	0.1518	0.423
Plasmodium vivax	sugar transporter, putative	0.0026	0	0.5
Brugia malayi	Cation transporter family protein	0.0077	0.1518	0.1518
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0396	0.0396
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0077	0.1518	0.1518
Trichomonas vaginalis	sugar transporter, putative	0.0026	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0286	0.0286
Trichomonas vaginalis	sugar transporter, putative	0.0026	0	0.5
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0077	0.1518	0.1518
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1518	0.1518
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0036	0.0286	0.0292
Echinococcus multilocularis	nAChR subunit	0.0077	0.1518	0.155
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1518	0.1518
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0077	0.1518	0.1518
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0036	0.0286	0.0292
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0036	0.0286	0.0292
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1518	0.1518
Echinococcus granulosus	glycine receptor subunit beta	0.0077	0.1518	0.155
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0077	0.1518	0.1518
Schistosoma mansoni	nAChR subunit	0.0077	0.1518	0.155
Mycobacterium ulcerans	sugar transporter	0.0026	0	0.5
Echinococcus multilocularis	glycine receptor subunit beta	0.0077	0.1518	0.155
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0072	0.1362	0.1391
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0042	0.0463	0.0463
Brugia malayi	hypothetical protein	0.0036	0.0286	0.0286
Trichomonas vaginalis	sugar transporter, putative	0.0026	0	0.5
Echinococcus granulosus	sodium:glucose cotransporter 2	0.0039	0.0396	0.0405
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0042	0.0463	0.0463
Trichomonas vaginalis	sugar transporter, putative	0.0026	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1518	0.1518
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0077	0.1518	0.155
Trichomonas vaginalis	sugar transport protein, putative	0.0026	0	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0026	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1518	0.1518
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0286	0.0286
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.0382	0.039
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0463	0.0463
Loa Loa (eye worm)	GABA receptor subunit	0.0042	0.0463	0.0463
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0147	0.3587	0.3664
Trichomonas vaginalis	sugar transporter, putative	0.0026	0	0.5
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0026	0	0.5
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0364	1	1
Echinococcus granulosus	sodium:glucose cotransporter	0.0039	0.0396	0.0405
Trichomonas vaginalis	sugar transporter, putative	0.0026	0	0.5
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0147	0.3587	0.3664
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0077	0.1518	0.155
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1518	0.1518
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0026	0	0.5
Echinococcus granulosus	sodium coupled monocarboxylate transporter 1	0.0039	0.0396	0.0405
Schistosoma mansoni	nAChR subunit	0.0077	0.1518	0.155
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0077	0.1518	0.1518
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0077	0.1518	0.1518
Leishmania major	lanosterol synthase, putative	0.0126	0.2947	0.2947
Trichomonas vaginalis	sugar transporter, putative	0.0026	0	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0026	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1518	0.1518
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0077	0.1518	0.155
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0077	0.1518	0.1518
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0042	0.0463	0.0473
Trichomonas vaginalis	sugar transporter, putative	0.0026	0	0.5
Onchocerca volvulus		0.0136	0.3254	0.9071
Trichomonas vaginalis	sugar transporter, putative	0.0026	0	0.5
Plasmodium vivax	hexose transporter	0.0026	0	0.5
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0036	0.0286	0.0286
Echinococcus granulosus	glycine receptor subunit beta	0.0077	0.1518	0.155
Trichomonas vaginalis	sugar transporter, putative	0.0026	0	0.5
Schistosoma mansoni	high-affinity choline transporter	0.0357	0.9792	1
Trichomonas vaginalis	sugar transporter, putative	0.0026	0	0.5
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0036	0.0286	0.0286
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0147	0.3587	0.3587
Schistosoma mansoni	neurotransmitter gated ion channel	0.0036	0.0286	0.0292
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0147	0.3587	0.3587
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0042	0.0463	0.0463
Schistosoma mansoni	sodium/solute symporter	0.0039	0.0396	0.0405
Brugia malayi	hypothetical protein	0.0036	0.0286	0.0286
Schistosoma mansoni	neurotransmitter gated ion channel	0.0042	0.0463	0.0473
Trichomonas vaginalis	glucose transporter, putative	0.0026	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0463	0.0463
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1518	0.1518
Leishmania major	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.0136	0.3254	0.3254
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0077	0.1518	0.1518
Schistosoma mansoni	inositol transporter	0.0039	0.0396	0.0405
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1518	0.1518
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0286	0.0286
Trichomonas vaginalis	glucose transporter, putative	0.0026	0	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0026	0	0.5
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0036	0.0286	0.0286
Echinococcus granulosus	solute carrier family 5	0.0039	0.0396	0.0405
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0077	0.1518	0.1518
Trichomonas vaginalis	sugar transporter, putative	0.0026	0	0.5
Brugia malayi	excitatory GABA receptor EXP-1A	0.0077	0.1518	0.1518
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1518	0.1518
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0463	0.0463
Trichomonas vaginalis	sugar transporter, putative	0.0026	0	0.5
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0077	0.1518	0.1518
Trichomonas vaginalis	sugar transporter, putative	0.0026	0	0.5
Loa Loa (eye worm)	ACC-1 protein	0.0077	0.1518	0.1518
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0147	0.3587	0.3664
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0077	0.1518	0.155
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1518	0.1518
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0077	0.1518	0.155
Trichomonas vaginalis	sugar transporter, putative	0.0026	0	0.5
Echinococcus multilocularis	sodium:glucose cotransporter 2	0.0039	0.0396	0.0405
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0382	0.039
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0072	0.1362	0.1391
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0077	0.1518	0.1518
Brugia malayi	hypothetical protein	0.0036	0.0286	0.0286
Onchocerca volvulus		0.0036	0.0286	0.0798
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0	0.5
Onchocerca volvulus		0.0147	0.3587	1
Trichomonas vaginalis	sugar transporter, putative	0.0026	0	0.5
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0077	0.1518	0.155
Trichomonas vaginalis	sugar transporter, putative	0.0026	0	0.5
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0077	0.1518	0.1518
Toxoplasma gondii	transporter, solute:sodium symporter (SSS) family protein	0.0039	0.0396	1
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0026	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0463	0.0463
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0286	0.0286
Schistosoma mansoni	nAChR subunit	0.0077	0.1518	0.155
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0026	0	0.5
Schistosoma mansoni	acetylcholine receptor-related	0.0036	0.0286	0.0292
Trichomonas vaginalis	sugar transporter, putative	0.0026	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0286	0.0286
Trichomonas vaginalis	sugar transporter, putative	0.0026	0	0.5
Brugia malayi	Cation transporter family protein	0.0147	0.3587	0.3587
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0286	0.0286
Echinococcus multilocularis	high affinity choline transporter 1	0.0357	0.9792	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0077	0.1518	0.1518
Trichomonas vaginalis	sugar transporter, putative	0.0026	0	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0026	0	0.5
Entamoeba histolytica	hypothetical protein	0.0042	0.0463	1
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0	0.5
Trichomonas vaginalis	myo-inositol transporter, putative	0.0026	0	0.5
Leishmania major	C-8 sterol isomerase-like protein	0.0364	1	1
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0077	0.1518	0.155
Loa Loa (eye worm)	hypothetical protein	0.0364	1	1
Echinococcus granulosus	high affinity choline transporter 1	0.0357	0.9792	1
Trichomonas vaginalis	sugar transporter, putative	0.0026	0	0.5
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0077	0.1518	0.155
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0147	0.3587	0.3664
Trypanosoma cruzi	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.0136	0.3254	0.3254
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0364	1	1
Trypanosoma brucei	lanosterol synthase	0.0145	0.3537	0.3537
Brugia malayi	hypothetical protein	0.0039	0.0382	0.0382
Trichomonas vaginalis	sugar transporter, putative	0.0026	0	0.5
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0077	0.1518	0.155
Leishmania major	hypothetical protein, conserved	0.0136	0.3254	0.3254
Brugia malayi	GH02984p	0.0357	0.9792	0.9792
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1518	0.1518
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0036	0.0286	0.0286
Schistosoma mansoni	nAChR subunit	0.0077	0.1518	0.155
Trypanosoma cruzi	lanosterol synthase, putative	0.0145	0.3537	0.3537
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0036	0.0286	0.0286
Giardia lamblia	Sugar-proton symporter	0.0026	0	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0026	0	0.5
Trypanosoma cruzi	Emopamil binding protein, putative	0.0136	0.3254	0.3254
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0077	0.1518	0.1518
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0	0.5
Giardia lamblia	Hexose transporter	0.0026	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1518	0.1518
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0077	0.1518	0.155
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1518	0.1518
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0463	0.0463
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0463	0.0463
Trichomonas vaginalis	sugar transporter, putative	0.0026	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0357	0.9792	0.9792
Trichomonas vaginalis	sugar transporter, putative	0.0026	0	0.5
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0147	0.3587	0.3664
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0	0.5
Mycobacterium tuberculosis	Halimadienyl diphosphate synthase	0.0081	0.1615	1
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0042	0.0463	0.0473
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1518	0.1518
Trypanosoma cruzi	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.0136	0.3254	0.3254
Echinococcus granulosus	nAChR subunit	0.0077	0.1518	0.155
Schistosoma mansoni	inositol transporter	0.0039	0.0396	0.0405
Trichomonas vaginalis	sugar transporter, putative	0.0026	0	0.5
Onchocerca volvulus		0.0147	0.3587	1
Echinococcus multilocularis	glycine receptor subunit beta	0.0077	0.1518	0.155
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0036	0.0286	0.0292
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0077	0.1518	0.1518

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 50 uM	Inhibition of recombinant human secretory phospholipase A2 (sPLA2), chromogenic screening assay.	ChEMBL.	8809154
IC50 (binding)	> 50 uM	Inhibition of recombinant human secretory phospholipase A2 (sPLA2), chromogenic screening assay.	ChEMBL.	8809154

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 211263