Duration (functional)
|
> 3.5 hr
|
Duration of action (inhibtion of AII pressor response) following peroral administration at dose 3.0 mg/kg; >3.5<24
|
ChEMBL.
|
7562905
|
Duration (functional)
|
> 6 hr
|
Duration of action (inhibtion of AII pressor response) following intravenous injection at dose 1.0 mg/kg; >6<24
|
ChEMBL.
|
7562905
|
IC50 (binding)
|
= 9.376
|
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
|
ChEMBL.
|
No reference
|
IC50 (binding)
|
= 0.16 nM
|
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
|
ChEMBL.
|
7562905
|
IC50 (binding)
|
= 0.16 nM
|
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
|
ChEMBL.
|
7562905
|
IC50 (binding)
|
= 0.22 nM
|
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
|
ChEMBL.
|
7562905
|
IC50 (binding)
|
= 0.22 nM
|
In vitro inhibitory activity against angiotensin II type 1 receptor in rat adrenal membrane preparations.
|
ChEMBL.
|
7562905
|
IC50 (binding)
|
= 0.22 nM
|
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
|
ChEMBL.
|
7562905
|
IC50 (binding)
|
= 0.22 nM
|
In vitro inhibitory activity against angiotensin II type 1 receptor in rat adrenal membrane preparations.
|
ChEMBL.
|
7562905
|
IC50 (binding)
|
= 0.41 nM
|
In vitro inhibitory activity against Angiotensin II receptor, type 1 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.
|
ChEMBL.
|
7562905
|
IC50 (binding)
|
= 0.41 nM
|
In vitro inhibitory activity against Angiotensin II receptor, type 1 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.
|
ChEMBL.
|
7562905
|
IC50 (binding)
|
= 0.42 nM
|
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
|
ChEMBL.
|
7562905
|
IC50 (binding)
|
= 0.42 nM
|
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
|
ChEMBL.
|
7562905
|
IC50 (binding)
|
= 0.42 nM
|
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
|
ChEMBL.
|
No reference
|
IC50 (binding)
|
= 0.88 nM
|
In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.
|
ChEMBL.
|
7562905
|
IC50 (binding)
|
= 0.88 nM
|
In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.
|
ChEMBL.
|
7562905
|
IC50 (binding)
|
= 0.9 nM
|
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
|
ChEMBL.
|
7562905
|
IC50 (binding)
|
= 0.9 nM
|
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
|
ChEMBL.
|
7562905
|
IC50 (binding)
|
= 3.8 nM
|
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
|
ChEMBL.
|
7562905
|
IC50 (binding)
|
= 3.8 nM
|
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
|
ChEMBL.
|
7562905
|
Inhibition (functional)
|
= 71 %
|
In vivo inhibtion of AII pressor response was measured in conscious, normotensive rats after intravenous administration at dose 1.0 mg/kg
|
ChEMBL.
|
7562905
|
Inhibition (functional)
|
= 75 %
|
In vivo inhibtion of AII pressor response was measured in conscious, normotensive rats after peroral administration at dose 3.0 mg/kg
|
ChEMBL.
|
7562905
|
Ratio (binding)
|
= 0.5
|
IC50 ratio of AT2 receptor from rabbit aorta to AT1 receptor from rat midbrain.
|
ChEMBL.
|
7562905
|
Ratio (binding)
|
= 0.7
|
IC50 ratio 0f AT2 to AT1 receptor (rat adrenal)
|
ChEMBL.
|
7562905
|
Ratio (binding)
|
= 2.1
|
IC50 ratio of human adrenal AT2 receptor to AT1 receptor.
|
ChEMBL.
|
7562905
|
Ratio (binding)
|
= 4.2
|
IC50 ratio of human adrenal AT2 receptor to AT1 receptor.
|
ChEMBL.
|
7562905
|
Ratio (binding)
|
= 0.5
|
IC50 ratio of AT2 receptor from rabbit aorta to AT1 receptor from rat midbrain.
|
ChEMBL.
|
7562905
|
Ratio (binding)
|
= 0.7
|
IC50 ratio 0f AT2 to AT1 receptor (rat adrenal)
|
ChEMBL.
|
7562905
|
Ratio (binding)
|
= 2.1
|
IC50 ratio of human adrenal AT2 receptor to AT1 receptor.
|
ChEMBL.
|
7562905
|
Ratio (binding)
|
= 4.2
|
IC50 ratio of human adrenal AT2 receptor to AT1 receptor.
|
ChEMBL.
|
7562905
|