TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 302.348 | Formula: C15H14N2O3S
H donors: 3 H acceptors: 3 LogP: 2.91 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1)S(=O)(=O)Nc1cccc2c1[nH]c(c2)O
InChi: 1S/C15H14N2O3S/c1-10-5-7-12(8-6-10)21(19,20)17-13-4-2-3-11-9-14(18)16-15(11)13/h2-9,16-18H,1H3
InChiKey: VVKHDXMTXSEIEH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	glucose transport protein	0.0019	0.0237	0.3667
Brugia malayi	Cation transporter family protein	0.0018	0.0214	0.0214
Echinococcus multilocularis	solute carrier family 22	0.0019	0.0237	0.3667
Trichomonas vaginalis	sugar transporter, putative	0.0019	0.0237	1
Toxoplasma gondii	transporter, major facilitator family protein	0.0019	0.0237	0.5
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0018	0.0214	0.3322
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0237	0.0237
Echinococcus granulosus	gtp binding protein I alpha 1subunit	0.0014	0.0105	0.1623
Loa Loa (eye worm)	sugar transporter	0.0019	0.0237	0.0237
Brugia malayi	excitatory GABA receptor EXP-1A	0.0018	0.0214	0.0214
Trichomonas vaginalis	sugar transporter, putative	0.0019	0.0237	1
Brugia malayi	Cation transporter family protein	0.0018	0.0214	0.0214
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0018	0.0214	0.3322
Onchocerca volvulus		0.0019	0.0237	0.0662
Schistosoma mansoni	nAChR subunit	0.0018	0.0214	0.3322
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0019	0.0237	0.3667
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0214	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0214	0.0214
Onchocerca volvulus		0.0019	0.0237	0.0662
Trichomonas vaginalis	sugar transporter, putative	0.0019	0.0237	1
Trichomonas vaginalis	sugar transporter, putative	0.0019	0.0237	1
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0018	0.0214	0.3322
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0018	0.0214	0.3322
Trichomonas vaginalis	sugar transporter, putative	0.0019	0.0237	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0237	0.0237
Trichomonas vaginalis	sugar transporter, putative	0.0019	0.0237	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0214	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0105	0.0105
Toxoplasma gondii	facilitative glucose transporter GT1	0.0019	0.0237	0.5
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0018	0.0214	0.3322
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0019	0.0237	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0214	0.0214
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0019	0.0237	0.3667
Schistosoma mansoni	glucose transport protein	0.0019	0.0237	0.3667
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0237	0.0237
Onchocerca volvulus		0.0018	0.0214	0.0599
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0018	0.0214	0.3322
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0018	0.0214	0.0214
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0018	0.0214	0.0214
Trichomonas vaginalis	sugar transporter, putative	0.0019	0.0237	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0214	0.0214
Trichomonas vaginalis	sugar transporter, putative	0.0019	0.0237	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0645	1
Mycobacterium ulcerans	sugar transporter	0.0019	0.0237	0.5
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0237	0.0237
Trichomonas vaginalis	sugar transport protein, putative	0.0019	0.0237	1
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0019	0.0237	0.5
Trichomonas vaginalis	glucose transporter, putative	0.0019	0.0237	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0214	0.0214
Onchocerca volvulus		0.0018	0.0214	0.0599
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0018	0.0214	0.0214
Trypanosoma cruzi	Emopamil binding protein, putative	0.0152	0.3578	0.3422
Mycobacterium ulcerans	integral membrane transport protein	0.0019	0.0237	0.5
Brugia malayi	GTP-binding regulatory protein alpha chain - starfish, putative	0.0014	0.0105	0.0105
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0019	0.0237	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0019	0.0237	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0018	0.0214	0.0214
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0018	0.0214	0.0214
Schistosoma mansoni	sugar transporter	0.0019	0.0237	0.3667
Leishmania major	hypothetical protein, conserved	0.0152	0.3578	0.3422
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0018	0.0214	0.0214
Leishmania major	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.0152	0.3578	0.3422
Brugia malayi	major facilitator superfamily protein	0.0019	0.0237	0.0237
Echinococcus granulosus	solute carrier family 22	0.0019	0.0237	0.3667
Loa Loa (eye worm)	LGC-31 protein	0.0018	0.0214	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0237	0.0237
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0018	0.0214	0.3322
Giardia lamblia	Sugar-proton symporter	0.0019	0.0237	0.5
Echinococcus granulosus	solute carrier family 22	0.0019	0.0237	0.3667
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0019	0.0237	0.0237
Trichomonas vaginalis	sugar transporter, putative	0.0019	0.0237	1
Brugia malayi	Sugar transporter family protein	0.0019	0.0237	0.0237
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0019	0.0237	0.3667
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0237	1
Schistosoma mansoni	hypothetical protein	0.0036	0.0645	1
Schistosoma mansoni	GTP-binding protein (I) alpha-1subunit gnai1	0.0014	0.0105	0.1623
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0645	1
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0018	0.0214	0.3322
Schistosoma mansoni	sugar transporter	0.0019	0.0237	0.3667
Echinococcus granulosus	nAChR subunit	0.0018	0.0214	0.3322
Trypanosoma cruzi	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.0152	0.3578	0.3422
Onchocerca volvulus		0.0019	0.0237	0.0662
Echinococcus multilocularis	guanine nucleotide binding protein (G protein)	0.0014	0.0105	0.1623
Echinococcus granulosus	synaptic vesicle 2 protein	0.0019	0.0237	0.3667
Echinococcus granulosus	solute carrier family 22	0.0019	0.0237	0.3667
Schistosoma mansoni	nAChR subunit	0.0018	0.0214	0.3322
Trichomonas vaginalis	sugar transporter, putative	0.0019	0.0237	1
Trichomonas vaginalis	sugar transporter, putative	0.0019	0.0237	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0018	0.0214	0.0214
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0018	0.0214	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0214	0.0214
Onchocerca volvulus		0.0018	0.0214	0.0599
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0019	0.0237	0.5
Onchocerca volvulus		0.0019	0.0237	0.0662
Brugia malayi	Major Facilitator Superfamily protein	0.0019	0.0237	0.0237
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0018	0.0214	0.3322
Schistosoma mansoni	trimeric G-protein alpha o subunit	0.0014	0.0105	0.1623
Echinococcus multilocularis	gtp binding protein (I) alpha 1subunit	0.0014	0.0105	0.1623
Brugia malayi	Cation transporter family protein	0.0018	0.0214	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0237	0.0237
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0018	0.0214	0.0214
Trichomonas vaginalis	sugar transporter, putative	0.0019	0.0237	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0237	0.0237
Onchocerca volvulus		0.0019	0.0237	0.0662
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0214	0.0214
Trichomonas vaginalis	sugar transporter, putative	0.0019	0.0237	1
Onchocerca volvulus		0.0019	0.0237	0.0662
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0214	0.0214
Loa Loa (eye worm)	sugar transporter	0.0019	0.0237	0.0237
Onchocerca volvulus	Putative transporter	0.0019	0.0237	0.0662
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0237	0.0237
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0018	0.0214	0.3322
Onchocerca volvulus		0.0018	0.0214	0.0599
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0019	0.0237	0.3667
Trichomonas vaginalis	sugar transporter, putative	0.0019	0.0237	1
Schistosoma mansoni	sugar transporter	0.0019	0.0237	0.3667
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0018	0.0214	0.3322
Schistosoma mansoni	nAChR subunit	0.0018	0.0214	0.3322
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0018	0.0214	0.3322
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0018	0.0214	0.3322
Trichomonas vaginalis	sugar transporter, putative	0.0019	0.0237	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0019	0.0237	0.3667
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0019	0.0237	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0019	0.0237	1
Echinococcus granulosus	guanine nucleotide binding protein G protein	0.0014	0.0105	0.1623
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0237	0.0237
Brugia malayi	major facilitator superfamily protein	0.0019	0.0237	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0214	0.0214
Loa Loa (eye worm)	hypothetical protein	0.001	0.0008	0.0008
Schistosoma mansoni	hypothetical protein	0.0019	0.0237	0.3667
Brugia malayi	Sugar transporter family protein	0.0019	0.0237	0.0237
Echinococcus multilocularis	glycine receptor subunit beta	0.0018	0.0214	0.3322
Trichomonas vaginalis	sugar transporter, putative	0.0019	0.0237	1
Trichomonas vaginalis	myo-inositol transporter, putative	0.0019	0.0237	1
Trichomonas vaginalis	sugar transporter, putative	0.0019	0.0237	1
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0237	1
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0018	0.0214	0.3322
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0014	0.0105	0.1623
Loa Loa (eye worm)	heterotrimeric G protein alpha subunit	0.0014	0.0105	0.0105
Schistosoma mansoni	nAChR subunit	0.0018	0.0214	0.3322
Entamoeba histolytica	hypothetical protein	0.0036	0.0645	1
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0018	0.0214	0.0214
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0406	1	1
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0019	0.0237	0.5
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0018	0.0214	0.3322
Trichomonas vaginalis	sugar transporter, putative	0.0019	0.0237	1
Echinococcus multilocularis	solute carrier family 22	0.0019	0.0237	0.3667
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0237	0.0237
Echinococcus granulosus	solute carrier family 22	0.0019	0.0237	0.3667
Onchocerca volvulus		0.0019	0.0237	0.0662
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0214	0.0214
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0018	0.0214	0.3322
Trichomonas vaginalis	sugar transporter, putative	0.0019	0.0237	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0018	0.0214	0.0214
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0018	0.0214	0.3322
Entamoeba histolytica	hypothetical protein	0.0036	0.0645	1
Onchocerca volvulus		0.0152	0.3578	1
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0018	0.0214	0.0214
Onchocerca volvulus		0.0019	0.0237	0.0662
Trichomonas vaginalis	sugar transporter, putative	0.0019	0.0237	1
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0018	0.0214	0.3322
Trichomonas vaginalis	sugar transporter, putative	0.0019	0.0237	1
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0018	0.0214	0.3322
Trichomonas vaginalis	sugar transporter, putative	0.0019	0.0237	1
Echinococcus granulosus	guanine nucleotide binding protein G protein	0.0014	0.0105	0.1623
Plasmodium vivax	sugar transporter, putative	0.0019	0.0237	0.5
Brugia malayi	hypothetical protein	0.0019	0.0237	0.0237
Onchocerca volvulus		0.0018	0.0214	0.0599
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0105	0.0105
Schistosoma mansoni	sugar transporter	0.0019	0.0237	0.3667
Brugia malayi	hypothetical protein	0.0036	0.0645	0.0645
Trichomonas vaginalis	sugar transporter, putative	0.0019	0.0237	1
Onchocerca volvulus		0.0019	0.0237	0.0662
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0214	0.0214
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0018	0.0214	0.0214
Plasmodium vivax	hexose transporter	0.0019	0.0237	0.5
Onchocerca volvulus		0.0019	0.0237	0.0662
Brugia malayi	hypothetical protein	0.0019	0.0237	0.0237
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0018	0.0214	0.0214
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0018	0.0214	0.3322
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0018	0.0214	0.0214
Brugia malayi	Major Facilitator Superfamily protein	0.0019	0.0237	0.0237
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0018	0.0214	0.0214
Brugia malayi	Sugar transporter family protein	0.0019	0.0237	0.0237
Echinococcus multilocularis	solute carrier family 22	0.0019	0.0237	0.3667
Toxoplasma gondii	sugar transporter ST3	0.0019	0.0237	0.5
Echinococcus multilocularis	nAChR subunit	0.0018	0.0214	0.3322
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0019	0.0237	0.3667
Onchocerca volvulus		0.0019	0.0237	0.0662
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0214	0.0214
Onchocerca volvulus		0.0019	0.0237	0.0662
Onchocerca volvulus		0.0019	0.0237	0.0662
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0019	0.0237	0.3667
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0018	0.0214	0.3322
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0237	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0237	0.0237
Onchocerca volvulus		0.0018	0.0214	0.0599
Trichomonas vaginalis	sugar transporter, putative	0.0019	0.0237	1
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0018	0.0214	0.3322
Onchocerca volvulus		0.0019	0.0237	0.0662
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0019	0.0237	0.3667
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0237	1
Brugia malayi	Major Facilitator Superfamily protein	0.0019	0.0237	0.0237
Toxoplasma gondii	sugar transporter ST2	0.0019	0.0237	0.5
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0018	0.0214	0.0214
Echinococcus multilocularis	solute carrier family 22	0.0019	0.0237	0.3667
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0019	0.0237	0.3667
Onchocerca volvulus		0.0019	0.0237	0.0662
Brugia malayi	hypothetical protein	0.0019	0.0237	0.0237
Echinococcus granulosus	glycine receptor subunit beta	0.0018	0.0214	0.3322
Loa Loa (eye worm)	ACC-1 protein	0.0018	0.0214	0.0214
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0237	1
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0018	0.0214	0.0214
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0018	0.0214	0.3322
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0018	0.0214	0.0214
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0018	0.0214	0.0214
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0018	0.0214	0.0214
Schistosoma mansoni	glucose transporter	0.0019	0.0237	0.3667
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0237	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0214	0.0214
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0018	0.0214	0.3322
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0105	0.0105
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0014	0.0105	0.1623
Echinococcus multilocularis	glycine receptor subunit beta	0.0018	0.0214	0.3322
Brugia malayi	Guanine nucleotide-binding protein alpha-3 subunit, putative	0.0014	0.0105	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0406	1	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0214	0.0214
Trypanosoma cruzi	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.0152	0.3578	0.3422
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0237	1
Loa Loa (eye worm)	GTP-binding regulatory protein alpha chain	0.0014	0.0105	0.0105
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0406	1	1
Giardia lamblia	Hexose transporter	0.0019	0.0237	0.5
Entamoeba histolytica	hypothetical protein	0.0036	0.0645	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0019	0.0237	0.3667
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0237	0.0237
Loa Loa (eye worm)	ACC-1 protein	0.0018	0.0214	0.0214
Trypanosoma cruzi	Emopamil binding protein, putative	0.0152	0.3578	0.3422
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0018	0.0214	0.0214
Echinococcus granulosus	glycine receptor subunit beta	0.0018	0.0214	0.3322
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0237	1
Loa Loa (eye worm)	hypothetical protein	0.0208	0.4988	0.4988
Trichomonas vaginalis	sugar transporter, putative	0.0019	0.0237	1
Onchocerca volvulus		0.0019	0.0237	0.0662
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0237	1
Trichomonas vaginalis	sugar transporter, putative	0.0019	0.0237	1
Leishmania major	C-8 sterol isomerase-like protein	0.0406	1	1
Trichomonas vaginalis	sugar transporter, putative	0.0019	0.0237	1
Plasmodium falciparum	hexose transporter	0.0019	0.0237	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0019	0.0237	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0214	0.0214
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0237	1
Schistosoma mansoni	nAChR subunit	0.0018	0.0214	0.3322
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0019	0.0237	0.5
Onchocerca volvulus	Putative nachr subunit	0.0018	0.0214	0.0599
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0214	0.0214
Schistosoma mansoni	nAChR subunit	0.0018	0.0214	0.3322
Trichomonas vaginalis	sugar transporter, putative	0.0019	0.0237	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0214	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0237	0.0237
Echinococcus multilocularis	guanine nucleotide binding protein (G protein)	0.0014	0.0105	0.1623
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0214	0.0214
Schistosoma mansoni	glucose transport protein	0.0019	0.0237	0.3667
Trypanosoma brucei	Emopamil binding protein, putative	0.0152	0.3578	0.3422
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0018	0.0214	0.3322
Trichomonas vaginalis	sugar transporter, putative	0.0019	0.0237	1
Trichomonas vaginalis	sugar transporter, putative	0.0019	0.0237	1
Trichomonas vaginalis	glucose transporter, putative	0.0019	0.0237	1
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0019	0.0237	0.3667
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0019	0.0237	0.3667
Schistosoma mansoni	nAChR subunit	0.0018	0.0214	0.3322
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0645	1
Trichomonas vaginalis	glucose transporter, putative	0.0019	0.0237	1
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0018	0.0214	0.3322
Brugia malayi	guanine nucleotide-binding protein alpha-7 subunit, putative	0.0014	0.0105	0.0105
Trichomonas vaginalis	sugar transporter, putative	0.0019	0.0237	1
Trichomonas vaginalis	sugar transporter, putative	0.0019	0.0237	1
Trichomonas vaginalis	sugar transporter, putative	0.0019	0.0237	1
Trichomonas vaginalis	sugar transporter, putative	0.0019	0.0237	1
Toxoplasma gondii	sugar transporter ST1	0.0019	0.0237	0.5
Entamoeba histolytica	hypothetical protein	0.0036	0.0645	1
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0018	0.0214	0.3322
Schistosoma mansoni	GTP-binding protein (I) alpha-1subunit gnai1	0.0014	0.0105	0.1623
Trichomonas vaginalis	sugar transporter, putative	0.0019	0.0237	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	0	Compound was tested against bovine brain tubulin polymerization; active	ChEMBL.	10866386
Cell cycle analysis (functional)	G2/M arrest 0	Effect of the compound on the cell cycle progression using P388 cells at 4.0 ug/mL for 24 hr; G2/M arrest	ChEMBL.	10866386
IC50 (functional)	= 0.093 ug ml-1	In vitro antiproliferative activity of the compound (4 ug/mL) was measured against KB cancer cell line using MTT colorimetric assay	ChEMBL.	10866386
IC50 (functional)	= 0.093 ug ml-1	In vitro antiproliferative activity of the compound (4 ug/mL) was measured against KB cancer cell line using MTT colorimetric assay	ChEMBL.	10866386
IC50 (functional)	= 0.14 ug ml-1	In vitro antiproliferative activity of the compound (4 ug/mL) was measured against P388 cancer cell line using MTT colorimetric assay	ChEMBL.	10866386
IC50 (functional)	= 0.14 ug ml-1	In vitro antiproliferative activity of the compound (4 ug/mL) was measured against P388 cancer cell line using MTT colorimetric assay	ChEMBL.	10866386
IC50 (functional)	= 0.17 ug ml-1	In vitro antiproliferative activity of the compound (4 ug/mL) was measured against colon 38 cancer cell line using MTT colorimetric assay	ChEMBL.	10866386
IC50 (functional)	= 0.17 ug ml-1	In vitro antiproliferative activity of the compound (4 ug/mL) was measured against colon 38 cancer cell line using MTT colorimetric assay	ChEMBL.	10866386

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	10866386
Mus musculus	ChEMBL23	10866386

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 23846