Detailed information for compound 264269

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 150.221 | Formula: C9H14N2
  • H donors: 2 H acceptors: 0 LogP: 0.88 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1NCC(c2c1cc[nH]2)C
  • InChi: 1S/C9H14N2/c1-6-5-11-7(2)8-3-4-10-9(6)8/h3-4,6-7,10-11H,5H2,1-2H3
  • InChiKey: JZEKCFQKDODDOM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Peroxidasin homolog 0.0239 0.73 0.7758
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0049 0.0052
Entamoeba histolytica hypothetical protein, conserved 0.0306 0.9409 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0022 0.043 0.1913
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0049 0.0052
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0237 0.7226 0.7226
Mycobacterium leprae Probable lipase LipE 0.0037 0.0888 1
Onchocerca volvulus 0.0037 0.0888 0.0944
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0413 0.0439
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0184 0.1005
Trypanosoma brucei trypanothione reductase 0.0064 0.1765 0.9457
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0049 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0049 0.0052
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0022 0.043 0.0599
Trichomonas vaginalis mercuric reductase, putative 0.0022 0.043 0.4837
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0049 0.0052
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0049
Mycobacterium ulcerans lipase LipD 0.0037 0.0888 1
Loa Loa (eye worm) hypothetical protein 0.0239 0.73 0.73
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0888 1
Schistosoma mansoni nuclear hormone receptor 0.001 0.0049 0.0045
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0888 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0049 0.0049
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0049 0.0052
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0888 0.1238
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0049 0.0045
Leishmania major hypothetical protein, conserved 0.0037 0.0888 0.4505
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0049 0.0052
Brugia malayi beta-lactamase family protein 0.0037 0.0888 0.0944
Loa Loa (eye worm) hypothetical protein 0.0239 0.73 0.73
Echinococcus granulosus transcription factor Dp 1 0.0039 0.096 0.1013
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0049 0.0045
Onchocerca volvulus Peroxidasin homolog 0.0239 0.73 0.7758
Onchocerca volvulus Dual oxidase homolog 0.0239 0.73 0.7758
Giardia lamblia Sgs1 DNA helicase, putative 0.0009 0.0007 0.017
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0007 0.0007
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0022 0.043 0.1913
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0888 0.4505
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0049 0.0045
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0049 0.0045
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0022 0.043 0.5
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0022 0.043 0.0449
Toxoplasma gondii NADPH-glutathione reductase 0.0022 0.043 0.2404
Onchocerca volvulus 0.0037 0.0888 0.0944
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0049
Onchocerca volvulus 0.001 0.0049 0.0052
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0049 0.0049
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0049 0.0045
Loa Loa (eye worm) hypothetical protein 0.0017 0.0273 0.0273
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0239 0.73 0.73
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.1861 0.1971
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0022 0.043 0.1913
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0022 0.043 0.0599
Onchocerca volvulus Peroxidase homolog 0.0239 0.73 0.7758
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.1861 0.1971
Leishmania major trypanothione reductase 0.0064 0.1765 0.9457
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0049 0.0045
Brugia malayi Thioredoxin reductase 0.0064 0.1765 0.1875
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0022 0.043 0.1913
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0022 0.043 0.2404
Trichomonas vaginalis esterase, putative 0.0037 0.0888 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0049 0.0052
Echinococcus granulosus thioredoxin glutathione reductase 0.0064 0.1765 0.1869
Loa Loa (eye worm) hypothetical protein 0.0239 0.73 0.73
Brugia malayi Animal haem peroxidase family protein 0.0239 0.73 0.7758
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0888 0.1238
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0888 0.0944
Echinococcus multilocularis peroxidasin 0.0239 0.73 0.7757
Brugia malayi hypothetical protein 0.0239 0.73 0.7758
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0888 0.0937
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0329 0.1832
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0888 0.1238
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0022 0.043 0.0599
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0022 0.043 0.1913
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0049 0.0045
Onchocerca volvulus Peroxidase homolog 0.0239 0.73 0.7758
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0049 0.0052
Loa Loa (eye worm) hypothetical protein 0.0306 0.9409 0.9409
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0235 0.7174 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0016 0.0242 0.0257
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0049 0.0052
Trypanosoma cruzi trypanothione reductase, putative 0.0064 0.1765 0.9457
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.1861 0.1899
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0049 0.0052
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0049
Brugia malayi Peroxidasin 0.0239 0.73 0.7758
Mycobacterium tuberculosis Probable oxidoreductase 0.0022 0.043 0.0599
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0049 0.0045
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0022 0.043 0.2404
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0049 0.0045
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0888 1
Echinococcus multilocularis protein cereblon 0.0306 0.9409 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0049 0.0045
Onchocerca volvulus Chorion peroxidase homolog 0.0239 0.73 0.7758
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0888 0.1238
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0413 0.4652
Brugia malayi Animal haem peroxidase family protein 0.0239 0.73 0.7758
Echinococcus multilocularis thyroid hormone receptor alpha 0.0139 0.4128 0.4383
Schistosoma mansoni hypothetical protein 0.0173 0.5212 0.5536
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0016 0.0242 0.0257
Loa Loa (eye worm) hypothetical protein 0.0009 0.0007 0.0007
Brugia malayi Blistered cuticle protein 3 0.0239 0.73 0.7758
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0888 0.1238
Mycobacterium ulcerans beta-lactamase 0.0037 0.0888 1
Brugia malayi hypothetical protein 0.0124 0.3666 0.3896
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0022 0.043 0.1526
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0888 0.0937
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0888 0.0937
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0888 0.0937
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0888 0.1238
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0049
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0049 0.0045
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0049
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0888 0.4505
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0129 0.3801 0.4035
Brugia malayi hypothetical protein 0.0306 0.9409 1
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0049 0.0045
Schistosoma mansoni peroxidasin 0.0239 0.73 0.7757
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0049 0.0045
Loa Loa (eye worm) hypothetical protein 0.0239 0.73 0.73
Brugia malayi follicle stimulating hormone receptor 0.0237 0.7226 0.768
Onchocerca volvulus 0.0239 0.73 0.7758
Loa Loa (eye worm) hypothetical protein 0.0239 0.73 0.73
Loa Loa (eye worm) hypothetical protein 0.0239 0.73 0.73
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.1861 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0049 0.0045
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0888 0.4438
Mycobacterium tuberculosis Conserved protein 0.0037 0.0888 0.1238
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0888 1
Loa Loa (eye worm) beta-lactamase 0.0037 0.0888 0.0888
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0413 0.4652
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.1861 1
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0888 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0049 0.0052
Onchocerca volvulus Protein cereblon homolog 0.0306 0.9409 1
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0049 0.0045
Schistosoma mansoni hypothetical protein 0.0306 0.9409 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0049 0.0045
Loa Loa (eye worm) hypothetical protein 0.0037 0.0888 0.0888
Loa Loa (eye worm) hypothetical protein 0.0239 0.73 0.73
Loa Loa (eye worm) hypothetical protein 0.0037 0.0888 0.0888
Mycobacterium ulcerans hypothetical protein 0.0037 0.0888 1
Schistosoma mansoni hypothetical protein 0.0129 0.3801 0.4035
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0022 0.043 0.1913
Loa Loa (eye worm) blistered cuticle protein 3 0.0239 0.73 0.73
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0049 0.0052
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0888 0.0888
Loa Loa (eye worm) hypothetical protein 0.0037 0.0888 0.0888
Loa Loa (eye worm) animal heme peroxidase 0.0239 0.73 0.73
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.1861 1
Loa Loa (eye worm) animal heme peroxidase 0.0239 0.73 0.73
Giardia lamblia NADH oxidase lateral transfer candidate 0.0022 0.043 1
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0413 0.0432
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0049 0.0045
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0129 0.3801 0.4035
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0049 0.0052
Brugia malayi Animal haem peroxidase family protein 0.0239 0.73 0.7758
Loa Loa (eye worm) hypothetical protein 0.0037 0.0888 0.0888
Brugia malayi Animal haem peroxidase family protein 0.0239 0.73 0.7758
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0049 0.0049
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0022 0.043 0.0457
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.043 0.1913
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0049 0.0045
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0049
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.043 0.1913
Brugia malayi Animal haem peroxidase family protein 0.0239 0.73 0.7758
Plasmodium falciparum thioredoxin reductase 0.0064 0.1765 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.1861 0.1977
Trichomonas vaginalis glutathione reductase, putative 0.0022 0.043 0.4837
Plasmodium falciparum thioredoxin reductase 0.0022 0.043 0.2404
Schistosoma mansoni peroxidasin 0.0239 0.73 0.7757
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0049 0.0052
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.1861 0.1971
Loa Loa (eye worm) animal heme peroxidase 0.0239 0.73 0.73
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0022 0.043 0.4837
Loa Loa (eye worm) hypothetical protein 0.0239 0.73 0.73
Onchocerca volvulus 0.0239 0.73 0.7758
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0049
Schistosoma mansoni thyroid hormone receptor 0.0139 0.4128 0.4383
Echinococcus granulosus geminin 0.0173 0.5212 0.5536
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0007 0.00000000073963
Plasmodium falciparum glutathione reductase 0.0022 0.043 0.2404
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.096 0.1013
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0022 0.043 0.4837
Trypanosoma cruzi trypanothione reductase, putative 0.0022 0.043 0.1913
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0049 0.0045
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.1861 1
Brugia malayi nuclear hormone receptor 0.001 0.0049 0.0052
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0049 0.0052
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0049 0.0049
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0049 0.0049
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0022 0.043 0.5
Echinococcus granulosus peroxidasin 0.0239 0.73 0.7757
Toxoplasma gondii ABC1 family protein 0.0037 0.0888 0.5014
Plasmodium vivax thioredoxin reductase, putative 0.0064 0.1765 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0049 0.0049
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0888 0.4505
Toxoplasma gondii thioredoxin reductase 0.0064 0.1765 1
Mycobacterium tuberculosis Conserved protein 0.0037 0.0888 0.1238
Loa Loa (eye worm) animal heme peroxidase 0.0239 0.73 0.73
Loa Loa (eye worm) glutathione reductase 0.0064 0.1765 0.1765
Echinococcus multilocularis thioredoxin glutathione reductase 0.0064 0.1765 0.1869
Loa Loa (eye worm) hypothetical protein 0.0037 0.0888 0.0888
Loa Loa (eye worm) hypothetical protein 0.0239 0.73 0.73
Schistosoma mansoni hypothetical protein 0.0173 0.5212 0.5536
Loa Loa (eye worm) hypothetical protein 0.0239 0.73 0.73
Treponema pallidum NADH oxidase 0.0022 0.043 0.5
Loa Loa (eye worm) thioredoxin reductase 0.0064 0.1765 0.1765
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0022 0.043 0.4837
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0049 0.0052
Echinococcus multilocularis geminin 0.0173 0.5212 0.5536
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0049 0.0052
Brugia malayi beta-lactamase family protein 0.0037 0.0888 0.0944
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0049 0.0052
Brugia malayi beta-lactamase 0.0037 0.0888 0.0944
Echinococcus granulosus FTZ F1 alpha 0.001 0.0049 0.0045
Onchocerca volvulus 0.0239 0.73 0.7758
Brugia malayi glutathione reductase 0.0064 0.1765 0.1875
Plasmodium vivax glutathione reductase, putative 0.0064 0.1765 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0049 0.0045
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0049 0.0045
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0022 0.043 0.1913
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.043 0.1913
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0022 0.043 0.1913
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0268 0.0277
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0049 0.0045
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.043 0.1913
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0049 0.0052
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0007 0.0008
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0888 0.1238
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0022 0.043 0.2404
Plasmodium falciparum glutathione reductase 0.0064 0.1765 1
Brugia malayi steroid hormone receptor 0.001 0.0049 0.0052
Loa Loa (eye worm) hypothetical protein 0.0037 0.0888 0.0888
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0049 0.0049
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0888 1
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0091 0.1027
Echinococcus granulosus bloom syndrome protein 0.0022 0.0413 0.0432
Mycobacterium tuberculosis Conserved protein 0.0037 0.0888 0.1238
Brugia malayi nuclear receptor NHR-88 0.001 0.0049 0.0052
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0007 0.0008
Echinococcus granulosus protein cereblon 0.0306 0.9409 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0064 0.1765 0.2459
Loa Loa (eye worm) hypothetical protein 0.0239 0.73 0.73
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.043 0.1913
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.043 0.1913
Schistosoma mansoni coup transcription factor 0.001 0.0049 0.0045
Loa Loa (eye worm) hypothetical protein 0.0239 0.73 0.73
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0022 0.043 0.0449
Brugia malayi ecdysteroid receptor 0.001 0.0049 0.0052
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0049 0.0045
Loa Loa (eye worm) RecQ helicase 0.0022 0.0413 0.0413
Schistosoma mansoni thyroid hormone receptor 0.0139 0.4128 0.4383
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0888 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.1861 0.1861
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0022 0.043 0.1526
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0022 0.043 0.1913
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0022 0.043 0.5
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0022 0.043 0.1913
Loa Loa (eye worm) hypothetical protein 0.0239 0.73 0.73
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0888 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0049 0.0045
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0022 0.043 0.0449
Onchocerca volvulus 0.0037 0.0888 0.0944

Activities

Activity type Activity value Assay description Source Reference
cLogP = 1.24 1-Octanol/water partition coefficient measured at 7.4 ChEMBL. 10741558
Inhibition (functional) = 26 % Compound was evaluated for inhibition of ADP-mediated platelet aggregation ChEMBL. 10741558
Inhibition (functional) = 26 % Compound was evaluated for inhibition of ADP-mediated platelet aggregation ChEMBL. 10741558
logD = -1.08 1-Octanol/water distribution coefficient measured at 7.4 ChEMBL. 10741558

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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