TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 519.68 | Formula: C26H45N7O4
H donors: 7 H acceptors: 4 LogP: -0.35 Rotable bonds: 22
Rule of 5 violations (Lipinski): 3
SMILES: NCCCCCCCCC[C@@H](C(=O)N[C@H](C(=O)Nc1ccccc1)CCCN=C(N)N)N[C@@H](C(=O)O)C
InChi: 1S/C26H45N7O4/c1-19(25(36)37)31-21(15-10-5-3-2-4-6-11-17-27)24(35)33-22(16-12-18-30-26(28)29)23(34)32-20-13-8-7-9-14-20/h7-9,13-14,19,21-22,31H,2-6,10-12,15-18,27H2,1H3,(H,32,34)(H,33,35)(H,36,37)(H4,28,29,30)/t19-,21+,22+/m1/s1
InChiKey: WUAZNNQUKKZSIX-HJNYFJLDSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	Starlite/ChEMBL	No references
Homo sapiens	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	Starlite/ChEMBL	No references
Homo sapiens	matrix metallopeptidase 1 (interstitial collagenase)	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Matrixin family protein	matrix metallopeptidase 1 (interstitial collagenase)	403 aa	401 aa	27.7 %
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	477 aa	431 aa	34.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0036	0.0397	0.0397
Echinococcus granulosus	biogenic amine 5HT receptor	0.0074	0.1681	0.1681
Loa Loa (eye worm)	hypothetical protein	0.009	0.2213	0.2511
Schistosoma mansoni	glycogen phosphorylase	0.0221	0.6642	0.6642
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0211	0.6324	0.7175
Schistosoma mansoni	hypothetical protein	0.0118	0.3166	0.3166
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0074	0.1681	0.1681
Brugia malayi	Matrixin family protein	0.0074	0.167	0.1895
Schistosoma mansoni	hypothetical protein	0.0074	0.1681	0.1681
Loa Loa (eye worm)	G-protein coupled receptor	0.0074	0.1681	0.1907
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0397	0.045
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Brugia malayi	mbt repeat family protein	0.0047	0.0775	0.0879
Loa Loa (eye worm)	matrixin family protein	0.0178	0.5201	0.5901
Brugia malayi	hypothetical protein	0.0074	0.1681	0.1907
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0074	0.1681	0.1681
Brugia malayi	Bromodomain containing protein	0.0036	0.0393	0.0445
Brugia malayi	Matrixin family protein	0.0074	0.167	0.1895
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0034	0.0318	0.0318
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0074	0.1681	0.1681
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0074	0.1681	0.1681
Onchocerca volvulus		0.0074	0.1681	0.253
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0074	0.1681	0.253
Loa Loa (eye worm)	hypothetical protein	0.0066	0.1419	0.161
Echinococcus granulosus	neuropeptide Y receptor	0.0074	0.1681	0.1681
Toxoplasma gondii	LsmAD domain-containing protein	0.0049	0.085	0.5
Loa Loa (eye worm)	matrixin family protein	0.0163	0.4703	0.5336
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Echinococcus granulosus	g protein coupled receptor	0.0074	0.1681	0.1681
Loa Loa (eye worm)	neuropeptide F receptor	0.0074	0.1681	0.1907
Echinococcus granulosus	neuropeptide FF receptor 2	0.0074	0.1681	0.1681
Echinococcus multilocularis	serotonin receptor	0.0074	0.1681	0.1681
Loa Loa (eye worm)	hypothetical protein	0.0091	0.2245	0.2547
Brugia malayi	Melatonin receptor type 1A	0.0074	0.1681	0.1907
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0074	0.1681	0.1681
Echinococcus granulosus	rhodopsin orphan GPCR	0.0074	0.1681	0.1681
Brugia malayi	putative neuropeptide receptor	0.0074	0.1681	0.1907
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0186	0.5466	0.5466
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0118	0.3166	0.3166
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0186	0.5466	0.5466
Echinococcus granulosus	tm gpcr rhodopsin	0.0074	0.1681	0.1681
Schistosoma mansoni	biogenic amine receptor	0.0074	0.1681	0.1681
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Trypanosoma cruzi	PAB1-binding protein , putative	0.0049	0.085	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0211	0.6324	0.6324
Loa Loa (eye worm)	hypothetical protein	0.0074	0.167	0.1895
Brugia malayi	sulfakinin receptor protein	0.0074	0.1681	0.1907
Echinococcus granulosus	tm gpcr rhodopsin	0.0074	0.1681	0.1681
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0034	0.0318	0.0318
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0074	0.1681	0.1907
Plasmodium falciparum	ataxin-2 like protein, putative	0.0049	0.085	0.5
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0074	0.1681	0.1681
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0047	0.0775	0.1167
Schistosoma mansoni	amine GPCR	0.0074	0.1681	0.1681
Schistosoma mansoni	nuclear hormone receptor	0.0036	0.0397	0.0397
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0074	0.1681	0.1907
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0036	0.0397	0.045
Brugia malayi	hypothetical protein	0.0074	0.1681	0.1907
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Schistosoma mansoni	amine GPCR	0.0074	0.1681	0.1681
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Schistosoma mansoni	biogenic amine receptor	0.0074	0.1681	0.1681
Trypanosoma cruzi	PAB1-binding protein , putative	0.0049	0.085	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0074	0.1681	0.1681
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0074	0.1681	0.1681
Loa Loa (eye worm)	hypothetical protein	0.004	0.053	0.0602
Schistosoma mansoni	hypothetical protein	0.0104	0.2711	0.2711
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0397	0.045
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0056	0.107	0.107
Echinococcus multilocularis	somatostatin receptor	0.0074	0.1681	0.1681
Echinococcus multilocularis	Glycosyl transferase, family 35	0.0221	0.6642	0.6642
Schistosoma mansoni	matrix metallopeptidase-7 (M10 family)	0.0074	0.167	0.167
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0036	0.0397	0.045
Loa Loa (eye worm)	matrix metalloproteinase	0.0074	0.167	0.1895
Brugia malayi	carbohydrate phosphorylase	0.0221	0.6642	0.7536
Echinococcus multilocularis	fmrfamide receptor	0.0074	0.1681	0.1681
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0074	0.1681	0.1681
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0074	0.1681	0.1681
Brugia malayi	hypothetical protein	0.0074	0.1681	0.1907
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0036	0.0397	0.045
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0074	0.1681	0.1681
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0056	0.107	0.107
Echinococcus multilocularis	GPCR, family 2	0.0042	0.0598	0.0598
Onchocerca volvulus		0.0074	0.1681	0.253
Echinococcus multilocularis	neuropeptides capa receptor	0.0074	0.1681	0.1681
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0074	0.1681	0.1681
Brugia malayi	Matrixin family protein	0.0074	0.167	0.1895
Brugia malayi	Dopamine receptor	0.0074	0.1681	0.1907
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0036	0.0397	0.0397
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0395	0.0448
Echinococcus multilocularis	sex peptide receptor	0.0074	0.1681	0.1681
Echinococcus multilocularis	serotonin receptor	0.0074	0.1681	0.1681
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0036	0.0397	0.0397
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0074	0.1681	0.1681
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0036	0.0397	0.045
Brugia malayi	Bromodomain containing protein	0.007	0.1555	0.1764
Schistosoma mansoni	hypothetical protein	0.032	1	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0074	0.1681	0.1907
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Echinococcus multilocularis	geminin	0.032	1	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0074	0.1681	0.1907
Brugia malayi	neuropeptide F receptor	0.0074	0.1681	0.1907
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0036	0.0397	0.0397
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0074	0.1681	0.1907
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0036	0.0397	0.0397
Echinococcus granulosus	muscleblind protein	0.0285	0.8814	0.8814
Echinococcus multilocularis	g protein coupled receptor	0.0074	0.1681	0.1681
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0211	0.6324	0.6324
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0211	0.6324	0.6324
Echinococcus granulosus	somatostatin receptor	0.0074	0.1681	0.1681
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0074	0.1681	0.1681
Echinococcus granulosus	neuropeptide receptor A26	0.0074	0.1681	0.1681
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0074	0.1681	0.253
Mycobacterium ulcerans	glycogen phosphorylase GlgP	0.0095	0.2406	1
Brugia malayi	hypothetical protein	0.0074	0.1681	0.1907
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0054	0.0996	0.0996
Schistosoma mansoni	myosin xvIII	0.0074	0.1681	0.1681
Schistosoma mansoni	thyroid hormone receptor	0.0154	0.4383	0.4383
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0397	0.045
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0074	0.1681	0.1681
Onchocerca volvulus		0.0074	0.1681	0.253
Brugia malayi	larval opioid receptor	0.0074	0.1681	0.1907
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0074	0.1681	0.1681
Schistosoma mansoni	hypothetical protein	0.0042	0.0598	0.0598
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0074	0.1681	0.1681
Brugia malayi	latrophilin 2 splice variant baaae	0.0091	0.2245	0.2547
Giardia lamblia	Glycogen phosphorylase	0.0221	0.6642	0.5
Onchocerca volvulus		0.0074	0.1681	0.253
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0074	0.1681	0.1681
Echinococcus granulosus	orexin receptor type 2	0.0074	0.1681	0.1681
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Schistosoma mansoni	hypothetical protein	0.0042	0.0598	0.0598
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0074	0.1681	0.1681
Echinococcus granulosus	rhodopsin orphan GPCR	0.0074	0.1681	0.1681
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Schistosoma mansoni	neuropeptide f receptor 76f	0.0074	0.1681	0.1681
Schistosoma mansoni	neuropeptide receptor	0.0074	0.1681	0.1681
Echinococcus multilocularis	fmrfamide receptor	0.0074	0.1681	0.1681
Loa Loa (eye worm)	hypothetical protein	0.0074	0.167	0.1895
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0397	0.045
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0074	0.1681	0.1681
Loa Loa (eye worm)	mbt repeat family protein	0.0047	0.0775	0.0879
Brugia malayi	G protein-coupled receptor	0.0074	0.1681	0.1907
Echinococcus multilocularis	neuropeptide Y receptor	0.0074	0.1681	0.1681
Echinococcus granulosus	G protein coupled receptor 139	0.0074	0.1681	0.1681
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0036	0.0397	0.0397
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0036	0.0397	0.045
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0133	0.3663	0.4156
Brugia malayi	follicle stimulating hormone receptor	0.0074	0.1681	0.1907
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0036	0.0397	0.0397
Brugia malayi	Dopamine receptor protein 2	0.0074	0.1681	0.1907
Echinococcus granulosus	Glycosyl transferase family 35	0.0221	0.6642	0.6642
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0074	0.1681	0.1681
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	0.0268	0.8234	0.8234
Onchocerca volvulus		0.0074	0.1681	0.253
Echinococcus granulosus	rhodopsin orphan GPCR	0.0074	0.1681	0.1681
Echinococcus granulosus	hypothetical protein	0.0074	0.1681	0.1681
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0054	0.0996	0.0996
Echinococcus granulosus	FTZ F1 alpha	0.0036	0.0397	0.0397
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0074	0.1681	0.1681
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0036	0.0397	0.045
Echinococcus multilocularis	neuropeptide receptor A26	0.0074	0.1681	0.1681
Echinococcus multilocularis	glycogen phosphorylase	0.0221	0.6642	0.6642
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0036	0.0397	0.045
Echinococcus granulosus	rhodopsin orphan GPCR	0.0074	0.1681	0.1681
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0036	0.0397	0.0397
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0036	0.0397	0.0397
Echinococcus granulosus	rhodopsin orphan GPCR	0.0074	0.1681	0.1681
Brugia malayi	hypothetical protein	0.0074	0.1681	0.1907
Trypanosoma brucei	PAB1-binding protein , putative	0.0049	0.085	0.5
Loa Loa (eye worm)	hypothetical protein	0.0285	0.8814	1
Schistosoma mansoni	neuropeptide receptor	0.0074	0.1681	0.1681
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0118	0.3166	0.3166
Schistosoma mansoni	neuropeptide F-like receptor	0.0074	0.1681	0.1681
Schistosoma mansoni	retinoic acid receptor RXR	0.0036	0.0397	0.0397
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Entamoeba histolytica	glycogen phosphorylase, putative	0.0221	0.6642	1
Echinococcus multilocularis	allatostatin A receptor	0.0074	0.1681	0.1681
Brugia malayi	Matrix metalloprotease, N-terminal domain containing protein	0.009	0.2213	0.2511
Echinococcus granulosus	g-protein coupled receptor	0.0074	0.1681	0.1681
Schistosoma mansoni	amine GPCR	0.0074	0.1681	0.1681
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0074	0.1681	0.1681
Brugia malayi	G protein-coupled receptor F59B2.13	0.0074	0.1681	0.1907
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.0775	0.0775
Onchocerca volvulus		0.0074	0.1681	0.253
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0598	0.0679
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0036	0.0397	0.0397
Loa Loa (eye worm)	hypothetical protein	0.0133	0.3663	0.4156
Schistosoma mansoni	neuropeptide receptor	0.0074	0.1681	0.1681
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Loa Loa (eye worm)	hypothetical protein	0.0074	0.167	0.1895
Onchocerca volvulus		0.0036	0.0397	0.0597
Schistosoma mansoni	amine GPCR	0.0074	0.1681	0.1681
Echinococcus granulosus	neuropeptide s receptor	0.0074	0.1681	0.1681
Brugia malayi	GnHR receptor homolog	0.0074	0.1681	0.1907
Onchocerca volvulus		0.0074	0.1681	0.253
Loa Loa (eye worm)	hypothetical protein	0.0285	0.8814	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0074	0.1681	0.1681
Echinococcus multilocularis	FTZ F1 alpha	0.0036	0.0397	0.0397
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0074	0.1681	0.1681
Schistosoma mansoni	histamine h1 receptor	0.0074	0.1681	0.1681
Brugia malayi	Latrophilin receptor protein 2	0.0042	0.0598	0.0679
Brugia malayi	putative neuropeptide receptor NPR1	0.0074	0.1681	0.1907
Loa Loa (eye worm)	TYRA-2 protein	0.0074	0.1681	0.1907
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0074	0.1681	0.1681
Onchocerca volvulus		0.0074	0.1681	0.253
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0074	0.1681	0.1907
Echinococcus multilocularis	muscleblind protein 1	0.0285	0.8814	0.8814
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0074	0.1681	0.1681
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0074	0.1681	0.1681
Onchocerca volvulus		0.0104	0.2711	0.4081
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0996	0.113
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0221	0.6642	0.5
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0074	0.1681	0.1681
Schistosoma mansoni	hypothetical protein	0.0074	0.1681	0.1681
Schistosoma mansoni	hypothetical protein	0.0042	0.0598	0.0598
Schistosoma mansoni	hypothetical protein	0.0091	0.2245	0.2245
Schistosoma mansoni	opsin-like receptor	0.0074	0.1681	0.1681
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Echinococcus granulosus	g protein coupled receptor	0.0074	0.1681	0.1681
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0074	0.1681	0.1681
Brugia malayi	Muscleblind-like protein	0.0285	0.8814	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0074	0.1681	0.1907
Schistosoma mansoni	opsin-like receptor	0.0074	0.1681	0.1681
Echinococcus multilocularis	neuropeptide receptor	0.0074	0.1681	0.1681
Schistosoma mansoni	glycogen phosphorylase	0.0095	0.2406	0.2406
Echinococcus multilocularis	orexin receptor type 2	0.0074	0.1681	0.1681
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0211	0.6324	0.7175
Loa Loa (eye worm)	steroid hormone receptor	0.0036	0.0397	0.045
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Brugia malayi	neuropeptide F receptor	0.0074	0.1681	0.1907
Echinococcus granulosus	fmrfamide receptor	0.0074	0.1681	0.1681
Plasmodium vivax	ataxin-2 like protein, putative	0.0049	0.085	0.5
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0036	0.0397	0.045
Brugia malayi	nuclear hormone receptor	0.0036	0.0397	0.045
Brugia malayi	Hemopexin family protein	0.0104	0.2711	0.3076
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0074	0.1681	0.1681
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0074	0.1681	0.1681
Chlamydia trachomatis	glycogen phosphorylase	0.0221	0.6642	0.5
Loa Loa (eye worm)	neuropeptide F receptor	0.0074	0.1681	0.1907
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0133	0.3663	0.4156
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0074	0.1681	0.1681
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0074	0.1681	0.1681
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Brugia malayi	hypothetical protein	0.0032	0.0258	0.0293
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0074	0.1681	0.1681
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.0775	0.0775
Onchocerca volvulus		0.0074	0.1681	0.253
Schistosoma mansoni	neuropeptide F-like receptor	0.0074	0.1681	0.1681
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0054	0.0996	0.113
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0042	0.0598	0.0598
Echinococcus granulosus	rhodopsin orphan GPCR	0.0074	0.1681	0.1681
Echinococcus granulosus	polycomb protein SCMH1	0.0047	0.0775	0.0775
Onchocerca volvulus	Matrilysin homolog	0.0074	0.167	0.2514
Brugia malayi	Steroid receptor seven-up type 2	0.0036	0.0397	0.045
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0074	0.1681	0.1681
Echinococcus multilocularis	g protein coupled receptor	0.0074	0.1681	0.1681
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0036	0.0397	0.0397
Echinococcus granulosus	histone acetyltransferase MYST2	0.0054	0.0996	0.0996
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0036	0.0397	0.045
Schistosoma mansoni	hypothetical protein	0.0074	0.1681	0.1681
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0036	0.0397	0.045
Echinococcus granulosus	glycogen phosphorylase	0.0221	0.6642	0.6642
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0074	0.1681	0.1907
Brugia malayi	mbt repeat family protein	0.0047	0.0775	0.0879
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0074	0.1681	0.1681
Echinococcus multilocularis	neuropeptide Y receptor	0.0074	0.1681	0.1681
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0036	0.0397	0.045
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0074	0.1681	0.1681
Brugia malayi	hypothetical protein	0.0049	0.085	0.0965
Brugia malayi	nuclear receptor NHR-88	0.0036	0.0397	0.045
Brugia malayi	hypothetical protein	0.0074	0.1681	0.1907
Loa Loa (eye worm)	hypothetical protein	0.0038	0.047	0.0533
Schistosoma mansoni	neuropeptide receptor	0.0074	0.1681	0.1681
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0074	0.1681	0.1681
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0211	0.6324	0.6324
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0036	0.0397	0.045
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Brugia malayi	Serotonin receptor	0.0074	0.1681	0.1907
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0397	0.045
Echinococcus granulosus	rhodopsin orphan GPCR	0.0074	0.1681	0.1681
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0074	0.1681	0.1681
Onchocerca volvulus		0.0074	0.1681	0.253
Brugia malayi	G-protein coupled receptor	0.0074	0.1681	0.1907
Loa Loa (eye worm)	hypothetical protein	0.0049	0.085	0.0965
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0211	0.6324	0.6324
Onchocerca volvulus		0.0074	0.167	0.2514
Onchocerca volvulus		0.0074	0.1681	0.253
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0036	0.0397	0.045
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0036	0.0397	0.0397
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Mycobacterium tuberculosis	Probable glycogen phosphorylase GlgP	0.0095	0.2406	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0154	0.4383	0.4383
Brugia malayi	G-protein coupled receptor	0.0074	0.1681	0.1907
Echinococcus granulosus	dro:myosuppressin receptor	0.0074	0.1681	0.1681
Schistosoma mansoni	hypothetical protein	0.0074	0.1681	0.1681
Echinococcus granulosus	neuropeptides capa receptor	0.0074	0.1681	0.1681
Echinococcus granulosus	tm gpcr rhodopsin	0.0074	0.1681	0.1681
Schistosoma mansoni	amine GPCR	0.0074	0.1681	0.1681
Onchocerca volvulus		0.0074	0.1681	0.253
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Echinococcus multilocularis	muscleblind protein	0.0285	0.8814	0.8814
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0036	0.0397	0.0397
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0074	0.1681	0.1681
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0036	0.0397	0.045
Brugia malayi	hypothetical protein	0.0074	0.1681	0.1907
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0074	0.1681	0.1681
Schistosoma mansoni	hypothetical protein	0.032	1	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0397	0.045
Echinococcus multilocularis	ecdysone induced protein 78C	0.0036	0.0397	0.0397
Echinococcus granulosus	g protein coupled receptor	0.0074	0.1681	0.1681
Echinococcus granulosus	allatostatin A receptor	0.0074	0.1681	0.1681
Brugia malayi	photoreceptor-specific nuclear receptor	0.0036	0.0397	0.045
Entamoeba histolytica	glycogen phosphorylase, putative	0.0221	0.6642	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0074	0.1681	0.1681
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0211	0.6324	0.6324
Onchocerca volvulus	Matrilysin homolog	0.0163	0.4703	0.7081
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0074	0.1681	0.1907
Onchocerca volvulus	Glycogen phosphorylase homolog	0.0221	0.6642	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0074	0.1681	0.1681
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0036	0.0397	0.045
Plasmodium falciparum	ataxin-2 like protein, putative	0.0049	0.085	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0074	0.1681	0.1681
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0221	0.6642	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0074	0.1681	0.1681
Schistosoma mansoni	coup transcription factor	0.0036	0.0397	0.0397
Echinococcus multilocularis	glycogen phosphorylase	0.0221	0.6642	0.6642
Brugia malayi	Dopamine receptor protein 1	0.0074	0.1681	0.1907
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0074	0.1681	0.1681
Schistosoma mansoni	growth hormone secretagogue receptor	0.0074	0.1681	0.1681
Onchocerca volvulus		0.0074	0.1681	0.253
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0042	0.0598	0.0598
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0042	0.0598	0.0679
Echinococcus multilocularis	neuropeptide s receptor	0.0074	0.1681	0.1681
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0042	0.0598	0.0679
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0036	0.0397	0.045
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0074	0.1681	0.1681
Mycobacterium leprae	PROBABLE HYDROLASE	0.009	0.2213	0.5
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0047	0.0775	0.0775
Schistosoma mansoni	bromodomain containing protein	0.0059	0.1184	0.1184
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0036	0.0397	0.0397
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0775	0.0879
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0133	0.3663	0.4156
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Brugia malayi	Matrixin family protein	0.0178	0.5201	0.5901
Loa Loa (eye worm)	glycogen phosphorylase	0.0221	0.6642	0.7536
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0074	0.1681	0.1681
Brugia malayi	ORL1-like opioid receptor	0.0074	0.1681	0.1907
Echinococcus granulosus	neuropeptide Y receptor	0.0074	0.1681	0.1681
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0036	0.0397	0.0397
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0036	0.0397	0.0397
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0047	0.0775	0.0775
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.0268	0.8234	0.8234
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0074	0.1681	0.1907
Brugia malayi	Nuclear hormone receptor-like 1	0.0036	0.0397	0.045
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0074	0.1681	0.1681
Onchocerca volvulus		0.0074	0.1681	0.253
Leishmania major	hypothetical protein, conserved	0.0049	0.085	0.5
Brugia malayi	RE15519p	0.0074	0.1681	0.1907
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0036	0.0397	0.0597
Onchocerca volvulus	Bile acid receptor homolog	0.0036	0.0397	0.0597
Echinococcus granulosus	sex peptide receptor	0.0074	0.1681	0.1681
Echinococcus granulosus	SAM and MBT domain containing protein	0.0047	0.0775	0.0775
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0054	0.0996	0.0996
Schistosoma mansoni	glycogen phosphorylase	0.0221	0.6642	0.6642
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0074	0.1681	0.1681
Schistosoma mansoni	adenoreceptor	0.0074	0.1681	0.1681
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0036	0.0397	0.0397
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0042	0.0598	0.0598
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0036	0.0397	0.0397
Schistosoma mansoni	RAR-like nuclear receptor	0.0036	0.0397	0.0397
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0074	0.1681	0.1681
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0074	0.1681	0.1681
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0036	0.0397	0.045
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Loa Loa (eye worm)	melatonin receptor type 1A	0.0074	0.1681	0.1907
Echinococcus granulosus	glycogen phosphorylase	0.0221	0.6642	0.6642
Schistosoma mansoni	matrix metallopeptidase-9 (M10 family)	0.005	0.087	0.087
Echinococcus multilocularis	g-protein coupled receptor	0.0074	0.1681	0.1681
Onchocerca volvulus		0.0074	0.1681	0.253
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Echinococcus granulosus	neuropeptide receptor	0.0074	0.1681	0.1681
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0074	0.1681	0.1907
Echinococcus multilocularis	G protein coupled receptor 139	0.0074	0.1681	0.1681
Onchocerca volvulus		0.0074	0.1681	0.253
Echinococcus multilocularis	neuropeptide receptor	0.0074	0.1681	0.1681
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0074	0.1681	0.1907
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0036	0.0397	0.0397
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Brugia malayi	ecdysteroid receptor	0.0036	0.0397	0.045
Echinococcus granulosus	GPCR family 2	0.0042	0.0598	0.0598
Echinococcus granulosus	serotonin receptor	0.0074	0.1681	0.1681
Brugia malayi	hypothetical protein	0.0074	0.1681	0.1907
Brugia malayi	Matrixin family protein	0.0074	0.167	0.1895
Echinococcus multilocularis	dro:myosuppressin receptor	0.0074	0.1681	0.1681
Onchocerca volvulus		0.0047	0.0775	0.1167
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0074	0.1681	0.1681
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0036	0.0397	0.045
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0074	0.1681	0.1681
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0036	0.0397	0.045
Onchocerca volvulus	Matrix metalloproteinase homolog	0.0163	0.4703	0.7081
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0074	0.1681	0.1681
Schistosoma mansoni	opsin-like receptor	0.0074	0.1681	0.1681
Schistosoma mansoni	hypothetical protein	0.0042	0.0598	0.0598
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0074	0.1681	0.1681
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0074	0.1681	0.1681
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1681	0.1907
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0036	0.0397	0.0397
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0397	0.045
Echinococcus multilocularis	g protein coupled receptor	0.0074	0.1681	0.1681
Echinococcus multilocularis	neuropeptides capa receptor	0.0074	0.1681	0.1681
Brugia malayi	hypothetical protein	0.0074	0.1681	0.1907
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0074	0.1681	0.1681
Brugia malayi	AKH receptor	0.0074	0.1681	0.1907
Schistosoma mansoni	thyroid hormone receptor	0.0154	0.4383	0.4383
Onchocerca volvulus	Protein ultraspiracle homolog	0.0036	0.0397	0.0597
Brugia malayi	hypothetical protein	0.0074	0.1681	0.1907
Brugia malayi	Serotonin receptor	0.0074	0.1681	0.1907
Echinococcus granulosus	biogenic amine 5HT receptor	0.0074	0.1681	0.1681
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0397	0.045
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0054	0.0996	0.0996
Echinococcus multilocularis	polycomb protein SCMH1	0.0047	0.0775	0.0775
Schistosoma mansoni	hypothetical protein	0.0287	0.8877	0.8877
Echinococcus granulosus	neuropeptide receptor	0.0074	0.1681	0.1681
Loa Loa (eye worm)	MBCTL1	0.0054	0.0996	0.113
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0074	0.1681	0.1681
Echinococcus granulosus	ecdysone induced protein 78C	0.0036	0.0397	0.0397
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0036	0.0397	0.045
Onchocerca volvulus		0.0074	0.1681	0.253
Brugia malayi	steroid hormone receptor	0.0036	0.0397	0.045
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0211	0.6324	0.6324
Schistosoma mansoni	biogenic amine receptor	0.0074	0.1681	0.1681
Echinococcus granulosus	7TM GPCR rhodopsin	0.0074	0.1681	0.1681
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0042	0.0598	0.0598

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 0.11 uM	Inhibition of human gelatinase A (MMP-2)	ChEMBL.	No reference
Ki (binding)	= 0.11 uM	Inhibition of human gelatinase A (MMP-2)	ChEMBL.	No reference
Ki (binding)	= 0.37 uM	Inhibition of human fibroblast stromelysin (MMP-3)	ChEMBL.	No reference
Ki (binding)	= 0.37 uM	Inhibition of human fibroblast stromelysin (MMP-3)	ChEMBL.	No reference
Ki (binding)	> 10 uM	Inhibition of human fibroblast collagenase (MMP-1)	ChEMBL.	No reference
Ki (binding)	> 10 uM	Inhibition of human fibroblast collagenase (MMP-1)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL150386

Bibliographic References

No literature references available for this target.

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Detailed information for compound 260427