Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cavia porcellus | Platelet activating factor receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | egf-like domain protein | 0.0639 | 0.1882 | 0.1675 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.1179 | 0.4682 | 0.3135 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0711 | 0.2253 | 0.5 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0395 | 0.0614 | 0.2333 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0711 | 0.2253 | 0.5 |
Onchocerca volvulus | 0.046 | 0.0951 | 0.414 | |
Loa Loa (eye worm) | matrixin family protein | 0.0719 | 0.2297 | 0.2297 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0395 | 0.0614 | 0.5 |
Onchocerca volvulus | 0.0324 | 0.0248 | 0.1079 | |
Brugia malayi | Matrixin family protein | 0.0324 | 0.0248 | 0.0941 |
Loa Loa (eye worm) | hypothetical protein | 0.0639 | 0.1882 | 0.1882 |
Mycobacterium ulcerans | hydrolase | 0.0395 | 0.0614 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0784 | 0.2633 | 1 |
Brugia malayi | Hemopexin family protein | 0.046 | 0.0951 | 0.3611 |
Brugia malayi | Matrixin family protein | 0.0324 | 0.0248 | 0.0941 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0711 | 0.2253 | 0.2253 |
Loa Loa (eye worm) | AStacin protease | 0.1378 | 0.5714 | 0.5714 |
Onchocerca volvulus | Matrilysin homolog | 0.0324 | 0.0248 | 0.1079 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0324 | 0.0248 | 0.0248 |
Brugia malayi | Fibulin-1 precursor | 0.0711 | 0.2253 | 0.8557 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0639 | 0.1882 | 0.1882 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0719 | 0.2297 | 1 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0395 | 0.0614 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0324 | 0.0248 | 0.0248 |
Echinococcus multilocularis | Tolloid protein 1 | 0.2205 | 1 | 1 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0639 | 0.1882 | 0.7146 |
Schistosoma mansoni | hypothetical protein | 0.046 | 0.0951 | 0.0721 |
Loa Loa (eye worm) | hypothetical protein | 0.0639 | 0.1882 | 0.1882 |
Brugia malayi | Matrixin family protein | 0.0324 | 0.0248 | 0.0941 |
Loa Loa (eye worm) | hypothetical protein | 0.0324 | 0.0248 | 0.0248 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.2205 | 1 | 1 |
Onchocerca volvulus | Arrow homolog | 0.0639 | 0.1882 | 0.8192 |
Loa Loa (eye worm) | hypothetical protein | 0.0324 | 0.0248 | 0.0248 |
Loa Loa (eye worm) | hypothetical protein | 0.2115 | 0.9535 | 0.9535 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.1179 | 0.4682 | 0.3135 |
Loa Loa (eye worm) | hypothetical protein | 0.0898 | 0.3223 | 0.3223 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.2205 | 1 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0719 | 0.2297 | 1 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0711 | 0.2253 | 0.8557 |
Loa Loa (eye worm) | matrixin family protein | 0.0784 | 0.2633 | 0.2633 |
Brugia malayi | Matrixin family protein | 0.0324 | 0.0248 | 0.0941 |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 0.0614 | 0.0614 |
Loa Loa (eye worm) | hypothetical protein | 0.0711 | 0.2253 | 0.2253 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 8.5 uM | Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF) | ChEMBL. | 2909744 |
IC50 (functional) | = 8.5 uM | Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF) | ChEMBL. | 2909744 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.