TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 343.345 | Formula: C19H22NSe+
H donors: 1 H acceptors: 0 LogP: 3.99 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: [Se]1CC2CC(C1)[C@@H]([NH2+][C@@H]2c1ccccc1)c1ccccc1
InChi: 1S/C19H21NSe/c1-3-7-14(8-4-1)18-16-11-17(13-21-12-16)19(20-18)15-9-5-2-6-10-15/h1-10,16-20H,11-13H2/p+1/t16?,17?,18-,19+
InChiKey: BNVNNCWBHSPZAS-YHFFBGSDSA-O

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0188	0.0348
Trypanosoma cruzi	hexose transporter, putative	0.0036	0.0593	0.6969
Schistosoma mansoni	protein kinase	0.0035	0.0584	0.0707
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0188	0.0348
Brugia malayi	RNA, U transporter 1	0.0089	0.1694	0.3071
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0569	0.0684
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0016	0.0188	0.2227
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0045	0.0774	1
Echinococcus granulosus	General substrate transporter	0.01	0.1907	0.2694
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0035	0.0584	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0188	0.0111
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0035	0.0569	0.0885
Plasmodium falciparum	lysine--tRNA ligase	0.0026	0.0385	0.0201
Onchocerca volvulus		0.0016	0.0188	0.0144
Schistosoma mansoni	glucose transport protein	0.0116	0.2243	0.32
Onchocerca volvulus		0.0016	0.0188	0.0144
Brugia malayi	Sugar transporter family protein	0.0016	0.0188	0.0144
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.004	0.0688	0.9608
Toxoplasma gondii	sugar transporter ST3	0.0016	0.0188	0.0134
Schistosoma mansoni	protein kinase	0.0035	0.0584	0.0707
Echinococcus multilocularis	ubiquitin conjugating enzyme E2 N	0.0042	0.0709	0.0894
Trypanosoma cruzi	glucose transporter, putative	0.0016	0.0188	0.0184
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0022	0.0305	0.938
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0035	0.0584	0.0707
Giardia lamblia	Lysyl-tRNA synthetase	0.0026	0.0385	0.5182
Echinococcus granulosus	carboxylesterase 5A	0.0075	0.1403	0.1937
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1403	0.1937
Leishmania major	ubiquitin-conjugating enzyme e2, putative	0.0042	0.0709	1
Echinococcus multilocularis	snurportin 1	0.0335	0.6768	1
Brugia malayi	Major Facilitator Superfamily protein	0.0016	0.0188	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0569	0.0684
Echinococcus granulosus	dna polymerase eta	0.0016	0.0177	0.0095
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0116	0.2243	0.32
Onchocerca volvulus		0.0016	0.0188	0.0144
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0016	0.0188	0.0111
Brugia malayi	Ubiquitin conjugating enzyme protein 13	0.0042	0.0709	0.1156
Toxoplasma gondii	lysine-tRNA ligase	0.0026	0.0385	0.0437
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0188	0.0348
Trypanosoma cruzi	sugar transporter, putative	0.0016	0.0188	0.0184
Leishmania major	hypothetical protein, conserved	0.0016	0.0188	0.0207
Echinococcus granulosus	lamin dm0	0.0029	0.0458	0.0517
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0023	0.0329	0.0323
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0035	0.0584	0.0404
Brugia malayi	Carboxylesterase family protein	0.0075	0.1403	0.2505
Schistosoma mansoni	sugar transporter	0.0016	0.0188	0.0111
Loa Loa (eye worm)	ubiquitin conjugating enzyme protein 13	0.0042	0.0709	0.0894
Schistosoma mansoni	hypothetical protein	0.0335	0.6768	1
Schistosoma mansoni	sugar transporter	0.0016	0.0188	0.0111
Echinococcus granulosus	solute carrier family 22	0.0016	0.0188	0.0111
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0188	0.0348
Echinococcus granulosus	solute carrier family 22	0.0016	0.0188	0.0111
Brugia malayi	ubiquitin conjugating enzyme protein 13	0.0042	0.0709	0.1156
Onchocerca volvulus		0.0016	0.0188	0.0144
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0035	0.0584	0.0743
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0188	0.0348
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0188	0.0348
Trichomonas vaginalis	glucose transporter, putative	0.0036	0.0593	0.2252
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0435	0.0482
Onchocerca volvulus		0.0016	0.0188	0.0144
Schistosoma mansoni	serine/threonine protein kinase	0.0035	0.0584	0.0707
Schistosoma mansoni	protein kinase	0.0035	0.0584	0.0707
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0014	0.0144	0.0046
Brugia malayi	lysyl-tRNA synthetase	0.0026	0.0385	0.0528
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0016	0.0188	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0188	0.0111
Schistosoma mansoni	glucose transport protein	0.0116	0.2243	0.32
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0447	0.05
Brugia malayi	hypothetical protein	0.0016	0.0188	0.0144
Trypanosoma brucei	sugar transporter, putative	0.0016	0.0188	0.2227
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0035	0.0569	0.0684
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0188	0.0348
Trypanosoma brucei	importin beta-1 subunit, putative	0.0031	0.05	0.6358
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0188	0.0111
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.004	0.0688	0.8554
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0116	0.2243	0.32
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0335	0.6768	1
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0188	0.0111
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0045	0.0774	1
Brugia malayi	Pax transcription factor protein 2	0.0262	0.5259	1
Schistosoma mansoni	importin beta-1	0.0031	0.05	0.058
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0116	0.2243	0.32
Brugia malayi	Cam kinase protein 1	0.0035	0.0584	0.0914
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0188	0.0348
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0035	0.0584	0.0743
Loa Loa (eye worm)	acetylcholinesterase 1	0.0075	0.1403	0.1937
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0188	0.0111
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0035	0.0584	0.0404
Echinococcus granulosus	acetylcholinesterase	0.0075	0.1403	0.1937
Brugia malayi	Intermediate filament tail domain containing protein	0.0029	0.0458	0.0668
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0016	0.0188	0.5781
Plasmodium vivax	importin-beta 2, putative	0.0031	0.05	0.0318
Trypanosoma brucei	DNA polymerase kappa, putative	0.0045	0.0774	1
Trichomonas vaginalis	CAMK family protein kinase	0.0035	0.0584	0.2208
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0188	0.0111
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0023	0.0329	0.0323
Schistosoma mansoni	sugar transporter	0.0016	0.0188	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0458	0.0517
Trypanosoma cruzi	hexose transporter, putative	0.0036	0.0593	0.6969
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0188	0.0348
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0188	0.0348
Brugia malayi	Major Facilitator Superfamily protein	0.0016	0.0188	0.0144
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0188	0.0348
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0035	0.0584	0.0707
Mycobacterium ulcerans	integral membrane transport protein	0.0016	0.0188	0.1238
Brugia malayi	Major Facilitator Superfamily protein	0.0016	0.0188	0.0144
Leishmania major	glucose transporter, lmgt1	0.0036	0.0593	0.7828
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.004	0.0688	0.0902
Echinococcus multilocularis	dna polymerase kappa	0.0045	0.0774	0.0993
Trypanosoma brucei	glucose transporter, putative	0.0036	0.0593	0.76
Loa Loa (eye worm)	intermediate filament protein	0.0029	0.0458	0.0517
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0035	0.0569	0.0684
Echinococcus multilocularis	lysyl tRNA synthetase	0.0026	0.0385	0.0408
Trypanosoma brucei	unspecified product	0.0011	0.0076	0.0743
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.004	0.0688	0.8855
Entamoeba histolytica	hypothetical protein	0.0026	0.0385	0.3921
Trypanosoma cruzi	ubiquitin-conjugating enzyme E2, putative	0.0042	0.0709	0.8903
Loa Loa (eye worm)	ubiquitin conjugating enzyme protein 13	0.0042	0.0709	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0036	0.0593	0.2252
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0014	0.0146	0.0049
Echinococcus multilocularis	dna polymerase eta	0.0016	0.0177	0.0095
Echinococcus granulosus	calcium dependent protein kinase	0.0033	0.0539	0.0638
Entamoeba histolytica	Ran family GTPase	0.0023	0.0329	0.285
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0188	0.0111
Trypanosoma brucei	importin beta-1 subunit, putative	0.0031	0.05	0.6358
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0035	0.0584	0.7476
Schistosoma mansoni	ubiquitin conjugating enzyme 13	0.0042	0.0709	0.0894
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.004	0.0688	0.9608
Echinococcus multilocularis	lamin dm0	0.0029	0.0458	0.0517
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0188	0.0348
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0016	0.0188	0.1238
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0116	0.2243	0.32
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0026	0.0385	0.349
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0035	0.0584	0.0707
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0116	0.2243	0.32
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0188	0.0111
Toxoplasma gondii	sugar transporter ST1	0.0016	0.0188	0.0134
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0026	0.0385	0.3046
Toxoplasma gondii	transporter, major facilitator family protein	0.0016	0.0188	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0133	0.0029
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0377	0.1236
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0029	0.0458	0.0517
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0035	0.0584	0.0404
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0035	0.0584	0.0404
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0188	0.0348
Schistosoma mansoni	lysyl-tRNA synthetase	0.0026	0.0385	0.0408
Toxoplasma gondii	protein kinase, putative	0.0327	0.6607	1
Trichomonas vaginalis	glucose transporter, putative	0.0016	0.0188	0.0348
Giardia lamblia	Prolyl-tRNA synthetase	0.0035	0.0569	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0016	0.0177	0.5442
Leishmania major	myo-inositol/proton symporter (MIT)	0.0016	0.0188	0.0207
Trichomonas vaginalis	ubiquitin-conjugating enzyme E2, putative	0.0042	0.0709	0.2795
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0035	0.0569	0.0885
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0014	0.0144	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0188	0.0111
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0045	0.0774	1
Giardia lamblia	DINP protein human, muc B family	0.0023	0.0325	0.36
Plasmodium falciparum	ubiquitin-conjugating enzyme E2 N, putative	0.0042	0.0709	0.0531
Toxoplasma gondii	sugar transporter ST2	0.0016	0.0188	0.0134
Plasmodium falciparum	proline--tRNA ligase	0.004	0.0688	0.051
Trypanosoma cruzi	hexose transporter, putative	0.0016	0.0188	0.0184
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0188	0.0348
Schistosoma mansoni	hypothetical protein	0.0184	0.3659	0.5328
Echinococcus multilocularis	importin subunit beta 1	0.0031	0.05	0.058
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0188	0.0348
Trichomonas vaginalis	ran, putative	0.0023	0.0329	0.1009
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0187	0.3715	0.3595
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0325	0.4045
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0023	0.0329	0.2538
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0016	0.0188	0.0111
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0491	1	1
Brugia malayi	polk-prov protein	0.0034	0.055	0.0848
Echinococcus granulosus	lysyl tRNA synthetase	0.0026	0.0385	0.0408
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0026	0.0385	0.4845
Plasmodium falciparum	hexose transporter	0.0116	0.2243	0.2094
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0188	0.0348
Plasmodium vivax	hexose transporter	0.0116	0.2243	0.2094
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0045	0.0774	1
Schistosoma mansoni	lamin	0.0029	0.0458	0.0517
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0188	0.0348
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0187	0.3715	0.5555
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0016	0.0177	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0188	0.0111
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0026	0.0385	0.1276
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0023	0.0329	0.3688
Onchocerca volvulus		0.0016	0.0188	0.0144
Onchocerca volvulus		0.0016	0.0188	0.0144
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0016	0.0177	0.0095
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0023	0.0329	0.0323
Trichomonas vaginalis	myo-inositol transporter, putative	0.0016	0.0188	0.0348
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.0584	0.0707
Trypanosoma brucei	glucose transporter, putative	0.0036	0.0593	0.76
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0188	0.0111
Brugia malayi	Sugar transporter family protein	0.0116	0.2243	0.4138
Trypanosoma brucei	DNA polymerase kappa, putative	0.0045	0.0774	1
Echinococcus granulosus	ubiquitin conjugating enzyme E2 N	0.0042	0.0709	0.0894
Trypanosoma brucei	glucose transporter 2A	0.0036	0.0593	0.76
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0036	0.0593	0.76
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0036	0.0593	0.76
Trypanosoma brucei	DNA polymerase IV, putative	0.0038	0.0626	0.8035
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0016	0.0188	0.5
Trypanosoma brucei	glucose transporter, putative	0.0036	0.0593	0.76
Schistosoma mansoni	sugar transporter	0.0016	0.0188	0.0111
Trypanosoma brucei	unspecified product	0.0011	0.0076	0.0743
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.004	0.0688	0.8554
Trypanosoma cruzi	ubiquitin-conjugating enzyme E2, putative	0.0042	0.0709	0.8903
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0188	0.0348
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0144	0.0046
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0188	0.0348
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.2243	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0045	0.0774	1
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0188	0.0348
Toxoplasma gondii	HEAT repeat-containing protein	0.0031	0.05	0.0613
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.032	0.0967
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0016	0.0188	0.0111
Entamoeba histolytica	protein kinase, putative	0.0035	0.0584	0.7652
Plasmodium vivax	lysine--tRNA ligase, putative	0.0026	0.0385	0.0201
Schistosoma mansoni	glucose transport protein	0.0116	0.2243	0.32
Schistosoma mansoni	DNA polymerase eta	0.0016	0.0177	0.0095
Onchocerca volvulus		0.0016	0.0188	0.0144
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0023	0.0329	0.0143
Schistosoma mansoni	glucose transporter	0.0016	0.0188	0.0111
Echinococcus granulosus	importin subunit beta 1	0.0031	0.05	0.058
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0188	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0188	0.0111
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0188	0.0348
Trypanosoma brucei	glucose transporter, putative	0.0036	0.0593	0.76
Leishmania major	glucose transporter, lmgt3	0.0036	0.0593	0.7828
Trypanosoma cruzi	hexose transporter	0.0036	0.0593	0.6969
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0035	0.0584	0.0404
Echinococcus multilocularis	acetylcholinesterase	0.0075	0.1403	0.1937
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0188	0.0348
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0116	0.2243	0.32
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0188	0.0111
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0016	0.0188	0.1238
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0177	0.0095
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0116	0.2243	0.32
Brugia malayi	ImpB/MucB/SamB family protein	0.0016	0.0177	0.0123
Trypanosoma brucei	DNA polymerase kappa, putative	0.0018	0.0224	0.2708
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0036	0.0593	0.76
Echinococcus granulosus	solute carrier family 22	0.0016	0.0188	0.0111
Echinococcus granulosus	solute carrier family 22	0.0016	0.0188	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1403	0.1937
Plasmodium falciparum	protein kinase 7	0.0327	0.6607	0.6542
Onchocerca volvulus		0.0016	0.0188	0.0144
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0023	0.0329	0.0143
Trypanosoma brucei	DNA polymerase kappa, putative	0.0034	0.055	0.7027
Treponema pallidum	prolyl-tRNA synthetase	0.0012	0.0105	0.5
Trypanosoma cruzi	hexose transporter, putative	0.0036	0.0593	0.6969
Entamoeba histolytica	hypothetical protein	0.0025	0.0377	0.3763
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0023	0.0329	0.0417
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0035	0.0584	0.0914
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0013	0.0114	0.35
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0035	0.0584	0.0707
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0026	0.0385	0.4189
Trypanosoma brucei	DNA polymerase eta, putative	0.0016	0.0177	0.2081
Toxoplasma gondii	ubiquitin-conjugating enzyme subfamily protein	0.0042	0.0709	0.0934
Brugia malayi	Sugar transporter family protein	0.0016	0.0188	0.0144
Echinococcus granulosus	geminin	0.0184	0.3659	0.5328
Trichomonas vaginalis	ubiquitin-conjugating enzyme E2, putative	0.0042	0.0709	0.2795
Trypanosoma brucei	DNA polymerase kappa, putative	0.0045	0.0774	1
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0035	0.0584	0.0404
Trichomonas vaginalis	sugar transport protein, putative	0.0016	0.0188	0.0348
Schistosoma mansoni	ran	0.0023	0.0329	0.0323
Brugia malayi	hypothetical protein	0.0016	0.0188	0.0144
Trypanosoma brucei	unspecified product	0.0038	0.0626	0.8035
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0188	0.0348
Trypanosoma brucei	DNA polymerase kappa, putative	0.0045	0.0774	1
Echinococcus granulosus	intermediate filament protein	0.0029	0.0458	0.0517
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0377	0.1236
Trypanosoma brucei	DNA polymerase IV, putative	0.0045	0.0774	1
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.0584	0.0707
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0188	0.0348
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0035	0.0569	0.7373
Echinococcus multilocularis	geminin	0.0184	0.3659	0.5328
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0016	0.0176	0.0094
Trichomonas vaginalis	importin beta-1, putative	0.0025	0.0377	0.1236
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0188	0.0348
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0116	0.2243	0.32
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0035	0.0584	0.0404
Plasmodium falciparum	importin beta, putative	0.0031	0.05	0.0318
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0188	0.0111
Brugia malayi	hypothetical protein	0.0016	0.0188	0.0144
Trypanosoma brucei	glucose transporter, putative	0.0036	0.0593	0.76
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0187	0.3715	0.3595
Echinococcus granulosus	synaptic vesicle 2 protein	0.0016	0.0188	0.0111
Mycobacterium ulcerans	DNA polymerase IV	0.0045	0.0774	1
Leishmania major	DNA polymerase kappa, putative	0.0023	0.0325	0.2787
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0188	0.0348
Echinococcus multilocularis	carboxylesterase 5A	0.0075	0.1403	0.1937
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0188	0.0348
Trypanosoma brucei	DNA polymerase kappa, putative	0.0045	0.0774	1
Echinococcus multilocularis	acetylcholinesterase	0.0075	0.1403	0.1937
Loa Loa (eye worm)	pax transcription factor protein 2	0.0262	0.5259	0.7733
Echinococcus granulosus	snurportin 1	0.0335	0.6768	1
Onchocerca volvulus		0.0029	0.0458	0.0668
Brugia malayi	ImpB/MucB/SamB family protein	0.0016	0.0177	0.0123
Schistosoma mansoni	intermediate filament proteins	0.0029	0.0458	0.0517
Trypanosoma brucei	DNA polymerase kappa, putative	0.0018	0.0224	0.2708
Brugia malayi	intermediate filament protein	0.0029	0.0458	0.0668
Echinococcus multilocularis	General substrate transporter	0.01	0.1907	0.2694
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0188	0.0111
Toxoplasma gondii	facilitative glucose transporter GT1	0.0116	0.2243	0.3292
Onchocerca volvulus		0.0262	0.5259	1
Mycobacterium ulcerans	DNA polymerase IV	0.0045	0.0774	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0188	0.0111
Brugia malayi	Carboxylesterase family protein	0.0075	0.1403	0.2505
Brugia malayi	cytoplasmic intermediate filament protein	0.0016	0.0176	0.0122
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0016	0.0177	0.0095
Loa Loa (eye worm)	sugar transporter	0.0016	0.0188	0.0111
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0016	0.0188	0.0111
Trypanosoma brucei	glucose transporter 1E	0.0036	0.0593	0.76
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0188	0.0348
Echinococcus multilocularis	lamin	0.0029	0.0458	0.0517
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0385	0.0408
Echinococcus granulosus	acetylcholinesterase	0.0075	0.1403	0.1937
Leishmania major	protein kinase, putative	0.0035	0.0584	0.7652
Schistosoma mansoni	ran	0.0023	0.0329	0.0323
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0035	0.0584	0.0707
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0188	0.0348
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0188	0.0348
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0013	0.0114	0.35
Trypanosoma brucei	DNA polymerase kappa, putative	0.0045	0.0774	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0018	0.0224	0.2708
Onchocerca volvulus		0.0016	0.0188	0.0144
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0188	0.0348
Plasmodium vivax	ubiquitin-conjugating enzyme E2 N, putative	0.0042	0.0709	0.0531
Entamoeba histolytica	ubiquitin-conjugating enzyme family protein	0.0042	0.0709	1
Schistosoma mansoni	hypothetical protein	0.0184	0.3659	0.5328
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0035	0.0584	0.0404
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0023	0.0329	0.2538
Schistosoma mansoni	lamin	0.0029	0.0458	0.0517
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0584	0.0707
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0035	0.0569	0.2139
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0025	0.0377	0.335
Brugia malayi	Importin beta-1 subunit	0.0031	0.05	0.075
Onchocerca volvulus	Putative transporter	0.0016	0.0188	0.0144
Trypanosoma brucei	glucose transporter, putative	0.0036	0.0593	0.76
Brugia malayi	major facilitator superfamily protein	0.0016	0.0188	0.0144
Trypanosoma brucei	glucose transporter, putative	0.0036	0.0593	0.76
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0016	0.0188	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0133	0.0029
Plasmodium vivax	proline--tRNA ligase, putative	0.004	0.0688	0.051
Echinococcus multilocularis	calcium dependent protein kinase	0.0033	0.0539	0.0638
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0013	0.0114	0.35
Entamoeba histolytica	protein kinase, putative	0.0035	0.0584	0.7652
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0593	0.2252
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0026	0.0385	0.4189
Trypanosoma brucei	glucose transporter, putative	0.0036	0.0593	0.76
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0023	0.0329	0.035
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0188	0.0111
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0188	0.0348
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0035	0.0569	0.0684
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0593	0.2252
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0035	0.0569	0.0684
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0188	0.0348
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0188	0.0348
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0188	0.0348
Trypanosoma cruzi	hexose transporter, putative	0.002	0.0257	0.1342
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0022	0.0305	0.938
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0045	0.0774	0.3103
Trypanosoma brucei	DNA polymerase kappa, putative	0.0034	0.055	0.7027
Onchocerca volvulus		0.0016	0.0188	0.0144
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.0584	0.0707
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0023	0.0329	0.409
Mycobacterium ulcerans	sugar transporter	0.0016	0.0188	0.1238
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0016	0.0177	0.0095
Chlamydia trachomatis	lysine--tRNA ligase	0.0026	0.0385	1
Mycobacterium ulcerans	carboxylesterase, LipT	0.0013	0.0114	0.013
Onchocerca volvulus		0.0016	0.0188	0.0144
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0023	0.0325	0.2787
Trichomonas vaginalis	DNA polymerase eta, putative	0.0045	0.0774	0.3103
Loa Loa (eye worm)	hypothetical protein	0.0034	0.055	0.0656
Echinococcus granulosus	dna polymerase kappa	0.0045	0.0774	0.0993
Trichomonas vaginalis	sugar transporter, putative	0.0036	0.0593	0.2252
Onchocerca volvulus		0.0016	0.0188	0.0144
Trypanosoma brucei	DNA polymerase kappa, putative	0.0045	0.0774	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.05	0.058
Loa Loa (eye worm)	sugar transporter	0.0116	0.2243	0.32
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0188	0.0348
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0075	0.1403	0.1937
Trypanosoma brucei	ubiquitin-protein ligase, putative	0.0042	0.0709	0.9131
Leishmania major	importin beta-1 subunit, putative	0.0025	0.0377	0.3763
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0035	0.0584	0.0707
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.0584	0.0707
Onchocerca volvulus		0.0016	0.0188	0.0144
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0035	0.0584	0.0743
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0188	0.0348
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0035	0.0569	1
Leishmania major	lysyl-tRNA synthetase, putative	0.0026	0.0385	0.3921
Trypanosoma brucei	DNA polymerase IV, putative	0.0045	0.0774	1
Onchocerca volvulus		0.0029	0.0458	0.0668
Trypanosoma brucei	DNA polymerase kappa, putative	0.0045	0.0774	1
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0036	0.0593	0.7828
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0188	0.0348
Leishmania major	GTP-binding protein, putative	0.0023	0.0329	0.285
Onchocerca volvulus		0.0016	0.0188	0.0144
Echinococcus granulosus	lamin	0.0029	0.0458	0.0517
Echinococcus multilocularis	musashi	0.0029	0.0458	0.0517
Loa Loa (eye worm)	carboxylesterase	0.0075	0.1403	0.1937
Leishmania major	glucose transporter, lmgt2	0.0036	0.0593	0.7828
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0023	0.0325	1
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0188	0.0348
Schistosoma mansoni	lysyl-tRNA synthetase	0.0026	0.0385	0.0408
Schistosoma mansoni	hypothetical protein	0.0116	0.2243	0.32
Onchocerca volvulus		0.0016	0.0188	0.0144
Trichomonas vaginalis	glucose transporter, putative	0.0036	0.0593	0.2252
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0188	0.0348
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0016	0.0188	0.5781
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0016	0.0177	0.0095
Trichomonas vaginalis	sugar transporter, putative	0.0036	0.0593	0.2252
Brugia malayi	major facilitator superfamily protein	0.0016	0.0188	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0188	0.0111

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 270 beats min-1	Tested for Sustained ventricular tacycardia in dogs at a dose of 3 mg/kg Expt-2	ChEMBL.	3572967
Activity (functional)	= 280 beats min-1	Tested for Sustained ventricular tacycardia in dogs at a dose of 6 mg/kg Expt-2	ChEMBL.	3572967
Effect (functional)	SL 0	Relative effect of the compound on normal sinus rate in dogs;Slight decerease	ChEMBL.	3572967
Effect (functional)	SL 0	Relative effect of the compound on normal sinus rate in dogs;Slight increase	ChEMBL.	3572967
Effect (functional)	NC 0	Relative effect of the compound on mean blood pressure in dogs;NC=no change in mean BP	ChEMBL.	3572967
Effect (functional)	mod 0	Relative effect of the compound on mean blood pressure in dogs; Moderate change in mean BP	ChEMBL.	3572967
Effect (functional)	0	Relative effect of the compound on abolition of ventricular tachycardia in dogs	ChEMBL.	3572967
Effect (functional)	0	Relative effect of the compound on slowing of ventricular tachycardia in dogs; slowing of VT	ChEMBL.	3572967
Effect (functional)	0	Relative effect of the compound on exacerbation of ventricular tachycardia in dogs; exacerbation of VT	ChEMBL.	3572967
MBP (functional)	= 20	Tested for mean blood pressure with ventricular tachycardia in dogs at a dose of 6 mg/kg Expt-2	ChEMBL.	3572967
MBP (functional)	= 30	Tested for mean blood pressure with ventricular tachycardia in dogs at a dose of 3 mg/kg Expt-2	ChEMBL.	3572967
MBP (functional)	= 80	Tested for mean blood pressure without ventricular tachycardia in dogs at a dose of 6 mg/kg Expt-2	ChEMBL.	3572967
MBP (functional)	= 82	Tested for mean blood pressure without ventricular tachycardia in dogs at a dose of 3 mg/kg Expt-2	ChEMBL.	3572967
MBP (functional)	= 125	Tested for mean blood pressure without ventricular tachycardia in dogs at a dose of 3 mg/kg Expt-1	ChEMBL.	3572967
MBP (functional)	= 125	Tested for mean blood pressure without ventricular tachycardia in dogs at a dose of 6 mg/kg Expt-1	ChEMBL.	3572967
NSR (functional)	= 140	Tested for Norman sinus rhythm in dogs at a dose of 6 mg/kg Expt-2	ChEMBL.	3572967
NSR (functional)	= 145	Tested for Norman sinus rhythm in dogs at a dose of 6 mg/kg Expt-1	ChEMBL.	3572967
NSR (functional)	= 150	Tested for Norman sinus rhythm in dogs at a dose of 3 mg/kg Expt-1	ChEMBL.	3572967
NSR (functional)	= 150	Tested for Norman sinus rhythm in dogs at a dose of 3 mg/kg Expt-2	ChEMBL.	3572967

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 376440

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 284025