Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | retinoic acid receptor, alpha | Starlite/ChEMBL | References |
Homo sapiens | retinoic acid receptor, gamma | Starlite/ChEMBL | References |
Homo sapiens | retinoic acid receptor, beta | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | Get druggable targets OG5_131607 | All targets in OG5_131607 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_131607 | All targets in OG5_131607 |
Brugia malayi | nuclear hormone receptor | Get druggable targets OG5_131607 | All targets in OG5_131607 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | Get druggable targets OG5_131607 | All targets in OG5_131607 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | glyoxalase I, putative | 0.0044 | 0.0084 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.0084 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0044 | 0.0084 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0044 | 0.0084 | 1 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0037 | 0 | 0.5 |
Trypanosoma cruzi | lactoylglutathione lyase-like protein, putative | 0.0044 | 0.0084 | 1 |
Plasmodium falciparum | glyoxalase I | 0.0044 | 0.0084 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0787 | 0.9748 | 1 |
Onchocerca volvulus | Putative protein | 0.0298 | 0.3395 | 0.3339 |
Mycobacterium leprae | conserved hypothetical protein | 0.0044 | 0.0084 | 1 |
Trypanosoma cruzi | lactoylglutathione lyase-like protein, putative | 0.0044 | 0.0084 | 1 |
Mycobacterium tuberculosis | Conserved protein TB27.3 | 0.0044 | 0.0084 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0044 | 0.0084 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0044 | 0.0084 | 1 |
Leishmania major | glyoxalase I,trypanothione-dependent glyoxalase I | 0.0044 | 0.0084 | 1 |
Brugia malayi | lactoylglutathione lyase | 0.0044 | 0.0084 | 0.0086 |
Mycobacterium ulcerans | hypothetical protein | 0.0044 | 0.0084 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.0084 | 0.5 |
Echinococcus multilocularis | 0.0037 | 0 | 0.5 | |
Brugia malayi | 4-hydroxyphenylpyruvate dioxygenase family protein | 0.0298 | 0.3395 | 0.3482 |
Toxoplasma gondii | glyoxalase family protein | 0.0044 | 0.0084 | 1 |
Plasmodium falciparum | glyoxalase I | 0.0044 | 0.0084 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0044 | 0.0084 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0769 | 0.9524 | 0.9769 |
Mycobacterium tuberculosis | Cadmium inducible protein CadI | 0.0044 | 0.0084 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0044 | 0.0084 | 1 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0787 | 0.9748 | 1 |
Mycobacterium ulcerans | glyoxalase GloA | 0.0044 | 0.0084 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0084 | 0.0086 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.0037 | 0 | 0.5 |
Loa Loa (eye worm) | 4-hydroxyphenylpyruvate dioxygenase | 0.0298 | 0.3395 | 0.3482 |
Mycobacterium ulcerans | glyoxalase GloA | 0.0044 | 0.0084 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0044 | 0.0084 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | gynecophoral canal protein | 0.0044 | 0.0084 | 1 |
Plasmodium vivax | glyoxalase I, putative | 0.0044 | 0.0084 | 0.5 |
Toxoplasma gondii | glyoxalase I, putative | 0.0044 | 0.0084 | 1 |
Mycobacterium ulcerans | biphenyl-2,3-diol 1,2-dioxygenase | 0.0044 | 0.0084 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0044 | 0.0084 | 1 |
Schistosoma mansoni | 4-hydroxyphenylpyruvate dioxygenase | 0.0044 | 0.0084 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (binding) | = 33 nM | Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from beta retinoic acid receptor (beta RAR) using transactivation assay | ChEMBL. | 10098666 |
Kd (binding) | = 33 nM | Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from beta retinoic acid receptor (beta RAR) using transactivation assay | ChEMBL. | 10098666 |
Kd (binding) | = 42 nM | Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from Retinoic acid receptor gamma using transactivation assay | ChEMBL. | 10098666 |
Kd (binding) | = 42 nM | Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from Retinoic acid receptor gamma using transactivation assay | ChEMBL. | 10098666 |
Kd (binding) | = 147 nM | Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from alpha retinoic acid receptor (alpha RAR) using transactivation assay | ChEMBL. | 10098666 |
Kd (binding) | = 147 nM | Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from alpha retinoic acid receptor (alpha RAR) using transactivation assay | ChEMBL. | 10098666 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.