Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dopamine transporter | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin transporter | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 3 | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 4 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0952 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0952 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0952 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0952 | 1 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0365 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0952 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0952 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0952 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0952 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0952 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0952 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0952 | 1 | 1 |
Onchocerca volvulus | 0.0365 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.0952 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 41.4 nM | Inhibitory activity against dopamine transporter (DAT) labeled with [3H]-WIN- 35,428 in rat brain striatal membrane. | ChEMBL. | 9513598 |
IC50 (binding) | = 271.2 nM | Inhibitory activity against serotonin transporter (SERT) labeled with [3H]-citalopram in rat brain striatal membrane. | ChEMBL. | 9513598 |
Ki (binding) | = 0.45 nM | Binding affinity of the compound towards dopamine transporter (DAT) by using [125I]-RTI-55 radioligand | ChEMBL. | 12213078 |
Ki (binding) | = 0.45 nM | Binding affinity of the compound towards dopamine transporter (DAT) by using [125I]-RTI-55 radioligand | ChEMBL. | 12213078 |
Ki (binding) | = 47 nM | Binding affinity for serotonin transporter (SERT) using [125I]-RTI-55 | ChEMBL. | 12213078 |
Ki (binding) | = 47 nM | Binding affinity for serotonin transporter (SERT) using [125I]-RTI-55 | ChEMBL. | 12213078 |
Ratio (binding) | = 104 | Ratio of Ki value towards Serotonin transporter (SERT) to that of Dopamine transporter (DAT) | ChEMBL. | 12213078 |
Ratio (binding) | = 104 | Ratio of Ki value towards Serotonin transporter (SERT) to that of Dopamine transporter (DAT) | ChEMBL. | 12213078 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.