TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 365.465 | Formula: C23H27NO3
H donors: 1 H acceptors: 1 LogP: 4.29 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1OC1CCCC1)C1(CCNC1=O)Cc1ccccc1
InChi: 1S/C23H27NO3/c1-26-20-12-11-18(15-21(20)27-19-9-5-6-10-19)23(13-14-24-22(23)25)16-17-7-3-2-4-8-17/h2-4,7-8,11-12,15,19H,5-6,9-10,13-14,16H2,1H3,(H,24,25)
InChiKey: QECAOTVWRHOMKG-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphodiesterase 4D, cAMP-specific	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	IPR002073,3'5'-cyclic nucleotide phosphodiesterase,domain-containing	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4C, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	Get druggable targets OG5_128242	All targets in OG5_128242
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_128242	All targets in OG5_128242
Neospora caninum	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Cryptosporidium parvum	membrane associated HD superfamily cyclic nucleotide phosphodiesterase domain containing protein	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	Get druggable targets OG5_128242	All targets in OG5_128242
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0016	0.0026	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0026	0.0429
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0014	0.0015	0.0055
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0014	0.0015	0.0055
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0016	0.0026	0.0098
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0012	0.0009	0.0033
Trichomonas vaginalis	ribonuclease H1, putative	0.0668	0.2637	1
Brugia malayi	Pao retrotransposon peptidase family protein	0.0057	0.0187	0.068
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0023	0.0054	0.0151
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0023	0.0054	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0023	0.0054	0.0151
Trichomonas vaginalis	glutathione reductase, putative	0.0023	0.0054	0.0151
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0023	0.0054	0.004
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0057	0.0187	0.0711
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.0014	0.0015	0.0055
Trypanosoma cruzi	hypothetical protein, conserved	0.0057	0.0187	0.0659
Echinococcus multilocularis	glutamate receptor 2	0.0014	0.0018	0.0068
Schistosoma mansoni	hypothetical protein	0.0057	0.0187	0.0179
Trypanosoma brucei	RNA helicase, putative	0.2504	1	1
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0112	0.0408	0.1499
Loa Loa (eye worm)	PDE1B protein	0.0014	0.0015	0.0144
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0016	0.0026	0.0098
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0016	0.0026	0.0017
Plasmodium falciparum	thioredoxin reductase	0.0068	0.0232	1
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0014	0.0018	0.0068
Brugia malayi	hypothetical protein	0.0057	0.0187	0.068
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0023	0.0054	0.0045
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0023	0.0054	1
Trichomonas vaginalis	reverse transcriptases, putative	0.0057	0.0187	0.0659
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0026	0.0429
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0015	0.0144
Trypanosoma brucei	ingi protein (ORF1)	0.0724	0.2865	0.2854
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0016	0.0026	0.0065
Trypanosoma brucei	unspecified product	0.0724	0.2865	0.2854
Brugia malayi	hypothetical protein	0.0057	0.0187	0.068
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0016	0.0026	0.0017
Trypanosoma cruzi	trypanothione reductase, putative	0.0068	0.0232	0.0828
Trichomonas vaginalis	reverse transcriptases, putative	0.0057	0.0187	0.0659
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0016	0.0026	0.0098
Plasmodium vivax	thioredoxin reductase, putative	0.0068	0.0232	1
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0098	0.0353	0.1339
Trypanosoma cruzi	trypanothione reductase, putative	0.0023	0.0054	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0026	0.0429
Brugia malayi	steroid hormone receptor	0.0016	0.0026	0.0065
Plasmodium falciparum	thioredoxin reductase	0.0023	0.0054	0.1827
Brugia malayi	nuclear hormone receptor	0.0016	0.0026	0.0065
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0016	0.0026	0.0429
Brugia malayi	reverse transcriptase	0.0057	0.0187	0.068
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0016	0.0026	0.0065
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0023	0.0054	0.1827
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0016	0.0026	0.0429
Echinococcus granulosus	FTZ F1 alpha	0.0016	0.0026	0.0098
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0016	0.0026	0.0065
Brugia malayi	Nuclear hormone receptor-like 1	0.0016	0.0026	0.0065
Leishmania major	trypanothione reductase	0.0068	0.0232	0.0828
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0015	0.0144
Brugia malayi	Pao retrotransposon peptidase family protein	0.0057	0.0187	0.068
Schistosoma mansoni	glutamate receptor NMDA	0.0014	0.0018	0.0009
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0014	0.0015	0.0006
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0098	0.0353	0.1339
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0016	0.0026	0.0065
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0023	0.0054	0.0206
Brugia malayi	Zinc knuckle family protein	0.0057	0.0187	0.068
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0016	0.0026	0.0065
Brugia malayi	Thioredoxin reductase	0.0068	0.0232	0.0848
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0023	0.0054	0.0151
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0112	0.0408	0.1546
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0023	0.0054	0.1827
Brugia malayi	reverse transcriptase	0.0057	0.0187	0.068
Brugia malayi	Pao retrotransposon peptidase family protein	0.0057	0.0187	0.068
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.0014	0.0015	0.0055
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0014	0.0018	0.0068
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0014	0.0015	0.0022
Brugia malayi	Pao retrotransposon peptidase family protein	0.0057	0.0187	0.068
Plasmodium falciparum	glutathione reductase	0.0023	0.0054	0.1827
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0023	0.0054	0.0173
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0014	0.0015	0.0022
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0014	0.0015	0.0055
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0057	0.0187	0.0711
Loa Loa (eye worm)	steroid hormone receptor	0.0016	0.0026	0.0429
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0016	0.0026	0.0098
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0057	0.0187	0.0711
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0023	0.0054	0.0151
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0023	0.0054	0.004
Brugia malayi	Pao retrotransposon peptidase family protein	0.0057	0.0187	0.068
Brugia malayi	Pao retrotransposon peptidase family protein	0.0057	0.0187	0.068
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0023	0.0054	0.2126
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.0014	0.0015	0.0022
Brugia malayi	glutathione reductase	0.0068	0.0232	0.0848
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0068	0.0232	0.0879
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0014	0.0018	0.0068
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0016	0.0026	0.0017
Echinococcus granulosus	thioredoxin glutathione reductase	0.0068	0.0232	0.0879
Echinococcus granulosus	RNA directed DNA polymerase	0.0057	0.0187	0.0711
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0014	0.0015	0.0006
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0112	0.0408	0.1546
Echinococcus granulosus	glutamate receptor 2	0.0014	0.0018	0.0068
Wolbachia endosymbiont of Brugia malayi	ribonuclease HI	0.0668	0.2637	1
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0017	0.0029	0.0078
Loa Loa (eye worm)	glutathione reductase	0.0068	0.0232	0.5591
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0023	0.0054	0.004
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0016	0.0026	0.0429
Mycobacterium tuberculosis	Probable oxidoreductase	0.0023	0.0054	0.2126
Schistosoma mansoni	thyroid hormone receptor	0.0016	0.0026	0.0017
Brugia malayi	Pao retrotransposon peptidase family protein	0.0057	0.0187	0.068
Brugia malayi	Pao retrotransposon peptidase family protein	0.0057	0.0187	0.068
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0023	0.0054	0.0151
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0014	0.0015	0.0055
Echinococcus granulosus	nmda type glutamate receptor	0.0016	0.0024	0.0092
Brugia malayi	hypothetical protein	0.0057	0.0187	0.068
Schistosoma mansoni	retinoic acid receptor RXR	0.023	0.0882	0.0874
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0016	0.0026	0.0098
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0023	0.0054	0.0151
Toxoplasma gondii	ribonuclease HI protein	0.0668	0.2637	1
Echinococcus granulosus	KRAB A domain containing protein	0.0057	0.0187	0.0711
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0023	0.0054	0.004
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0014	0.0015	0.0006
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0014	0.0018	0.0068
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0023	0.0054	0.0206
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0023	0.0054	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0016	0.0026	0.0065
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0016	0.0026	0.0098
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0057	0.0187	0.0711
Echinococcus multilocularis	FTZ F1 alpha	0.0016	0.0026	0.0098
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0068	0.0232	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0016	0.0026	0.0065
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0014	0.0018	0.0068
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0014	0.0018	0.0068
Giardia lamblia	Reverse transcriptase/endonuclease, putative	0.0057	0.0187	0.0659
Trichomonas vaginalis	mercuric reductase, putative	0.0023	0.0054	0.0151
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0016	0.0026	0.0429
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0012	0.0009	0.0033
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0014	0.0015	0.0006
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0112	0.0408	0.1546
Echinococcus granulosus	ribonuclease H1	0.0668	0.2637	1
Schistosoma mansoni	phosphoglucomutase	0.0668	0.2637	0.2631
Brugia malayi	Zinc knuckle family protein	0.0057	0.0187	0.068
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0026	0.0429
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0026	0.0429
Brugia malayi	Pao retrotransposon peptidase family protein	0.0057	0.0187	0.068
Plasmodium falciparum	glutathione reductase	0.0068	0.0232	1
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0023	0.0054	0.2126
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0026	0.0429
Schistosoma mansoni	scy1(yeast) protein kinase-like	0.0057	0.0187	0.0179
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0016	0.0026	0.0098
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.023	0.0882	0.3346
Onchocerca volvulus		0.0057	0.0187	0.0619
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0014	0.0015	0.0022
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0112	0.0408	0.1546
Plasmodium vivax	glutathione reductase, putative	0.0068	0.0232	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0016	0.0026	0.0065
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0057	0.0187	0.0711
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0014	0.0015	0.0055
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0014	0.0015	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0015	0.0144
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0221	0.0848	0.3214
Mycobacterium tuberculosis	Possible maturase	0.0057	0.0187	0.8034
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0016	0.0026	0.0065
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0023	0.0054	0.0151
Toxoplasma gondii	thioredoxin reductase	0.0068	0.0232	0.0828
Schistosoma mansoni	hypothetical protein	0.0057	0.0187	0.0179
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0023	0.0054	0.2126
Trypanosoma brucei	trypanothione reductase	0.0068	0.0232	0.0218
Schistosoma mansoni	coup transcription factor	0.0016	0.0026	0.0017
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0057	0.0187	0.0711
Brugia malayi	RNase H family protein	0.0668	0.2637	1
Echinococcus multilocularis	nmda type glutamate receptor	0.0016	0.0024	0.0092
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0014	0.0015	0.0055
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0014	0.0015	0.0006
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0016	0.0026	0.0065
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0023	0.0054	0.0151
Brugia malayi	hypothetical protein	0.0057	0.0187	0.068
Brugia malayi	ecdysteroid receptor	0.0016	0.0026	0.0065
Onchocerca volvulus	Ribonuclease H1 homolog	0.0668	0.2637	1
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0023	0.0054	0.0151
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0057	0.0187	0.0711
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0016	0.0026	0.0098
Brugia malayi	Pao retrotransposon peptidase family protein	0.0057	0.0187	0.068
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0014	0.0015	0.0006
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.0014	0.0015	0.0006
Treponema pallidum	ribonuclease H (rnhA)	0.0668	0.2637	1
Trypanosoma brucei	Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative	0.0057	0.0187	0.0173
Toxoplasma gondii	NADPH-glutathione reductase	0.0023	0.0054	0.0151
Trypanosoma brucei	hypothetical protein, conserved	0.0724	0.2865	0.2854
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0057	0.0187	0.0711
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0057	0.0187	0.0711
Trichomonas vaginalis	NeSL-1_NeSL reverse transcriptases, putative	0.0057	0.0187	0.0659
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0057	0.0187	0.0711
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0014	0.0015	0.0006
Brugia malayi	reverse transcriptase	0.0057	0.0187	0.068
Echinococcus multilocularis	ecdysone induced protein 78C	0.0016	0.0026	0.0098
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0023	0.0054	0.5
Schistosoma mansoni	thyroid hormone receptor	0.0016	0.0026	0.0017
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0014	0.0015	0.0144
Trypanosoma brucei	ingi protein (ORF1)	0.0724	0.2865	0.2854
Schistosoma mansoni	RAR-like nuclear receptor	0.0016	0.0026	0.0017
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0023	0.0054	0.0151
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0112	0.0408	0.1499
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0016	0.0026	0.0065
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0057	0.0187	0.0711
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0014	0.0015	0.0022
Echinococcus multilocularis	ribonuclease H1	0.0668	0.2637	1
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0057	0.0187	0.0711
Giardia lamblia	Ribonuclease H	0.0668	0.2637	1
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0408	1
Brugia malayi	Pao retrotransposon peptidase family protein	0.0057	0.0187	0.068
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0014	0.0018	0.0068
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.0098	0.0353	0.8634
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0016	0.0026	0.0098
Trypanosoma brucei	SLACS reverse transcriptase, putative	0.0057	0.0187	0.0173
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0016	0.0026	0.0098
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0016	0.0026	0.0017
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0057	0.0187	0.0711
Brugia malayi	nuclear receptor NHR-88	0.0016	0.0026	0.0065
Trypanosoma cruzi	ribonuclease H1, putative	0.0668	0.2637	1
Brugia malayi	Pao retrotransposon peptidase family protein	0.0057	0.0187	0.068
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0016	0.0026	0.0065
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0016	0.0026	0.0017
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0016	0.0026	0.0065
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0023	0.0054	1
Echinococcus multilocularis	RNA directed DNA polymerase	0.0057	0.0187	0.0711
Brugia malayi	Pao retrotransposon peptidase family protein	0.0057	0.0187	0.068
Brugia malayi	Pao retrotransposon peptidase family protein	0.0057	0.0187	0.068
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0023	0.0054	0.0151
Giardia lamblia	Reverse transcriptase/endonuclease, putative	0.0057	0.0187	0.0659
Echinococcus granulosus	ecdysone induced protein 78C	0.0016	0.0026	0.0098
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0016	0.0026	0.0017
Leishmania major	ribonuclease H1, putative	0.0668	0.2637	1
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0112	0.0408	0.0399
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0014	0.0018	0.0068
Trypanosoma brucei	ribonuclease H1	0.0668	0.2637	0.2627
Schistosoma mansoni	protein kinase	0.0057	0.0187	0.0179
Onchocerca volvulus		0.0057	0.0187	0.0619
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0014	0.0015	0.0022
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0023	0.0054	0.1827
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0016	0.0026	0.0098
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0014	0.0015	0.0006
Schistosoma mansoni	phosphoglucomutase	0.0668	0.2637	0.2631
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0023	0.0054	0.0151
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0016	0.0026	0.0098
Onchocerca volvulus	Telomerase reverse transcriptase homolog	0.0057	0.0187	0.0619
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0016	0.0026	0.0429
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0014	0.0015	0.0055
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.0014	0.0015	0.0055
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0016	0.0026	0.0429
Trichomonas vaginalis	reverse transcriptase [C. elegans], putative	0.0057	0.0187	0.0659
Schistosoma mansoni	phosphoglucomutase	0.0668	0.2637	0.2631
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0016	0.0026	0.0429
Giardia lamblia	Reverse transcriptase/endonuclease, putative	0.0057	0.0187	0.0659
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0026	0.0429
Schistosoma mansoni	nuclear hormone receptor	0.0016	0.0026	0.0017
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0016	0.0024	0.0092
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0017	0.0029	0.0078
Giardia lamblia	Reverse transcriptase/endonuclease, putative	0.0057	0.0187	0.0659
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0026	0.0429
Brugia malayi	photoreceptor-specific nuclear receptor	0.0016	0.0026	0.0065
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0098	0.0353	0.131
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0014	0.0015	0.0055
Trypanosoma brucei	retrotransposon hot spot protein 4 (RHS4), interrupted	0.0724	0.2865	0.2854
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0016	0.0026	0.0098
Schistosoma mansoni	serine/threonine protein kinase	0.0057	0.0187	0.0179
Trypanosoma cruzi	ribonuclease H1, putative	0.0668	0.2637	1
Brugia malayi	RNase H family protein	0.0668	0.2637	1
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0057	0.0187	0.0711
Treponema pallidum	NADH oxidase	0.0023	0.0054	0.0182
Trypanosoma brucei	SLACS retrotransposable element (part), putative	0.0057	0.0187	0.0173
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.0014	0.0015	0.0055
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0023	0.0054	0.1827
Brugia malayi	Steroid receptor seven-up type 2	0.0016	0.0026	0.0065
Echinococcus multilocularis	glutamate receptor 2	0.0012	0.0009	0.0033
Brugia malayi	RNase H family protein	0.0668	0.2637	1
Loa Loa (eye worm)	thioredoxin reductase	0.0068	0.0232	0.5591
Giardia lamblia	Reverse transcriptase/endonuclease	0.0057	0.0187	0.0659
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0023	0.0054	0.0151
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0023	0.0054	0.0151

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1000 nM	In vitro inhibition of phosphodiesterase (PDE IV) from guinea pig macrophages.	ChEMBL.	9871693
IC50 (binding)	= 1000 nM	In vitro inhibition of phosphodiesterase (PDE IV) from guinea pig macrophages.	ChEMBL.	9871693
Ki (binding)	= 787 nM	Affinity for phosphodiesterase (PDE IV) in guinea pig brain membrane using [3H]-rolipram displacement.	ChEMBL.	9871693
Ki (binding)	= 787 nM	Affinity for phosphodiesterase (PDE IV) in guinea pig brain membrane using [3H]-rolipram displacement.	ChEMBL.	9871693

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 226914