Detailed information for compound 272952

Basic information

Technical information
  • TDR Targets ID: 272952
  • Name: 5-(4-chlorophenyl)-N'-methyl-4-phenyl-N-[4-(t rifluoromethyl)phenyl]sulfonyl-3,4-dihydropyr azole-2-carboximidamide
  • MW: 520.954 | Formula: C24H20ClF3N4O2S
  • H donors: 1 H acceptors: 2 LogP: 5.52 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: C/N=C(/N1CC(C(=N1)c1ccc(cc1)Cl)c1ccccc1)\NS(=O)(=O)c1ccc(cc1)C(F)(F)F
  • InChi: 1S/C24H20ClF3N4O2S/c1-29-23(31-35(33,34)20-13-9-18(10-14-20)24(26,27)28)32-15-21(16-5-3-2-4-6-16)22(30-32)17-7-11-19(25)12-8-17/h2-14,21H,15H2,1H3,(H,29,31)
  • InChiKey: NMOHILMYXVQGHO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-(4-chlorophenyl)-N'-methyl-4-phenyl-N-[4-(trifluoromethyl)phenyl]sulfonyl-3,4-dihydropyrazole-2-carboxamidine
  • 3-(4-chlorophenyl)-N'-methyl-4-phenyl-N-[4-(trifluoromethyl)phenyl]sulfonyl-2-pyrazoline-1-carboxamidine
  • 3-(4-chlorophenyl)-N'-methyl-4-phenyl-N-[4-(trifluoromethyl)phenyl]sulfonyl-4,5-dihydropyrazole-1-carboximidamide
  • 3-(4-chlorophenyl)-N'-methyl-4-phenyl-N-[4-(trifluoromethyl)phenyl]sulfonyl-4,5-dihydropyrazole-1-carboxamidine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cannabinoid receptor 2 (macrophage) Starlite/ChEMBL References
Homo sapiens cannabinoid receptor 1 (brain) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cyclins 0.0017 0.0135 0.0583
Echinococcus granulosus dual specificity 0.009 0.1299 0.5851
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0034 0.0399 0.1777
Loa Loa (eye worm) hypothetical protein 0.0025 0.0264 0.1036
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0025 0.0264 0.1165
Trypanosoma cruzi metacaspase, putative 0.005 0.0668 0.4204
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0065 0.0229
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0105 0.1547 0.6071
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0065 0.0229
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0025 0.0264 0.1165
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0668 0.4068
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.0126
Plasmodium falciparum metacaspase-like protein 0.005 0.0668 1
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0025 0.0264 0.1036
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0105 0.1547 0.6971
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0012 0.0045 0.0174
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0017 0.0135 0.0695
Loa Loa (eye worm) hypothetical protein 0.0025 0.0264 0.1036
Entamoeba histolytica protein kinase, putative 0.003 0.0339 0.1852
Brugia malayi Troponin I 0.0118 0.1759 0.6895
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.009 0.1299 0.8369
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0065 0.0229
Trypanosoma brucei Metacaspase-4 0.005 0.0668 0.4204
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0065 0.0229
Loa Loa (eye worm) hypothetical protein 0.0089 0.1286 0.5049
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0025 0.0264 0.1165
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0668 0.4068
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0177
Loa Loa (eye worm) hypothetical protein 0.0047 0.0612 0.2402
Echinococcus multilocularis caspase 8 0.005 0.0668 0.2992
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0025 0.0264 0.1165
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0025 0.0264 0.1165
Echinococcus granulosus glycine receptor subunit alpha 1 0.0025 0.0264 0.1165
Onchocerca volvulus 0.0017 0.0135 0.0531
Echinococcus multilocularis cyclins 0.0017 0.0135 0.0583
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0109 0.1606 0.7239
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0025 0.0264 0.1013
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0025 0.0264 0.1165
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0133 0.2 0.9019
Toxoplasma gondii PHD-finger domain-containing protein 0.0011 0.0032 0.0023
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0037 0.0458 0.2041
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0069 0.097 0.4358
Loa Loa (eye worm) SRC-1 0.0037 0.0458 0.1796
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0045 0.0151
Trypanosoma brucei metacaspase 0.005 0.0668 0.4204
Toxoplasma gondii hypothetical protein 0.0013 0.0068 0.0408
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0025 0.0264 0.1036
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.005 0.0668 0.6787
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0103 0.0378
Schistosoma mansoni neurotransmitter gated ion channel 0.0014 0.0076 0.0317
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0017 0.0135 0.0583
Trypanosoma cruzi metacaspase 5, putative 0.005 0.0668 0.4204
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0025 0.0264 0.1165
Loa Loa (eye worm) hypothetical protein 0.0144 0.2179 0.8551
Brugia malayi Cation transporter family protein 0.0025 0.0264 0.1013
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0391 0.5669
Trypanosoma cruzi cyclin, putative 0.0017 0.0135 0.0695
Trichomonas vaginalis cyclin D, putative 0.0017 0.0135 0.0476
Echinococcus granulosus phd:f box containing protein 0.0011 0.003 0.0106
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0014 0.0076 0.0317
Echinococcus granulosus tyrosine protein kinase Fyn 0.0037 0.0458 0.2041
Loa Loa (eye worm) hypothetical protein 0.007 0.0985 0.3867
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0103 0.0435
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0877 0.3939
Loa Loa (eye worm) hypothetical protein 0.0014 0.0076 0.03
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0025 0.0264 0.1013
Trypanosoma cruzi metacaspase 5, putative 0.005 0.0668 0.4204
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0668 0.4068
Loa Loa (eye worm) hypothetical protein 0.0025 0.0264 0.1036
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0065 0.0229
Loa Loa (eye worm) troponin I 0.0118 0.1759 0.6903
Trypanosoma brucei mitotic cyclin 6 0.0017 0.0135 0.0695
Trypanosoma cruzi cyclin 6, putative 0.0017 0.0135 0.0695
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0025 0.0264 0.1165
Schistosoma mansoni cyclin B3 0.0017 0.0135 0.0583
Plasmodium falciparum cyclin 0.0017 0.0135 0.1652
Loa Loa (eye worm) hypothetical protein 0.0014 0.0076 0.03
Brugia malayi Troponin T 0.007 0.0985 0.3852
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0025 0.0264 0.1165
Brugia malayi SRC-1 0.0037 0.0458 0.1775
Loa Loa (eye worm) hypothetical protein 0.0014 0.0076 0.03
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0391 0.1742
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0025 0.0264 0.1013
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0014 0.0076 0.0275
Loa Loa (eye worm) hypothetical protein 0.0118 0.1759 0.6903
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0177
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0668 0.4068
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0668 0.4068
Echinococcus granulosus tyrosine protein kinase Fyn 0.0037 0.0458 0.2041
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0025 0.0264 0.1013
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0025 0.0264 0.1013
Onchocerca volvulus 0.0047 0.0612 0.2402
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0103 0.0435
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0877 0.3939
Loa Loa (eye worm) hypothetical protein 0.0025 0.0264 0.1036
Loa Loa (eye worm) hypothetical protein 0.0025 0.0264 0.1036
Schistosoma mansoni hypothetical protein 0.0015 0.0103 0.0435
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0025 0.0264 0.1013
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0037 0.0458 0.2041
Loa Loa (eye worm) TK protein kinase 0.003 0.0339 0.1331
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0668 0.4068
Loa Loa (eye worm) hypothetical protein 0.0014 0.0076 0.03
Onchocerca volvulus 0.0012 0.0045 0.0177
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0504 0.225
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0014 0.0076 0.0275
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0065 0.0229
Onchocerca volvulus 0.0025 0.0264 0.1036
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0025 0.0264 0.1013
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0135 0.0476
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0177
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0011 0.003 0.0106
Loa Loa (eye worm) hypothetical protein 0.0017 0.0135 0.0531
Schistosoma mansoni nAChR subunit 0.0025 0.0264 0.1165
Trichomonas vaginalis cyclin B, putative 0.0017 0.0135 0.0476
Trichomonas vaginalis cyclins, putative 0.0017 0.0135 0.0476
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0077 0.1096 0.4929
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0025 0.0264 0.1165
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0177
Onchocerca volvulus Alhambra homolog 0.0033 0.0391 0.1536
Loa Loa (eye worm) hypothetical protein 0.0025 0.0264 0.1036
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0025 0.0264 0.1036
Onchocerca volvulus 0.0025 0.0264 0.1036
Schistosoma mansoni nAChR subunit 0.0025 0.0264 0.1165
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0012 0.0045 0.0174
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1547 1
Brugia malayi Protein kinase domain containing protein 0.009 0.1299 0.5087
Loa Loa (eye worm) ACC-1 protein 0.0025 0.0264 0.1036
Loa Loa (eye worm) acetylcholine receptor protein 0.0012 0.0045 0.0177
Brugia malayi TAR-binding protein 0.0063 0.0877 0.3425
Entamoeba histolytica cyclin, putative 0.0017 0.0135 0.0476
Entamoeba histolytica serine/threonine protein kinase, putative 0.0105 0.1547 1
Schistosoma mansoni troponin I 0.0118 0.1759 0.793
Loa Loa (eye worm) hypothetical protein 0.0057 0.0773 0.3033
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.007 0.0985 0.3867
Echinococcus granulosus troponin i 0.0118 0.1759 0.793
Echinococcus multilocularis peregrin 0.0033 0.0391 0.1742
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0877 0.3939
Echinococcus granulosus apoptotic protease activating factor 1 0.0047 0.0612 0.274
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0504 0.225
Echinococcus granulosus glycine receptor subunit alpha 1 0.0025 0.0264 0.1165
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0012 0.0045 0.0151
Loa Loa (eye worm) hypothetical protein 0.0011 0.003 0.0117
Schistosoma mansoni caspase-3 (C14 family) 0.0133 0.2 0.9019
Trichomonas vaginalis cyclin B, putative 0.0017 0.0135 0.0476
Trichomonas vaginalis cyclin A, putative 0.0017 0.0135 0.0476
Loa Loa (eye worm) hypothetical protein 0.0015 0.0103 0.0403
Schistosoma mansoni hypothetical protein 0.0047 0.0612 0.274
Loa Loa (eye worm) troponin T 0.007 0.0985 0.3867
Loa Loa (eye worm) jmjC domain-containing protein 0.0011 0.003 0.0117
Schistosoma mansoni tyrosine kinase 0.0037 0.0458 0.2041
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0065 0.0229
Echinococcus granulosus cyclin b3 0.0017 0.0135 0.0583
Trichomonas vaginalis cyclin B3, putative 0.0017 0.0135 0.0476
Loa Loa (eye worm) hypothetical protein 0.005 0.0668 0.262
Entamoeba histolytica hypothetical protein 0.009 0.1299 0.833
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0177
Echinococcus granulosus tyrosine protein kinase HCK 0.003 0.0339 0.1505
Schistosoma mansoni hypothetical protein 0.0033 0.0391 0.1742
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0025 0.0264 0.1165
Echinococcus multilocularis tyrosine protein kinase HCK 0.003 0.0339 0.1505
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0037 0.0458 0.2041
Entamoeba histolytica hypothetical protein 0.0071 0.1005 0.6345
Brugia malayi Cyclin, N-terminal domain containing protein 0.0017 0.0135 0.0507
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0668 0.4068
Schistosoma mansoni caspase-7 (C14 family) 0.0133 0.2 0.9019
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0012 0.0045 0.0177
Loa Loa (eye worm) hypothetical protein 0.0014 0.0076 0.03
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0504 0.225
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0011 0.0032 0.0023
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0632 0.2481
Echinococcus granulosus GPCR family 2 0.0015 0.0103 0.0435
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0177
Brugia malayi hypothetical protein 0.0012 0.0045 0.0151
Brugia malayi Bromodomain containing protein 0.0033 0.0391 0.1515
Schistosoma mansoni neurotransmitter gated ion channel 0.0012 0.0045 0.0174
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0105 0.1547 0.6971
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0077 0.1096 0.4929
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0025 0.0264 0.1013
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0065 0.0229
Loa Loa (eye worm) hypothetical protein 0.0025 0.0264 0.1036
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.005 0.0668 0.2992
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0025 0.0264 0.1165
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0011 0.0032 0.0034
Loa Loa (eye worm) hypothetical protein 0.0011 0.003 0.0117
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0177
Loa Loa (eye worm) cyclin domain-containing protein 0.0017 0.0135 0.0531
Echinococcus granulosus glycine receptor subunit beta 0.0025 0.0264 0.1165
Echinococcus granulosus tyrosine protein kinase Src64B 0.0037 0.0458 0.2041
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0025 0.0264 0.1165
Toxoplasma gondii aldehyde dehydrogenase 0.0069 0.097 1
Brugia malayi Troponin T 0.007 0.0985 0.3852
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.0698 0.427
Echinococcus multilocularis glycine receptor subunit beta 0.0025 0.0264 0.1165
Echinococcus granulosus lysine specific demethylase 6a 0.0011 0.003 0.0106
Brugia malayi PHD-finger family protein 0.0033 0.0391 0.1515
Onchocerca volvulus Putative nachr subunit 0.0025 0.0264 0.1036
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0177
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0668 0.4068
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0037 0.0458 0.2041
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1547 1
Loa Loa (eye worm) TK protein kinase 0.0034 0.0399 0.1566
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0668 0.4068
Loa Loa (eye worm) Smad1 0.0009 0.0007 0.0026
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0052 0.07 0.4285
Echinococcus granulosus tyrosine protein kinase Fyn 0.0037 0.0458 0.2041
Entamoeba histolytica cyclin family protein 0.0017 0.0135 0.0476
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0877 0.3442
Trypanosoma cruzi cyclin, putative 0.0017 0.0135 0.0695
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0034 0.0399 0.1777
Entamoeba histolytica hypothetical protein 0.0071 0.1005 0.6345
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0037 0.0458 0.2041
Schistosoma mansoni neurotransmitter gated ion channel 0.0012 0.0045 0.0174
Echinococcus granulosus cyclins 0.0017 0.0135 0.0583
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0012 0.0045 0.0151
Echinococcus multilocularis GPCR, family 2 0.0015 0.0103 0.0435
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0012 0.0045 0.0151
Onchocerca volvulus 0.0012 0.0045 0.0177
Brugia malayi Cation transporter family protein 0.0025 0.0264 0.1013
Echinococcus granulosus JmjC domain containing protein 4 0.0011 0.003 0.0106
Brugia malayi hypothetical protein 0.0012 0.0045 0.0151
Trypanosoma brucei metacaspase MCA3 0.005 0.0668 0.4204
Echinococcus granulosus muscleblind protein 0.0144 0.2179 0.983
Echinococcus multilocularis nAChR subunit 0.0014 0.0076 0.0317
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0025 0.0264 0.1013
Echinococcus multilocularis caspase 2 0.0097 0.1422 0.6406
Echinococcus granulosus tyrosine protein kinase Src42A 0.0033 0.0382 0.17
Echinococcus granulosus nAChR subunit 0.0025 0.0264 0.1165
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0025 0.0264 0.1036
Schistosoma mansoni hypothetical protein 0.0118 0.1759 0.793
Loa Loa (eye worm) LGC-31 protein 0.0025 0.0264 0.1036
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1547 1
Brugia malayi Cell death protein 3 precursor 0.0097 0.1422 0.557
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0025 0.0264 0.1036
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0037 0.0458 0.2041
Onchocerca volvulus 0.0167 0.2548 1
Schistosoma mansoni troponin I 0.0118 0.1759 0.793
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0177
Echinococcus granulosus jumonji domain containing 1A 0.0011 0.003 0.0106
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0177
Loa Loa (eye worm) hypothetical protein 0.0014 0.0076 0.03
Brugia malayi hypothetical protein 0.0071 0.1005 0.3929
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0032 0.0101
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0103 0.0435
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.1005 0.4519
Echinococcus multilocularis tyrosine protein kinase Srms 0.0034 0.0399 0.1777
Echinococcus multilocularis cyclin B 0.0017 0.0135 0.0583
Schistosoma mansoni nAChR subunit 0.0025 0.0264 0.1165
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0014 0.0076 0.0275
Echinococcus multilocularis lysine specific demethylase 6a 0.0011 0.003 0.0106
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0668 0.4068
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0045 0.0151
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.005 0.0668 0.6787
Onchocerca volvulus Cell death protein 3 homolog 0.0097 0.1422 0.5581
Leishmania major cyclin 0.0017 0.0135 0.0695
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0105 0.1547 1
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1547 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.0038 0.047 0.21
Loa Loa (eye worm) RNA binding protein 0.0063 0.0877 0.3442
Brugia malayi Troponin T 0.007 0.0985 0.3852
Brugia malayi excitatory GABA receptor EXP-1A 0.0025 0.0264 0.1013
Brugia malayi hypothetical protein 0.0012 0.0045 0.0151
Trypanosoma cruzi metacaspase, putative 0.005 0.0668 0.4204
Schistosoma mansoni hypothetical protein 0.0033 0.0387 0.1722
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.1005 0.4519
Schistosoma mansoni hypothetical protein 0.0015 0.0103 0.0435
Echinococcus granulosus oncosphere protein Tso22e 0.0147 0.2216 1
Echinococcus multilocularis cyclin b3 0.0017 0.0135 0.0583
Schistosoma mansoni nAChR subunit 0.0025 0.0264 0.1165
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0025 0.0264 0.1165
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0632 0.2462
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0011 0.0032 0.0116
Schistosoma mansoni serine/threonine protein kinase 0.009 0.1299 0.5851
Schistosoma mansoni nAChR subunit 0.0025 0.0264 0.1165
Echinococcus multilocularis phd:f box containing protein 0.0011 0.003 0.0106
Brugia malayi jmjC domain containing protein 0.004 0.0504 0.1957
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0037 0.0458 0.2041
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0025 0.0264 0.1013
Echinococcus granulosus tyrosine protein kinase Src42A 0.0037 0.0458 0.2041
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0177
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0391 0.3848
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0668 0.4068
Brugia malayi hypothetical protein 0.0012 0.0045 0.0151
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0103 0.0403
Schistosoma mansoni hypothetical protein 0.0071 0.1005 0.4519
Trichomonas vaginalis cyclins, putative 0.0017 0.0135 0.0476
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0668 0.4068
Schistosoma mansoni tyrosine kinase 0.0037 0.0458 0.2041
Echinococcus multilocularis nAChR subunit 0.0025 0.0264 0.1165
Onchocerca volvulus Troponin I homolog 0.0118 0.1759 0.6903
Trypanosoma cruzi polo-like protein kinase, putative 0.0105 0.1547 1
Trichomonas vaginalis cyclins, putative 0.0017 0.0135 0.0476
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0177
Onchocerca volvulus 0.0014 0.0076 0.03
Entamoeba histolytica protein kinase, putative 0.009 0.1299 0.833
Schistosoma mansoni troponin I 0.0118 0.1759 0.793
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0025 0.0264 0.1165
Loa Loa (eye worm) hypothetical protein 0.0025 0.0264 0.1036
Loa Loa (eye worm) jmjC domain-containing protein 0.0011 0.003 0.0117
Trypanosoma cruzi metacaspase, putative 0.005 0.0668 0.4204
Entamoeba histolytica cyclin family protein 0.0017 0.0135 0.0476
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0011 0.0032 0.0014
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0037 0.0458 0.2041
Schistosoma mansoni phd/f-box containing protein 0.0011 0.003 0.0106
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0045 0.0151
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0007 0.0026
Brugia malayi MH2 domain containing protein 0.0136 0.2044 0.8017
Echinococcus multilocularis cyclins 0.0017 0.0135 0.0583
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0025 0.0264 0.1013
Entamoeba histolytica hypothetical protein 0.0014 0.0076 0.008
Brugia malayi AF-10 protein 0.0011 0.0032 0.0101
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0025 0.0264 0.1013
Echinococcus granulosus cyclin B3 1 0.0017 0.0135 0.0583
Brugia malayi serine/threonine-protein kinase plk-2 0.0105 0.1547 0.6061
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0012 0.0045 0.0177
Brugia malayi Cyclin, N-terminal domain containing protein 0.0017 0.0135 0.0507
Loa Loa (eye worm) hypothetical protein 0.0025 0.0264 0.1036
Brugia malayi hypothetical protein 0.007 0.0985 0.3852
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.009 0.1299 0.8369
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0065 0.0229
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0069 0.097 0.4358
Loa Loa (eye worm) hypothetical protein 0.0025 0.0264 0.1036
Echinococcus multilocularis caspase 0.0133 0.2 0.9019
Echinococcus multilocularis troponin i 0.0118 0.1759 0.793
Loa Loa (eye worm) hypothetical protein 0.0048 0.0632 0.2481
Onchocerca volvulus 0.0014 0.0076 0.03
Brugia malayi Troponin family protein 0.0118 0.1759 0.6895
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0177
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0103 0.0435
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.1547 0.6971
Echinococcus granulosus cyclin B 0.0017 0.0135 0.0583
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0025 0.0264 0.1165
Echinococcus granulosus tar DNA binding protein 0.0063 0.0877 0.3939
Loa Loa (eye worm) hypothetical protein 0.0014 0.0076 0.03
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.0698 0.427
Echinococcus multilocularis oncosphere protein tso22e oncosphere protein tso22d oncosphere protein tso22c oncosphere protein tso22b oncosphere protein tso22 0.0147 0.2216 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0065 0.0229
Loa Loa (eye worm) hypothetical protein 0.0167 0.2548 1
Plasmodium falciparum phd finger protein, putative 0.0033 0.0391 0.5669
Schistosoma mansoni nAChR subunit 0.0012 0.0045 0.0174
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0025 0.0264 0.1165
Echinococcus multilocularis jumonji domain containing 1A 0.0011 0.003 0.0106
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0668 0.4068
Schistosoma mansoni hypothetical protein 0.0011 0.0032 0.0116
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0668 0.4068
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0032 0.0034
Loa Loa (eye worm) hypothetical protein 0.0017 0.0135 0.0531
Echinococcus multilocularis cyclins 0.0017 0.0135 0.0583
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0103 0.0378
Brugia malayi jmjC domain containing protein 0.0011 0.003 0.0092
Echinococcus granulosus caspase 8 0.005 0.0668 0.2992
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0065 0.0229
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1547 1
Trypanosoma brucei metacaspase 5, putative 0.005 0.0668 0.4204
Echinococcus granulosus caspase 2 0.0097 0.1422 0.6406
Brugia malayi jmjC domain containing protein 0.0011 0.003 0.0092
Trypanosoma brucei metacaspase MCA2 0.005 0.0668 0.4204
Echinococcus multilocularis muscleblind protein 0.0144 0.2179 0.983
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0011 0.0032 0.0014
Trichomonas vaginalis cyclins, putative 0.0017 0.0135 0.0476
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0014 0.0076 0.0275
Echinococcus granulosus cyclins 0.0017 0.0135 0.0583
Loa Loa (eye worm) hypothetical protein 0.0033 0.0391 0.1536
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0011 0.003 0.0106
Schistosoma mansoni acetylcholine receptor-related 0.0012 0.0045 0.0174
Brugia malayi hypothetical protein 0.0167 0.2548 1
Loa Loa (eye worm) GABA receptor subunit 0.0014 0.0076 0.03
Loa Loa (eye worm) hypothetical protein 0.0089 0.1286 0.5049
Echinococcus multilocularis glycine receptor subunit beta 0.0025 0.0264 0.1165
Schistosoma mansoni nAChR subunit 0.0025 0.0264 0.1165
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0877 0.3939
Echinococcus granulosus glycine receptor subunit alpha 1 0.0025 0.0264 0.1165
Schistosoma mansoni kinase 0.0054 0.072 0.3228
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0007 0.0026
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0025 0.0264 0.1165
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.097 0.4358
Plasmodium vivax hypothetical protein, conserved 0.005 0.0668 1
Schistosoma mansoni jumonji domain containing protein 0.0086 0.1247 0.5613
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.005 0.0668 0.2601
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0504 0.1977
Echinococcus multilocularis jumonji domain containing protein 0.0046 0.0601 0.2688
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0025 0.0264 0.1013
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0391 0.1536
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0391 0.1742
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0877 0.3425
Leishmania major hypothetical protein, conserved 0.0025 0.0254 0.1474
Brugia malayi Cyclin, N-terminal domain containing protein 0.0017 0.0135 0.0507
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0037 0.0458 0.2041
Giardia lamblia Kinase, PLK 0.0105 0.1547 1
Echinococcus multilocularis caspase 3 0.0083 0.1189 0.5353
Leishmania major metacaspase, putative 0.005 0.0668 0.4204
Loa Loa (eye worm) hypothetical protein 0.0077 0.1096 0.43
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0632 0.2462
Loa Loa (eye worm) hypothetical protein 0.0014 0.0076 0.03
Onchocerca volvulus 0.0025 0.0264 0.1036
Brugia malayi RNA binding protein 0.0063 0.0877 0.3425
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0025 0.0264 0.1165
Schistosoma mansoni cyclins 0.0017 0.0135 0.0583
Echinococcus multilocularis dual specificity 0.009 0.1299 0.5851
Loa Loa (eye worm) hypothetical protein 0.0025 0.0264 0.1036
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0025 0.0254 0.1474
Brugia malayi Muscleblind-like protein 0.0144 0.2179 0.8547
Echinococcus granulosus caspase 0.0133 0.2 0.9019
Echinococcus granulosus caspase 3 0.0083 0.1189 0.5353
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.009 0.1299 0.8369
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0025 0.0264 0.1013
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0877 0.3939
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0109 0.1606 0.7239
Echinococcus multilocularis tyrosine protein kinase Blk 0.0034 0.0399 0.1777
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0033 0.0382 0.17
Loa Loa (eye worm) hypothetical protein 0.0025 0.0264 0.1036
Echinococcus granulosus jumonji domain containing protein 0.0046 0.0601 0.2688
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0012 0.0045 0.0174
Loa Loa (eye worm) hypothetical protein 0.0025 0.0264 0.1036
Brugia malayi jmjC domain containing protein 0.0109 0.1606 0.6294
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0069 0.097 0.6195
Echinococcus granulosus cyclins 0.0017 0.0135 0.0583
Trypanosoma cruzi metacaspase, putative 0.005 0.0668 0.4204
Echinococcus granulosus glycine receptor subunit beta 0.0025 0.0264 0.1165
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0065 0.0229
Entamoeba histolytica hypothetical protein 0.0071 0.1005 0.6345
Brugia malayi hypothetical protein 0.0077 0.1096 0.4286
Loa Loa (eye worm) transcription factor SMAD2 0.0136 0.2044 0.8022
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0147 0.2216 0.8698
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.009 0.1299 0.8369
Plasmodium vivax metacaspase 1, putative 0.005 0.0668 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0105 0.1547 1
Entamoeba histolytica protein kinase, putative 0.009 0.1299 0.833
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0668 0.4068
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0025 0.0254 0.1474
Loa Loa (eye worm) hypothetical protein 0.0097 0.1422 0.5581
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0037 0.0458 0.2041
Onchocerca volvulus 0.0025 0.0264 0.1036
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.005 0.0668 0.6787
Giardia lamblia PHD finger protein 15 0.0033 0.0391 0.1815
Schistosoma mansoni cyclin B 0.0017 0.0135 0.0583
Onchocerca volvulus 0.0012 0.0045 0.0177
Schistosoma mansoni tsg101-related 0.0064 0.0889 0.3992
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0011 0.003 0.0106
Echinococcus multilocularis apoptotic protease activating factor 1 0.0047 0.0612 0.274
Schistosoma mansoni troponin t invertebrate 0.0147 0.2216 1
Echinococcus granulosus tyrosine protein kinase Blk 0.0034 0.0399 0.1777
Loa Loa (eye worm) ACC-1 protein 0.0025 0.0264 0.1036
Loa Loa (eye worm) hypothetical protein 0.0118 0.1759 0.6903
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0025 0.0264 0.1165
Schistosoma mansoni jumonji domain containing protein 0.0011 0.003 0.0106
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0065 0.0229
Schistosoma mansoni tsg101-related 0.0052 0.07 0.3137
Brugia malayi protein-tyrosine kinase 0.0034 0.0399 0.1545
Loa Loa (eye worm) hypothetical protein 0.0025 0.0264 0.1036
Loa Loa (eye worm) hypothetical protein 0.0033 0.0387 0.1519
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0012 0.0045 0.0174
Trichomonas vaginalis hypothetical protein 0.0037 0.0461 0.2672
Onchocerca volvulus 0.0025 0.0264 0.1036
Schistosoma mansoni tsg101-related 0.0064 0.0889 0.3992
Loa Loa (eye worm) hypothetical protein 0.0025 0.0264 0.1036
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0133 0.2 0.9019
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0012 0.0045 0.0174
Plasmodium falciparum metacaspase 1 0.005 0.0668 1
Trichomonas vaginalis cyclins, putative 0.0017 0.0135 0.0476
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0387 0.1497
Trichomonas vaginalis cyclin D, putative 0.0017 0.0135 0.0476
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0025 0.0264 0.1165
Entamoeba histolytica cyclin, putative 0.0017 0.0135 0.0476
Mycobacterium ulcerans UDP-galactopyranose mutase Glf 0.0631 1 1
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.009 0.1299 0.5099
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0177
Schistosoma mansoni hypothetical protein 0.0015 0.0103 0.0435
Echinococcus multilocularis lysine specific demethylase 5A 0.004 0.0504 0.225
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1547 1
Echinococcus multilocularis cyclins 0.0017 0.0135 0.0583
Trichomonas vaginalis cyclin B, putative 0.0017 0.0135 0.0476
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0017 0.0135 0.0583
Schistosoma mansoni caspase-7 (C14 family) 0.0097 0.1422 0.6406
Trichomonas vaginalis cyclin B, putative 0.0017 0.0135 0.0476
Brugia malayi jmjC domain containing protein 0.0011 0.003 0.0092
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0877 0.3442
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.1005 0.4519
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.097 0.4358
Entamoeba histolytica hypothetical protein 0.0071 0.1005 0.6345
Loa Loa (eye worm) hypothetical protein 0.0014 0.0076 0.03
Schistosoma mansoni troponin I 0.0118 0.1759 0.793
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1547 1
Brugia malayi Cation transporter family protein 0.0025 0.0264 0.1013
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0177
Echinococcus granulosus tyrosine kinase 0.0034 0.0399 0.1777
Brugia malayi hypothetical protein 0.0012 0.0045 0.0151
Echinococcus granulosus cyclins 0.0017 0.0135 0.0583
Echinococcus granulosus cyclins 0.0017 0.0135 0.0583
Loa Loa (eye worm) hypothetical protein 0.0025 0.0264 0.1036
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0025 0.0264 0.1165
Trichomonas vaginalis cyclin B, putative 0.0017 0.0135 0.0476
Trypanosoma cruzi CYC2-like cyclin, putative 0.0017 0.0135 0.0695
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0025 0.0264 0.1013
Brugia malayi PHD-finger family protein 0.0011 0.0032 0.0101
Loa Loa (eye worm) jmjC domain-containing protein 0.0011 0.003 0.0117
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0391 0.3848
Echinococcus multilocularis JmjC domain containing protein 4 0.0011 0.003 0.0106
Schistosoma mansoni phosphatidylserine receptor 0.0011 0.003 0.0106
Loa Loa (eye worm) hypothetical protein 0.0025 0.0264 0.1036
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0037 0.0458 0.2041
Loa Loa (eye worm) troponin 0.007 0.0985 0.3867
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0877 0.3939
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0025 0.0264 0.1013
Echinococcus multilocularis cyclin B3 1 0.0017 0.0135 0.0583
Loa Loa (eye worm) hypothetical protein 0.0025 0.0264 0.1036
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0025 0.0264 0.1165
Loa Loa (eye worm) hypothetical protein 0.0025 0.0264 0.1036
Schistosoma mansoni acetylcholine receptor subunit beta 0.0012 0.0045 0.0174
Loa Loa (eye worm) MH2 domain-containing protein 0.0136 0.2044 0.8022
Loa Loa (eye worm) jmjC domain-containing protein 0.0069 0.096 0.3768
Onchocerca volvulus Serine\/threonine kinase homolog 0.0105 0.1547 0.6071
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0025 0.0264 0.1165
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0065 0.0229
Echinococcus multilocularis muscleblind protein 1 0.0144 0.2179 0.983
Brugia malayi jmjC domain containing protein 0.0011 0.003 0.0092
Schistosoma mansoni hypothetical protein 0.0015 0.0103 0.0435
Brugia malayi hypothetical protein 0.0047 0.0612 0.2383
Echinococcus multilocularis cyclins 0.0017 0.0135 0.0583
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0391 0.1742
Echinococcus granulosus peregrin 0.0033 0.0391 0.1742
Loa Loa (eye worm) hypothetical protein 0.0144 0.2179 0.8551
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0014 0.0076 0.0317
Schistosoma mansoni nAChR subunit 0.0025 0.0264 0.1165
Schistosoma mansoni protein phosphatase 2C 0.0011 0.003 0.0106
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0025 0.0264 0.1036
Onchocerca volvulus 0.0025 0.0264 0.1036
Echinococcus multilocularis cyclins 0.0017 0.0135 0.0583
Trypanosoma brucei polo-like protein kinase 0.0105 0.1547 1
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0631 1 1
Entamoeba histolytica protein kinase domain containing protein 0.009 0.1299 0.833
Schistosoma mansoni nAChR subunit 0.0012 0.0045 0.0174
Echinococcus granulosus nAChR subunit 0.0014 0.0076 0.0317

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 8.9 mg kg-1 In vivo effective dose to antagonise cannabinoid receptor 1 agonist (CP-55,940) induced hypotension in rat upon peroral administration ChEMBL. 14736243
ED50 (functional) = 8.9 mg kg-1 In vivo effective dose to antagonise cannabinoid receptor 1 agonist (CP-55,940) induced hypotension in rat upon peroral administration ChEMBL. 14736243
Kd (functional) = 9.3 Antagonistic activity towards cannabinoid receptor 1 expressed as [3H]-Arachidonic acid release in CHO cells ChEMBL. 14736243
Ki (binding) = 221 nM Displacement of CP-55,940 binding from recombinant human cannabinoid receptor 1 expressed in CHO cells ChEMBL. 14736243
Ki (binding) = 221 nM Displacement of CP-55,940 binding from recombinant human cannabinoid receptor 1 expressed in CHO cells ChEMBL. 14736243
Ki (binding) > 1000 nM Affinity to displace CP-55,940 binding from Cannabinoid receptor 2 of human expressed in CHO cells ChEMBL. 14736243
Ki (binding) > 1000 nM Affinity to displace CP-55,940 binding from Cannabinoid receptor 2 of human expressed in CHO cells ChEMBL. 14736243
LED (functional) = 3 mg kg-1 In vivo least effective dose required to antagonise cannabinoid receptor 1 agonist (WIN-55,212) induced hypothermia in mouse upon peroral administration ChEMBL. 14736243
LED (functional) = 3 mg kg-1 In vivo least effective dose required to antagonise cannabinoid receptor 1 agonist (WIN-55,212) induced hypothermia in mouse upon peroral administration ChEMBL. 14736243
pA2 (functional) = 9.3 Antagonistic activity towards cannabinoid receptor 1 expressed as [3H]-Arachidonic acid release in CHO cells ChEMBL. 14736243

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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