Detailed information for compound 274149

Basic information

Technical information
  • TDR Targets ID: 274149
  • Name: 2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamide
  • MW: 218.252 | Formula: C12H14N2O2
  • H donors: 1 H acceptors: 2 LogP: 0.12 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=O)CN1CC(CC1=O)c1ccccc1
  • InChi: 1S/C12H14N2O2/c13-11(15)8-14-7-10(6-12(14)16)9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,13,15)
  • InChiKey: LYONXVJRBWWGQO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2-oxo-4-phenyl-pyrrolidin-1-yl)acetamide
  • 2-(2-oxo-4-phenyl-1-pyrrolidinyl)acetamide
  • 2-(2-oxo-4-phenyl-pyrrolidin-1-yl)ethanamide
  • 2-(2-keto-4-phenyl-pyrrolidino)acetamide
  • 4-phenylpiracetam
  • 2-(2-keto-4-phenyl-pyrrolidin-1-yl)acetamide
  • 77472-70-9
  • 1-Pyrrolidineacetamide, 2-oxo-4-phenyl-
  • 2-Oxo-4-phenyl-1-pyrrolidineacetamide
  • BRN 5030440
  • 2-(2-Oxo-4-phenyl-pyrrolidin-1-yl)-acetamide
  • BAS 00896741
  • MLS000113218
  • SMR000109123
  • SDCCGMLS-0035015.P002
  • Oprea1_208829
  • Oprea1_429090

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens karyopherin (importin) beta 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi RNase H family protein 0.043 0.2536 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0096 0.0091
Mycobacterium tuberculosis Conserved protein 0.0043 0.0096 0.0289
Mycobacterium ulcerans lipase LipD 0.0043 0.0096 0.5
Brugia malayi beta-lactamase family protein 0.0043 0.0096 0.0219
Schistosoma mansoni phosphoglucomutase 0.043 0.2536 0.2505
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0096 0.5
Brugia malayi Pao retrotransposon peptidase family protein 0.0037 0.0052 0.0043
Loa Loa (eye worm) hypothetical protein 0.0043 0.0096 0.0257
Brugia malayi Pao retrotransposon peptidase family protein 0.0037 0.0052 0.0043
Brugia malayi Zinc knuckle family protein 0.0037 0.0052 0.0043
Leishmania major ribonuclease H1, putative 0.043 0.2536 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.004 0.0075 0.0056
Schistosoma mansoni tyrosine kinase 0.004 0.0075 0.0034
Mycobacterium tuberculosis Conserved protein 0.0043 0.0096 0.0289
Brugia malayi Pao retrotransposon peptidase family protein 0.0037 0.0052 0.0043
Echinococcus multilocularis tyrosine protein kinase Src42A 0.004 0.0075 0.0056
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.217 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.004 0.0075 0.0034
Brugia malayi Pao retrotransposon peptidase family protein 0.0037 0.0052 0.0043
Schistosoma mansoni adapter molecule crk 0.0035 0.0044 0.0002
Brugia malayi RNase H family protein 0.043 0.2536 1
Brugia malayi Tyrosine-protein kinase abl-1 0.004 0.0075 0.0135
Echinococcus granulosus tyrosine protein kinase Fyn 0.004 0.0075 0.0056
Echinococcus multilocularis tyrosine protein kinase Src64B 0.004 0.0075 0.0056
Echinococcus multilocularis RNA directed DNA polymerase 0.0037 0.0052 0.0018
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0037 0.0052 0.0018
Brugia malayi Pao retrotransposon peptidase family protein 0.0037 0.0052 0.0043
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.004 0.0075 0.0056
Brugia malayi Pao retrotransposon peptidase family protein 0.0037 0.0052 0.0043
Plasmodium falciparum importin beta, putative 0.0035 0.0042 0.5
Brugia malayi hypothetical protein 0.0037 0.0052 0.0043
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0037 0.0052 0.0018
Schistosoma mansoni tyrosine kinase 0.004 0.0075 0.0034
Echinococcus granulosus ribonuclease H1 0.043 0.2536 0.4172
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0096 0.0289
Schistosoma mansoni tyrosine kinase 0.004 0.0075 0.0034
Brugia malayi RNA, U transporter 1 0.0099 0.0447 0.1626
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.004 0.0075 0.0056
Trichomonas vaginalis reverse transcriptase [C. elegans], putative 0.0037 0.0052 0.0206
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0037 0.0052 0.0018
Brugia malayi hypothetical protein 0.0037 0.0052 0.0043
Echinococcus multilocularis c src tyrosine kinase 0.004 0.0075 0.0056
Brugia malayi hypothetical protein 0.0037 0.0052 0.0043
Loa Loa (eye worm) hypothetical protein 0.0043 0.0096 0.0257
Trypanosoma brucei SLACS reverse transcriptase, putative 0.0037 0.0052 0.0011
Echinococcus granulosus RNA directed DNA polymerase 0.0037 0.0052 0.0018
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0037 0.0052 0.0018
Echinococcus multilocularis NCK adaptor protein 0.0035 0.0044 0.0004
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0096 0.0055
Onchocerca volvulus 0.0043 0.0096 0.0177
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0096 0.0289
Loa Loa (eye worm) hypothetical protein 0.0035 0.0044 0.001
Brugia malayi hypothetical protein 0.0037 0.0052 0.0043
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0096 0.5
Trichomonas vaginalis ribonuclease H1, putative 0.043 0.2536 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.004 0.0075 0.0056
Echinococcus multilocularis ribonuclease H1 0.043 0.2536 0.4172
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0096 0.0289
Echinococcus multilocularis tyrosine protein kinase Fgr 0.004 0.0075 0.0056
Brugia malayi reverse transcriptase 0.0037 0.0052 0.0043
Toxoplasma gondii ribonuclease HI protein 0.043 0.2536 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0096 0.0257
Brugia malayi Pao retrotransposon peptidase family protein 0.0037 0.0052 0.0043
Trypanosoma brucei ingi protein (ORF1) 0.0466 0.2766 0.2736
Schistosoma mansoni scy1(yeast) protein kinase-like 0.0037 0.0052 0.0011
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0096 0.038
Onchocerca volvulus Ribonuclease H1 homolog 0.043 0.2536 1
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0096 0.0289
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0037 0.0052 0.0018
Brugia malayi Pao retrotransposon peptidase family protein 0.0037 0.0052 0.0043
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0052 0.0011
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.043 0.2536 0.5
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0035 0.0044 0.001
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0096 0.0055
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0037 0.0052 0.0018
Brugia malayi Variant SH3 domain containing protein 0.0035 0.0044 0.0009
Brugia malayi beta-lactamase family protein 0.0043 0.0096 0.0219
Brugia malayi beta-lactamase 0.0043 0.0096 0.0219
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0037 0.0052 0.0018
Toxoplasma gondii ABC1 family protein 0.0043 0.0096 0.0219
Echinococcus multilocularis growth factor receptor bound protein 2 0.0035 0.0044 0.0004
Schistosoma mansoni phosphoglucomutase 0.043 0.2536 0.2505
Loa Loa (eye worm) SRC-1 0.004 0.0075 0.0159
Brugia malayi Pao retrotransposon peptidase family protein 0.0037 0.0052 0.0043
Brugia malayi Pao retrotransposon peptidase family protein 0.0037 0.0052 0.0043
Trypanosoma brucei Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative 0.0037 0.0052 0.0011
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0096 0.038
Echinococcus granulosus NCK adaptor protein 0.0035 0.0044 0.0004
Echinococcus granulosus KRAB A domain containing protein 0.0037 0.0052 0.0018
Echinococcus multilocularis tyrosine protein kinase Fyn 0.004 0.0075 0.0056
Brugia malayi Zinc knuckle family protein 0.0037 0.0052 0.0043
Loa Loa (eye worm) hypothetical protein 0.0043 0.0096 0.0257
Trypanosoma brucei ingi protein (ORF1) 0.0466 0.2766 0.2736
Mycobacterium ulcerans beta-lactamase 0.0043 0.0096 0.5
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0096 0.0289
Trichomonas vaginalis reverse transcriptases, putative 0.0037 0.0052 0.0206
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0096 0.038
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0037 0.0052 0.0018
Loa Loa (eye worm) hypothetical protein 0.0043 0.0096 0.0257
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0096 0.0219
Trypanosoma brucei RNA helicase, putative 0.1611 1 1
Leishmania major hypothetical protein, conserved 0.0043 0.0096 0.038
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0096 0.0289
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0037 0.0052 0.0018
Brugia malayi RNase H family protein 0.043 0.2536 1
Echinococcus granulosus c src tyrosine kinase 0.004 0.0075 0.0056
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0096 0.038
Schistosoma mansoni hypothetical protein 0.0372 0.217 0.2137
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0096 0.5
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.004 0.0075 0.0056
Trypanosoma cruzi ribonuclease H1, putative 0.043 0.2536 1
Brugia malayi Pao retrotransposon peptidase family protein 0.0037 0.0052 0.0043
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0037 0.0052 0.0018
Brugia malayi reverse transcriptase 0.0037 0.0052 0.0043
Trichomonas vaginalis NeSL-1_NeSL reverse transcriptases, putative 0.0037 0.0052 0.0206
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0096 0.0055
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0037 0.0052 0.0018
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0037 0.0052 0.0018
Giardia lamblia Ribonuclease H 0.043 0.2536 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0052 0.0206
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0096 0.0091
Onchocerca volvulus 0.0043 0.0096 0.0177
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.004 0.0075 0.0056
Brugia malayi Sex muscle abnormal protein 5 0.0035 0.0044 0.0009
Trypanosoma cruzi ribonuclease H1, putative 0.043 0.2536 1
Schistosoma mansoni hypothetical protein 0.0037 0.0052 0.0011
Trypanosoma brucei hypothetical protein, conserved 0.0466 0.2766 0.2736
Echinococcus multilocularis snurportin 1 0.0372 0.217 0.3559
Loa Loa (eye worm) beta-lactamase 0.0043 0.0096 0.0257
Mycobacterium ulcerans hypothetical protein 0.0043 0.0096 0.5
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0096 0.038
Echinococcus granulosus tyrosine protein kinase Fyn 0.004 0.0075 0.0056
Schistosoma mansoni nck2/grb4 0.0035 0.0044 0.0002
Mycobacterium leprae Probable lipase LipE 0.0043 0.0096 0.5
Echinococcus granulosus snurportin 1 0.0372 0.217 0.3559
Trichomonas vaginalis esterase, putative 0.0043 0.0096 0.038
Treponema pallidum ribonuclease H (rnhA) 0.043 0.2536 0.5
Trypanosoma brucei ribonuclease H1 0.043 0.2536 0.2505
Trypanosoma brucei SLACS retrotransposable element (part), putative 0.0037 0.0052 0.0011
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0035 0.0044 0.0002
Echinococcus granulosus tyrosine protein kinase Lyn 0.004 0.0075 0.0056
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0466 0.2766 0.2736
Brugia malayi Pao retrotransposon peptidase family protein 0.0037 0.0052 0.0043
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0035 0.0044 0.001
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.1576 1
Trichomonas vaginalis reverse transcriptases, putative 0.0037 0.0052 0.0206
Echinococcus multilocularis tyrosine protein kinase Fyn 0.004 0.0075 0.0056
Entamoeba histolytica hypothetical protein 0.0028 0 0.5
Schistosoma mansoni protein kinase 0.0037 0.0052 0.0011
Echinococcus granulosus tyrosine protein kinase Src42A 0.004 0.0075 0.0056
Schistosoma mansoni growth factor receptor-bound protein 0.0035 0.0044 0.0002
Echinococcus granulosus growth factor receptor bound protein 2 0.0035 0.0044 0.0004
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0037 0.0052 0.0018
Mycobacterium tuberculosis Conserved protein 0.0043 0.0096 0.0289
Brugia malayi Pao retrotransposon peptidase family protein 0.0037 0.0052 0.0043
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0096 0.0289
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0096 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0096 0.0257
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0981 0.602 1
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0096 0.038
Echinococcus granulosus tyrosine protein kinase Fyn 0.004 0.0075 0.0056
Schistosoma mansoni tyrosine kinase 0.004 0.0075 0.0034
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0981 0.602 1
Brugia malayi Variant SH3 domain containing protein 0.0035 0.0044 0.0009
Brugia malayi reverse transcriptase 0.0037 0.0052 0.0043
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0096 0.0257
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.004 0.0075 0.0056
Trypanosoma brucei unspecified product 0.0466 0.2766 0.2736
Onchocerca volvulus 0.0043 0.0096 0.0177
Schistosoma mansoni tyrosine kinase 0.0964 0.591 0.5893
Echinococcus multilocularis tyrosine protein kinase Abl 0.004 0.0075 0.0056
Schistosoma mansoni growth factor receptor-bound protein 0.0035 0.0044 0.0002
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0096 0.038
Schistosoma mansoni hypothetical protein 0.0037 0.0052 0.0011
Brugia malayi SRC-1 0.004 0.0075 0.0135
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0037 0.0052 0.0018
Brugia malayi Pao retrotransposon peptidase family protein 0.0037 0.0052 0.0043
Schistosoma mansoni phosphoglucomutase 0.043 0.2536 0.2505

Activities

Activity type Activity value Assay description Source Reference
Amnesia reversal (functional) = 0 % Ability to reverse electroconvulsive shock (ECS) induced amnesia in mice, after administering intraperitoneally, at a dose of 0.63 mg/kg ChEMBL. 6716406
Amnesia reversal (functional) = 0 % Ability to reverse electroconvulsive shock induced amnesia in mice, after administering intraperitoneally at a dose of 1.25 mg/kg ChEMBL. 6716406
Amnesia reversal (functional) = 0 % Ability to reverse electroconvulsive shock induced amnesia in mice, after administering intraperitoneally at a dose of 2.5 mg/kg ChEMBL. 6716406
Amnesia reversal (functional) = 0 % Ability to reverse electroconvulsive shock induced amnesia in mice, after administering intraperitoneally at a dose of 20.0 mg/kg ChEMBL. 6716406
Amnesia reversal (functional) = 0 % Ability to reverse electroconvulsive shock (ECS) induced amnesia in mice, after administering intraperitoneally, at a dose of 80.0 mg/kg ChEMBL. 6716406
Amnesia reversal (functional) = 0 % Ability to reverse electroconvulsive shock (ECS) induced amnesia in mice, after administering intraperitoneally, at a dose of 0.63 mg/kg ChEMBL. 6716406
Amnesia reversal (functional) = 0 % Ability to reverse electroconvulsive shock induced amnesia in mice, after administering intraperitoneally at a dose of 1.25 mg/kg ChEMBL. 6716406
Amnesia reversal (functional) = 0 % Ability to reverse electroconvulsive shock induced amnesia in mice, after administering intraperitoneally at a dose of 2.5 mg/kg ChEMBL. 6716406
Amnesia reversal (functional) = 0 % Ability to reverse electroconvulsive shock induced amnesia in mice, after administering intraperitoneally at a dose of 20.0 mg/kg ChEMBL. 6716406
Amnesia reversal (functional) = 0 % Ability to reverse electroconvulsive shock (ECS) induced amnesia in mice, after administering intraperitoneally, at a dose of 80.0 mg/kg ChEMBL. 6716406
Amnesia reversal (functional) = 15 % Ability to reverse electroconvulsive shock induced amnesia in mice, after administering intraperitoneally at a dose of 5 mg/kg ChEMBL. 6716406
Amnesia reversal (functional) = 15 % Ability to reverse electroconvulsive shock induced amnesia in mice, after administering intraperitoneally at a dose of 5 mg/kg ChEMBL. 6716406
Potency (functional) = 0.631 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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