Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.6 uM | Compound is measured for surviving fractions of EMT6 tumor cells treated in culture with (0.50 microM) concentration of the compound for 1 h under hypoxic condition. | ChEMBL. | 7452674 |
ED50 (functional) | = 0.6 uM | Compound is measured for surviving fractions of EMT6 tumor cells treated in culture with (0.50 microM) concentration of the compound for 1 h under hypoxic condition. | ChEMBL. | 7452674 |
ED50 (functional) | = 3 uM | Compound is measured for surviving fractions of EMT6 tumor cells treated in culture with (0.50 microM) concentration of the compound for 1 h under aerobic condition. | ChEMBL. | 7452674 |
ED50 (functional) | = 3 uM | Compound is measured for surviving fractions of EMT6 tumor cells treated in culture with (0.50 microM) concentration of the compound for 1 h under aerobic condition. | ChEMBL. | 7452674 |
Ratio (functional) | = 50 | Ratio of toxicity in areobic conditions to hypoxic condition of EMT6 cells | ChEMBL. | 7452674 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.