Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.002 | 0.0468 | 0.5 |
Trypanosoma brucei | carnitine O-palmitoyltransferase, putative | 0.0034 | 0.0896 | 0.7724 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0034 | 0.0896 | 0.0832 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.1197 | 0.1197 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0023 | 0.0533 | 0.0125 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0188 | 0.5609 | 0.6244 |
Leishmania major | importin beta-1 subunit, putative | 0.0023 | 0.0533 | 0.095 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.1197 | 0.1332 |
Schistosoma mansoni | importin beta-1 | 0.0028 | 0.0695 | 0.0773 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.0695 | 0.5986 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0188 | 0.5609 | 1 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.002 | 0.0468 | 0.0521 |
Brugia malayi | Choline O-acetyltransferase | 0.0034 | 0.0896 | 0.0896 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0034 | 0.0896 | 0.0896 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.1197 | 0.1332 |
Leishmania major | GTP-binding protein, putative | 0.002 | 0.0468 | 0.0835 |
Schistosoma mansoni | choline o-acyltransferase | 0.0034 | 0.0896 | 0.0998 |
Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.002 | 0.0468 | 0.6744 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1197 | 0.1332 |
Leishmania major | carnitine/choline acetyltransferase, putative | 0.0034 | 0.0896 | 0.1598 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.116 | 1 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.0034 | 0.0896 | 0.1598 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0034 | 0.0896 | 0.0998 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0533 | 0.459 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0034 | 0.0896 | 0.0832 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.002 | 0.0468 | 0.0468 |
Schistosoma mansoni | inositol monophosphatase | 0.0043 | 0.116 | 0.1292 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0144 | 0.4276 | 0.476 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.116 | 0.1346 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.1565 | 0.1742 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0188 | 0.5609 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0034 | 0.0896 | 0.0832 |
Trichomonas vaginalis | ran, putative | 0.002 | 0.0468 | 0.4037 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0043 | 0.116 | 1 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.002 | 0.0468 | 0.0468 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 1 | 1 |
Trypanosoma cruzi | carnitine O-acetyltransferase, putative | 0.0034 | 0.0896 | 0.0832 |
Brugia malayi | Inositol-1 | 0.0043 | 0.116 | 0.116 |
Brugia malayi | RNA, U transporter 1 | 0.0079 | 0.2274 | 0.2274 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.1197 | 0.1332 |
Schistosoma mansoni | survival motor neuron protein | 0.0056 | 0.1565 | 0.1742 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0034 | 0.0896 | 0.7724 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0043 | 0.116 | 1 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0038 | 0.1022 | 0.5 |
Schistosoma mansoni | choline o-acyltransferase | 0.0034 | 0.0896 | 0.0998 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.0034 | 0.0896 | 0.0832 |
Brugia malayi | Choline O-acetyltransferase | 0.0034 | 0.0896 | 0.0896 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.8304 | 0.8304 |
Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.002 | 0.0468 | 0.6744 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0188 | 0.5609 | 0.6244 |
Trypanosoma cruzi | choline/carnitine O-acetyltransferase, putative | 0.0034 | 0.0896 | 0.0832 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0034 | 0.0896 | 0.0998 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0695 | 0.0695 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0043 | 0.116 | 0.1292 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0034 | 0.0896 | 0.0832 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0034 | 0.0896 | 0.0896 |
Onchocerca volvulus | 0.0056 | 0.1565 | 1 | |
Trichomonas vaginalis | importin beta-1, putative | 0.0023 | 0.0533 | 0.459 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0275 | 0.8304 | 0.9245 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0043 | 0.116 | 1 |
Brugia malayi | Muscleblind-like protein | 0.0144 | 0.4276 | 0.4276 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0533 | 0.459 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0038 | 0.1022 | 0.5 |
Plasmodium falciparum | importin beta, putative | 0.0028 | 0.0695 | 1 |
Schistosoma mansoni | ran | 0.002 | 0.0468 | 0.0521 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.1197 | 0.1332 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0034 | 0.0896 | 0.0896 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0034 | 0.0896 | 0.0998 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0034 | 0.0896 | 0.0832 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0043 | 0.116 | 1 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.116 | 0.2069 |
Echinococcus granulosus | importin subunit beta 1 | 0.0028 | 0.0695 | 0.0773 |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.0034 | 0.0896 | 0.0832 |
Echinococcus granulosus | muscleblind protein | 0.0144 | 0.4276 | 0.476 |
Schistosoma mansoni | inositol monophosphatase | 0.0043 | 0.116 | 0.1292 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0034 | 0.0896 | 0.7724 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0188 | 0.5609 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1197 | 0.1332 |
Brugia malayi | Importin beta-1 subunit | 0.0028 | 0.0695 | 0.0695 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.4276 | 0.4276 |
Trypanosoma brucei | GTP-binding nuclear protein rtb2, putative | 0.002 | 0.0468 | 0.4037 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0034 | 0.0896 | 0.0896 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0028 | 0.0695 | 0.0773 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.116 | 0.1346 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0028 | 0.0695 | 0.5986 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0297 | 0.8983 | 0.8983 |
Loa Loa (eye worm) | inositol-1 | 0.0043 | 0.116 | 0.116 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.0533 | 0.459 |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | 0.0034 | 0.0896 | 0.7724 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0043 | 0.116 | 0.1292 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1197 | 0.1332 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.0695 | 0.5986 |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.0034 | 0.0896 | 0.0832 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0034 | 0.0896 | 0.0896 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0043 | 0.116 | 0.5 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0034 | 0.0896 | 0.7724 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.002 | 0.0468 | 0.0521 |
Echinococcus multilocularis | snurportin 1 | 0.0297 | 0.8983 | 1 |
Plasmodium vivax | importin-beta 2, putative | 0.0028 | 0.0695 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0056 | 0.1565 | 0.1565 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0043 | 0.116 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0297 | 0.8983 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0896 | 0.0896 |
Echinococcus granulosus | choline O acetyltransferase | 0.0034 | 0.0896 | 0.0998 |
Brugia malayi | hypothetical protein | 0.0275 | 0.8304 | 0.8304 |
Echinococcus granulosus | snurportin 1 | 0.0297 | 0.8983 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0034 | 0.0896 | 0.0832 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.002 | 0.0468 | 0.4037 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0043 | 0.116 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.4276 | 0.4276 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0275 | 0.8304 | 0.9245 |
Schistosoma mansoni | ran | 0.002 | 0.0468 | 0.0521 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.1197 | 0.1197 |
Echinococcus multilocularis | muscleblind protein | 0.0144 | 0.4276 | 0.476 |
Entamoeba histolytica | Ran family GTPase | 0.002 | 0.0468 | 0.4037 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | ND 0 mg kg-1 | The ED50 value of compound was measured for 50% inhibition for analgesia in mice after oral administration by the hot-plate method; Not Determined. | ChEMBL. | 6446605 |
Inhibition (functional) | = 25 % | Analgesia was determined by writhing test in mice after 100 mg/kg oral administration; Range is 25-49%. | ChEMBL. | 6446605 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.