TDR Targets

Basic information

Technical information

TDR Targets ID: 251762
Name: 2-(4-hydroxy-2-oxo-3H-1,3-benzothiazol-7-yl)e thyl-[6-(4-phenylbutoxy)hexyl]azanium; 2,2,2- trifluoroacetate
MW: 556.637 | Formula: C27H35F3N2O5S
H donors: 4 H acceptors: 5 LogP: 4.41 Rotable bonds: 16
Rule of 5 violations (Lipinski): 2
SMILES: OC(=O)C(F)(F)F.Oc1sc2c(n1)c(O)ccc2CCNCCCCCCOCCCCc1ccccc1
InChi: 1S/C25H34N2O3S.C2HF3O2/c28-22-14-13-21(24-23(22)27-25(29)31-24)15-17-26-16-7-1-2-8-18-30-19-9-6-12-20-10-4-3-5-11-20;3-2(4,5)1(6)7/h3-5,10-11,13-14,26,28H,1-2,6-9,12,15-19H2,(H,27,29);(H,6,7)
InChiKey: KDIZFBDKMGSDHH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(4-hydroxy-2-oxo-3H-1,3-benzothiazol-7-yl)ethyl-[6-(4-phenylbutoxy)hexyl]ammonium; 2,2,2-trifluoroacetate
2-(4-hydroxy-2-oxo-3H-1,3-benzothiazol-7-yl)ethyl-[6-(4-phenylbutoxy)hexyl]azanium; 2,2,2-trifluoroethanoate
2-(4-hydroxy-2-keto-3H-1,3-benzothiazol-7-yl)ethyl-[6-(4-phenylbutoxy)hexyl]ammonium; 2,2,2-trifluoroacetate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	M1-family alanyl aminopeptidase	0.0025	0.0234	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0022	0.0165	0.0154
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0015	0.0023	0.0042
Trypanosoma cruzi	cysteine peptidase, putative	0.0022	0.0165	0.1256
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.0025	0.0234	0.1867
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0072	0.1155	0.1145
Echinococcus multilocularis	dna polymerase eta	0.0019	0.0119	0.0108
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0022	0.0165	0.4465
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0165	0.0571
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0.0119	1
Brugia malayi	Cathepsin L-like precursor	0.0022	0.0165	0.0541
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0072	0.1155	1
Brugia malayi	hypothetical protein	0.0025	0.0234	0.0785
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0165	0.1256
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0072	0.1155	1
Toxoplasma gondii	cathepsin CPL	0.0022	0.0165	0.4465
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0165	0.143
Onchocerca volvulus		0.0022	0.0165	0.0541
Leishmania major	cytochrome p450-like protein	0.0019	0.0121	0.0109
Brugia malayi	Cathepsin L-like precursor	0.0022	0.0165	0.0541
Echinococcus multilocularis	cysteine protease	0.0022	0.0165	0.0154
Schistosoma mansoni	cathepsin F (C01 family)	0.0015	0.0023	0.0104
Loa Loa (eye worm)	leukotriene A4 hydrolase	0.0025	0.0234	0.0828
Echinococcus granulosus	dna polymerase eta	0.0019	0.0119	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0023	0.0044
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0022	0.0165	0.1256
Brugia malayi	Cathepsin L-like precursor	0.0022	0.0165	0.0541
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0234	0.0828
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0165	0.143
Trypanosoma cruzi	aminopeptidase, putative	0.0072	0.1155	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0119	0.1032
Leishmania major	puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0025	0.0234	0.1196
Leishmania major	cathepsin L-like protease	0.0022	0.0165	0.0534
Entamoeba histolytica	cysteine proteinase, putative	0.0022	0.0165	0.1256
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0022	0.0165	0.4465
Onchocerca volvulus		0.0022	0.0165	0.0541
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0025	0.0234	0.1867
Schistosoma mansoni	ap endonuclease	0.0019	0.0109	0.0858
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0165	0.143
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0119	0.0849
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0025	0.0234	0.0223
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0109	0.0762
Echinococcus multilocularis	muscleblind protein	0.015	0.2706	0.2698
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0109	0.0345
Onchocerca volvulus		0.0022	0.0165	0.0541
Trypanosoma brucei	cytochrome P450, putative	0.0019	0.0121	0.1045
Onchocerca volvulus	Cathepsin L homolog	0.0022	0.0165	0.0541
Trypanosoma cruzi	cytochrome P450, putative	0.0019	0.0121	0.0863
Brugia malayi	Peptidase family M1 containing protein	0.0072	0.1155	0.402
Loa Loa (eye worm)	cytochrome P450 family protein	0.0019	0.0121	0.0406
Loa Loa (eye worm)	CYP4Cod1	0.0019	0.0121	0.0406
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.0119	0.1032
Schistosoma mansoni	family M1 non-peptidase homologue (M01 family)	0.0046	0.0656	0.5636
Trypanosoma brucei	aminopeptidase, putative	0.0025	0.0234	0.203
Echinococcus granulosus	leukotriene A 4 hydrolase	0.0025	0.0234	0.0223
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0022	0.0165	0.1256
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0165	0.143
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0025	0.0234	0.1867
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0109	0.0098
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0119	0.0944
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0109	0.0762
Leishmania major	cysteine peptidase A (CPA)	0.0022	0.0165	0.0534
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0072	0.1155	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0022	0.0165	0.0154
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0165	0.1256
Trypanosoma brucei	Aminopeptidase M1, putative	0.0072	0.1155	1
Onchocerca volvulus	Cathepsin L homolog	0.0022	0.0165	0.0541
Leishmania major	cathepsin L-like protease	0.0022	0.0165	0.0534
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0119	0.0094
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0111	0.1936	0.7141
Loa Loa (eye worm)	ctsf protein	0.0022	0.0165	0.0571
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0109	0.0098
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0119	0.0849
Trypanosoma cruzi	cysteine peptidase, putative	0.0022	0.0165	0.1256
Loa Loa (eye worm)	fibroinase	0.0022	0.0165	0.0571
Trypanosoma brucei	unspecified product	0.0019	0.0119	0.1032
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0165	0.1256
Loa Loa (eye worm)	hypothetical protein	0.015	0.2706	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0165	0.1256
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0109	0.0947
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0119	0.1032
Loa Loa (eye worm)	cysteine protease	0.0022	0.0165	0.0571
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0072	0.1155	0.1145
Trypanosoma cruzi	aminopeptidase, putative	0.0025	0.0234	0.1867
Schistosoma mansoni	cathepsin F (C01 family)	0.0022	0.0165	0.1347
Leishmania major	cathepsin L-like protease	0.0022	0.0165	0.0534
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0119	0.0379
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0165	0.1256
Loa Loa (eye worm)	TATA binding protein associated factor	0.0025	0.0234	0.0828
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0072	0.1155	0.1145
Brugia malayi	Papain family cysteine protease containing protein	0.0022	0.0165	0.0541
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0165	0.1256
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0165	0.1256
Leishmania major	cathepsin L-like protease	0.0022	0.0165	0.0534
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0019	0.0121	0.0109
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0119	0.1032
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0119	0.1032
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0119	0.0108
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0165	0.143
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0165	0.1256
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0025	0.0234	0.0223
Leishmania major	cathepsin L-like protease	0.0022	0.0165	0.0534
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0119	0.0094
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0019	0.0119	0.0094
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0119	0.1032
Plasmodium falciparum	M1-family alanyl aminopeptidase, putative	0.0025	0.0234	1
Brugia malayi	cathepsin L-like precursor	0.0015	0.0023	0.0042
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0022	0.0165	0.0154
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0165	0.1256
Loa Loa (eye worm)	aminopeptidase N	0.0072	0.1155	0.4243
Loa Loa (eye worm)	hypothetical protein	0.0086	0.1437	0.5289
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0022	0.0165	0.0154
Schistosoma mansoni	ap endonuclease	0.0019	0.0109	0.0858
Entamoeba histolytica	aminopeptidase, putative	0.0072	0.1155	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0022	0.0165	0.0571
Schistosoma mansoni	Tata binding protein associated factor (M01 family)	0.0025	0.0234	0.1952
Loa Loa (eye worm)	hypothetical protein	0.0132	0.2357	0.8705
Onchocerca volvulus	Cathepsin F homolog	0.0022	0.0165	0.0541
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0165	0.1256
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0023	0.0044
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0109	0.0364
Echinococcus multilocularis	leukotriene A 4 hydrolase	0.0025	0.0234	0.0223
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0019	0.0119	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0165	0.1256
Trypanosoma cruzi	cysteine peptidase, putative	0.0022	0.0165	0.1256
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0119	0.0944
Echinococcus multilocularis	aminopeptidase N	0.0157	0.2856	0.2848
Leishmania major	cathepsin L-like protease	0.0022	0.0165	0.0534
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0025	0.0234	1
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0109	0.0762
Echinococcus granulosus	aminopeptidase N	0.0157	0.2856	0.2848
Echinococcus granulosus	muscleblind protein	0.015	0.2706	0.2698
Brugia malayi	Cathepsin L-like precursor	0.0015	0.0023	0.0042
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0165	0.143
Trypanosoma brucei	Aminopeptidase M1, putative	0.0072	0.1155	1
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0019	0.0119	0.0849
Entamoeba histolytica	cysteine protease, putative	0.0022	0.0165	0.1256
Loa Loa (eye worm)	hypothetical protein	0.015	0.2706	1
Onchocerca volvulus		0.0015	0.0023	0.0042
Brugia malayi	Cathepsin L-like precursor	0.0015	0.0023	0.0042
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0165	0.1256
Onchocerca volvulus		0.0022	0.0165	0.0541
Brugia malayi	Peptidase family M1 containing protein	0.0025	0.0234	0.0785
Entamoeba histolytica	cysteine proteinase, putative	0.0022	0.0165	0.1256
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0109	0.0762
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0119	0.0108
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0022	0.0165	0.0154
Brugia malayi	Peptidase family M1 containing protein	0.0157	0.2856	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0656	0.2392
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0072	0.1155	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0049	0.0705	0.2576
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0072	0.1155	0.1145
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0165	0.1256
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0072	0.1155	0.1145
Onchocerca volvulus		0.0157	0.2856	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0165	0.1256
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0072	0.1155	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0165	0.143
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0025	0.0234	0.1867
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0165	0.143
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0165	0.1256
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0046	0.0656	0.0645
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0025	0.0234	0.1867
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0072	0.1155	0.1145
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0165	0.1256
Brugia malayi	Cathepsin L-like precursor	0.0022	0.0165	0.0541
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0072	0.1155	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0165	0.143
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0119	0.1032
Echinococcus multilocularis	muscleblind protein 1	0.015	0.2706	0.2698
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0072	0.1155	0.1145
Trypanosoma cruzi	DNA polymerase eta, putative	0.0019	0.0119	0.0849
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0119	0.1032
Brugia malayi	Cathepsin L-like precursor	0.0022	0.0165	0.0541
Brugia malayi	Cytochrome P450 family protein	0.0019	0.0121	0.0385
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0119	0.1032
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0119	0.1032
Onchocerca volvulus		0.0022	0.0165	0.0541
Echinococcus granulosus	cathepsin l1	0.0015	0.0023	0.0012
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0119	0.1032
Brugia malayi	hypothetical protein	0.0072	0.1155	0.402
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0022	0.0165	0.4465
Schistosoma mansoni	cathepsin F (C01 family)	0.0022	0.0165	0.1347
Schistosoma mansoni	DNA polymerase eta	0.0019	0.0119	0.0944
Schistosoma mansoni	aminopeptidase A (M01 family)	0.0025	0.0234	0.1952
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0119	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0119	0.0401
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0165	0.1256
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0022	0.0165	0.0571
Echinococcus granulosus	cathepsin l1	0.0022	0.0165	0.0154
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0119	0.1032
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0019	0.0119	0.0849
Leishmania major	DNA polymerase eta, putative	0.0019	0.0119	0.0094
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0165	0.143
Trypanosoma cruzi	cytochrome P450, putative	0.0019	0.0121	0.0863
Trypanosoma cruzi	cruzipain precursor, putative	0.0022	0.0165	0.1256
Brugia malayi	Muscleblind-like protein	0.015	0.2706	0.9473
Leishmania major	DNA polymerase kappa, putative	0.0019	0.0119	0.0094
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0165	0.1256
Leishmania major	cathepsin L-like protease	0.0022	0.0165	0.0534
Toxoplasma gondii	aminopeptidase N protein	0.0025	0.0234	1
Brugia malayi	Cytochrome P450 family protein	0.0019	0.0121	0.0385
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	0.0025	0.0234	0.1952
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0025	0.0234	1
Brugia malayi	TATA binding protein associated factor	0.0025	0.0234	0.0785
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0022	0.0165	0.0154
Leishmania major	cathepsin L-like protease	0.0022	0.0165	0.0534
Onchocerca volvulus		0.0072	0.1155	0.402
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0109	0.5
Plasmodium vivax	vivapain-2	0.0022	0.0165	0.4465
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.0046	0.0656	0.559
Mycobacterium ulcerans	aminopeptidase N PepN	0.0072	0.1155	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0656	0.2392
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0234	0.0828
Toxoplasma gondii	aminopeptidase n, putative	0.0025	0.0234	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0019	0.0121	0.0406
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0072	0.1155	0.1145
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0072	0.1155	1
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0072	0.1155	0.1145
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0119	0.0379
Brugia malayi	Cathepsin L-like precursor	0.0022	0.0165	0.0541
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0234	0.0828
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0109	0.0762
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0072	0.1155	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0517	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0022	0.0165	0.1256
Toxoplasma gondii	aminopeptidase N, putative	0.0025	0.0234	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0165	0.1256
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.0072	0.1155	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0165	0.143
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0165	0.1256
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0119	0.0401
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0165	0.1256
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0109	0.5
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0119	0.1032
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0119	0.0108
Mycobacterium ulcerans	aminopeptidase N PepN	0.0025	0.0234	0.1196
Onchocerca volvulus		0.0022	0.0165	0.0541
Brugia malayi	Cytochrome P450 family protein	0.0049	0.0705	0.244
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0023	0.0044
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0165	0.1256
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0119	0.1032
Trichomonas vaginalis	DNA polymerase eta, putative	0.0019	0.0119	0.0849
Plasmodium vivax	vivapain-2	0.0022	0.0165	0.4465
Echinococcus multilocularis	cysteine protease	0.0022	0.0165	0.0154
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0119	0.0849
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0025	0.0234	0.1196
Giardia lamblia	DINP protein human, muc B family	0.0019	0.0119	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0119	0.0849
Onchocerca volvulus		0.0025	0.0234	0.0785
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0072	0.1155	0.1145
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0165	0.1256
Onchocerca volvulus		0.0022	0.0165	0.0541

Activities

Activity type	Activity value	Assay description	Source	Reference
pKH (binding)	= 9.33	Tested in vitro for binding activity to Dopamine receptor D2 in bovine pituitary membranes (D2-LB)	ChEMBL.	9836607
pKH (binding)	= 9.33	Tested in vitro for binding activity to Dopamine receptor D2 in bovine pituitary membranes (D2-LB)	ChEMBL.	9836607
pKL (binding)	= 7.11	Tested in vitro for binding activity to Dopamine receptor D2 in bovine pituitary membranes (D2-LB)	ChEMBL.	9836607
pKL (binding)	= 7.11	Tested in vitro for binding activity to Dopamine receptor D2 in bovine pituitary membranes (D2-LB)	ChEMBL.	9836607
p[A]50 (binding)		Tested in vitro for binding activity to Dopamine receptor D2 in field stimulated rabbit ear artery (D2-REA); f denotes 'Data compromised by high R1-adenoceptor agonist activity'	ChEMBL.	9836607
p[A]50 (binding)	= 6.85	Tested in vitro for binding activity to Alpha-1 adrenergic receptor in field stimulated rabbit ear artery (REA).	ChEMBL.	9836607
p[A]50 (binding)	= 7.33	Tested in vitro for binding activity to Beta-2 adrenergic receptor in guinea pig trachea (GPT).	ChEMBL.	9836607
p[A]50 (binding)	0	Tested in vitro for binding activity to Dopamine receptor D2 in field stimulated rabbit ear artery (D2-REA); f denotes 'Data compromised by high R1-adenoceptor agonist activity'	ChEMBL.	9836607
p[A]50 (binding)	= 6.85	Tested in vitro for binding activity to Alpha-1 adrenergic receptor in field stimulated rabbit ear artery (REA).	ChEMBL.	9836607
p[A]50 (binding)	= 7.33	Tested in vitro for binding activity to Beta-2 adrenergic receptor in guinea pig trachea (GPT).	ChEMBL.	9836607

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL147425
PubChem: 10530815

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 251762