Detailed information for compound 264269

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 150.221 | Formula: C9H14N2
  • H donors: 2 H acceptors: 0 LogP: 0.88 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1NCC(c2c1cc[nH]2)C
  • InChi: 1S/C9H14N2/c1-6-5-11-7(2)8-3-4-10-9(6)8/h3-4,6-7,10-11H,5H2,1-2H3
  • InChiKey: JZEKCFQKDODDOM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis esterase, putative 0.0037 0.0888 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0022 0.043 0.0599
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0049 0.0049
Onchocerca volvulus 0.001 0.0049 0.0052
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0049 0.0045
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0888 0.0944
Treponema pallidum NADH oxidase 0.0022 0.043 0.5
Loa Loa (eye worm) animal heme peroxidase 0.0239 0.73 0.73
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0888 0.1238
Mycobacterium tuberculosis Conserved protein 0.0037 0.0888 0.1238
Loa Loa (eye worm) hypothetical protein 0.0306 0.9409 0.9409
Loa Loa (eye worm) animal heme peroxidase 0.0239 0.73 0.73
Loa Loa (eye worm) hypothetical protein 0.0239 0.73 0.73
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0049 0.0052
Brugia malayi ecdysteroid receptor 0.001 0.0049 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0049 0.0052
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0049 0.0052
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0022 0.043 0.4837
Loa Loa (eye worm) hypothetical protein 0.0037 0.0888 0.0888
Schistosoma mansoni hypothetical protein 0.0129 0.3801 0.4035
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.1861 0.1861
Loa Loa (eye worm) hypothetical protein 0.0037 0.0888 0.0888
Loa Loa (eye worm) hypothetical protein 0.0009 0.0007 0.0007
Brugia malayi Animal haem peroxidase family protein 0.0239 0.73 0.7758
Loa Loa (eye worm) hypothetical protein 0.0239 0.73 0.73
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.096 0.1013
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0049 0.0052
Onchocerca volvulus 0.0037 0.0888 0.0944
Brugia malayi hypothetical protein 0.0306 0.9409 1
Brugia malayi beta-lactamase family protein 0.0037 0.0888 0.0944
Toxoplasma gondii ABC1 family protein 0.0037 0.0888 0.5014
Giardia lamblia NADH oxidase lateral transfer candidate 0.0022 0.043 1
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0888 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0049 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0049 0.0052
Loa Loa (eye worm) hypothetical protein 0.0239 0.73 0.73
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0888 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.043 0.1913
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0049 0.0045
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0022 0.043 0.1913
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0007 0.0007
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0022 0.043 0.0599
Onchocerca volvulus Chorion peroxidase homolog 0.0239 0.73 0.7758
Schistosoma mansoni coup transcription factor 0.001 0.0049 0.0045
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0049 0.0045
Plasmodium vivax glutathione reductase, putative 0.0064 0.1765 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0022 0.043 0.2404
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0888 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0049 0.0052
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0022 0.043 0.0449
Echinococcus granulosus protein cereblon 0.0306 0.9409 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0273 0.0273
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.1861 0.1899
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0049 0.0045
Brugia malayi Animal haem peroxidase family protein 0.0239 0.73 0.7758
Loa Loa (eye worm) hypothetical protein 0.0239 0.73 0.73
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0049 0.0045
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0049 0.0052
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0049 0.0052
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0022 0.043 0.1913
Onchocerca volvulus 0.0037 0.0888 0.0944
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0016 0.0242 0.0257
Mycobacterium ulcerans lipase LipD 0.0037 0.0888 1
Mycobacterium ulcerans beta-lactamase 0.0037 0.0888 1
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0888 0.1238
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0049
Trypanosoma cruzi trypanothione reductase, putative 0.0022 0.043 0.1913
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0129 0.3801 0.4035
Plasmodium falciparum glutathione reductase 0.0022 0.043 0.2404
Loa Loa (eye worm) animal heme peroxidase 0.0239 0.73 0.73
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0049 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0049 0.0052
Leishmania major hypothetical protein, conserved 0.0037 0.0888 0.4505
Onchocerca volvulus Peroxidase homolog 0.0239 0.73 0.7758
Echinococcus granulosus geminin 0.0173 0.5212 0.5536
Schistosoma mansoni peroxidasin 0.0239 0.73 0.7757
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0022 0.043 0.5
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.1861 0.1971
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0888 0.1238
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0888 0.4505
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0049
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0022 0.043 0.5
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0022 0.043 0.1526
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0184 0.1005
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0413 0.4652
Plasmodium falciparum thioredoxin reductase 0.0064 0.1765 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0888 0.1238
Brugia malayi Animal haem peroxidase family protein 0.0239 0.73 0.7758
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0888 0.1238
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0049 0.0052
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0049 0.0052
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0022 0.043 0.1913
Onchocerca volvulus 0.0239 0.73 0.7758
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0022 0.043 0.1526
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0049 0.0052
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0888 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0888 0.0888
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0888 1
Echinococcus granulosus transcription factor Dp 1 0.0039 0.096 0.1013
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0049
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0049 0.0052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0049 0.0049
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0413 0.0432
Brugia malayi nuclear hormone receptor 0.001 0.0049 0.0052
Schistosoma mansoni hypothetical protein 0.0173 0.5212 0.5536
Loa Loa (eye worm) hypothetical protein 0.0239 0.73 0.73
Loa Loa (eye worm) hypothetical protein 0.0037 0.0888 0.0888
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0888 1
Onchocerca volvulus Peroxidase homolog 0.0239 0.73 0.7758
Onchocerca volvulus 0.0037 0.0888 0.0944
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0237 0.7226 0.7226
Brugia malayi glutathione reductase 0.0064 0.1765 0.1875
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.1861 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.043 0.1913
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0049 0.0052
Brugia malayi follicle stimulating hormone receptor 0.0237 0.7226 0.768
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0022 0.043 0.4837
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.1861 1
Mycobacterium leprae Probable lipase LipE 0.0037 0.0888 1
Loa Loa (eye worm) hypothetical protein 0.0239 0.73 0.73
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0413 0.4652
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0049 0.0045
Loa Loa (eye worm) hypothetical protein 0.0239 0.73 0.73
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0888 0.4438
Loa Loa (eye worm) animal heme peroxidase 0.0239 0.73 0.73
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0022 0.043 0.1913
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.043 0.1913
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0016 0.0242 0.0257
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0049
Schistosoma mansoni hypothetical protein 0.0306 0.9409 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.043 0.1913
Toxoplasma gondii thioredoxin reductase 0.0064 0.1765 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.043 0.1913
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0049 0.0049
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0022 0.043 0.1913
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0888 0.0937
Loa Loa (eye worm) hypothetical protein 0.0239 0.73 0.73
Loa Loa (eye worm) thioredoxin reductase 0.0064 0.1765 0.1765
Loa Loa (eye worm) RecQ helicase 0.0022 0.0413 0.0413
Brugia malayi steroid hormone receptor 0.001 0.0049 0.0052
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0049 0.0052
Brugia malayi hypothetical protein 0.0124 0.3666 0.3896
Loa Loa (eye worm) hypothetical protein 0.0239 0.73 0.73
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0888 0.0937
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0049 0.0045
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0329 0.1832
Onchocerca volvulus Dual oxidase homolog 0.0239 0.73 0.7758
Plasmodium falciparum thioredoxin reductase 0.0022 0.043 0.2404
Schistosoma mansoni thyroid hormone receptor 0.0139 0.4128 0.4383
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0049 0.0045
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0022 0.043 0.1913
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0049 0.0045
Brugia malayi hypothetical protein 0.0239 0.73 0.7758
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0022 0.043 0.4837
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0049 0.0045
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0049 0.0045
Loa Loa (eye worm) hypothetical protein 0.0037 0.0888 0.0888
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0049 0.0045
Echinococcus granulosus thioredoxin glutathione reductase 0.0064 0.1765 0.1869
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.043 0.1913
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0049 0.0045
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0091 0.1027
Echinococcus multilocularis peroxidasin 0.0239 0.73 0.7757
Schistosoma mansoni thyroid hormone receptor 0.0139 0.4128 0.4383
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0022 0.043 0.0599
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0049 0.0045
Entamoeba histolytica hypothetical protein, conserved 0.0306 0.9409 1
Echinococcus granulosus FTZ F1 alpha 0.001 0.0049 0.0045
Mycobacterium tuberculosis Conserved protein 0.0037 0.0888 0.1238
Brugia malayi nuclear receptor NHR-88 0.001 0.0049 0.0052
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0049 0.0045
Mycobacterium tuberculosis Probable oxidoreductase 0.0022 0.043 0.0599
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0129 0.3801 0.4035
Loa Loa (eye worm) hypothetical protein 0.0239 0.73 0.73
Brugia malayi Thioredoxin reductase 0.0064 0.1765 0.1875
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0022 0.043 0.1913
Brugia malayi beta-lactamase family protein 0.0037 0.0888 0.0944
Mycobacterium ulcerans hypothetical protein 0.0037 0.0888 1
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0049 0.0045
Brugia malayi beta-lactamase 0.0037 0.0888 0.0944
Echinococcus multilocularis geminin 0.0173 0.5212 0.5536
Loa Loa (eye worm) hypothetical protein 0.0239 0.73 0.73
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0049 0.0045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0049 0.0049
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0049 0.0045
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0049
Onchocerca volvulus Peroxidasin homolog 0.0239 0.73 0.7758
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.1861 1
Schistosoma mansoni peroxidasin 0.0239 0.73 0.7757
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.1861 0.1971
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0888 0.4505
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0064 0.1765 0.2459
Echinococcus multilocularis thioredoxin glutathione reductase 0.0064 0.1765 0.1869
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0049 0.0052
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0022 0.043 0.0457
Brugia malayi Blistered cuticle protein 3 0.0239 0.73 0.7758
Trypanosoma brucei trypanothione reductase 0.0064 0.1765 0.9457
Loa Loa (eye worm) hypothetical protein 0.0037 0.0888 0.0888
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0888 0.1238
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.1861 1
Loa Loa (eye worm) beta-lactamase 0.0037 0.0888 0.0888
Echinococcus multilocularis protein cereblon 0.0306 0.9409 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0239 0.73 0.73
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0049 0.0052
Brugia malayi Animal haem peroxidase family protein 0.0239 0.73 0.7758
Loa Loa (eye worm) blistered cuticle protein 3 0.0239 0.73 0.73
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0022 0.043 0.1913
Plasmodium vivax thioredoxin reductase, putative 0.0064 0.1765 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0049 0.0049
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0022 0.043 0.2404
Schistosoma mansoni hypothetical protein 0.0173 0.5212 0.5536
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0049 0.0045
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0049 0.0045
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0888 0.0937
Brugia malayi Animal haem peroxidase family protein 0.0239 0.73 0.7758
Trichomonas vaginalis glutathione reductase, putative 0.0022 0.043 0.4837
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0888 1
Onchocerca volvulus 0.0239 0.73 0.7758
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0022 0.043 0.0449
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0007 0.00000000073963
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0049
Schistosoma mansoni nuclear hormone receptor 0.001 0.0049 0.0045
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0049 0.0045
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0049 0.0045
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0022 0.043 0.0449
Onchocerca volvulus Protein cereblon homolog 0.0306 0.9409 1
Brugia malayi Peroxidasin 0.0239 0.73 0.7758
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0049 0.0045
Giardia lamblia Sgs1 DNA helicase, putative 0.0009 0.0007 0.017
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0235 0.7174 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0007 0.0008
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0888 0.4505
Trichomonas vaginalis mercuric reductase, putative 0.0022 0.043 0.4837
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0888 1
Echinococcus granulosus bloom syndrome protein 0.0022 0.0413 0.0432
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.1861 0.1971
Mycobacterium tuberculosis Conserved protein 0.0037 0.0888 0.1238
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0049 0.0049
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0022 0.043 0.1913
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0888 0.1238
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0007 0.0008
Plasmodium falciparum glutathione reductase 0.0064 0.1765 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.1861 0.1977
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0022 0.043 0.1913
Loa Loa (eye worm) hypothetical protein 0.0239 0.73 0.73
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0049 0.0045
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0888 0.0937
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0049 0.0045
Onchocerca volvulus 0.0239 0.73 0.7758
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0049 0.0049
Echinococcus multilocularis thyroid hormone receptor alpha 0.0139 0.4128 0.4383
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0022 0.043 0.5
Loa Loa (eye worm) hypothetical protein 0.0037 0.0888 0.0888
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0022 0.043 0.2404
Loa Loa (eye worm) hypothetical protein 0.0239 0.73 0.73
Trypanosoma cruzi trypanothione reductase, putative 0.0064 0.1765 0.9457
Echinococcus granulosus peroxidasin 0.0239 0.73 0.7757
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0413 0.0439
Leishmania major trypanothione reductase 0.0064 0.1765 0.9457
Onchocerca volvulus Peroxidasin homolog 0.0239 0.73 0.7758
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0268 0.0277
Toxoplasma gondii NADPH-glutathione reductase 0.0022 0.043 0.2404
Loa Loa (eye worm) glutathione reductase 0.0064 0.1765 0.1765

Activities

Activity type Activity value Assay description Source Reference
cLogP = 1.24 1-Octanol/water partition coefficient measured at 7.4 ChEMBL. 10741558
Inhibition (functional) = 26 % Compound was evaluated for inhibition of ADP-mediated platelet aggregation ChEMBL. 10741558
Inhibition (functional) = 26 % Compound was evaluated for inhibition of ADP-mediated platelet aggregation ChEMBL. 10741558
logD = -1.08 1-Octanol/water distribution coefficient measured at 7.4 ChEMBL. 10741558

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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