Detailed information for compound 270968

Basic information

Technical information
  • TDR Targets ID: 270968
  • Name: (4S)-5-(4-chlorophenyl)-N'-methyl-4-phenyl-N- [4-(trifluoromethyl)phenyl]sulfonyl-3,4-dihyd ropyrazole-2-carboximidamide
  • MW: 520.954 | Formula: C24H20ClF3N4O2S
  • H donors: 1 H acceptors: 2 LogP: 5.52 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: C/N=C(/N1C[C@@H](C(=N1)c1ccc(cc1)Cl)c1ccccc1)\NS(=O)(=O)c1ccc(cc1)C(F)(F)F
  • InChi: 1S/C24H20ClF3N4O2S/c1-29-23(31-35(33,34)20-13-9-18(10-14-20)24(26,27)28)32-15-21(16-5-3-2-4-6-16)22(30-32)17-7-11-19(25)12-8-17/h2-14,21H,15H2,1H3,(H,29,31)/t21-/m1/s1
  • InChiKey: NMOHILMYXVQGHO-OAQYLSRUSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (4S)-5-(4-chlorophenyl)-N'-methyl-4-phenyl-N-[4-(trifluoromethyl)phenyl]sulfonyl-3,4-dihydropyrazole-2-carboxamidine
  • (4S)-3-(4-chlorophenyl)-N'-methyl-4-phenyl-N-[4-(trifluoromethyl)phenyl]sulfonyl-2-pyrazoline-1-carboxamidine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cannabinoid receptor 1 (brain) Starlite/ChEMBL References
Homo sapiens cannabinoid receptor 2 (macrophage) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0037 0.0458 0.2041
Toxoplasma gondii hypothetical protein 0.0013 0.0068 0.0408
Loa Loa (eye worm) hypothetical protein 0.0014 0.0076 0.03
Loa Loa (eye worm) hypothetical protein 0.0025 0.0264 0.1036
Brugia malayi jmjC domain containing protein 0.004 0.0504 0.1957
Loa Loa (eye worm) hypothetical protein 0.0025 0.0264 0.1036
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.009 0.1299 0.8369
Brugia malayi Cyclin, N-terminal domain containing protein 0.0017 0.0135 0.0507
Echinococcus granulosus cyclins 0.0017 0.0135 0.0583
Echinococcus granulosus GPCR family 2 0.0015 0.0103 0.0435
Loa Loa (eye worm) hypothetical protein 0.0144 0.2179 0.8551
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0877 0.3939
Loa Loa (eye worm) jmjC domain-containing protein 0.0011 0.003 0.0117
Echinococcus granulosus lysine specific demethylase 6a 0.0011 0.003 0.0106
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0025 0.0264 0.1165
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.009 0.1299 0.8369
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0014 0.0076 0.0275
Entamoeba histolytica serine/threonine protein kinase, putative 0.0105 0.1547 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0632 0.2481
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0877 0.3939
Echinococcus multilocularis tyrosine protein kinase Blk 0.0034 0.0399 0.1777
Loa Loa (eye worm) troponin 0.007 0.0985 0.3867
Echinococcus granulosus tyrosine protein kinase Blk 0.0034 0.0399 0.1777
Schistosoma mansoni tsg101-related 0.0064 0.0889 0.3992
Loa Loa (eye worm) hypothetical protein 0.0014 0.0076 0.03
Loa Loa (eye worm) hypothetical protein 0.0025 0.0264 0.1036
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0077 0.1096 0.4929
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1547 1
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.009 0.1299 0.8369
Trichomonas vaginalis cyclin D, putative 0.0017 0.0135 0.0476
Echinococcus multilocularis cyclins 0.0017 0.0135 0.0583
Loa Loa (eye worm) transcription factor SMAD2 0.0136 0.2044 0.8022
Schistosoma mansoni cyclins 0.0017 0.0135 0.0583
Loa Loa (eye worm) hypothetical protein 0.0089 0.1286 0.5049
Echinococcus multilocularis cyclin B3 1 0.0017 0.0135 0.0583
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0012 0.0045 0.0151
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0011 0.003 0.0106
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0017 0.0135 0.0695
Brugia malayi PHD-finger family protein 0.0011 0.0032 0.0101
Echinococcus multilocularis nAChR subunit 0.0014 0.0076 0.0317
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0014 0.0076 0.0275
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0631 1 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.1005 0.4519
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0037 0.0458 0.2041
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0177
Echinococcus multilocularis caspase 0.0133 0.2 0.9019
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0877 0.3425
Brugia malayi jmjC domain containing protein 0.0011 0.003 0.0092
Schistosoma mansoni tyrosine kinase 0.0037 0.0458 0.2041
Schistosoma mansoni serine/threonine protein kinase 0.009 0.1299 0.5851
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0025 0.0264 0.1165
Loa Loa (eye worm) hypothetical protein 0.0015 0.0103 0.0403
Trypanosoma cruzi cyclin, putative 0.0017 0.0135 0.0695
Entamoeba histolytica cyclin, putative 0.0017 0.0135 0.0476
Toxoplasma gondii PHD-finger domain-containing protein 0.0011 0.0032 0.0023
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0103 0.0435
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0387 0.1497
Echinococcus multilocularis lysine specific demethylase 6a 0.0011 0.003 0.0106
Entamoeba histolytica cyclin family protein 0.0017 0.0135 0.0476
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0025 0.0254 0.1474
Echinococcus multilocularis jumonji domain containing 1A 0.0011 0.003 0.0106
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0037 0.0458 0.2041
Loa Loa (eye worm) RNA binding protein 0.0063 0.0877 0.3442
Trypanosoma cruzi metacaspase, putative 0.005 0.0668 0.4204
Loa Loa (eye worm) TK protein kinase 0.003 0.0339 0.1331
Echinococcus granulosus cyclins 0.0017 0.0135 0.0583
Onchocerca volvulus 0.0012 0.0045 0.0177
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0037 0.0458 0.2041
Onchocerca volvulus Cell death protein 3 homolog 0.0097 0.1422 0.5581
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0025 0.0264 0.1013
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0011 0.003 0.0106
Entamoeba histolytica protein kinase, putative 0.009 0.1299 0.833
Schistosoma mansoni hypothetical protein 0.0071 0.1005 0.4519
Echinococcus granulosus JmjC domain containing protein 4 0.0011 0.003 0.0106
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0025 0.0264 0.1013
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0012 0.0045 0.0151
Echinococcus multilocularis cyclins 0.0017 0.0135 0.0583
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0877 0.3939
Echinococcus granulosus glycine receptor subunit beta 0.0025 0.0264 0.1165
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0017 0.0135 0.0583
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0025 0.0264 0.1013
Echinococcus multilocularis cyclins 0.0017 0.0135 0.0583
Echinococcus multilocularis cyclin b3 0.0017 0.0135 0.0583
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0177
Echinococcus granulosus troponin i 0.0118 0.1759 0.793
Echinococcus granulosus tyrosine protein kinase Src42A 0.0033 0.0382 0.17
Loa Loa (eye worm) hypothetical protein 0.0047 0.0612 0.2402
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0109 0.1606 0.7239
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0025 0.0264 0.1165
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0177
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0177
Onchocerca volvulus 0.0025 0.0264 0.1036
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0025 0.0264 0.1165
Brugia malayi Cyclin, N-terminal domain containing protein 0.0017 0.0135 0.0507
Brugia malayi AF-10 protein 0.0011 0.0032 0.0101
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0033 0.0382 0.17
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0025 0.0264 0.1013
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0017 0.0135 0.0583
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0025 0.0264 0.1013
Brugia malayi hypothetical protein 0.0077 0.1096 0.4286
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0025 0.0264 0.1165
Trypanosoma cruzi cyclin, putative 0.0017 0.0135 0.0695
Trichomonas vaginalis cyclin B, putative 0.0017 0.0135 0.0476
Trypanosoma cruzi polo-like protein kinase, putative 0.0105 0.1547 1
Brugia malayi MH2 domain containing protein 0.0136 0.2044 0.8017
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0668 0.4068
Echinococcus granulosus jumonji domain containing 1A 0.0011 0.003 0.0106
Brugia malayi Troponin T 0.007 0.0985 0.3852
Echinococcus granulosus nAChR subunit 0.0014 0.0076 0.0317
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0668 0.4068
Echinococcus granulosus tyrosine protein kinase HCK 0.003 0.0339 0.1505
Entamoeba histolytica hypothetical protein 0.009 0.1299 0.833
Loa Loa (eye worm) MH2 domain-containing protein 0.0136 0.2044 0.8022
Brugia malayi Muscleblind-like protein 0.0144 0.2179 0.8547
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0037 0.0458 0.2041
Loa Loa (eye worm) cyclin domain-containing protein 0.0017 0.0135 0.0531
Loa Loa (eye worm) GABA receptor subunit 0.0014 0.0076 0.03
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0065 0.0229
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0668 0.4068
Brugia malayi Cation transporter family protein 0.0025 0.0264 0.1013
Echinococcus multilocularis cyclins 0.0017 0.0135 0.0583
Brugia malayi TAR-binding protein 0.0063 0.0877 0.3425
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0103 0.0378
Leishmania major hypothetical protein, conserved 0.0025 0.0254 0.1474
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0032 0.0034
Schistosoma mansoni neurotransmitter gated ion channel 0.0014 0.0076 0.0317
Echinococcus multilocularis nAChR subunit 0.0025 0.0264 0.1165
Echinococcus multilocularis glycine receptor subunit beta 0.0025 0.0264 0.1165
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0077 0.1096 0.4929
Entamoeba histolytica hypothetical protein 0.0071 0.1005 0.6345
Loa Loa (eye worm) hypothetical protein 0.0025 0.0264 0.1036
Trichomonas vaginalis cyclins, putative 0.0017 0.0135 0.0476
Giardia lamblia Kinase, PLK 0.0105 0.1547 1
Echinococcus multilocularis caspase 2 0.0097 0.1422 0.6406
Loa Loa (eye worm) hypothetical protein 0.0014 0.0076 0.03
Schistosoma mansoni hypothetical protein 0.0015 0.0103 0.0435
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0034 0.0399 0.1777
Onchocerca volvulus Alhambra homolog 0.0033 0.0391 0.1536
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.1005 0.4519
Brugia malayi excitatory GABA receptor EXP-1A 0.0025 0.0264 0.1013
Brugia malayi hypothetical protein 0.0071 0.1005 0.3929
Schistosoma mansoni nAChR subunit 0.0025 0.0264 0.1165
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0012 0.0045 0.0174
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0011 0.0032 0.0014
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0391 0.3848
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0103 0.0435
Plasmodium falciparum metacaspase-like protein 0.005 0.0668 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.1096 0.43
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0037 0.0458 0.2041
Echinococcus granulosus cyclins 0.0017 0.0135 0.0583
Brugia malayi Protein kinase domain containing protein 0.009 0.1299 0.5087
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0025 0.0264 0.1165
Schistosoma mansoni nAChR subunit 0.0025 0.0264 0.1165
Loa Loa (eye worm) hypothetical protein 0.0097 0.1422 0.5581
Echinococcus multilocularis phd:f box containing protein 0.0011 0.003 0.0106
Trichomonas vaginalis cyclins, putative 0.0017 0.0135 0.0476
Schistosoma mansoni nAChR subunit 0.0012 0.0045 0.0174
Brugia malayi Troponin T 0.007 0.0985 0.3852
Echinococcus multilocularis muscleblind protein 1 0.0144 0.2179 0.983
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0045 0.0151
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0668 0.4068
Schistosoma mansoni tyrosine kinase 0.0037 0.0458 0.2041
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0103 0.0378
Entamoeba histolytica hypothetical protein 0.0071 0.1005 0.6345
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0065 0.0229
Loa Loa (eye worm) hypothetical protein 0.0025 0.0264 0.1036
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0025 0.0264 0.1036
Echinococcus granulosus oncosphere protein Tso22e 0.0147 0.2216 1
Onchocerca volvulus 0.0014 0.0076 0.03
Loa Loa (eye worm) SRC-1 0.0037 0.0458 0.1796
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1547 1
Leishmania major metacaspase, putative 0.005 0.0668 0.4204
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0668 0.4068
Loa Loa (eye worm) hypothetical protein 0.0025 0.0264 0.1036
Echinococcus multilocularis caspase 3 0.0083 0.1189 0.5353
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0025 0.0264 0.1013
Echinococcus multilocularis caspase 8 0.005 0.0668 0.2992
Trypanosoma cruzi cyclin 6, putative 0.0017 0.0135 0.0695
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0037 0.0458 0.2041
Echinococcus granulosus jumonji domain containing protein 0.0046 0.0601 0.2688
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.009 0.1299 0.8369
Schistosoma mansoni protein phosphatase 2C 0.0011 0.003 0.0106
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0025 0.0264 0.1013
Brugia malayi Troponin I 0.0118 0.1759 0.6895
Loa Loa (eye worm) TK protein kinase 0.0034 0.0399 0.1566
Loa Loa (eye worm) hypothetical protein 0.0025 0.0264 0.1036
Onchocerca volvulus Serine\/threonine kinase homolog 0.0105 0.1547 0.6071
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0877 0.3939
Brugia malayi SRC-1 0.0037 0.0458 0.1775
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0012 0.0045 0.0174
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0069 0.097 0.4358
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0065 0.0229
Trypanosoma cruzi metacaspase 5, putative 0.005 0.0668 0.4204
Trichomonas vaginalis cyclins, putative 0.0017 0.0135 0.0476
Trichomonas vaginalis cyclins, putative 0.0017 0.0135 0.0476
Entamoeba histolytica protein kinase, putative 0.009 0.1299 0.833
Plasmodium falciparum phd finger protein, putative 0.0033 0.0391 0.5669
Loa Loa (eye worm) ACC-1 protein 0.0025 0.0264 0.1036
Brugia malayi hypothetical protein 0.0047 0.0612 0.2383
Schistosoma mansoni acetylcholine receptor subunit beta 0.0012 0.0045 0.0174
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0177
Echinococcus multilocularis glycine receptor subunit beta 0.0025 0.0264 0.1165
Echinococcus granulosus cyclins 0.0017 0.0135 0.0583
Schistosoma mansoni troponin I 0.0118 0.1759 0.793
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0877 0.3939
Schistosoma mansoni neurotransmitter gated ion channel 0.0012 0.0045 0.0174
Brugia malayi Troponin family protein 0.0118 0.1759 0.6895
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0632 0.2462
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0025 0.0264 0.1165
Echinococcus multilocularis lysine specific demethylase 5A 0.004 0.0504 0.225
Loa Loa (eye worm) hypothetical protein 0.0025 0.0264 0.1036
Trypanosoma brucei Metacaspase-4 0.005 0.0668 0.4204
Loa Loa (eye worm) hypothetical protein 0.0025 0.0264 0.1036
Onchocerca volvulus 0.0025 0.0264 0.1036
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0025 0.0264 0.1165
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0391 0.1742
Mycobacterium ulcerans UDP-galactopyranose mutase Glf 0.0631 1 1
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0037 0.0458 0.2041
Echinococcus granulosus tar DNA binding protein 0.0063 0.0877 0.3939
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0103 0.0435
Entamoeba histolytica protein kinase, putative 0.003 0.0339 0.1852
Schistosoma mansoni nAChR subunit 0.0025 0.0264 0.1165
Brugia malayi RNA binding protein 0.0063 0.0877 0.3425
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0069 0.097 0.4358
Loa Loa (eye worm) hypothetical protein 0.0118 0.1759 0.6903
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0177
Loa Loa (eye worm) hypothetical protein 0.0014 0.0076 0.03
Loa Loa (eye worm) hypothetical protein 0.0025 0.0264 0.1036
Loa Loa (eye worm) hypothetical protein 0.0033 0.0387 0.1519
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0025 0.0264 0.1013
Loa Loa (eye worm) hypothetical protein 0.007 0.0985 0.3867
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0014 0.0076 0.0317
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0668 0.4068
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0065 0.0229
Echinococcus granulosus caspase 0.0133 0.2 0.9019
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.005 0.0668 0.2601
Brugia malayi hypothetical protein 0.0012 0.0045 0.0151
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0177
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0668 0.4068
Echinococcus multilocularis dual specificity 0.009 0.1299 0.5851
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0065 0.0229
Echinococcus granulosus muscleblind protein 0.0144 0.2179 0.983
Loa Loa (eye worm) hypothetical protein 0.0144 0.2179 0.8551
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0504 0.225
Echinococcus multilocularis oncosphere protein tso22e oncosphere protein tso22d oncosphere protein tso22c oncosphere protein tso22b oncosphere protein tso22 0.0147 0.2216 1
Entamoeba histolytica protein kinase domain containing protein 0.009 0.1299 0.833
Echinococcus granulosus tyrosine protein kinase Fyn 0.0037 0.0458 0.2041
Trypanosoma cruzi polo-like protein kinase, putative 0.0105 0.1547 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0264 0.1036
Echinococcus multilocularis apoptotic protease activating factor 1 0.0047 0.0612 0.274
Loa Loa (eye worm) jmjC domain-containing protein 0.0011 0.003 0.0117
Entamoeba histolytica cyclin family protein 0.0017 0.0135 0.0476
Echinococcus granulosus cyclins 0.0017 0.0135 0.0583
Entamoeba histolytica hypothetical protein 0.0071 0.1005 0.6345
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0177
Plasmodium vivax metacaspase 1, putative 0.005 0.0668 1
Brugia malayi hypothetical protein 0.0012 0.0045 0.0151
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0177
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0025 0.0264 0.1165
Onchocerca volvulus 0.0167 0.2548 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0632 0.2462
Echinococcus multilocularis tyrosine protein kinase Srms 0.0034 0.0399 0.1777
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0103 0.0403
Loa Loa (eye worm) hypothetical protein 0.0057 0.0773 0.3033
Schistosoma mansoni jumonji domain containing protein 0.0086 0.1247 0.5613
Echinococcus granulosus caspase 2 0.0097 0.1422 0.6406
Loa Loa (eye worm) hypothetical protein 0.0025 0.0264 0.1036
Echinococcus granulosus caspase 3 0.0083 0.1189 0.5353
Entamoeba histolytica hypothetical protein 0.0071 0.1005 0.6345
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0025 0.0264 0.1013
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0011 0.0032 0.0116
Schistosoma mansoni troponin t invertebrate 0.0147 0.2216 1
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0668 0.4068
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0668 0.4068
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0025 0.0264 0.1013
Loa Loa (eye worm) hypothetical protein 0.0011 0.003 0.0117
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0025 0.0264 0.1165
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0177
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0025 0.0264 0.1013
Echinococcus multilocularis jumonji domain containing protein 0.0046 0.0601 0.2688
Loa Loa (eye worm) hypothetical protein 0.0014 0.0076 0.03
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0668 0.4068
Loa Loa (eye worm) troponin T 0.007 0.0985 0.3867
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.009 0.1299 0.5099
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1547 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0391 0.3848
Brugia malayi Cyclin, N-terminal domain containing protein 0.0017 0.0135 0.0507
Echinococcus multilocularis tyrosine protein kinase HCK 0.003 0.0339 0.1505
Schistosoma mansoni hypothetical protein 0.0033 0.0387 0.1722
Loa Loa (eye worm) hypothetical protein 0.0025 0.0264 0.1036
Loa Loa (eye worm) hypothetical protein 0.0025 0.0264 0.1036
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0105 0.1547 0.6071
Loa Loa (eye worm) hypothetical protein 0.0014 0.0076 0.03
Brugia malayi jmjC domain containing protein 0.0011 0.003 0.0092
Loa Loa (eye worm) acetylcholine receptor protein 0.0012 0.0045 0.0177
Echinococcus granulosus phd:f box containing protein 0.0011 0.003 0.0106
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1547 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0076 0.03
Trichomonas vaginalis cyclins, putative 0.0017 0.0135 0.0476
Trypanosoma cruzi metacaspase, putative 0.005 0.0668 0.4204
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0025 0.0264 0.1165
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.007 0.0985 0.3867
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0025 0.0264 0.1165
Loa Loa (eye worm) hypothetical protein 0.0014 0.0076 0.03
Schistosoma mansoni cyclin B 0.0017 0.0135 0.0583
Echinococcus multilocularis GPCR, family 2 0.0015 0.0103 0.0435
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0504 0.225
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0177
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0037 0.0458 0.2041
Loa Loa (eye worm) hypothetical protein 0.005 0.0668 0.262
Brugia malayi PHD-finger family protein 0.0033 0.0391 0.1515
Echinococcus granulosus nAChR subunit 0.0025 0.0264 0.1165
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0177
Loa Loa (eye worm) hypothetical protein 0.0017 0.0135 0.0531
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0391 0.1742
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.1547 0.6971
Schistosoma mansoni neurotransmitter gated ion channel 0.0012 0.0045 0.0174
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0065 0.0229
Loa Loa (eye worm) hypothetical protein 0.0025 0.0264 0.1036
Toxoplasma gondii aldehyde dehydrogenase 0.0069 0.097 1
Echinococcus multilocularis muscleblind protein 0.0144 0.2179 0.983
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0014 0.0076 0.0317
Trypanosoma cruzi metacaspase, putative 0.005 0.0668 0.4204
Brugia malayi jmjC domain containing protein 0.0109 0.1606 0.6294
Onchocerca volvulus 0.0012 0.0045 0.0177
Echinococcus granulosus glycine receptor subunit alpha 1 0.0025 0.0264 0.1165
Brugia malayi Cation transporter family protein 0.0025 0.0264 0.1013
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0025 0.0264 0.1013
Trichomonas vaginalis cyclin B, putative 0.0017 0.0135 0.0476
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0391 0.1536
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0133 0.2 0.9019
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0012 0.0045 0.0177
Loa Loa (eye worm) hypothetical protein 0.0025 0.0264 0.1036
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.005 0.0668 0.6787
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0025 0.0264 0.1165
Brugia malayi Cation transporter family protein 0.0025 0.0264 0.1013
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0037 0.0458 0.2041
Echinococcus granulosus glycine receptor subunit beta 0.0025 0.0264 0.1165
Plasmodium falciparum cyclin 0.0017 0.0135 0.1652
Echinococcus granulosus cyclin B3 1 0.0017 0.0135 0.0583
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0391 0.1742
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.005 0.0668 0.2992
Entamoeba histolytica hypothetical protein 0.0014 0.0076 0.008
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0668 0.4068
Echinococcus granulosus glycine receptor subunit alpha 1 0.0025 0.0264 0.1165
Brugia malayi hypothetical protein 0.007 0.0985 0.3852
Brugia malayi Bromodomain containing protein 0.0033 0.0391 0.1515
Schistosoma mansoni nAChR subunit 0.0025 0.0264 0.1165
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0025 0.0264 0.1165
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1547 1
Echinococcus granulosus peregrin 0.0033 0.0391 0.1742
Schistosoma mansoni hypothetical protein 0.0015 0.0103 0.0435
Schistosoma mansoni tsg101-related 0.0064 0.0889 0.3992
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0877 0.3442
Loa Loa (eye worm) hypothetical protein 0.0033 0.0391 0.1536
Schistosoma mansoni nAChR subunit 0.0025 0.0264 0.1165
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0668 0.4068
Loa Loa (eye worm) hypothetical protein 0.0025 0.0264 0.1036
Loa Loa (eye worm) Smad1 0.0009 0.0007 0.0026
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0025 0.0254 0.1474
Trypanosoma cruzi metacaspase 5, putative 0.005 0.0668 0.4204
Onchocerca volvulus 0.0012 0.0045 0.0177
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0025 0.0264 0.1036
Echinococcus granulosus tyrosine protein kinase Fyn 0.0037 0.0458 0.2041
Echinococcus granulosus tyrosine protein kinase Lyn 0.0038 0.047 0.21
Schistosoma mansoni troponin I 0.0118 0.1759 0.793
Echinococcus granulosus tyrosine protein kinase Fyn 0.0037 0.0458 0.2041
Echinococcus multilocularis troponin i 0.0118 0.1759 0.793
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0014 0.0076 0.0275
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.097 0.4358
Trypanosoma cruzi CYC2-like cyclin, putative 0.0017 0.0135 0.0695
Trypanosoma cruzi metacaspase, putative 0.005 0.0668 0.4204
Echinococcus multilocularis cyclins 0.0017 0.0135 0.0583
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0007 0.0026
Brugia malayi protein-tyrosine kinase 0.0034 0.0399 0.1545
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0105 0.1547 1
Loa Loa (eye worm) LGC-31 protein 0.0025 0.0264 0.1036
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0007 0.0026
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0025 0.0264 0.1036
Echinococcus multilocularis cyclins 0.0017 0.0135 0.0583
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1547 1
Schistosoma mansoni nAChR subunit 0.0025 0.0264 0.1165
Brugia malayi hypothetical protein 0.0167 0.2548 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0105 0.1547 0.6971
Echinococcus granulosus tyrosine protein kinase Src42A 0.0037 0.0458 0.2041
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0668 0.4068
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0011 0.0032 0.0014
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0025 0.0264 0.1013
Onchocerca volvulus 0.0017 0.0135 0.0531
Echinococcus granulosus tyrosine kinase 0.0034 0.0399 0.1777
Brugia malayi serine/threonine-protein kinase plk-2 0.0105 0.1547 0.6061
Loa Loa (eye worm) hypothetical protein 0.0025 0.0264 0.1036
Brugia malayi hypothetical protein 0.0012 0.0045 0.0151
Schistosoma mansoni kinase 0.0054 0.072 0.3228
Schistosoma mansoni cyclin B3 0.0017 0.0135 0.0583
Onchocerca volvulus Troponin I homolog 0.0118 0.1759 0.6903
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0025 0.0264 0.1165
Brugia malayi hypothetical protein 0.0012 0.0045 0.0151
Trypanosoma brucei polo-like protein kinase 0.0105 0.1547 1
Brugia malayi jmjC domain containing protein 0.0011 0.003 0.0092
Schistosoma mansoni jumonji domain containing protein 0.0011 0.003 0.0106
Loa Loa (eye worm) hypothetical protein 0.0167 0.2548 1
Schistosoma mansoni hypothetical protein 0.0011 0.0032 0.0116
Trichomonas vaginalis cyclin D, putative 0.0017 0.0135 0.0476
Trypanosoma brucei metacaspase MCA2 0.005 0.0668 0.4204
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0109 0.1606 0.7239
Onchocerca volvulus 0.0025 0.0264 0.1036
Trichomonas vaginalis cyclin B, putative 0.0017 0.0135 0.0476
Schistosoma mansoni troponin I 0.0118 0.1759 0.793
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0103 0.0435
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0025 0.0264 0.1013
Brugia malayi Troponin T 0.007 0.0985 0.3852
Loa Loa (eye worm) jmjC domain-containing protein 0.0011 0.003 0.0117
Loa Loa (eye worm) hypothetical protein 0.0014 0.0076 0.03
Onchocerca volvulus 0.0025 0.0264 0.1036
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0012 0.0045 0.0174
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0632 0.2481
Trypanosoma brucei metacaspase 5, putative 0.005 0.0668 0.4204
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0045 0.0151
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0668 0.4068
Loa Loa (eye worm) hypothetical protein 0.0017 0.0135 0.0531
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0012 0.0045 0.0177
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0025 0.0264 0.1165
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0065 0.0229
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0177
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0668 0.4068
Plasmodium falciparum metacaspase 1 0.005 0.0668 1
Giardia lamblia PHD finger protein 15 0.0033 0.0391 0.1815
Trichomonas vaginalis cyclin A, putative 0.0017 0.0135 0.0476
Echinococcus granulosus apoptotic protease activating factor 1 0.0047 0.0612 0.274
Trypanosoma brucei mitotic cyclin 6 0.0017 0.0135 0.0695
Echinococcus granulosus caspase 8 0.005 0.0668 0.2992
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0032 0.0101
Schistosoma mansoni phd/f-box containing protein 0.0011 0.003 0.0106
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0105 0.1547 0.6971
Brugia malayi hypothetical protein 0.0012 0.0045 0.0151
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0177
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0011 0.003 0.0106
Schistosoma mansoni caspase-7 (C14 family) 0.0133 0.2 0.9019
Schistosoma mansoni nAChR subunit 0.0012 0.0045 0.0174
Echinococcus granulosus cyclin b3 0.0017 0.0135 0.0583
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.0126
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0025 0.0264 0.1165
Onchocerca volvulus 0.0025 0.0264 0.1036
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0135 0.0476
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0045 0.0151
Brugia malayi Cell death protein 3 precursor 0.0097 0.1422 0.557
Schistosoma mansoni hypothetical protein 0.0015 0.0103 0.0435
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0147 0.2216 0.8698
Echinococcus multilocularis JmjC domain containing protein 4 0.0011 0.003 0.0106
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0011 0.0032 0.0023
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.005 0.0668 0.6787
Loa Loa (eye worm) ACC-1 protein 0.0025 0.0264 0.1036
Echinococcus multilocularis cyclin B 0.0017 0.0135 0.0583
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1547 1
Echinococcus granulosus cyclin B 0.0017 0.0135 0.0583
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0025 0.0264 0.1013
Onchocerca volvulus Putative nachr subunit 0.0025 0.0264 0.1036
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0065 0.0229
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0065 0.0229
Plasmodium vivax hypothetical protein, conserved 0.005 0.0668 1
Brugia malayi jmjC domain containing protein 0.0011 0.003 0.0092
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0025 0.0264 0.1165
Loa Loa (eye worm) hypothetical protein 0.0011 0.003 0.0117
Schistosoma mansoni phosphatidylserine receptor 0.0011 0.003 0.0106
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0025 0.0264 0.1036
Schistosoma mansoni caspase-7 (C14 family) 0.0097 0.1422 0.6406
Echinococcus granulosus glycine receptor subunit alpha 1 0.0025 0.0264 0.1165
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0011 0.0032 0.0034
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0065 0.0229
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0504 0.1977
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0069 0.097 0.6195
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0012 0.0045 0.0151
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.0698 0.427
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0177
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0065 0.0229
Onchocerca volvulus 0.0025 0.0264 0.1036
Trichomonas vaginalis cyclin B, putative 0.0017 0.0135 0.0476
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0133 0.2 0.9019
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0012 0.0045 0.0174
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0052 0.07 0.4285
Schistosoma mansoni hypothetical protein 0.0015 0.0103 0.0435
Trichomonas vaginalis cyclin B, putative 0.0017 0.0135 0.0476
Schistosoma mansoni acetylcholine receptor-related 0.0012 0.0045 0.0174
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0065 0.0229
Schistosoma mansoni caspase-3 (C14 family) 0.0133 0.2 0.9019
Trichomonas vaginalis hypothetical protein 0.0037 0.0461 0.2672
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0034 0.0399 0.1777
Loa Loa (eye worm) hypothetical protein 0.0025 0.0264 0.1036
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.097 0.4358
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.1005 0.4519
Schistosoma mansoni nAChR subunit 0.0025 0.0264 0.1165
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0065 0.0229
Onchocerca volvulus 0.0014 0.0076 0.03
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0025 0.0264 0.1165
Trypanosoma brucei metacaspase MCA3 0.005 0.0668 0.4204
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0025 0.0264 0.1165
Echinococcus multilocularis peregrin 0.0033 0.0391 0.1742
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0014 0.0076 0.0275
Entamoeba histolytica cyclin, putative 0.0017 0.0135 0.0476
Echinococcus granulosus tyrosine protein kinase Src64B 0.0037 0.0458 0.2041
Loa Loa (eye worm) hypothetical protein 0.0118 0.1759 0.6903
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0025 0.0264 0.1165
Trichomonas vaginalis cyclin B3, putative 0.0017 0.0135 0.0476
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0025 0.0264 0.1165
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0391 0.5669
Trypanosoma brucei metacaspase 0.005 0.0668 0.4204
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0037 0.0458 0.2041
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0504 0.225
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.005 0.0668 0.6787
Onchocerca volvulus 0.0047 0.0612 0.2402
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0012 0.0045 0.0174
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0065 0.0229
Echinococcus granulosus dual specificity 0.009 0.1299 0.5851
Schistosoma mansoni hypothetical protein 0.0047 0.0612 0.274
Leishmania major cyclin 0.0017 0.0135 0.0695
Schistosoma mansoni tsg101-related 0.0052 0.07 0.3137
Schistosoma mansoni hypothetical protein 0.0118 0.1759 0.793
Schistosoma mansoni troponin I 0.0118 0.1759 0.793
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0877 0.3442
Loa Loa (eye worm) jmjC domain-containing protein 0.0069 0.096 0.3768
Schistosoma mansoni hypothetical protein 0.0033 0.0391 0.1742
Loa Loa (eye worm) hypothetical protein 0.0089 0.1286 0.5049
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0025 0.0264 0.1013
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0025 0.0264 0.1036
Echinococcus multilocularis cyclins 0.0017 0.0135 0.0583
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0025 0.0264 0.1036
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0025 0.0264 0.1165
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0025 0.0264 0.1165
Loa Loa (eye worm) troponin I 0.0118 0.1759 0.6903
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.0698 0.427
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0877 0.3939

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 2 mg kg-1 In vivo effective dose to antagonise cannabinoid receptor 1 agonist (CP-55,940) induced hypotension in rat upon peroral administration ChEMBL. 14736243
ED50 (functional) = 2 mg kg-1 In vivo effective dose to antagonise cannabinoid receptor 1 agonist (CP-55,940) induced hypotension in rat upon peroral administration ChEMBL. 14736243
Kd (functional) = 9 Antagonistic activity towards cannabinoid receptor 1 expressed as [3H]-Arachidonic acid release in CHO cells ChEMBL. 14736243
Ki (binding) = 3.515 nM Affinity to displace CP-55,940 binding from Cannabinoid receptor 2 of human expressed in CHO cells ChEMBL. 14736243
Ki (binding) = 35.9 nM Displacement of CP-55,940 binding from recombinant human cannabinoid receptor 1 expressed in CHO cells ChEMBL. 14736243
Ki (binding) = 35.9 nM Displacement of CP-55,940 binding from recombinant human cannabinoid receptor 1 expressed in CHO cells ChEMBL. 14736243
Ki (binding) = 3515 nM Affinity to displace CP-55,940 binding from Cannabinoid receptor 2 of human expressed in CHO cells ChEMBL. 14736243
LED (functional) = 1 mg kg-1 In vivo least effective dose required to antagonise cannabinoid receptor 1 agonist (WIN-55,212) induced hypothermia in mouse upon peroral administration ChEMBL. 14736243
LED (functional) = 1 mg kg-1 In vivo least effective dose required to antagonise cannabinoid receptor 1 agonist (WIN-55,212) induced hypothermia in mouse upon peroral administration ChEMBL. 14736243
pA2 (functional) = 9 Antagonistic activity towards cannabinoid receptor 1 expressed as [3H]-Arachidonic acid release in CHO cells ChEMBL. 14736243

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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