Detailed information for compound 2148701

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 367.11 | Formula: C18H17N5O2S
  • H donors: 4 H acceptors: 4 LogP: 3.47 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 0
  • SMILES: Oc1cccc(c1)NC(C(=O)Nc1nc2c(s1)c1cn[nH]c1cc2)(C)C
  • InChi: InChI=1S/C18H17N5O2S/c1-18(2,22-10-4-3-5-11(24)8-10)16(25)21-17-20-14-7-6-13-12(9-19-23-13)15(14)26-17/h3-9,22,24H,1-2H3,(H,19,23)(H,20,21,25)
  • InChiKey: RAOPEUTYHRNFHJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adrenergic, beta, receptor kinase 1 No references
Homo sapiens cyclin-dependent kinase 3 No references
Homo sapiens cyclin B1 No references
Homo sapiens cyclin E1 No references
Homo sapiens aurora kinase A No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_133273 All targets in OG5_133273
Echinococcus granulosus beta-adrenergic receptor kinase Get druggable targets OG5_131467 All targets in OG5_131467
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) cyclin domain-containing protein Get druggable targets OG5_133273 All targets in OG5_133273
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei gambiense cyclin 6,mitotic cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_131467 All targets in OG5_131467
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica serine/threonine- protein kinase 6 , putative Get druggable targets OG5_127024 All targets in OG5_127024
Onchocerca volvulus Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium hominis protein kinase (EC 2.7.1.-) p46XlEg22 Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma congolense mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania donovani CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Toxoplasma gondii aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus G protein coupled receptor kinase 1 Get druggable targets OG5_131467 All targets in OG5_131467
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis G protein coupled receptor kinase 1 Get druggable targets OG5_131467 All targets in OG5_131467
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium berghei serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin A, putative Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium vivax serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Neospora caninum hypothetical protein Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium hominis mitotic cyclin-CYC2 Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis beta adrenergic receptor kinase Get druggable targets OG5_131467 All targets in OG5_131467
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium yoelii putative protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium parvum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania donovani cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_131467 All targets in OG5_131467
Plasmodium knowlesi serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi aurora B kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi serine/threonine-protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica serine/threonine- protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K08850 aurora kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi serine/threonine kinase 12 Get druggable targets OG5_127024 All targets in OG5_127024
Giardia lamblia G2/mitotic-specific cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum G protein-coupled receptor kinase 1, putative Get druggable targets OG5_131467 All targets in OG5_131467
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131467 All targets in OG5_131467
Leishmania infantum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma congolense Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani Aurora I-related kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K00924 G-protein-coupled Receptor Kinase [EC:2.7.1.-], putative Get druggable targets OG5_131467 All targets in OG5_131467
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase , putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Serine/threonine-protein kinase 12, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127024 All targets in OG5_127024
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) AGC/GRK/BARK protein kinase Get druggable targets OG5_131467 All targets in OG5_131467
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis AGC family protein kinase 0.0069 0.1468 0.8805
Echinococcus multilocularis cyclin dependent kinase 5 0.0053 0.0865 0.1437
Entamoeba histolytica protein kinase, putative 0.0069 0.1468 0.8703
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.0865 0.0865
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0865 0.1437
Trichomonas vaginalis cyclin B3, putative 0.0043 0.0485 0.078
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.0865 0.1437
Echinococcus multilocularis cyclin dependent kinase 0.0053 0.0865 0.1437
Plasmodium falciparum serine/threonine protein kinase, putative 0.0069 0.1468 1
Brugia malayi serine/threonine kinase 12 0.0069 0.1468 0.1033
Trichomonas vaginalis cyclins, putative 0.0073 0.1615 1
Giardia lamblia Aurora kinase 0.0069 0.1468 0.8703
Brugia malayi cell division control protein 2 homolog 0.0053 0.0865 0.0399
Echinococcus multilocularis cyclin B 0.0073 0.1615 0.4277
Trypanosoma cruzi CYC2-like cyclin, putative 0.0073 0.1615 1
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0069 0.1468 1
Echinococcus granulosus cyclin dependent kinase 5 0.0053 0.0865 0.1437
Trichomonas vaginalis cyclins, putative 0.0073 0.1615 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0073 0.1615 0.1187
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0865 0.3878
Trichomonas vaginalis cyclin B, putative 0.0073 0.1615 1
Trichomonas vaginalis cyclins, putative 0.0043 0.0485 0.078
Trypanosoma cruzi cyclin 6, putative 0.0073 0.1615 1
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0053 0.0865 0.0865
Giardia lamblia G2/mitotic-specific cyclin B 0.0073 0.1615 1
Plasmodium falciparum protein kinase 5 0.0053 0.0865 0.386
Schistosoma mansoni protein kinase 0.0069 0.1468 0.3722
Echinococcus multilocularis aurora kinase A 0.0069 0.1468 0.3722
Loa Loa (eye worm) AUR protein kinase 0.0069 0.1468 0.1468
Onchocerca volvulus 0.0073 0.1615 0.5
Trichomonas vaginalis cyclin B, putative 0.0073 0.1615 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0812 0.0812
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0053 0.0865 0.5603
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.0865 0.336
Giardia lamblia Kinase, CMGC CDK 0.0053 0.0865 0.336
Entamoeba histolytica protein kinase domain containing protein 0.0069 0.1468 0.8703
Schistosoma mansoni serine/threonine protein kinase 0.0069 0.1468 0.3722
Trichomonas vaginalis AGC family protein kinase 0.0069 0.1468 0.8805
Trichomonas vaginalis cyclin D, putative 0.0043 0.0485 0.078
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0069 0.1468 0.8703
Loa Loa (eye worm) AUR protein kinase 0.0069 0.1468 0.1468
Echinococcus granulosus aurora kinase A 0.0069 0.1468 0.3722
Echinococcus granulosus cyclin B 0.0073 0.1615 0.4277
Brugia malayi serine/threonine-protein kinase 6 0.0069 0.1468 0.1033
Schistosoma mansoni cyclin B 0.0073 0.1615 0.4277
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0865 0.3878
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0073 0.1615 1
Trichomonas vaginalis cyclin D, putative 0.0043 0.0485 0.078
Loa Loa (eye worm) hypothetical protein 0.0073 0.1615 0.1615
Trichomonas vaginalis cyclin B, putative 0.0073 0.1615 1
Brugia malayi serine/threonine protein kinase 6 0.0069 0.1468 0.1033
Schistosoma mansoni serine/threonine protein kinase 0.0113 0.3126 1
Echinococcus multilocularis beta adrenergic receptor kinase 0.0113 0.3126 1
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0113 0.3126 0.3126
Echinococcus multilocularis G protein coupled receptor kinase 1 0.0101 0.269 0.8349
Trichomonas vaginalis cyclin A, putative 0.0073 0.1615 1
Entamoeba histolytica cyclin, putative 0.0073 0.1615 1
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0069 0.1468 0.3722
Loa Loa (eye worm) cyclin domain-containing protein 0.0043 0.0485 0.0485
Leishmania major cyclin 0.0073 0.1615 1
Loa Loa (eye worm) AUR protein kinase 0.0069 0.1468 0.1468
Trypanosoma brucei aurora B kinase 0.0069 0.1468 0.8047
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0069 0.1468 0.8703
Loa Loa (eye worm) hypothetical protein 0.0073 0.1615 0.1615
Brugia malayi Cyclin, N-terminal domain containing protein 0.0073 0.1615 0.1187
Trichomonas vaginalis cyclins, putative 0.0073 0.1615 1
Trypanosoma brucei mitotic cyclin 6 0.0073 0.1615 1
Echinococcus granulosus G protein coupled receptor kinase 1 0.0101 0.269 0.8349
Schistosoma mansoni serine/threonine protein kinase 0.0113 0.3126 1
Leishmania major protein kinase, putative 0.0069 0.1468 0.8047
Giardia lamblia Kinase, CMGC CDK 0.0053 0.0865 0.336
Loa Loa (eye worm) cyclin domain-containing protein 0.0295 1 1
Echinococcus granulosus cyclin dependent kinase 0.0053 0.0865 0.1437
Trichomonas vaginalis cyclin B, putative 0.0043 0.0485 0.078
Echinococcus granulosus cyclin dependent kinase 1 0.0053 0.0865 0.1437
Trypanosoma cruzi cyclin, putative 0.0073 0.1615 1
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0865 0.3878
Entamoeba histolytica protein kinase , putative 0.0069 0.1468 0.8703
Trichomonas vaginalis AGC family protein kinase 0.0069 0.1468 0.8805
Echinococcus granulosus beta-adrenergic receptor kinase 0.0113 0.3126 1
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.0865 0.336
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0069 0.1468 0.3722
Trypanosoma cruzi cyclin, putative 0.0073 0.1615 1
Trypanosoma cruzi aurora B kinase, putative 0.0069 0.1468 0.8047
Trichomonas vaginalis cyclin B, putative 0.0073 0.1615 1
Trichomonas vaginalis AGC family protein kinase 0.0069 0.1468 0.8805
Brugia malayi Protein kinase domain containing protein 0.0053 0.0865 0.0399
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0485 0.078
Entamoeba histolytica protein kinase, putative 0.0069 0.1468 0.8703
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.0865 0.0865
Trichomonas vaginalis cyclins, putative 0.0073 0.1615 1
Toxoplasma gondii aurora kinase 0.0069 0.1468 1
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0865 0.1437
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0053 0.0865 0.1437
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.0865 0.1437
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0069 0.1468 0.8703

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 29 nM Inhibition of N-terminal His6-tagged recombinant full-length human Aurora A expressed in Sf21 cells ChEMBL. No reference
IC50 (binding) = 33 nM Inhibition of C-terminal His6-tagged human full length Cdk3/N-terminal GST-tagged human full length Cyclin E expressed in Sf21 cells ChEMBL. No reference
IC50 (binding) = 33 nM Inhibition of C-terminal His6-tagged human full length Cdk2/N-terminal GST-tagged human full length Cyclin E expressed in Sf21 cells ChEMBL. No reference
IC50 (binding) = 115 nM Inhibition of C-terminal His6-tagged human full length Cdk1/N-terminal GST-tagged human full length Cyclin B expressed in Sf21 cells ChEMBL. No reference
IC50 (binding) = 0.0078 uM Inhibition of human recombinant beta-ARK1 expressed in Sf9 cells using biotinated-RRREEEEESAAA substrate and [gamma33P]-ATP incubated for 60 mins by liquid scintillation counting method ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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