Detailed information for compound 211568

Basic information

Technical information
  • TDR Targets ID: 211568
  • Name: N-(cyanomethyl)-4-methyl-2-(3-pyridin-3-ylphe nyl)pentanamide
  • MW: 307.39 | Formula: C19H21N3O
  • H donors: 1 H acceptors: 3 LogP: 3.2 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CCNC(=O)C(c1cccc(c1)c1cccnc1)CC(C)C
  • InChi: 1S/C19H21N3O/c1-14(2)11-18(19(23)22-10-8-20)16-6-3-5-15(12-16)17-7-4-9-21-13-17/h3-7,9,12-14,18H,10-11H2,1-2H3,(H,22,23)
  • InChiKey: IHQHRMDKNBEEEL-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-(cyanomethyl)-4-methyl-2-[3-(3-pyridyl)phenyl]pentanamide
  • N-(cyanomethyl)-4-methyl-2-[3-(3-pyridyl)phenyl]valeramide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin L Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References
Homo sapiens cathepsin S Starlite/ChEMBL References
Homo sapiens cathepsin K Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin S 281 aa 226 aa 34.1 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.149 0.1376
Brugia malayi Cathepsin L-like cysteine proteinase 0.0059 0.2207 0.2102
Schistosoma mansoni hypothetical protein 0.0036 0.0707 0.0707
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.392 1
Loa Loa (eye worm) cathepsin B 0.007 0.2882 0.2786
Echinococcus multilocularis cathepsin L cysteine protease 0.0086 0.392 0.3816
Entamoeba histolytica cysteine proteinase 1, putative 0.0047 0.1408 0.3304
Leishmania major cathepsin L-like protease 0.0086 0.392 1
Entamoeba histolytica cysteine proteinase, putative 0.0086 0.392 1
Leishmania major cathepsin L-like protease 0.0086 0.392 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.007 0.2882 0.7233
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.392 1
Leishmania major cathepsin L-like protease 0.0086 0.392 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.392 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.392 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.1408 0.1408
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.1408 0.3304
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.392 1
Plasmodium vivax unspecified product 0.0047 0.1408 0.3366
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0086 0.392 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.392 1
Brugia malayi Cathepsin L-like precursor 0.0059 0.2207 0.2102
Plasmodium vivax vivapain-2 0.0086 0.392 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.392 1
Echinococcus multilocularis cysteine protease 0.0086 0.392 0.3816
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0086 0.392 0.3816
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0086 0.392 1
Onchocerca volvulus 0.0086 0.392 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.392 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0086 0.392 1
Echinococcus granulosus cathepsin L 0.0047 0.1408 0.1261
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.1766 0.1656
Brugia malayi Cathepsin L-like precursor 0.0086 0.392 0.3838
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.392 1
Loa Loa (eye worm) fibroinase 0.0086 0.392 0.3838
Brugia malayi Cathepsin L-like precursor 0.0059 0.2207 0.2102
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.2207 0.2102
Leishmania major cathepsin L-like protease 0.0086 0.392 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.392 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.392 1
Schistosoma mansoni cathepsin F (C01 family) 0.0059 0.2207 0.2207
Leishmania major cysteine peptidase A (CPA) 0.0086 0.392 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0086 0.392 0.3816
Entamoeba histolytica cysteine protease, putative 0.0086 0.392 1
Entamoeba histolytica cysteine protease, putative 0.0047 0.1408 0.3304
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.1408 0.1408
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0086 0.392 0.3816
Trypanosoma cruzi cysteine proteinase, putative 0.0047 0.1408 0.1292
Echinococcus granulosus cathepsin L cysteine protease 0.0047 0.1408 0.1261
Echinococcus granulosus cathepsin L cysteine proteinase 0.0086 0.392 0.3816
Trypanosoma cruzi cruzipain precursor, putative 0.0086 0.392 0.3838
Trypanosoma brucei cysteine peptidase C (CPC) 0.007 0.2882 0.7233
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.392 1
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.392 0.3838
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.392 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.2207 0.5434
Entamoeba histolytica cysteine proteinase 2 0.0047 0.1408 0.3304
Plasmodium falciparum cysteine proteinase falcipain 1 0.0047 0.1408 0.3304
Brugia malayi Cathepsin L-like precursor 0.0086 0.392 0.3838
Trypanosoma cruzi cysteine proteinase, putative 0.0047 0.1408 0.1292
Loa Loa (eye worm) hypothetical protein 0.0052 0.1766 0.1656
Loa Loa (eye worm) cysteine protease 0.0086 0.392 0.3838
Schistosoma mansoni cathepsin s 0.0027 0.0133 0.0133
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0168 0.0036
Onchocerca volvulus 0.0086 0.392 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.392 1
Entamoeba histolytica cysteine protease, putative 0.0047 0.1408 0.3304
Plasmodium vivax vivapain-1 0.0047 0.1408 0.3366
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0086 0.392 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.007 0.2882 0.2786
Loa Loa (eye worm) hypothetical protein 0.0036 0.0707 0.0583
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.2207 0.5434
Toxoplasma gondii cathepsin CPL 0.0086 0.392 1
Echinococcus multilocularis cathepsin L 0.0047 0.1408 0.1261
Onchocerca volvulus Cathepsin L homolog 0.0086 0.392 1
Onchocerca volvulus 0.0086 0.392 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.1766 0.1656
Echinococcus multilocularis cysteine protease 0.0086 0.392 0.3816
Echinococcus multilocularis cathepsin b 0.0181 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.149 0.149
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.149 0.149
Loa Loa (eye worm) hypothetical protein 0.0181 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0086 0.392 0.392
Brugia malayi Papain family cysteine protease containing protein 0.0086 0.392 0.3838
Brugia malayi Cathepsin L-like precursor 0.0086 0.392 0.3838
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.1408 0.1408
Echinococcus multilocularis cathepsin b 0.0181 1 1
Entamoeba histolytica cysteine protease, putative 0.0047 0.1408 0.3304
Entamoeba histolytica cysteine proteinase, putative 0.0059 0.2207 0.5434
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.1408 0.1292
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.392 1
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.392 0.3838
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0086 0.392 1
Onchocerca volvulus 0.0086 0.392 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0086 0.392 0.3838
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.392 1
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.1408 0.1292
Brugia malayi Cathepsin L-like precursor 0.0086 0.392 0.3838
Brugia malayi Cathepsin L-like precursor 0.0086 0.392 0.3838
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.1408 0.3304
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.1408 0.3304
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.392 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.392 1
Entamoeba histolytica cysteine protease, putative 0.0047 0.1408 0.3304
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0086 0.392 0.3838
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.1766 0.1656
Schistosoma mansoni cathepsin F (C01 family) 0.0086 0.392 0.392
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.1408 0.1292
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.392 1
Entamoeba histolytica cysteine protease, putative 0.0047 0.1408 0.3304
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.007 0.2882 0.7233
Loa Loa (eye worm) ctsf protein 0.0086 0.392 0.3838
Onchocerca volvulus 0.0086 0.392 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.2207 0.2102
Echinococcus granulosus cathepsin l1 0.0086 0.392 0.3816
Loa Loa (eye worm) hypothetical protein 0.0059 0.2207 0.2102
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.392 1
Brugia malayi Cathepsin L-like precursor 0.0086 0.392 0.3838
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.149 0.1345
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.392 1
Brugia malayi cathepsin L-like precursor 0.0059 0.2207 0.2102
Leishmania major cathepsin L-like protease 0.0086 0.392 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.392 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.149 0.1345
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.149 0.1345
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.007 0.2882 0.2882
Entamoeba histolytica cysteine protease, putative 0.0047 0.1408 0.3304
Toxoplasma gondii cathepsin B 0.007 0.2882 0.7233
Entamoeba histolytica cysteine protease, putative 0.0047 0.1408 0.3304
Leishmania major cathepsin L-like protease 0.0086 0.392 1
Brugia malayi Flap endonuclease-1 0.0027 0.0168 0.0036
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.392 0.3838
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.392 1
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0707 0.0583
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.392 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.392 1
Entamoeba histolytica cysteine protease, putative 0.0047 0.1408 0.3304
Echinococcus granulosus cathepsin l1 0.0059 0.2207 0.2074
Plasmodium vivax vivapain-3 0.0047 0.1408 0.3366
Onchocerca volvulus Cathepsin F homolog 0.0086 0.392 1
Trypanosoma cruzi cysteine protease, putative 0.0047 0.1408 0.1292
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.1408 0.3304
Entamoeba histolytica cysteine protease, putative 0.0047 0.1408 0.3304
Leishmania major cathepsin L-like protease 0.0086 0.392 1
Giardia lamblia Cathepsin B precursor 0.007 0.2882 1
Echinococcus granulosus cathepsin b 0.0181 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.392 1
Plasmodium vivax vivapain-2 0.0086 0.392 1
Entamoeba histolytica cysteine proteinase, putative 0.0086 0.392 1
Entamoeba histolytica cysteine protease, putative 0.0047 0.1408 0.3304
Echinococcus multilocularis cathepsin L cysteine protease 0.0086 0.392 0.3816
Entamoeba histolytica cysteine protease, putative 0.0047 0.1408 0.3304
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.392 1
Onchocerca volvulus Cathepsin L homolog 0.0086 0.392 1
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.392 0.3838
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0168 0.0036
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.149 0.149
Onchocerca volvulus 0.0086 0.392 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.392 1
Giardia lamblia Cathepsin B precursor 0.007 0.2882 1
Onchocerca volvulus 0.0086 0.392 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.1408 0.3304
Leishmania major cathepsin L-like protease 0.0086 0.392 1
Giardia lamblia Cathepsin B precursor 0.007 0.2882 1
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0168 0.0093
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0047 0.1408 0.1292
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.392 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0181 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.1408 0.3304
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.392 1
Entamoeba histolytica cysteine protease, putative 0.0047 0.1408 0.3304
Echinococcus granulosus cysteine protease 0.0047 0.1408 0.1261
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.392 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 1 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.149 0.1376
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0181 1 1
Echinococcus granulosus cathepsin b 0.0181 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.1408 0.3304
Entamoeba histolytica cysteine protease, putative 0.0047 0.1408 0.3304
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.149 0.1345
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.392 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.392 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.392 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.392 0.3838
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.1408 0.3304
Loa Loa (eye worm) hypothetical protein 0.0059 0.2207 0.2102

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 803 nM In vitro inhibitory activity against human cathepsin K, using 2 microM of Z -Leu-Arg-AMC as substrate ChEMBL. 12904076
IC50 (binding) = 803 nM In vitro inhibitory activity against human cathepsin K, using 2 microM of Z -Leu-Arg-AMC as substrate ChEMBL. 12904076
IC50 (binding) = 5952 nM In vitro inhibitory activity against human cathepsin L, using 2 microM of Z -Leu-Arg-AMC as substrate ChEMBL. 12904076
IC50 (binding) = 5952 nM In vitro inhibitory activity against human cathepsin L, using 2 microM of Z -Leu-Arg-AMC as substrate ChEMBL. 12904076
IC50 (binding) = 8039 nM In vitro inhibitory activity against human cathepsin S, using 2 microM of Z -Leu-Arg-AMC as substrate ChEMBL. 12904076
IC50 (binding) = 8039 nM In vitro inhibitory activity against human cathepsin S, using 2 microM of Z -Leu-Arg-AMC as substrate ChEMBL. 12904076
IC50 (binding) > 10000 nM In vitro inhibitory activity against human cathepsin B, using 2 microM of Z -Leu-Arg-AMC as substrate ChEMBL. 12904076
IC50 (binding) > 10000 nM In vitro inhibitory activity against human cathepsin B, using 2 microM of Z -Leu-Arg-AMC as substrate ChEMBL. 12904076

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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