Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Angiotensin II receptor (AT-1) type-1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0121 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.0996 | 0.0996 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0335 | 0.1854 | 0.303 |
Loa Loa (eye worm) | hypothetical protein | 0.0625 | 0.4374 | 0.4374 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0236 | 0.0996 | 0.0996 |
Echinococcus multilocularis | integrin alpha ps | 0.0178 | 0.0493 | 0.1109 |
Leishmania major | calpain, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0121 | 0 | 0.5 |
Echinococcus multilocularis | family C2 unassigned peptidase (C02 family) | 0.0335 | 0.1854 | 0.4169 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 0.0493 | 0.0806 |
Trypanosoma brucei | calpain-like protein, putative | 0.0121 | 0 | 0.5 |
Plasmodium vivax | calpain, putative | 0.0121 | 0 | 0.5 |
Schistosoma mansoni | integrin alpha-ps | 0.0371 | 0.2166 | 0.3539 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.0493 | 0.0493 |
Trypanosoma brucei | calpain-like protein, putative | 0.0121 | 0 | 0.5 |
Schistosoma mansoni | integrin alpha-ps | 0.0193 | 0.0626 | 0.1023 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.012 | 0.012 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.1728 | 0.1728 |
Trypanosoma brucei | antigen, putative | 0.0121 | 0 | 0.5 |
Echinococcus multilocularis | calpain A | 0.0335 | 0.1854 | 0.4169 |
Echinococcus granulosus | cathepsin b | 0.0135 | 0.012 | 0.027 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.0681 | 0.0681 |
Echinococcus multilocularis | integrin alpha ps | 0.0371 | 0.2166 | 0.4871 |
Loa Loa (eye worm) | calpain family protein 1 | 0.032 | 0.1728 | 0.1728 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0135 | 0.012 | 0.0196 |
Echinococcus multilocularis | cathepsin b | 0.0135 | 0.012 | 0.027 |
Echinococcus granulosus | integrin alpha ps | 0.0371 | 0.2166 | 0.4871 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C2, putative | 0.0121 | 0 | 0.5 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.032 | 0.1728 | 0.2824 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0135 | 0.012 | 1 |
Echinococcus multilocularis | integrin alpha 3 | 0.0634 | 0.4447 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0135 | 0.012 | 0.0196 |
Brugia malayi | calpain family protein 1 | 0.032 | 0.1728 | 0.2824 |
Echinococcus multilocularis | calpain family protein 1, d | 0.0236 | 0.0996 | 0.224 |
Brugia malayi | calpain family protein 1 | 0.032 | 0.1728 | 0.2824 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0135 | 0.012 | 0.0196 |
Echinococcus granulosus | cathepsin b | 0.0135 | 0.012 | 0.027 |
Loa Loa (eye worm) | hypothetical protein | 0.0284 | 0.1414 | 0.1414 |
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0121 | 0 | 0.5 |
Echinococcus granulosus | integrin alpha ps | 0.0178 | 0.0493 | 0.1109 |
Loa Loa (eye worm) | hypothetical protein | 0.0649 | 0.4579 | 0.4579 |
Echinococcus multilocularis | cathepsin b | 0.0135 | 0.012 | 0.027 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0135 | 0.012 | 0.0196 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0827 | 0.6119 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.0626 | 0.0626 |
Echinococcus granulosus | integrin alpha 3 | 0.0634 | 0.4447 | 1 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.0625 | 0.4374 | 0.7147 |
Schistosoma mansoni | integrin alpha | 0.0827 | 0.6119 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0456 | 0.2907 | 0.2907 |
Trypanosoma brucei | calpain-like protein, putative | 0.0121 | 0 | 0.5 |
Onchocerca volvulus | 0.0199 | 0.0681 | 0.5 | |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0135 | 0.012 | 0.0196 |
Trypanosoma brucei | calpain-like cysteine peptidase, putative | 0.0121 | 0 | 0.5 |
Echinococcus granulosus | family C2 unassigned peptidase C02 family | 0.0335 | 0.1854 | 0.4169 |
Echinococcus multilocularis | integrin alpha ps | 0.0371 | 0.2166 | 0.4871 |
Echinococcus granulosus | calpain A | 0.0335 | 0.1854 | 0.4169 |
Trypanosoma brucei | calpain-like protein, putative | 0.0121 | 0 | 0.5 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0335 | 0.1854 | 0.303 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.2 uM | Inhibitory concentration that gives 50% displacement of specific binding at labeled angiotensin II type 1 receptor in rat adrenal cortical membranes. | ChEMBL. | 12593652 |
IC50 (binding) | = 1.2 uM | Inhibitory concentration that gives 50% displacement of specific binding at labeled angiotensin II type 1 receptor in rat adrenal cortical membranes. | ChEMBL. | 12593652 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.