TDR Targets

Basic information

Technical information

TDR Targets ID: 259092
Name: 4-(2-carbamimidoylpyridin-4-yl)pyridine-2-car boximidamide
MW: 240.264 | Formula: C12H12N6
H donors: 2 H acceptors: 2 LogP: 0.01 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: NC(=N)c1nccc(c1)c1ccnc(c1)C(=N)N
InChi: 1S/C12H12N6/c13-11(14)9-5-7(1-3-17-9)8-2-4-18-10(6-8)12(15)16/h1-6H,(H3,13,14)(H3,15,16)
InChiKey: YYMQJGIRGGDLAL-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

4-(2-carbamimidoyl-4-pyridyl)pyridine-2-carboxamidine
4-(2-carbamimidoyl-4-pyridyl)-2-pyridinecarboxamidine
4-(2-amidino-4-pyridyl)picolinamidine

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Diamine oxidase	Starlite/ChEMBL	References
Rattus norvegicus	S-adenosylmethionine decarboxylase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Cryptosporidium parvum	extracellular protein with a signal peptide sequence, MAM domain and a Cu amine oxidase domain	Get druggable targets OG5_127171	All targets in OG5_127171
Trypanosoma cruzi	S-adenosylmethionine decarboxylase proenzyme, putative	Get druggable targets OG5_128279	All targets in OG5_128279
Trypanosoma brucei gambiense	S-adenosylmethionine decarboxylase	Get druggable targets OG5_128279	All targets in OG5_128279
Leishmania braziliensis	S-adenosylmethionine decarboxylase	Get druggable targets OG5_128279	All targets in OG5_128279
Candida albicans	one of two likely copper amine oxidase genes	Get druggable targets OG5_127171	All targets in OG5_127171
Trypanosoma brucei	S-adenosylmethionine decarboxylase	Get druggable targets OG5_128279	All targets in OG5_128279
Leishmania major	S-adenosylmethionine decarboxylase	Get druggable targets OG5_128279	All targets in OG5_128279
Leishmania mexicana	S-adenosylmethionine decarboxylase proenzyme	Get druggable targets OG5_128279	All targets in OG5_128279
Echinococcus granulosus	amiloride sensitive amine oxidase	Get druggable targets OG5_127171	All targets in OG5_127171
Toxoplasma gondii	hypothetical protein	Get druggable targets OG5_127171	All targets in OG5_127171
Loa Loa (eye worm)	S-adenosylmethionine decarboxylase proenzyme	Get druggable targets OG5_128279	All targets in OG5_128279
Leishmania infantum	S-adenosylmethionine decarboxylase	Get druggable targets OG5_128279	All targets in OG5_128279
Schistosoma mansoni	copper/topaquinone oxidase	Get druggable targets OG5_127171	All targets in OG5_127171
Candida albicans	S-adenosylmethionine decarboxylase	Get druggable targets OG5_128279	All targets in OG5_128279
Candida albicans	one of two likely peroxisomal copper amine oxidase genes	Get druggable targets OG5_127171	All targets in OG5_127171
Cryptosporidium hominis	amiloride binding protein 1	Get druggable targets OG5_127171	All targets in OG5_127171
Candida albicans	S-adenosylmethionine decarboxylase	Get druggable targets OG5_128279	All targets in OG5_128279
Echinococcus granulosus	S adenosylmethionine decarboxylase proenzyme	Get druggable targets OG5_128279	All targets in OG5_128279
Neospora caninum	hypothetical protein	Get druggable targets OG5_127171	All targets in OG5_127171
Trypanosoma brucei	S-adenosylmethionine decarboxylase proenzyme, putative	Get druggable targets OG5_128279	All targets in OG5_128279
Echinococcus multilocularis	S adenosylmethionine decarboxylase proenzyme	Get druggable targets OG5_128279	All targets in OG5_128279
Trypanosoma brucei	S-adenosylmethionine decarboxylase	Get druggable targets OG5_128279	All targets in OG5_128279
Schistosoma japonicum	ko:K00276 copper amine oxidase [EC1.4.3.6], putative	Get druggable targets OG5_127171	All targets in OG5_127171
Leishmania donovani	S-adenosylmethionine decarboxylase	Get druggable targets OG5_128279	All targets in OG5_128279
Trypanosoma congolense	S-adenosylmethionine decarboxylase proenzyme, putative	Get druggable targets OG5_128279	All targets in OG5_128279
Schistosoma japonicum	IPR000269,Copper amine oxidase,domain-containing	Get druggable targets OG5_127171	All targets in OG5_127171
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_127171	All targets in OG5_127171
Candida albicans	one of two likely copper amine oxidase genes	Get druggable targets OG5_127171	All targets in OG5_127171
Candida albicans	one of two likely peroxisomal copper amine oxidase genes	Get druggable targets OG5_127171	All targets in OG5_127171
Trypanosoma cruzi	S-adenosylmethionine decarboxylase proenzyme, putative	Get druggable targets OG5_128279	All targets in OG5_128279
Echinococcus multilocularis	amiloride sensitive amine oxidase	Get druggable targets OG5_127171	All targets in OG5_127171
Brugia malayi	S-adenosylmethionine decarboxylase proenzyme	Get druggable targets OG5_128279	All targets in OG5_128279

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus		S-adenosylmethionine decarboxylase 1	333 aa	288 aa	45.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	PAB1-binding protein , putative	0.0034	0.0188	0.0696
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0483	0.3125
Echinococcus multilocularis	GPCR, family 2	0.0021	0.0075	0.0229
Leishmania major	DNA polymerase eta, putative	0.0106	0.0827	0.2901
Trichomonas vaginalis	modulator of drug activity B, putative	0.0016	0.0031	0.0125
Echinococcus multilocularis	dna polymerase kappa	0.0108	0.0841	0.2701
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0081	0.0601	0.2019
Trichomonas vaginalis	DNA helicase recq1, putative	0.0061	0.0429	0.1966
Plasmodium vivax	DNA repair protein REV1, putative	0.0022	0.0083	0.03
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0016	0.0031	0.0125
Trypanosoma brucei	S-adenosylmethionine decarboxylase	0.0129	0.1032	0.389
Leishmania major	S-adenosylmethionine decarboxylase	0.0129	0.1032	0.37
Entamoeba histolytica	iron-sulfur flavoprotein, putative	0.0016	0.0031	0.0076
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.0311	0.2648	1
Trichomonas vaginalis	chromobox protein, putative	0.0049	0.0317	0.1447
Brugia malayi	ImpB/MucB/SamB family protein	0.0106	0.0827	0.1139
Loa Loa (eye worm)	hypothetical protein	0.0186	0.1538	1
Giardia lamblia	Flap structure-specific endonuclease	0.0035	0.0198	0.0479
Trypanosoma brucei	chrX additional, unordered contigs	0.0022	0.0083	0.03
Trypanosoma cruzi	DNA polymerase eta, putative	0.0057	0.0388	0.1455
Trichomonas vaginalis	modulator of drug activity B, putative	0.0016	0.0031	0.0125
Trichomonas vaginalis	flap endonuclease-1, putative	0.0035	0.0198	0.0897
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0031	0.0125
Brugia malayi	latrophilin 2 splice variant baaae	0.0046	0.0294	0.0402
Entamoeba histolytica	hypothetical protein	0.0016	0.0031	0.0076
Trypanosoma brucei	DNA polymerase kappa, putative	0.0058	0.0402	0.1506
Plasmodium falciparum	DNA repair protein REV1, putative	0.0022	0.0083	0.03
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0087	0.0659	0.2116
Trichomonas vaginalis	modulator of drug activity B, putative	0.0016	0.0031	0.0125
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0033	0.0176	0.0362
Trypanosoma brucei	DNA polymerase kappa, putative	0.0058	0.0403	0.1512
Schistosoma mansoni	copper/topaquinone oxidase	0.0103	0.0801	0.6775
Echinococcus granulosus	GPCR family 2	0.0021	0.0075	0.0229
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0021	0.0075	0.0098
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0021	0.0075	0.0229
Entamoeba histolytica	hypothetical protein	0.0013	0.0004	0.0009
Plasmodium falciparum	telomerase reverse transcriptase	0.0311	0.2648	1
Brugia malayi	ImpB/MucB/SamB family protein	0.0072	0.0522	0.0716
Plasmodium falciparum	ataxin-2 like protein, putative	0.0034	0.0188	0.0696
Giardia lamblia	NADPH oxidoreductase, putative	0.0016	0.0031	0.0067
Schistosoma mansoni	thyroid hormone receptor	0.0146	0.118	1
Trypanosoma brucei	hypothetical protein, conserved	0.0022	0.0083	0.03
Giardia lamblia	DINP protein human, muc B family	0.0081	0.0601	0.1475
Trypanosoma brucei	DNA polymerase kappa, putative	0.0108	0.0841	0.3165
Trichomonas vaginalis	modulator of drug activity B, putative	0.0016	0.0031	0.0125
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0033	0.0176	0.0652
Trypanosoma brucei	DNA polymerase kappa, putative	0.0108	0.0841	0.3165
Echinococcus multilocularis	bloom syndrome protein	0.0061	0.0429	0.1373
Entamoeba histolytica	hypothetical protein	0.0087	0.0659	0.1627
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0031	0.0125
Leishmania major	telomerase reverse transcriptase, putative	0.0311	0.2648	1
Loa Loa (eye worm)	RNA binding protein	0.0041	0.0253	0.1624
Echinococcus multilocularis	S adenosylmethionine decarboxylase proenzyme	0.0129	0.1032	0.332
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0067	0.0483	0.0663
Trypanosoma brucei	DNA damage repair protein, putative	0.0022	0.0083	0.03
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0031	0.0125
Schistosoma mansoni	hypothetical protein	0.0087	0.0659	0.5573
Entamoeba histolytica	hypothetical protein	0.0087	0.0659	0.1627
Trypanosoma brucei	PAB1-binding protein , putative	0.0034	0.0188	0.0696
Trypanosoma brucei	DNA polymerase kappa, putative	0.0108	0.0841	0.3165
Echinococcus multilocularis	dna polymerase eta	0.0106	0.0827	0.2658
Toxoplasma gondii	ATPase, AAA family protein	0.0013	0.0004	0.0014
Schistosoma mansoni	tar DNA-binding protein	0.0041	0.0253	0.2118
Giardia lamblia	NADPH oxidoreductase, putative	0.0016	0.0031	0.0067
Schistosoma mansoni	hypothetical protein	0.0021	0.0075	0.0604
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0021	0.0075	0.0229
Brugia malayi	chromobox protein homolog 3	0.0027	0.0127	0.0171
Loa Loa (eye worm)	transcription factor SMAD2	0.0161	0.1317	0.8557
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0022	0.0083	0.0314
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0108	0.0841	0.3165
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0021	0.0075	0.0463
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0127	0.0572
Leishmania major	hypothetical protein, conserved	0.0034	0.0188	0.0408
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0031	0.0125
Entamoeba histolytica	recQ family helicase, putative	0.0033	0.0176	0.0434
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.0311	0.2648	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0021	0.0075	0.0229
Toxoplasma gondii	RNA-directed DNA polymerase	0.0311	0.2648	1
Schistosoma mansoni	hypothetical protein	0.0046	0.0294	0.2469
Plasmodium vivax	S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative	0.0063	0.0444	0.1666
Mycobacterium leprae	PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])	0.0013	0.0004	0.5
Trichomonas vaginalis	modulator of drug activity B, putative	0.0016	0.0031	0.0125
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0035	0.0198	0.0747
Schistosoma mansoni	tar DNA-binding protein	0.0041	0.0253	0.2118
Trypanosoma brucei	DNA polymerase eta, putative	0.0106	0.0827	0.3114
Schistosoma mansoni	blooms syndrome DNA helicase	0.0048	0.0315	0.2645
Plasmodium vivax	telomerase reverse transcriptase, putative	0.0311	0.2648	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0188	0.12
Echinococcus granulosus	histone lysine N methyltransferase NSD3	0.0021	0.0076	0.0232
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0015	0.0021	0.0056
Onchocerca volvulus		0.0053	0.0356	0.0353
Brugia malayi	Latrophilin receptor protein 2	0.0021	0.0075	0.0098
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0146	0.118	0.3797
Trichomonas vaginalis	modulator of drug activity B, putative	0.0016	0.0031	0.0125
Brugia malayi	RNA recognition motif domain containing protein	0.0041	0.0253	0.0344
Trypanosoma cruzi	DNA polymerase eta, putative	0.0106	0.0827	0.3114
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0108	0.0841	0.3866
Leishmania major	DNA polymerase eta, putative	0.0057	0.0388	0.1191
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0025	0.011	0.0343
Trichomonas vaginalis	modulator of drug activity B, putative	0.0016	0.0031	0.0125
Echinococcus granulosus	chromobox protein 1	0.0049	0.0317	0.1011
Schistosoma mansoni	chromobox protein	0.0049	0.0317	0.2663
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0016	0.0031	0.0125
Toxoplasma gondii	BRCA1 C Terminus (BRCT) domain-containing protein	0.0031	0.0162	0.0612
Trypanosoma cruzi	hypothetical protein, conserved	0.0022	0.0083	0.03
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0257	0.2169	1
Trypanosoma cruzi	S-adenosylmethionine decarboxylase proenzyme, putative	0.0129	0.1032	0.389
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0108	0.0841	0.3165
Trypanosoma brucei	DNA polymerase kappa, putative	0.0058	0.0402	0.1506
Echinococcus multilocularis	amiloride sensitive amine oxidase	0.0103	0.0801	0.2573
Echinococcus multilocularis	flap endonuclease 1	0.0035	0.0198	0.0627
Trypanosoma cruzi	PAB1-binding protein , putative	0.0034	0.0188	0.0696
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0072	0.0522	0.1672
Schistosoma mansoni	SET domain protein	0.0021	0.0076	0.0612
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0075	0.0463
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0031	0.0125
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0027	0.0127	0.0124
Trypanosoma brucei	DNA polymerase kappa, putative	0.0108	0.0841	0.3165
Trichomonas vaginalis	modulator of drug activity B, putative	0.0016	0.0031	0.0125
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0108	0.0841	0.3165
Trypanosoma brucei	DNA polymerase IV, putative	0.0108	0.0841	0.3165
Schistosoma mansoni	DNA helicase recq5	0.0025	0.011	0.0904
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0072	0.0522	0.4404
Brugia malayi	Bloom's syndrome protein homolog	0.0061	0.0429	0.0588
Entamoeba histolytica	hypothetical protein	0.0087	0.0659	0.1627
Schistosoma mansoni	DNA polymerase IV / kappa	0.0022	0.0083	0.0675
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0827	0.5367
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0031	0.0125
Plasmodium falciparum	S-adenosylmethionine decarboxylase/ornithine decarboxylase	0.0063	0.0444	0.1666
Trypanosoma brucei	unspecified product	0.0099	0.0762	0.2866
Mycobacterium ulcerans	DNA polymerase IV	0.0108	0.0841	1
Echinococcus multilocularis	histone lysine N methyltransferase NSD3	0.0021	0.0076	0.0232
Schistosoma mansoni	transcription factor LCR-F1	0.0087	0.0659	0.5573
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0057	0.0246
Echinococcus granulosus	bloom syndrome protein	0.0061	0.0429	0.1373
Brugia malayi	hypothetical protein	0.0022	0.0081	0.0107
Echinococcus granulosus	chromobox protein 1	0.0049	0.0317	0.1011
Giardia lamblia	NADPH oxidoreductase, putative	0.0016	0.0031	0.0067
Toxoplasma gondii	hypothetical protein	0.0052	0.0348	0.1314
Trypanosoma cruzi	S-adenosylmethionine decarboxylase proenzyme, putative	0.0129	0.1032	0.389
Schistosoma mansoni	flap endonuclease-1	0.0032	0.0168	0.1395
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0031	0.0125
Trypanosoma cruzi	DNA damage repair protein, putative	0.0022	0.0083	0.03
Trichomonas vaginalis	modulator of drug activity B, putative	0.0016	0.0031	0.0125
Wolbachia endosymbiont of Brugia malayi	NAD-dependent DNA ligase, Lig	0.0013	0.0004	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0031	0.0125
Echinococcus granulosus	amiloride sensitive amine oxidase	0.0103	0.0801	0.2573
Brugia malayi	S-adenosylmethionine decarboxylase proenzyme	0.0129	0.1032	0.1422
Mycobacterium ulcerans	hypothetical protein	0.0022	0.0083	0.0949
Trypanosoma brucei	DNA polymerase IV, putative	0.0108	0.0841	0.3165
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0087	0.0659	0.2116
Schistosoma mansoni	hypothetical protein	0.0021	0.0075	0.0604
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0025	0.011	0.0693
Schistosoma mansoni	tar DNA-binding protein	0.0041	0.0253	0.2118
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0041	0.0253	0.1624
Loa Loa (eye worm)	MH2 domain-containing protein	0.0161	0.1317	0.8557
Trichomonas vaginalis	chromobox protein, putative	0.0049	0.0317	0.1447
Trichomonas vaginalis	modulator of drug activity B, putative	0.0016	0.0031	0.0125
Schistosoma mansoni	chromobox protein	0.0049	0.0317	0.2663
Schistosoma mansoni	tar DNA-binding protein	0.0041	0.0253	0.2118
Echinococcus granulosus	flap endonuclease 1	0.0035	0.0198	0.0627
Schistosoma mansoni	tar DNA-binding protein	0.0041	0.0253	0.2118
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0031	0.0125
Trichomonas vaginalis	modulator of drug activity B, putative	0.0016	0.0031	0.0125
Trichomonas vaginalis	modulator of drug activity B, putative	0.0016	0.0031	0.0125
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0041	0.0249	0.094
Brugia malayi	Telomerase reverse transcriptase	0.0828	0.7237	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0081	0.0601	0.2259
Entamoeba histolytica	hypothetical protein	0.0087	0.0659	0.1627
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0075	0.0466
Entamoeba histolytica	DNA repair and recombination protein RAD52, putative	0.047	0.4053	1
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0031	0.0125
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0057	0.0246
Trichomonas vaginalis	DNA helicase recq, putative	0.0033	0.0176	0.0796
Plasmodium vivax	ataxin-2 like protein, putative	0.0034	0.0188	0.0696
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0081	0.0601	1
Echinococcus granulosus	dna polymerase eta	0.0106	0.0827	0.2658
Trypanosoma brucei	hypothetical protein, conserved	0.0022	0.0083	0.03
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0041	0.0253	0.0944
Brugia malayi	TAR-binding protein	0.0041	0.0253	0.0344
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.0013	0.0004	0.0009
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0135	0.1084	0.3487
Trypanosoma cruzi	hypothetical protein, conserved	0.0022	0.0083	0.03
Loa Loa (eye worm)	TAR-binding protein	0.0041	0.0253	0.1624
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0016	0.0031	0.0125
Schistosoma mansoni	hypothetical protein	0.0135	0.1084	0.9182
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0031	0.0125
Trichomonas vaginalis	modulator of drug activity B, putative	0.0016	0.0031	0.0125
Echinococcus multilocularis	chromobox protein 1	0.0049	0.0317	0.1011
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0072	0.0522	0.1672
Trypanosoma brucei	telomerase reverse transcriptase	0.0311	0.2648	1
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0402	0.2595
Mycobacterium ulcerans	DNA polymerase IV	0.0108	0.0841	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0108	0.0841	0.3165
Giardia lamblia	Telomerase catalytic subunit	0.0311	0.2648	0.653
Echinococcus multilocularis	tar DNA binding protein	0.0041	0.0253	0.0804
Loa Loa (eye worm)	heterochromatin protein 1	0.0049	0.0317	0.2042
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0021	0.0075	0.0229
Brugia malayi	hypothetical protein	0.0087	0.0659	0.0907
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0057	0.0388	0.1467
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0033	0.0176	0.0652
Trichomonas vaginalis	chromobox protein, putative	0.0029	0.0146	0.0656
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0127	0.0572
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0025	0.011	0.0343
Trichomonas vaginalis	modulator of drug activity B, putative	0.0016	0.0031	0.0125
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0031	0.0125
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0035	0.0198	0.0734
Brugia malayi	hypothetical protein	0.0034	0.0188	0.0255
Plasmodium vivax	flap endonuclease 1, putative	0.0035	0.0198	0.0734
Schistosoma mansoni	cellular tumor antigen P53	0.0053	0.0356	0.2998
Giardia lamblia	Sgs1 DNA helicase, putative	0.0025	0.011	0.0263
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0031	0.0125
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0031	0.0125
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0025	0.011	0.0147
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0031	0.0125
Trichomonas vaginalis	DNA polymerase eta, putative	0.0108	0.0841	0.3866
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.0013	0.0004	0.0014
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0031	0.0125
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0031	0.0125
Trichomonas vaginalis	FMN-dependent NADH-azoreductase, putative	0.0016	0.0031	0.0125
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.0025	0.011	0.0402
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0031	0.0125
Chlamydia trachomatis	DNA ligase	0.0013	0.0004	0.5
Trypanosoma brucei	DNA polymerase kappa, putative	0.0058	0.0403	0.1512
Trypanosoma brucei	DNA polymerase IV, putative	0.0099	0.0762	0.2866
Brugia malayi	polk-prov protein	0.0058	0.0402	0.0551
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0025	0.011	0.0343
Brugia malayi	RNA binding protein	0.0041	0.0253	0.0344
Echinococcus granulosus	dna polymerase kappa	0.0108	0.0841	0.2701
Loa Loa (eye worm)	flap endonuclease-1	0.0035	0.0198	0.1265
Trichomonas vaginalis	DNA helicase recq, putative	0.0061	0.0429	0.1966
Echinococcus multilocularis	tumor protein p63	0.0362	0.3102	1
Trypanosoma brucei	S-adenosylmethionine decarboxylase proenzyme, putative	0.0129	0.1032	0.389
Trichomonas vaginalis	modulator of drug activity B, putative	0.0016	0.0031	0.0125
Trypanosoma brucei	DNA polymerase kappa, putative	0.0108	0.0841	0.3165
Schistosoma mansoni	hypothetical protein	0.0015	0.0021	0.0149
Plasmodium falciparum	ataxin-2 like protein, putative	0.0034	0.0188	0.0696
Schistosoma mansoni	hypothetical protein	0.0021	0.0075	0.0604
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0031	0.0125
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0072	0.0522	0.1287
Schistosoma mansoni	hypothetical protein	0.0103	0.0801	0.6775
Echinococcus granulosus	S adenosylmethionine decarboxylase proenzyme	0.0129	0.1032	0.332
Brugia malayi	Flap endonuclease-1	0.0035	0.0198	0.0268
Trichomonas vaginalis	modulator of drug activity B, putative	0.0016	0.0031	0.0125
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0025	0.011	0.0415
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0025	0.011	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0025	0.011	0.0693
Brugia malayi	MH2 domain containing protein	0.0161	0.1317	0.1815
Trypanosoma brucei	DNA polymerase kappa, putative	0.0108	0.0841	0.3165
Trypanosoma cruzi	DNA damage repair protein, putative	0.0022	0.0083	0.03
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0356	0.2299
Echinococcus multilocularis	chromobox protein 1	0.0049	0.0317	0.1011
Schistosoma mansoni	DNA helicase recq1	0.0025	0.011	0.0904
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0067	0.0483	0.0663
Entamoeba histolytica	Flap nuclease, putative	0.0035	0.0198	0.0488
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0031	0.0125
Loa Loa (eye worm)	S-adenosylmethionine decarboxylase proenzyme	0.0129	0.1032	0.6703
Schistosoma mansoni	hypothetical protein	0.0021	0.0075	0.0604
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0031	0.0125
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0025	0.011	0.0343
Entamoeba histolytica	Rad52/22 family double-strand break repair protein, putative	0.0134	0.1071	0.2643
Trypanosoma brucei	unspecified product	0.0049	0.0324	0.1213
Toxoplasma gondii	LsmAD domain-containing protein	0.0034	0.0188	0.0709
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0035	0.0198	0.0447
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0035	0.0198	0.0734
Trichomonas vaginalis	modulator of drug activity B, putative	0.0016	0.0031	0.0125
Trypanosoma brucei	S-adenosylmethionine decarboxylase	0.0129	0.1032	0.389
Trypanosoma brucei	DNA polymerase kappa, putative	0.0058	0.0403	0.1512
Leishmania major	DNA polymerase kappa, putative	0.0081	0.0601	0.2019
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0031	0.0125
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0015	0.0021	0.0056
Plasmodium falciparum	flap endonuclease 1	0.0035	0.0198	0.0734
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0072	0.0522	0.4404
Brugia malayi	Heterochromatin protein 1	0.0049	0.0317	0.0433
Trypanosoma brucei	DNA polymerase kappa, putative	0.0108	0.0841	0.3165
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0072	0.0522	0.3377
Trichomonas vaginalis	modulator of drug activity B, putative	0.0016	0.0031	0.0125
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0029	0.0146	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0127	0.0807
Schistosoma mansoni	DNA polymerase eta	0.0106	0.0827	0.7
Treponema pallidum	DNA ligase (lig)	0.0013	0.0004	0.5
Trichomonas vaginalis	chromobox protein, putative	0.0029	0.0146	0.0656
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0054	0.0363	0.136
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0108	0.0841	0.3165
Trichomonas vaginalis	modulator of drug activity B, putative	0.0016	0.0031	0.0125
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0067	0.0483	0.3125
Trypanosoma brucei	DNA polymerase kappa, putative	0.0108	0.0841	0.3165
Entamoeba histolytica	hypothetical protein	0.0134	0.1071	0.2643
Loa Loa (eye worm)	RecQ helicase	0.0061	0.0429	0.2773
Schistosoma mansoni	thyroid hormone receptor	0.0146	0.118	1
Trichomonas vaginalis	modulator of drug activity B, putative	0.0016	0.0031	0.0125
Giardia lamblia	DNA repair protein RAD52	0.047	0.4053	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0294	0.1893
Echinococcus granulosus	tumor protein p63	0.0362	0.3102	1
Echinococcus granulosus	tar DNA binding protein	0.0041	0.0253	0.0804
Entamoeba histolytica	modulator of drug activity B homolog, putative	0.0016	0.0031	0.0076
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0025	0.011	0.0415
Onchocerca volvulus		0.0021	0.0075	0.0072
Giardia lamblia	DNA damage repair protein	0.0022	0.0083	0.0196
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0135	0.1084	0.3487
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0257	0.2169	1
Trypanosoma brucei	DNA damage repair protein, putative	0.0022	0.0083	0.03
Trypanosoma brucei	unspecified product	0.0049	0.0324	0.1213

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.18 uM	Inhibitory concentration of compound against S-Adenosylmethionine decarboxylase (SAMDC) from rat liver	ChEMBL.	8421290
IC50 (binding)	= 0.18 uM	Inhibitory concentration of compound against S-Adenosylmethionine decarboxylase (SAMDC) from rat liver	ChEMBL.	8421290
IC50 (binding)	= 12.9 uM	In vitro inhibition of Diamine oxidase (DAO) from rat small intestine.	ChEMBL.	8421290
IC50 (binding)	= 12.9 uM	In vitro inhibition of Diamine oxidase (DAO) from rat small intestine.	ChEMBL.	8421290
IC50 (functional)	> 151 uM	Antiproliferative activity against human T24 bladder carcinoma cells	ChEMBL.	8421290
IC50 (functional)	> 151 uM	Antiproliferative activity against human T24 bladder carcinoma cells	ChEMBL.	8421290
Inhibition (binding)		Evaluated for inhibition of rat liver ornithine decarboxylase (ODC) at concentrations of 50 microM; No inhibition	ChEMBL.	8421290
Inhibition (binding)	0	Evaluated for inhibition of rat liver ornithine decarboxylase (ODC) at concentrations of 50 microM; No inhibition	ChEMBL.	8421290

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL433513
PubChem: 10263668

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 259092