Detailed information for compound 224151

Basic information

Technical information
  • TDR Targets ID: 224151
  • Name: 2-(cyclopropanecarbonylamino)-N-(2,4,6-trimet hylphenyl)-1,3-thiazole-5-carboxamide
  • MW: 329.417 | Formula: C17H19N3O2S
  • H donors: 2 H acceptors: 3 LogP: 3.18 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1CC1)Nc1ncc(s1)C(=O)Nc1c(C)cc(cc1C)C
  • InChi: 1S/C17H19N3O2S/c1-9-6-10(2)14(11(3)7-9)19-16(22)13-8-18-17(23-13)20-15(21)12-4-5-12/h6-8,12H,4-5H2,1-3H3,(H,19,22)(H,18,20,21)
  • InChiKey: OTRYTNJSIZLUNP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(cyclopropanecarbonylamino)-N-(2,4,6-trimethylphenyl)thiazole-5-carboxamide
  • 2-[[cyclopropyl(oxo)methyl]amino]-N-(2,4,6-trimethylphenyl)-5-thiazolecarboxamide
  • 2-(cyclopropylcarbonylamino)-N-(2,4,6-trimethylphenyl)-1,3-thiazole-5-carboxamide
  • 2-(cyclopropanecarbonylamino)-N-mesityl-thiazole-5-carboxamide
  • 2-[(cyclopropyl-oxomethyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazolecarboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens LCK proto-oncogene, Src family tyrosine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis aldehyde reductase 0.0006 0.0065 0.0095
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0009 0.0154 0.0225
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0182 0.0266
Schistosoma mansoni suppressor of cytokine signaling 0.0005 0.0004 0.0006
Trypanosoma cruzi aldo-keto reductase 0.0009 0.0154 0.0586
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.1891 0.704
Leishmania major prostaglandin f synthase, putative 0.0009 0.0154 0.0586
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0005 0.0026 0.0037
Onchocerca volvulus 0.0005 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0009 0.0155 0.0227
Loa Loa (eye worm) hypothetical protein 0.0005 0.0026 0.0037
Brugia malayi Protein-tyrosine phosphatase 0.0005 0.0026 0.0035
Onchocerca volvulus 0.0009 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0006
Echinococcus multilocularis tyrosine kinase 0.0006 0.0047 0.0069
Echinococcus granulosus tyrosine protein kinase Fyn 0.001 0.0199 0.0291
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0005 0.0026 0.0035
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0005 0.0026 0.0037
Trichomonas vaginalis helicase, putative 0.0007 0.0093 0.6033
Loa Loa (eye worm) hypothetical protein 0.0005 0.0026 0.0037
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.001 0.0199 0.0291
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0005 0.0004 0.0006
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0009 0.0154 0.0225
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0009 0.0154 0.0225
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0005 0.0004 0.0006
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0005 0.0004 0.0006
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0005 0.0026 0.0035
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0081 0.2621 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.001 0.0199 0.0291
Onchocerca volvulus 0.0005 0.0026 0.0026
Echinococcus granulosus c src tyrosine kinase 0.001 0.0199 0.0291
Onchocerca volvulus 0.0005 0.0004 0.0004
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0005 0.0026 0.0035
Loa Loa (eye worm) TK/FER protein kinase 0.0006 0.0047 0.0069
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0009 0.0154 0.0225
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0926 0.1355
Plasmodium vivax telomerase reverse transcriptase, putative 0.0081 0.2621 0.5
Echinococcus multilocularis aldo keto reductase 0.0009 0.0154 0.0225
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0116 0.017
Schistosoma mansoni tyrosine kinase 0.001 0.0199 0.0291
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0005 0.0026 0.0037
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0093 0.6033
Onchocerca volvulus 0.0005 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0005 0.0026 0.0037
Echinococcus granulosus tyrosine protein kinase shark 0.0006 0.0047 0.0069
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0009 0.0154 0.0225
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0005 0.0026 0.1664
Onchocerca volvulus 0.0005 0.0004 0.0004
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0154 1
Echinococcus granulosus SHC transforming protein 3 0.0005 0.0004 0.0006
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0005 0.0026 0.0037
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0009 0.0154 0.0225
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0005 0.0004 0.0006
Onchocerca volvulus 0.0005 0.0026 0.0026
Entamoeba histolytica protein kinase, putative 0.0005 0.0004 0.0251
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0009 0.0154 0.0225
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0005 0.0026 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0093 0.6033
Echinococcus granulosus tyrosine protein kinase Srms 0.0006 0.0047 0.0069
Schistosoma mansoni tyrosine kinase 0.0006 0.0047 0.0069
Entamoeba histolytica aldose reductase, putative 0.0009 0.0154 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.001 0.0199 0.0291
Schistosoma mansoni SH2A 0.0005 0.0004 0.0006
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0116 0.017
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0006
Entamoeba histolytica aldose reductase, putative 0.0009 0.0154 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0005 0.0026 0.0037
Schistosoma mansoni protein tyrosine phosphatase 0.0005 0.0026 0.0037
Echinococcus granulosus growth factor receptor bound protein 2 0.0009 0.0155 0.0227
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0006 0.0047 0.0069
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0005 0.0026 0.0037
Onchocerca volvulus 0.0006 0.0047 0.0047
Loa Loa (eye worm) TK/FER protein kinase 0.0006 0.0047 0.0069
Schistosoma mansoni cpg binding protein 0.0033 0.0988 0.1445
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.001 0.0199 0.0291
Trypanosoma brucei protein tyrosine phosphatase 1 0.0005 0.0026 0.0098
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0005 0.0026 0.0037
Loa Loa (eye worm) hypothetical protein 0.0005 0.0026 0.0037
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0005 0.0026 0.1664
Brugia malayi SH2 domain containing protein 0.0005 0.0004 0.0005
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0009 0.0154 0.0213
Loa Loa (eye worm) hypothetical protein 0.0005 0.0026 0.0037
Echinococcus multilocularis SH2 domain containing protein 7 0.0005 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0005 0.0026 0.0037
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0009 0.0154 0.0225
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0005 0.0026 0.0037
Onchocerca volvulus 0.0009 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0005 0.0026 0.0037
Onchocerca volvulus 0.0005 0.0026 0.0026
Echinococcus granulosus hypothetical protein 0.0005 0.0004 0.0006
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0204 0.6835 1
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.001 0.0199 0.0291
Brugia malayi Protein-tyrosine phosphatase 1 0.0005 0.0026 0.0035
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0006
Echinococcus multilocularis tensin 0.0005 0.0004 0.0006
Echinococcus multilocularis aldo keto reductase 0.0009 0.0154 0.0225
Brugia malayi Tensin 0.0005 0.0004 0.0005
Brugia malayi SH2 domain containing protein 0.0006 0.0047 0.0066
Echinococcus granulosus N chimaerin 0.0005 0.0004 0.0006
Echinococcus multilocularis c src tyrosine kinase 0.001 0.0199 0.0291
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0009 0.0154 0.0586
Plasmodium falciparum telomerase reverse transcriptase 0.0081 0.2621 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0006 0.0047 0.0069
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0093 0.6033
Brugia malayi Variant SH3 domain containing protein 0.0009 0.0155 0.0215
Loa Loa (eye worm) oxidoreductase 0.0009 0.0154 0.0225
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.001 0.0181 0.0265
Schistosoma mansoni cpg binding protein 0.0032 0.0926 0.1355
Echinococcus multilocularis tyrosine protein kinase Src64B 0.001 0.0199 0.0291
Echinococcus granulosus suppressor of cytokine signaling 6 0.0005 0.0004 0.0006
Trypanosoma brucei prostaglandin f synthase 0.0009 0.0154 0.0586
Loa Loa (eye worm) SH2 domain-containing protein 0.0005 0.0004 0.0006
Leishmania major tyrosine specific protein phosphatase, putative 0.0005 0.0026 0.0098
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0154 1
Onchocerca volvulus 0.0005 0.0026 0.0026
Echinococcus granulosus tyrosine kinase 0.0006 0.0047 0.0069
Echinococcus multilocularis tyrosine protein kinase Blk 0.0006 0.0047 0.0069
Echinococcus multilocularis tensin 0.0005 0.0004 0.0006
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0093 0.6033
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0006
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0005 0.0026 0.0037
Loa Loa (eye worm) hypothetical protein 0.0005 0.0026 0.0037
Loa Loa (eye worm) TK/FER protein kinase 0.0006 0.0047 0.0069
Toxoplasma gondii RNA-directed DNA polymerase 0.0081 0.2621 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0093 0.6033
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.001 0.0181 0.0265
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0005 0.0026 0.0035
Echinococcus multilocularis 0.0005 0.0004 0.0006
Onchocerca volvulus 0.0005 0.0004 0.0004
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0005 0.0026 0.0037
Leishmania major aldo-keto reductase-like protein 0.0009 0.0154 0.0586
Onchocerca volvulus 0.0005 0.0026 0.0026
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0005 0.0004 0.0006
Loa Loa (eye worm) oxidoreductase 0.0009 0.0154 0.0225
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0009 0.0154 1
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0081 0.2621 1
Onchocerca volvulus 0.0005 0.0026 0.0026
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0093 0.6033
Schistosoma mansoni growth factor receptor-bound protein 0.0009 0.0155 0.0227
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0009 0.0154 0.0225
Loa Loa (eye worm) hypothetical protein 0.0005 0.0026 0.0037
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0005 0.0026 0.0037
Schistosoma mansoni protein tyrosine phosphatase 0.0005 0.0026 0.0037
Loa Loa (eye worm) hypothetical protein 0.0005 0.0026 0.0037
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0005 0.0026 0.0037
Onchocerca volvulus 0.0006 0.0047 0.0047
Onchocerca volvulus 0.0006 0.0047 0.0047
Onchocerca volvulus 0.0005 0.0004 0.0004
Loa Loa (eye worm) oxidoreductase 0.0009 0.0154 0.0225
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0154 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0005 0.0026 0.0037
Echinococcus granulosus aldehyde reductase 0.0006 0.0065 0.0095
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0093 0.6033
Schistosoma mansoni protein tyrosine phosphatase 0.0005 0.0026 0.0037
Loa Loa (eye worm) oxidoreductase 0.0009 0.0154 0.0225
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.001 0.0181 0.0265
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0005 0.0004 0.0006
Echinococcus multilocularis tyrosine protein kinase Srms 0.0006 0.0047 0.0069
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0005 0.0026 0.0035
Brugia malayi Protein-tyrosine phosphatase 0.0005 0.0026 0.0035
Echinococcus granulosus aldo keto reductase 0.0009 0.0154 0.0225
Mycobacterium tuberculosis Probable oxidoreductase 0.0009 0.0154 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0006
Brugia malayi SRC-1 0.001 0.0199 0.0275
Leishmania major telomerase reverse transcriptase, putative 0.0081 0.2621 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.001 0.0181 0.0265
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0005 0.0026 0.0035
Onchocerca volvulus 0.0006 0.0047 0.0047
Echinococcus granulosus tyrosine protein kinase Src42A 0.0005 0.0004 0.0006
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0005 0.0026 0.0037
Trichomonas vaginalis aldo/keto reductase, putative 0.0009 0.0154 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0009 0.0154 1
Onchocerca volvulus 0.0005 0.0026 0.0026
Echinococcus granulosus suppressor of cytokine signaling 7 0.0005 0.0004 0.0006
Echinococcus granulosus tyrosine protein kinase Blk 0.0006 0.0047 0.0069
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0009 0.0154 0.0225
Brugia malayi Variant SH3 domain containing protein 0.0005 0.0004 0.0005
Brugia malayi SH2 domain containing protein 0.0005 0.0004 0.0005
Echinococcus multilocularis aldo keto reductase 0.0009 0.0154 0.0225
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0005 0.0026 0.0037
Entamoeba histolytica aldose reductase, putative 0.0009 0.0154 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0006
Onchocerca volvulus 0.0005 0.0026 0.0026
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0005 0.0026 0.0037
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0005 0.0026 0.0037
Onchocerca volvulus 0.0005 0.0026 0.0026
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.001 0.0199 0.0291
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0093 0.6033
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0006 0.0047 0.0069
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0005 0.0026 0.0035
Schistosoma mansoni tensin 0.0005 0.0004 0.0006
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0005 0.0026 0.0037
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0009 0.0154 0.0225
Loa Loa (eye worm) TK/FER protein kinase 0.0006 0.0047 0.0069
Schistosoma mansoni tyrosine kinase 0.001 0.0199 0.0291
Brugia malayi hypothetical protein 0.0005 0.0026 0.0035
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0182 0.0266
Loa Loa (eye worm) TK/FER protein kinase 0.0006 0.0047 0.0069
Loa Loa (eye worm) protein-tyrosine phosphatase 0.001 0.0181 0.0265
Schistosoma mansoni aldo-keto reductase 0.0009 0.0154 0.0225
Echinococcus granulosus tyrosine protein kinase Btk29A 0.001 0.0199 0.0291
Mycobacterium ulcerans oxidoreductase 0.0009 0.0154 0.5
Onchocerca volvulus 0.0009 0.0154 0.0154
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0009 0.0154 0.0225
Echinococcus multilocularis SH2 motif 0.0005 0.0004 0.0006
Echinococcus multilocularis tyrosine protein kinase Fyn 0.001 0.0199 0.0291
Loa Loa (eye worm) TK/ABL protein kinase 0.0006 0.0047 0.0069
Schistosoma mansoni cpg binding protein 0.0033 0.0988 0.1445
Brugia malayi protein-tyrosine kinase 0.0006 0.0047 0.0066
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0009 0.0154 0.0225
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0009 0.0154 0.0213
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0005 0.0026 0.0035
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0154 1
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0005 0.0026 0.0037
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0005 0.0026 0.0037
Loa Loa (eye worm) hypothetical protein 0.0005 0.0026 0.0037
Brugia malayi SH2 domain containing protein 0.0006 0.0047 0.0066
Onchocerca volvulus 0.0005 0.0026 0.0026
Echinococcus multilocularis tyrosine protein kinase Src42A 0.001 0.0199 0.0291
Loa Loa (eye worm) TK/FER protein kinase 0.0006 0.0047 0.0069
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0005 0.0026 0.0037
Echinococcus multilocularis tyrosine protein kinase Abl 0.001 0.0199 0.0291
Loa Loa (eye worm) hypothetical protein 0.0005 0.0026 0.0037
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0009 0.0154 0.0225
Onchocerca volvulus 0.0005 0.0026 0.0026
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0204 0.6835 1
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0005 0.0026 0.0098
Echinococcus granulosus SH2 motif 0.0005 0.0004 0.0006
Echinococcus granulosus aldo keto reductase 0.0009 0.0154 0.0225
Echinococcus granulosus aldo keto reductase 0.0009 0.0154 0.0225
Brugia malayi Telomerase reverse transcriptase 0.0216 0.7227 1
Onchocerca volvulus 0.0006 0.0047 0.0047
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0093 0.6033
Brugia malayi hypothetical protein 0.0005 0.0026 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0093 0.6033
Brugia malayi hypothetical protein 0.0005 0.0004 0.0005
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0005 0.0026 0.0037
Schistosoma mansoni nck2/grb4 0.0009 0.0155 0.0227
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0116 0.017
Loa Loa (eye worm) hypothetical protein 0.0005 0.0026 0.0037
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0005 0.0026 0.0037
Echinococcus multilocularis signal transduction protein lnk realted 0.0005 0.0004 0.0006
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0005 0.0004 0.0006
Echinococcus granulosus SH2 domain containing protein 7 0.0005 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0006
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0005 0.0026 0.0037
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0005 0.0026 0.0098
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0009 0.0154 0.0213
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0009 0.0155 0.0227
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0005 0.0004 0.0006
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0005 0.0026 0.0037
Giardia lamblia Aldose reductase 0.0009 0.0154 0.0493
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0005 0.0026 0.0035
Onchocerca volvulus 0.0006 0.0047 0.0047
Loa Loa (eye worm) protein tyrosine phosphatase 0.0005 0.0026 0.0037
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0005 0.0026 0.0037
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0005 0.0026 0.0037
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0009 0.0154 0.0586
Onchocerca volvulus 0.0005 0.0026 0.0026
Schistosoma mansoni shc transforming protein 0.0005 0.0004 0.0006
Schistosoma mansoni signal transduction protein lnk-related 0.0005 0.0004 0.0006
Brugia malayi CXXC zinc finger family protein 0.0032 0.0926 0.1282
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0005 0.0004 0.0006
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0005 0.0026 0.0037
Schistosoma mansoni hypothetical protein 0.0005 0.0004 0.0006
Echinococcus multilocularis tyrosine protein kinase Fyn 0.001 0.0199 0.0291
Echinococcus multilocularis aldo keto reductase 0.0009 0.0154 0.0225
Loa Loa (eye worm) histone methyltransferase 0.001 0.0182 0.0266
Trichomonas vaginalis aldo/keto reductase, putative 0.0009 0.0154 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0005 0.0026 0.0037
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0006
Schistosoma mansoni tyrosine kinase 0.001 0.0199 0.0291
Onchocerca volvulus 0.0009 0.0154 0.0154
Giardia lamblia Telomerase catalytic subunit 0.0081 0.2621 1
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0005 0.0026 0.1664
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0005 0.0026 0.0037
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0005 0.0026 0.0037
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0006 0.0047 0.0069
Echinococcus granulosus hypothetical protein 0.0009 0.0154 0.0225
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0005 0.0026 0.0037
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0005 0.0026 0.0037
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0005 0.0026 0.0035
Schistosoma mansoni pcd6 interacting protein-related 0.0005 0.0026 0.0037
Echinococcus granulosus SH2 motif 0.0005 0.0004 0.0006
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0009 0.0154 0.0225
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0009 0.0154 1
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0005 0.0026 0.0037
Schistosoma mansoni growth factor receptor-bound protein 0.0009 0.0155 0.0227
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0005 0.0026 0.0037
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0005 0.0026 0.0037
Echinococcus multilocularis hypothetical protein 0.0005 0.0026 0.0037
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0005 0.0026 0.0037
Brugia malayi Protein kinase domain containing protein 0.0006 0.0047 0.0066
Echinococcus granulosus tyrosine protein kinase ABL1 0.0006 0.0047 0.0069
Loa Loa (eye worm) hypothetical protein 0.0005 0.0026 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0093 0.6033
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0005 0.0004 0.0251
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0005 0.0026 0.0037
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0005 0.0004 0.0006
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0154 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0116 0.017
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0005 0.0026 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0093 0.6033
Schistosoma mansoni pol-related 0.0009 0.0154 0.0225
Onchocerca volvulus 4.1 G protein, putative homolog 0.0005 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0006
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0009 0.0155 0.0227
Echinococcus multilocularis tyrosine protein kinase shark 0.0006 0.0047 0.0069
Echinococcus granulosus NCK adaptor protein 0.0009 0.0155 0.0227
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0154 1
Trypanosoma brucei telomerase reverse transcriptase 0.0081 0.2621 1
Entamoeba histolytica SH2 domain containing protein 0.0005 0.0004 0.0251
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0154 1
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0005 0.0026 0.0035
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0005 0.0026 0.0037
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0093 0.6033
Loa Loa (eye worm) hypothetical protein 0.0005 0.0026 0.0037
Schistosoma mansoni suppressor of cytokine signaling 0.0005 0.0004 0.0006
Loa Loa (eye worm) SH2 domain-containing protein 0.0005 0.0004 0.0006
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0005 0.0026 0.0037
Brugia malayi STAT protein, DNA binding domain containing protein 0.0005 0.0004 0.0005
Loa Loa (eye worm) TK protein kinase 0.0006 0.0047 0.0069
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0005 0.0026 0.0035
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0005 0.0026 0.0035
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0005 0.0026 0.0037
Onchocerca volvulus 0.0005 0.0026 0.0026
Schistosoma mansoni tensin-related 0.0005 0.0004 0.0006
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0005 0.0026 0.0037
Echinococcus granulosus tyrosine protein kinase Src42A 0.001 0.0199 0.0291
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0005 0.0004 0.0004
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0005 0.0026 0.0037
Trichomonas vaginalis aldo/keto reductase, putative 0.0009 0.0154 1
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0178 0.0246
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0005 0.0026 0.0035
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0009 0.0154 0.0225
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0005 0.0004 0.0006
Onchocerca volvulus 0.0005 0.0026 0.0026
Brugia malayi Protein kinase domain containing protein 0.0006 0.0047 0.0066
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0009 0.0154 0.0225
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0003 0.0004
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0009 0.0155 0.0227
Echinococcus granulosus protein tyrosine phosphatase n9 0.0005 0.0026 0.0037
Brugia malayi tRNA modification GTPase TrmE family protein 0.0005 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0005 0.0026 0.0037
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0005 0.0026 0.0037
Brugia malayi Protein kinase domain containing protein 0.0006 0.0047 0.0066
Brugia malayi Variant SH3 domain containing protein 0.0005 0.0004 0.0005
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0005 0.0026 0.0037
Onchocerca volvulus 0.0005 0.0026 0.0026
Echinococcus multilocularis SHC transforming protein 3 0.0005 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0005 0.0026 0.0037
Brugia malayi Protein kinase domain containing protein 0.0006 0.0047 0.0066
Schistosoma mansoni tensin 0.0005 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0005 0.0026 0.0037
Echinococcus granulosus tyrosine protein kinase Lyn 0.001 0.0199 0.0291
Brugia malayi hypothetical protein 0.0005 0.0026 0.0035
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0005 0.0026 0.0037
Echinococcus multilocularis growth factor receptor bound protein 2 0.0009 0.0155 0.0227
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0005 0.0004 0.0006
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0005 0.0026 0.0035
Trypanosoma brucei aldo-keto reductase, putative 0.0009 0.0154 0.0586
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0005 0.0026 0.0037
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0005 0.0026 0.0037
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0005 0.0026 0.0098
Brugia malayi RhoGAP domain containing protein 0.0005 0.0004 0.0005
Schistosoma mansoni hypothetical protein 0.0005 0.0004 0.0006
Echinococcus granulosus signal transduction protein lnk realted 0.0005 0.0004 0.0006
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0204 0.6835 0.9458
Loa Loa (eye worm) TK/FER protein kinase 0.0006 0.0047 0.0069
Loa Loa (eye worm) hypothetical protein 0.0005 0.0026 0.0037
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0006 0.0047 0.0069
Loa Loa (eye worm) hypothetical protein 0.0005 0.0026 0.0037
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0005 0.0026 0.0037
Brugia malayi Sex muscle abnormal protein 5 0.0009 0.0155 0.0215
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0005 0.0026 0.0037
Echinococcus multilocularis SH2 motif 0.0005 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0005 0.0026 0.0037
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.001 0.0199 0.0291
Brugia malayi Protein kinase domain containing protein 0.0006 0.0047 0.0066
Echinococcus multilocularis cpg binding protein 0.0033 0.0988 0.1445
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0154 1
Onchocerca volvulus 0.0005 0.0026 0.0026
Loa Loa (eye worm) TK/FER protein kinase 0.0006 0.0047 0.0069
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0005 0.0004 0.0006
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0005 0.0026 0.0037
Brugia malayi SH2 domain containing protein 0.0005 0.0004 0.0005
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.001 0.0199 0.0291
Schistosoma mansoni tyrosine kinase 0.0006 0.0047 0.0069
Onchocerca volvulus 0.0005 0.0026 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0093 0.6033
Schistosoma mansoni adapter molecule crk 0.0009 0.0155 0.0227
Brugia malayi cytokine inducible SH2-containing protein 5 0.0005 0.0004 0.0005
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.0181 0.025
Echinococcus multilocularis SH2 motif 0.0005 0.0004 0.0006
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0005 0.0026 0.0037
Echinococcus multilocularis NCK adaptor protein 0.0009 0.0155 0.0227
Brugia malayi SH2 domain containing protein 0.0005 0.0004 0.0005
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0005 0.0004 0.0006
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0005 0.0004 0.0006
Onchocerca volvulus 0.0005 0.0004 0.0004
Echinococcus granulosus expressed conserved protein 0.0005 0.0004 0.0006
Echinococcus granulosus tensin 0.0005 0.0004 0.0006
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0005 0.0026 0.0037
Loa Loa (eye worm) SH2 domain-containing protein 0.0005 0.0004 0.0006
Echinococcus granulosus tyrosine protein kinase Fyn 0.001 0.0199 0.0291
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0005 0.0026 0.0098
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0154 1
Loa Loa (eye worm) SRC-1 0.001 0.0199 0.0291
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0005 0.0026 0.0035
Loa Loa (eye worm) STAT protein 0.0005 0.0004 0.0006
Onchocerca volvulus 0.0005 0.0026 0.0026
Brugia malayi hypothetical protein 0.0006 0.0047 0.0066
Brugia malayi SH2 domain containing protein 0.0005 0.0004 0.0005
Echinococcus granulosus SH2 domain containing adapter protein F 0.0005 0.0004 0.0006
Echinococcus multilocularis 0.0005 0.0026 0.0037
Schistosoma mansoni GTPase activating protein 0.0005 0.0004 0.0006
Onchocerca volvulus 0.0005 0.0026 0.0026
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0005 0.0026 0.0035
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0006
Trichomonas vaginalis pten, drome, putative 0.0005 0.0026 0.1664
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0006
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0005 0.0026 0.0037
Onchocerca volvulus 0.0009 0.0154 0.0154
Trypanosoma cruzi aldo/keto reductase, putative 0.0009 0.0154 0.0586
Loa Loa (eye worm) oxidoreductase 0.0009 0.0154 0.0225
Loa Loa (eye worm) hypothetical protein 0.0005 0.0026 0.0037
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0006 0.0047 0.3092
Brugia malayi SH2 domain containing protein 0.0005 0.0004 0.0005
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0005 0.0026 0.0035
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0005 0.0026 0.0037
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0009 0.0154 1
Brugia malayi Variant SH3 domain containing protein 0.0009 0.0155 0.0215
Giardia lamblia Aldose reductase 0.0009 0.0154 0.0493
Brugia malayi hypothetical protein 0.0005 0.0026 0.0035
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0006 0.0047 0.0069
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0005 0.0026 0.0037
Echinococcus multilocularis tyrosine protein kinase Fgr 0.001 0.0199 0.0291
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0093 0.6033
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.001 0.0199 0.0291
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0006
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0005 0.0026 0.0035
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0009 0.0154 0.0225
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0005 0.0026 0.0035
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0116 0.017
Brugia malayi SH2 domain containing protein 0.0005 0.0004 0.0005
Onchocerca volvulus 0.0005 0.0026 0.0026
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.001 0.0181 0.0265
Schistosoma mansoni tensin 0.0005 0.0004 0.0006
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0005 0.0026 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0093 0.6033
Schistosoma mansoni aldo-keto reductase 0.0009 0.0154 0.0225
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0005 0.0026 0.0037
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0005 0.0026 0.0035
Loa Loa (eye worm) hypothetical protein 0.0005 0.0026 0.0037
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0005 0.0004 0.0006
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0009 0.0154 0.0225
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0005 0.0004 0.0004
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0005 0.0026 0.0037
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0009 0.0154 0.0225
Loa Loa (eye worm) hypothetical protein 0.0005 0.0026 0.0037
Loa Loa (eye worm) hypothetical protein 0.0005 0.0026 0.0037
Schistosoma mansoni serine/threonine protein kinase 0.0006 0.0044 0.0064
Onchocerca volvulus 0.0032 0.0926 0.0926
Echinococcus granulosus tyrosine kinase 0.0006 0.0047 0.0069
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0009 0.0154 0.0213
Onchocerca volvulus 0.0005 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0006 0.0047 0.0069
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0005 0.0026 0.0037
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0005 0.0026 0.0035
Loa Loa (eye worm) TK/FER protein kinase 0.0006 0.0047 0.0069
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0154 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.2135 0.3123
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0005 0.0026 0.0037
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0005 0.0026 0.0037
Echinococcus granulosus cpg binding protein 0.0033 0.0988 0.1445
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0005 0.0026 0.0037
Onchocerca volvulus 0.0009 0.0154 0.0154
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0093 0.6033
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0154 1
Onchocerca volvulus 0.0005 0.0026 0.0026
Brugia malayi Tyrosine-protein kinase abl-1 0.001 0.0199 0.0275
Schistosoma mansoni tyrosine kinase 0.001 0.0199 0.0291
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0009 0.0154 0.0225
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0006
Echinococcus granulosus tyrosine protein kinase Src64B 0.001 0.0199 0.0291
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0204 0.6835 1
Schistosoma mansoni vav2 0.0005 0.0004 0.0006
Echinococcus multilocularis N chimaerin 0.0005 0.0004 0.0006
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0154 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0204 0.6835 1
Brugia malayi hypothetical protein 0.0005 0.0026 0.0035
Schistosoma mansoni tensin-related 0.0005 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0005 0.0026 0.0037

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.018 uM Inhibitory activity of the compound human Lck(hLck) kinase ChEMBL. 14592495
IC50 (binding) = 0.018 uM Inhibitory activity of the compound human Lck(hLck) kinase ChEMBL. 14592495

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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