Detailed information for compound 256422

Basic information

Technical information
  • TDR Targets ID: 256422
  • Name: 6-methoxy-N-propyl-1,2,3,4-tetrahydronaphthal en-1-amine
  • MW: 219.323 | Formula: C14H21NO
  • H donors: 1 H acceptors: 0 LogP: 2.94 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCNC1CCCc2c1ccc(c2)OC
  • InChi: 1S/C14H21NO/c1-3-9-15-14-6-4-5-11-10-12(16-2)7-8-13(11)14/h7-8,10,14-15H,3-6,9H2,1-2H3
  • InChiKey: MKOLGKCIUFRHQH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-methoxy-N-propyl-tetralin-1-amine
  • 6-methoxy-N-propyl-1-tetralinamine
  • (6-methoxytetralin-1-yl)-propyl-amine
  • 52373-07-6
  • 1,2,3,4-Tetrahydro-6-methoxy-N-propyl-1-naphthalenamine
  • 1-Naphthalenamine, 1,2,3,4-tetrahydro-6-methoxy-N-propyl-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0022 0.5
Brugia malayi DOMON domain containing protein 0.033 0.0933 0.1779
Toxoplasma gondii cytochrome p450 superfamily protein 0.0776 0.2315 1
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.002 0.0038
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.0542 0.1032
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0022 0.004
Brugia malayi jmjC domain containing protein 0.0034 0.002 0.0035
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.0608 1
Brugia malayi jmjC domain containing protein 0.0093 0.0202 0.0383
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0035 0.0022 0.004
Trichomonas vaginalis set domain proteins, putative 0.0231 0.0629 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0022 0.004
Plasmodium falciparum phd finger protein, putative 0.0028 0.0001 0.5
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.002 0.0019
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0022 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0022 0.004
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.1722 0.5241 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0022 0.5
Echinococcus granulosus peregrin 0.0028 0.0001 0.0002
Schistosoma mansoni peptidylglycine monooxygenase 0.1722 0.5241 0.524
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0022 0.0042
Loa Loa (eye worm) hypothetical protein 0.0035 0.0022 0.004
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0022 0.5
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0022 0.0021
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.002 0.0019
Brugia malayi DOMON domain containing protein 0.033 0.0933 0.1779
Brugia malayi DOMON domain containing protein 0.033 0.0933 0.1779
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0202 0.0383
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0003 0.0002
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0036 0.0066
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.002 0.0035
Loa Loa (eye worm) hypothetical protein 0.0035 0.0022 0.004
Mycobacterium leprae Probable lipase LipE 0.0035 0.0022 0.5
Loa Loa (eye worm) DOMON domain-containing protein 0.033 0.0933 0.1779
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0003 0.0004
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0049 0.0064 0.012
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0022 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0003 0.0002
Mycobacterium ulcerans hypothetical protein 0.0035 0.0022 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0003 0.0002
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0022 0.004
Loa Loa (eye worm) hypothetical protein 0.0035 0.0022 0.004
Mycobacterium ulcerans lipase LipD 0.0035 0.0022 0.5
Loa Loa (eye worm) hypothetical protein 0.1722 0.5241 1
Onchocerca volvulus 0.0035 0.0022 0.0222
Mycobacterium ulcerans beta-lactamase 0.0035 0.0022 0.5
Loa Loa (eye worm) hypothetical protein 0.0029 0.0003 0.0004
Schistosoma mansoni peptidyl-glycine monooxygenase 0.1722 0.5241 0.524
Brugia malayi Pre-SET motif family protein 0.0203 0.0542 0.1032
Onchocerca volvulus 0.0035 0.0022 0.0222
Echinococcus granulosus jumonji domain containing protein 0.004 0.0036 0.0068
Giardia lamblia PHD finger protein 15 0.0028 0.0001 0.5
Leishmania major hypothetical protein, conserved 0.0035 0.0022 0.5
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.002 0.0035
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.1722 0.5241 1
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0022 0.5
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.1722 0.5241 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0022 0.0021
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.1722 0.5241 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0095 0.0179
Loa Loa (eye worm) DOMON domain-containing protein 0.033 0.0933 0.1779
Brugia malayi beta-lactamase family protein 0.0035 0.0022 0.004
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0874 0.2617 0.4992
Onchocerca volvulus 0.033 0.0933 1
Brugia malayi beta-lactamase 0.0035 0.0022 0.004
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0202 0.0385
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.1722 0.5241 1
Brugia malayi beta-lactamase family protein 0.0035 0.0022 0.004
Onchocerca volvulus 0.033 0.0933 1
Brugia malayi Pre-SET motif family protein 0.0029 0.0003 0.0004
Toxoplasma gondii ABC1 family protein 0.0035 0.0022 0.0089
Loa Loa (eye worm) hypothetical protein 0.0035 0.0022 0.004
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0022 0.5
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0003 0.0006
Loa Loa (eye worm) beta-lactamase 0.0035 0.0022 0.004
Plasmodium vivax SET domain protein, putative 0.0029 0.0003 0.1018
Onchocerca volvulus 0.0035 0.0022 0.0222
Onchocerca volvulus 0.0029 0.0003 0.0023
Onchocerca volvulus 0.0231 0.0629 0.6735
Loa Loa (eye worm) DOMON domain-containing protein 0.033 0.0933 0.1779
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0003 0.0009
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0142 0.0141
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0848 0.2537 0.484

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 0 Inhibition of Monoamine oxidase (MAO); Inactive ChEMBL. 3959029

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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