Detailed information for compound 23332

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 536.575 | Formula: C27H25FN4O5S
  • H donors: 1 H acceptors: 5 LogP: 2.97 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C1CCOCCN1c1ccc(c(c1)F)NC(=O)c1cc(nn1c1cc2ccccc2cc1S(=O)(=O)C)C
  • InChi: 1S/C27H25FN4O5S/c1-17-13-24(32(30-17)23-14-18-5-3-4-6-19(18)15-25(23)38(2,35)36)27(34)29-22-8-7-20(16-21(22)28)31-10-12-37-11-9-26(31)33/h3-8,13-16H,9-12H2,1-2H3,(H,29,34)
  • InChiKey: AKVZOCDPJXEMRI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens coagulation factor X Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Troponin T 0.0064 0.0633 0.3302
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0037 0.0314 0.0447
Echinococcus multilocularis lysosomal alpha glucosidase 0.0175 0.1917 0.1865
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0437 0.1302
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0238 0.1243
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0621 0.3109
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0335 0.0983
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0041 0.036 0.0298
Schistosoma mansoni rab6-interacting 0.0021 0.013 0.0652
Trichomonas vaginalis cyclins, putative 0.0018 0.0092 0.022
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0335 0.0983
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0421 0.1253
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0421 0.1253
Entamoeba histolytica cyclin family protein 0.0018 0.0092 0.022
Loa Loa (eye worm) TK protein kinase 0.0037 0.0314 0.1636
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0346 0.0284
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1001 0.307
Schistosoma mansoni egf-like domain protein 0.0016 0.0072 0.0359
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0041 0.036 0.053
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0377 0.0315
Schistosoma mansoni tsg101-related 0.0059 0.0569 0.2846
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0052 0.0096
Schistosoma mansoni tsg101-related 0.0048 0.0443 0.2219
Echinococcus granulosus laminin 0.0016 0.0072 0.0014
Schistosoma mansoni caspase-7 (C14 family) 0.0122 0.1304 0.6526
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0346 0.1016
Plasmodium falciparum metacaspase-like protein 0.0046 0.0421 1
Mycobacterium ulcerans UDP-galactopyranose mutase Glf 0.0579 0.6616 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0346 0.3454
Trichomonas vaginalis cyclin A, putative 0.0018 0.0092 0.022
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0122 0.1304 0.1248
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0064 0.0333
Brugia malayi protein-tyrosine kinase 0.0037 0.0314 0.1636
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0036 0.03 0.0238
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.1333 0.6956
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0286 0.321 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0346 0.3093
Leishmania major cyclin 0.0018 0.0092 0.0417
Loa Loa (eye worm) hypothetical protein 0.0089 0.0921 0.4807
Trypanosoma brucei metacaspase 0.0046 0.0421 0.421
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0175 0.1917 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.013 0.0067
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.013 0.0119
Loa Loa (eye worm) hypothetical protein 0.004 0.0346 0.1803
Brugia malayi Cyclin, N-terminal domain containing protein 0.0018 0.0092 0.0479
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0048 0.0443 0.1322
Echinococcus granulosus tyrosine protein kinase Fyn 0.0041 0.036 0.053
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0615 0.3208
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0238 0.3834
Schistosoma mansoni hypothetical protein 0.0033 0.0272 0.1362
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0335 0.0983
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0041 0.036 0.053
Schistosoma mansoni loxhd1 0.0021 0.013 0.0652
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0335 0.0983
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1001 0.307
Brugia malayi MH2 domain containing protein 0.0125 0.1333 0.6956
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.1001 1
Trypanosoma brucei metacaspase MCA2 0.0046 0.0421 0.421
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.01 0.1043 0.0986
Schistosoma mansoni hypothetical protein 0.0182 0.1998 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0046 0.0421 0.678
Loa Loa (eye worm) hypothetical protein 0.0018 0.0092 0.0479
Brugia malayi hypothetical protein 0.0042 0.0375 0.1958
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0335 0.0983
Echinococcus granulosus tyrosine protein kinase Src64B 0.0041 0.036 0.053
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.0346 0.0814
Trypanosoma brucei glucosidase, putative 0.0039 0.0335 0.3351
Echinococcus multilocularis cyclins 0.0018 0.0092 0.0028
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0335 0.0983
Brugia malayi hypothetical protein 0.0021 0.013 0.068
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0071 0.0706 0.0646
Trypanosoma brucei metacaspase 5, putative 0.0046 0.0421 0.421
Trichomonas vaginalis cyclin D, putative 0.0018 0.0092 0.022
Schistosoma mansoni hypothetical protein 0.0043 0.0384 0.1924
Trypanosoma cruzi metacaspase 5, putative 0.0046 0.0421 0.4081
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0335 0.3203
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0052 0.0096
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.0335 0.1749
Brugia malayi DnaJ domain containing protein 0.006 0.0581 0.3033
Loa Loa (eye worm) hypothetical protein 0.0043 0.0384 0.2005
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0346 0.1016
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0023 0.0147 0.1281
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.1333 0.6956
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0335 0.0983
Entamoeba histolytica hypothetical protein 0.0042 0.0375 0.1108
Giardia lamblia PHD finger protein 15 0.003 0.0238 0.0469
Schistosoma mansoni cyclins 0.0018 0.0092 0.046
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0375 0.1878
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0059 0.0573 0.0911
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0375 0.0557
Toxoplasma gondii hypothetical protein 0.0014 0.0042 0.0673
Echinococcus granulosus cyclin B3 1 0.0018 0.0092 0.005
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0621 1
Echinococcus multilocularis geminin 0.0182 0.1998 0.1947
Echinococcus granulosus oncosphere protein Tso22e 0.0135 0.145 0.248
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0046 0.0421 0.2198
Entamoeba histolytica cyclin, putative 0.0018 0.0092 0.022
Echinococcus granulosus cyclins 0.0018 0.0092 0.005
Brugia malayi Fibulin-1 precursor 0.0016 0.0072 0.0375
Echinococcus multilocularis caspase 3 0.0076 0.0767 0.0708
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.321 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0286 0.321 1
Onchocerca volvulus Cell death protein 3 homolog 0.0089 0.0921 0.5371
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0041 0.036 0.0298
Loa Loa (eye worm) troponin 0.0064 0.0633 0.3302
Echinococcus multilocularis apoptotic protease activating factor 1 0.0043 0.0384 0.0323
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0016 0.0072 0.0359
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0421 0.1253
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0016 0.0072 0.0375
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.1001 1
Echinococcus multilocularis cyclins 0.0018 0.0092 0.0028
Echinococcus multilocularis neuropeptide receptor A26 0.0496 0.5653 0.5625
Echinococcus multilocularis cyclin B3 1 0.0018 0.0092 0.0028
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0052 0.0096
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0346 0.173
Echinococcus granulosus caspase 3 0.0076 0.0767 0.1258
Loa Loa (eye worm) hypothetical protein 0.0014 0.0052 0.0273
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0052 0.0312
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.013 0.0067
Echinococcus multilocularis peregrin 0.003 0.0238 0.0175
Trypanosoma cruzi metacaspase, putative 0.0046 0.0421 0.4081
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0377 0.056
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0346 0.1803
Echinococcus granulosus cyclins 0.0018 0.0092 0.005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.321 1
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0346 0.0284
Schistosoma mansoni hypothetical protein 0.003 0.0238 0.1192
Echinococcus multilocularis tyrosine protein kinase Blk 0.0037 0.0314 0.0251
Entamoeba histolytica serine/threonine protein kinase, putative 0.0096 0.1001 0.307
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0272 0.142
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1001 0.307
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0052 0.0096
Brugia malayi SRC-1 0.0041 0.036 0.1878
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0375 0.0313
Trichomonas vaginalis cyclin B3, putative 0.0018 0.0092 0.022
Loa Loa (eye worm) troponin I 0.0109 0.1146 0.5981
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0579 0.6616 1
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0437 0.1302
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0059 0.0573 0.0512
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0064 0.0633 0.3589
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0421 0.1253
Echinococcus granulosus cyclins 0.0018 0.0092 0.005
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0238 0.0312
Echinococcus multilocularis troponin i 0.0109 0.1146 0.109
Trypanosoma cruzi CYC2-like cyclin, putative 0.0018 0.0092 0.0716
Trichomonas vaginalis cyclins, putative 0.0018 0.0092 0.022
Loa Loa (eye worm) DnaJ domain-containing protein 0.006 0.0581 0.3033
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0621 0.0561
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.321 1
Echinococcus granulosus tyrosine kinase 0.0037 0.0314 0.0447
Entamoeba histolytica cyclin family protein 0.0018 0.0092 0.022
Echinococcus granulosus tyrosine protein kinase Fyn 0.0041 0.036 0.053
Schistosoma mansoni troponin I 0.0109 0.1146 0.5737
Loa Loa (eye worm) hypothetical protein 0.0109 0.1146 0.5981
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.321 1
Echinococcus granulosus RUN 0.0021 0.013 0.0119
Leishmania major metacaspase, putative 0.0046 0.0421 0.389
Brugia malayi hypothetical protein 0.0064 0.0633 0.3302
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0313 0.1565
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0122 0.1304 0.2219
Entamoeba histolytica protein kinase, putative 0.0033 0.0266 0.0766
Onchocerca volvulus Troponin I homolog 0.0109 0.1146 0.6763
Entamoeba histolytica cyclin, putative 0.0018 0.0092 0.022
Brugia malayi PHD-finger family protein 0.003 0.0238 0.1243
Schistosoma mansoni troponin t invertebrate 0.0135 0.145 0.7256
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0346 0.173
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0016 0.0072 0.0375
Onchocerca volvulus 0.0021 0.013 0.0482
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0018 0.0092 0.005
Brugia malayi Bromodomain containing protein 0.003 0.0238 0.1243
Trypanosoma cruzi cyclin, putative 0.0018 0.0092 0.0716
Schistosoma mansoni alpha-glucosidase 0.0151 0.1634 0.8176
Mycobacterium leprae Probable UDP-galactopyranose mutase Glf (UDP-galp mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0579 0.6616 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0041 0.036 0.0298
Loa Loa (eye worm) TK protein kinase 0.0033 0.0266 0.1388
Plasmodium falciparum phd finger protein, putative 0.003 0.0238 0.5655
Brugia malayi Troponin I 0.0109 0.1146 0.5981
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0016 0.0072 0.0375
Brugia malayi hypothetical protein 0.0071 0.0706 0.3684
Loa Loa (eye worm) cyclin domain-containing protein 0.0018 0.0092 0.0479
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0346 0.3308
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0041 0.036 0.0298
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.013 0.3093
Loa Loa (eye worm) hypothetical protein 0.0015 0.0064 0.0333
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0346 0.0504
Brugia malayi Cell death protein 3 precursor 0.0089 0.0921 0.4807
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0238 0.0175
Onchocerca volvulus Arrow homolog 0.0016 0.0072 0.012
Loa Loa (eye worm) hypothetical protein 0.0016 0.0072 0.0375
Loa Loa (eye worm) SRC-1 0.0041 0.036 0.1878
Loa Loa (eye worm) hypothetical protein 0.0018 0.0092 0.0479
Loa Loa (eye worm) hypothetical protein 0.0071 0.0706 0.3684
Brugia malayi jmjC domain containing protein 0.01 0.1043 0.5443
Schistosoma mansoni cyclin B3 0.0018 0.0092 0.046
Loa Loa (eye worm) hypothetical protein 0.0016 0.0072 0.0375
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0064 0.0333
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0046 0.0421 0.2108
Echinococcus multilocularis caspase 2 0.0089 0.0921 0.0863
Schistosoma mansoni jumonji domain containing protein 0.0079 0.0805 0.4029
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0621 0.3109
Loa Loa (eye worm) hypothetical protein 0.0049 0.0452 0.2356
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0346 0.1016
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.01 0.1043 0.1752
Schistosoma mansoni alpha-glucosidase 0.0151 0.1634 0.8176
Giardia lamblia Fructose-bisphosphate aldolase 0.0286 0.321 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0052 0.0096
Echinococcus granulosus cyclins 0.0018 0.0092 0.005
Echinococcus multilocularis cyclin b3 0.0018 0.0092 0.0028
Echinococcus multilocularis caspase 0.0122 0.1304 0.1248
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0052 0.0096
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.014 0.1509 0.1481
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0238 0.1192
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0421 0.1253
Echinococcus granulosus troponin i 0.0109 0.1146 0.1937
Echinococcus granulosus dnaJ subfamily C 6 0.006 0.0581 0.0926
Echinococcus granulosus cyclin b3 0.0018 0.0092 0.005
Trichomonas vaginalis cyclins, putative 0.0018 0.0092 0.022
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0452 0.2356
Treponema pallidum fructose-bisphosphate aldolase 0.0286 0.321 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0421 0.1253
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0018 0.0092 0.0417
Echinococcus multilocularis cyclins 0.0018 0.0092 0.0028
Schistosoma mansoni hypothetical protein 0.0015 0.0064 0.0319
Echinococcus granulosus neuropeptide receptor A26 0.0496 0.5653 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0346 0.0504
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0346 0.0504
Echinococcus multilocularis neuropeptide s receptor 0.0496 0.5653 0.5625
Loa Loa (eye worm) hypothetical protein 0.0021 0.013 0.068
Schistosoma mansoni cyclin B 0.0018 0.0092 0.046
Trichomonas vaginalis cyclins, putative 0.0018 0.0092 0.022
Brugia malayi Cyclin, N-terminal domain containing protein 0.0018 0.0092 0.0479
Schistosoma mansoni lipoxygenase 0.0021 0.013 0.0652
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0016 0.0072 0.0375
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0046 0.0421 0.678
Entamoeba histolytica hypothetical protein 0.0042 0.0375 0.1108
Trichomonas vaginalis cyclins, putative 0.0018 0.0092 0.022
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0037 0.0314 0.0251
Echinococcus multilocularis cyclins 0.0018 0.0092 0.0028
Brugia malayi Doublecortin family protein 0.0021 0.013 0.068
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0018 0.0092 0.0028
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0135 0.145 0.8639
Brugia malayi hypothetical protein 0.0021 0.013 0.068
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0023 0.0147 0.1471
Loa Loa (eye worm) troponin T 0.0064 0.0633 0.3302
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.321 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0072 0.0375
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0335 0.0983
Trichomonas vaginalis cyclin B, putative 0.0018 0.0092 0.022
Brugia malayi Troponin family protein 0.0109 0.1146 0.5981
Echinococcus granulosus tyrosine protein kinase Fyn 0.0041 0.036 0.053
Onchocerca volvulus 0.0043 0.0384 0.2053
Trypanosoma brucei metacaspase MCA3 0.0046 0.0421 0.421
Echinococcus multilocularis lysosomal alpha glucosidase 0.0175 0.1917 0.1865
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1001 0.307
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0621 0.0997
Schistosoma mansoni hypothetical protein 0.0182 0.1998 1
Plasmodium vivax hypothetical protein, conserved 0.003 0.0238 0.5655
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0621 0.6
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0041 0.036 0.0298
Brugia malayi Glycosyl hydrolases family 31 protein 0.0175 0.1917 1
Onchocerca volvulus Alhambra homolog 0.003 0.0238 0.1149
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0238 0.3834
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1001 0.307
Schistosoma mansoni alpha glucosidase 0.0039 0.0335 0.1678
Echinococcus granulosus tyrosine protein kinase HCK 0.0033 0.0266 0.0362
Echinococcus granulosus lysosomal alpha glucosidase 0.0175 0.1917 0.3315
Loa Loa (eye worm) hypothetical protein 0.0046 0.0421 0.2198
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0421 0.1253
Schistosoma mansoni hypothetical protein 0.0015 0.0064 0.0319
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0096 0.1001 0.0943
Trypanosoma brucei polo-like protein kinase 0.0096 0.1001 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0421 0.1253
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.321 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0041 0.036 0.0298
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.0335 0.0983
Echinococcus granulosus caspase 8 0.0046 0.0421 0.0639
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0346 0.0284
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0313 0.0445
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0041 0.036 0.0298
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0346 0.1016
Echinococcus multilocularis cyclins 0.0018 0.0092 0.0028
Trichomonas vaginalis cyclin B, putative 0.0018 0.0092 0.022
Brugia malayi serine/threonine-protein kinase plk-2 0.0096 0.1001 0.5221
Trichomonas vaginalis hypothetical protein 0.0034 0.0285 0.0824
Echinococcus granulosus tyrosine protein kinase Src42A 0.0041 0.036 0.053
Trypanosoma cruzi metacaspase, putative 0.0046 0.0421 0.4081
Trichomonas vaginalis cyclin B, putative 0.0018 0.0092 0.022
Trypanosoma cruzi metacaspase 5, putative 0.0046 0.0421 0.4081
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0052 0.0096
Schistosoma mansoni caspase-7 (C14 family) 0.0089 0.0921 0.4611
Echinococcus granulosus tyrosine protein kinase Src42A 0.0036 0.03 0.0423
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0421 0.1253
Schistosoma mansoni hypothetical protein 0.0109 0.1146 0.5737
Echinococcus granulosus cyclin B 0.0018 0.0092 0.005
Schistosoma mansoni troponin I 0.0109 0.1146 0.5737
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0313 0.025
Echinococcus granulosus caspase 0.0122 0.1304 0.2219
Schistosoma mansoni rab6-interacting 0.0021 0.013 0.0652
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0421 0.1253
Onchocerca volvulus 0.0154 0.167 1
Toxoplasma gondii calcium binding egf domain-containing protein 0.0016 0.0072 0.1155
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1001 0.307
Echinococcus multilocularis RUN 0.0021 0.013 0.0067
Schistosoma mansoni caspase-3 (C14 family) 0.0122 0.1304 0.6526
Onchocerca volvulus Serine\/threonine kinase homolog 0.0096 0.1001 0.5862
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.0335 0.0486
Echinococcus granulosus peregrin 0.003 0.0238 0.0312
Leishmania major hypothetical protein, conserved 0.0023 0.0147 0.1
Schistosoma mansoni tsg101-related 0.0059 0.0569 0.2846
Trichomonas vaginalis cyclin D, putative 0.0018 0.0092 0.022
Schistosoma mansoni tyrosine kinase 0.0041 0.036 0.1801
Schistosoma mansoni hypothetical protein 0.0015 0.0064 0.0319
Echinococcus multilocularis fibrillin 1 0.002 0.0115 0.0052
Echinococcus multilocularis laminin 0.0016 0.0072 0.0008
Schistosoma mansoni lipoxygenase 0.0059 0.0573 0.2868
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0313 0.1631
Echinococcus granulosus cyclins 0.0018 0.0092 0.005
Loa Loa (eye worm) doublecortin family protein 0.0021 0.013 0.068
Loa Loa (eye worm) hypothetical protein 0.0109 0.1146 0.5981
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.0335 0.2984
Echinococcus granulosus caspase 2 0.0089 0.0921 0.1534
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0421 0.1253
Echinococcus granulosus apoptotic protease activating factor 1 0.0043 0.0384 0.0574
Echinococcus multilocularis tyrosine protein kinase HCK 0.0033 0.0266 0.0203
Echinococcus multilocularis cyclin B 0.0018 0.0092 0.0028
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.321 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.1509 0.1481
Schistosoma mansoni troponin I 0.0109 0.1146 0.5737
Loa Loa (eye worm) hypothetical protein 0.0052 0.0491 0.2562
Loa Loa (eye worm) hypothetical protein 0.0033 0.0272 0.142
Loa Loa (eye worm) hypothetical protein 0.0016 0.0072 0.0375
Plasmodium falciparum cyclin 0.0018 0.0092 0.2182
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0096 0.1001 0.5221
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1001 0.307
Echinococcus multilocularis oncosphere protein tso22e oncosphere protein tso22d oncosphere protein tso22c oncosphere protein tso22b oncosphere protein tso22 0.0135 0.145 0.1395
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.1001 0.5008
Brugia malayi Troponin T 0.0064 0.0633 0.3302
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.013 0.0067
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0346 0.3308
Trichomonas vaginalis protein kinase inhibitor, putative 0.006 0.0581 0.1755
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0096 0.1001 0.1676
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0452 0.2356
Echinococcus granulosus geminin 0.0182 0.1998 0.3461
Echinococcus multilocularis dnaJ subfamily C 6 0.006 0.0581 0.0521
Brugia malayi jmjC domain containing protein 0.0037 0.0313 0.1631
Schistosoma mansoni hypothetical protein 0.0021 0.013 0.0652
Schistosoma mansoni kinase 0.0049 0.0452 0.2261
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0052 0.0273
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.013 0.3093
Brugia malayi Cyclin, N-terminal domain containing protein 0.0018 0.0092 0.0479
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.0335 0.0273
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0421 0.1253
Giardia lamblia Kinase, PLK 0.0096 0.1001 0.2914
Schistosoma mansoni hypothetical protein 0.0015 0.0064 0.0319
Brugia malayi Troponin T 0.0064 0.0633 0.3302
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0041 0.036 0.0298
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.0335 0.0983
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0046 0.0421 0.678
Echinococcus multilocularis tyrosine protein kinase Srms 0.0037 0.0314 0.0251
Echinococcus multilocularis cyclins 0.0018 0.0092 0.0028
Entamoeba histolytica hypothetical protein 0.0042 0.0375 0.1108
Entamoeba histolytica hypothetical protein 0.0042 0.0375 0.1108
Plasmodium vivax metacaspase 1, putative 0.0046 0.0421 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.013 0.068
Schistosoma mansoni hypothetical protein 0.0042 0.0375 0.1878
Onchocerca volvulus 0.0021 0.013 0.0482
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0092 0.022
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0335 0.3203
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.0335 0.1749
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.0335 0.5397
Echinococcus multilocularis cyclins 0.0018 0.0092 0.0028
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0052 0.0096
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0041 0.036 0.0298
Trypanosoma cruzi metacaspase, putative 0.0046 0.0421 0.4081
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.013 0.0119
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.321 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0335 0.0983
Echinococcus multilocularis Tolloid protein 1 0.0016 0.0072 0.0008
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0421 0.1253
Trypanosoma brucei Metacaspase-4 0.0046 0.0421 0.421
Trichomonas vaginalis cyclin B, putative 0.0018 0.0092 0.022
Loa Loa (eye worm) hypothetical protein 0.0154 0.167 0.8713
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0052 0.0312
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0096 0.1001 1
Onchocerca volvulus 0.0018 0.0092 0.0245
Echinococcus granulosus neuropeptide s receptor 0.0496 0.5653 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0313 0.1565
Schistosoma mansoni hypothetical protein 0.006 0.0581 0.2909
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0064 0.0333
Echinococcus granulosus tyrosine protein kinase Blk 0.0037 0.0314 0.0447
Trypanosoma cruzi cyclin, putative 0.0018 0.0092 0.0716
Brugia malayi hypothetical protein 0.0043 0.0384 0.2005
Echinococcus granulosus tyrosine protein kinase Lyn 0.0041 0.0364 0.0536
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0452 0.2356
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.0052 0.0523
Trypanosoma brucei mitotic cyclin 6 0.0018 0.0092 0.0918
Echinococcus multilocularis caspase 8 0.0046 0.0421 0.036
Schistosoma mansoni polycystin 1-related 0.0021 0.013 0.0652
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0071 0.0706 0.1149
Schistosoma mansoni tyrosine kinase 0.0041 0.036 0.1801
Trypanosoma cruzi cyclin 6, putative 0.0018 0.0092 0.0716
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0052 0.0096
Brugia malayi hypothetical protein 0.0154 0.167 0.8713
Loa Loa (eye worm) hypothetical protein 0.003 0.0238 0.1243
Plasmodium falciparum metacaspase 1 0.0046 0.0421 1
Brugia malayi Calcium binding EGF domain containing protein 0.0016 0.0072 0.0375
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0421 0.1253
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0421 0.1253
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.013 0.0119
Echinococcus granulosus Tolloid protein 1 0.0016 0.0072 0.0014
Toxoplasma gondii calcium binding egf domain-containing protein 0.0016 0.0072 0.1155
Trichomonas vaginalis cyclin B, putative 0.0018 0.0092 0.022
Loa Loa (eye worm) hypothetical protein 0.0016 0.0072 0.0375
Trypanosoma cruzi metacaspase, putative 0.0046 0.0421 0.4081
Loa Loa (eye worm) hypothetical protein 0.0064 0.0633 0.3302
Onchocerca volvulus 0.0101 0.106 0.6228
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0012 0.0022 0.0218
Plasmodium vivax hypothetical protein, conserved 0.0046 0.0421 1
Schistosoma mansoni troponin I 0.0109 0.1146 0.5737

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 23 nM Inhibitory concentration against human Coagulation factor X ChEMBL. 14980670
IC50 (binding) = 23 nM Inhibitory concentration against human Coagulation factor X ChEMBL. 14980670

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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