TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 550.904 | Formula: C36H62N4
H donors: 4 H acceptors: 0 LogP: 7.59 Rotable bonds: 27
Rule of 5 violations (Lipinski): 2
SMILES: Cc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1C
InChi: 1S/C36H62N4/c1-33-21-11-13-23-35(33)31-39-29-19-9-7-17-27-37-25-15-5-3-4-6-16-26-38-28-18-8-10-20-30-40-32-36-24-14-12-22-34(36)2/h11-14,21-24,37-40H,3-10,15-20,25-32H2,1-2H3
InChiKey: LJAHWUCLDQXGRN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Cavia porcellus	Muscarinic acetylcholine receptor M3	Starlite/ChEMBL	References
Homo sapiens	cholinergic receptor, muscarinic 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_133264	All targets in OG5_133264
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_133264	All targets in OG5_133264

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	Muscarinic acetylcholine receptor M3	587 aa	504 aa	26.8 %
Onchocerca volvulus	Glycoprotein hormone beta 5 homolog	Muscarinic acetylcholine receptor M3	587 aa	506 aa	34.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	beta tubulin	0.0249	0.3086	1
Plasmodium falciparum	DNA gyrase subunit A	0.032	0.4174	1
Echinococcus multilocularis	tubulin subunit TubB	0.0226	0.2731	0.4212
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0226	0.2731	0.4212
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0141	0.1431	0.4098
Schistosoma mansoni	tubulin subunit beta	0.0249	0.3086	0.4823
Trypanosoma brucei	beta tubulin	0.0249	0.3086	1
Plasmodium falciparum	tubulin beta chain	0.0249	0.3086	0.7206
Trypanosoma brucei	beta tubulin	0.0249	0.3086	1
Leishmania major	beta tubulin	0.0249	0.3086	1
Echinococcus granulosus	beta tubulin	0.0249	0.3086	0.4823
Entamoeba histolytica	tubulin family protein	0.0249	0.3086	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0447	0.6097	1
Brugia malayi	Cell division protein ftsZ	0.0065	0.0281	0.0461
Echinococcus multilocularis	tubulin alpha 3 chain	0.0226	0.2731	0.4212
Brugia malayi	Cytochrome P450 family protein	0.0051	0.0068	0.0112
Echinococcus granulosus	Tubulin alpha 1 chain	0.0226	0.2731	0.4212
Trypanosoma brucei	PAB1-binding protein , putative	0.0073	0.0393	0.0401
Trypanosoma brucei	alpha tubulin	0.0226	0.2731	0.8733
Echinococcus multilocularis	tubulin subunit beta	0.0249	0.3086	0.4823
Giardia lamblia	Beta tubulin	0.0249	0.3086	1
Entamoeba histolytica	tubulin alpha chain, putative	0.0226	0.2731	0.7638
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0393	0.0467
Trypanosoma cruzi	tubulin gamma chain	0.0151	0.1581	0.4635
Echinococcus multilocularis	tubulin alpha chain	0.0226	0.2731	0.4212
Brugia malayi	Tubulin beta chain	0.0085	0.0584	0.0957
Echinococcus multilocularis	Tubulin beta 2C chain	0.0249	0.3086	0.4823
Leishmania major	beta tubulin	0.0249	0.3086	1
Schistosoma mansoni	tubulin subunit beta	0.0249	0.3086	0.4823
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0705	0.0916
Schistosoma mansoni	hypothetical protein	0.0093	0.0705	0.073
Schistosoma mansoni	alpha tubulin	0.0226	0.2731	0.4212
Plasmodium falciparum	alpha tubulin 1	0.0226	0.2731	0.6293
Leishmania major	alpha tubulin	0.0226	0.2731	0.8733
Echinococcus granulosus	tubulin alpha chain	0.0226	0.2731	0.4212
Echinococcus multilocularis	tubulin alpha chain	0.0226	0.2731	0.4212
Loa Loa (eye worm)	tubulin gamma chain	0.0151	0.1581	0.2175
Loa Loa (eye worm)	TAR-binding protein	0.0066	0.0294	0.0325
Trypanosoma brucei	alpha tubulin, putative	0.0085	0.0584	0.1078
Leishmania major	alpha tubulin	0.0226	0.2731	0.8733
Brugia malayi	hypothetical protein	0.0073	0.0393	0.0645
Schistosoma mansoni	tubulin subunit alpha	0.0226	0.2731	0.4212
Leishmania major	beta tubulin	0.0249	0.3086	1
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0226	0.2731	0.3827
Echinococcus multilocularis	tubulin alpha 1C chain	0.0226	0.2731	0.4212
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0294	0.0023
Loa Loa (eye worm)	tubulin alpha 2	0.0161	0.1733	0.2393
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0294	0.0023
Brugia malayi	RNA recognition motif domain containing protein	0.0066	0.0294	0.0483
Entamoeba histolytica	tubulin alpha-1 chain	0.0226	0.2731	0.7638
Trypanosoma cruzi	alpha tubulin, putative	0.0226	0.2731	0.8733
Leishmania major	beta tubulin	0.0249	0.3086	1
Mycobacterium tuberculosis	Isocitrate lyase Icl (isocitrase) (isocitratase)	0.0702	1	1
Brugia malayi	beta-tubulin, identical	0.0249	0.3086	0.5062
Leishmania major	alpha tubulin	0.0226	0.2731	0.8733
Leishmania major	alpha tubulin	0.0226	0.2731	0.8733
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0136	0.1364	0.2237
Loa Loa (eye worm)	hypothetical protein	0.0419	0.5681	0.8069
Echinococcus multilocularis	peroxisome assembly protein 26	0.0226	0.2731	0.4212
Trypanosoma brucei	epsilon tubulin	0.0151	0.1581	0.4635
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0085	0.0584	0.1078
Loa Loa (eye worm)	tubulin alpha chain	0.0226	0.2731	0.3827
Trichomonas vaginalis	tubulin gamma chain, putative	0.0249	0.3086	1
Loa Loa (eye worm)	beta-tubulin	0.0249	0.3086	0.4338
Trichomonas vaginalis	tubulin beta chain, putative	0.0249	0.3086	1
Leishmania major	alpha tubulin	0.0226	0.2731	0.8733
Schistosoma mansoni	alpha tubulin	0.0226	0.2731	0.4212
Brugia malayi	Tubulin alpha-2 chain	0.0226	0.2731	0.4479
Brugia malayi	alpha-tubulin	0.0226	0.2731	0.4479
Brugia malayi	Tubulin beta-1 chain	0.0249	0.3086	0.5062
Echinococcus multilocularis	Tubulin beta 2C chain	0.0249	0.3086	0.4823
Brugia malayi	Tubulin gamma chain	0.0151	0.1581	0.2593
Toxoplasma gondii	alpha tubulin TUBA1	0.0226	0.2731	0.6293
Loa Loa (eye worm)	alpha-tubulin	0.0226	0.2731	0.3827
Loa Loa (eye worm)	hypothetical protein	0.0507	0.7024	1
Trypanosoma brucei	beta tubulin	0.0151	0.1581	0.4635
Echinococcus multilocularis	tubulin gamma 1 chain	0.0151	0.1581	0.2235
Mycobacterium tuberculosis	Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl)	0.0702	1	1
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0447	0.6097	1
Giardia lamblia	Alpha-tubulin	0.0226	0.2731	0.8733
Loa Loa (eye worm)	alpha-tubulin	0.0226	0.2731	0.3827
Echinococcus multilocularis	tubulin alpha 1C chain	0.0226	0.2731	0.4212
Trichomonas vaginalis	tubulin, putative	0.0249	0.3086	1
Trypanosoma brucei	alpha tubulin	0.0226	0.2731	0.8733
Echinococcus granulosus	tubulin beta 4A class IVa	0.0249	0.3086	0.4823
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0226	0.2731	0.4212
Mycobacterium tuberculosis	DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase)	0.032	0.4174	0.4005
Echinococcus granulosus	Tubulin alpha 1 chain	0.0226	0.2731	0.4212
Trichomonas vaginalis	tubulin gamma chain, putative	0.0151	0.1581	0.4635
Leishmania major	beta tubulin	0.0249	0.3086	1
Echinococcus granulosus	tubulin subunit TubB	0.0226	0.2731	0.4212
Trichomonas vaginalis	tubulin beta chain, putative	0.0226	0.2731	0.8733
Echinococcus multilocularis	geminin	0.0311	0.4027	0.6441
Trypanosoma brucei	epsilon tubulin	0.0151	0.1581	0.4635
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0249	0.3086	1
Leishmania major	hypothetical protein, conserved	0.0073	0.0393	0.0401
Leishmania major	beta tubulin	0.0249	0.3086	1
Toxoplasma gondii	DNA gyrase/topoisomerase IV, A subunit domain-containing protein	0.032	0.4174	1
Schistosoma mansoni	tubulin subunit beta	0.0249	0.3086	0.4823
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0294	0.0023
Brugia malayi	tubulin alpha chain - mouse	0.0226	0.2731	0.4479
Echinococcus granulosus	tubulin alpha 3 chain	0.0226	0.2731	0.4212
Plasmodium falciparum	tubulin epsilon chain, putative	0.0151	0.1581	0.334
Plasmodium falciparum	ataxin-2 like protein, putative	0.0073	0.0393	0.0289
Leishmania major	alpha tubulin	0.0226	0.2731	0.8733
Mycobacterium leprae	Isocitrate lyase	0.0329	0.4307	0.4142
Leishmania major	beta tubulin	0.0249	0.3086	1
Loa Loa (eye worm)	tubulin beta-1 chain	0.0249	0.3086	0.4338
Brugia malayi	Tubulin alpha chain	0.0226	0.2731	0.4479
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0226	0.2731	0.8733
Brugia malayi	Tubulin beta chain	0.0065	0.0281	0.0461
Loa Loa (eye worm)	tubulin alpha 2	0.0075	0.0433	0.0524
Schistosoma mansoni	hypothetical protein	0.0311	0.4027	0.6441
Leishmania major	beta tubulin	0.0249	0.3086	1
Schistosoma mansoni	hypothetical protein	0.0311	0.4027	0.6441
Echinococcus granulosus	tubulin subunit beta	0.0249	0.3086	0.4823
Echinococcus multilocularis	tubulin alpha 3 chain	0.0226	0.2731	0.4212
Echinococcus granulosus	Tubulin beta 2C chain	0.0249	0.3086	0.4823
Brugia malayi	RNA binding protein	0.0066	0.0294	0.0483
Trichomonas vaginalis	tubulin alpha chain, putative	0.0249	0.3086	1
Echinococcus granulosus	tar DNA binding protein	0.0066	0.0294	0.0023
Leishmania major	alpha tubulin	0.0226	0.2731	0.8733
Schistosoma mansoni	tubulin subunit beta	0.0249	0.3086	0.4823
Leishmania major	beta tubulin	0.0249	0.3086	1
Plasmodium vivax	tubulin alpha chain, putative	0.0226	0.2731	0.6293
Schistosoma mansoni	tubulin subunit epsilon	0.0151	0.1581	0.2235
Leishmania major	alpha tubulin	0.0226	0.2731	0.8733
Loa Loa (eye worm)	tubulin beta chain	0.0065	0.0281	0.0306
Echinococcus granulosus	tubulin epsilon chain	0.0151	0.1581	0.2235
Trypanosoma cruzi	epsilon tubulin, putative	0.0151	0.1581	0.4635
Leishmania major	beta tubulin	0.0249	0.3086	1
Leishmania major	alpha tubulin	0.0226	0.2731	0.8733
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0141	0.1431	0.1958
Brugia malayi	TAR-binding protein	0.0066	0.0294	0.0483
Mycobacterium ulcerans	isocitrate lyase Icl	0.0702	1	1
Schistosoma mansoni	tubulin subunit beta	0.0249	0.3086	0.4823
Echinococcus multilocularis	tubulin epsilon chain	0.0151	0.1581	0.2235
Loa Loa (eye worm)	hypothetical protein	0.0161	0.1733	0.2393
Leishmania major	beta tubulin	0.0249	0.3086	1
Trypanosoma brucei	beta tubulin	0.0249	0.3086	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0073	0.0393	0.0289
Onchocerca volvulus		0.0419	0.5681	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0136	0.1364	0.1862
Echinococcus granulosus	alpha tubulin	0.0226	0.2731	0.4212
Echinococcus granulosus	tubulin gamma 1 chain	0.0151	0.1581	0.2235
Brugia malayi	tubulin alpha-2 chain	0.0226	0.2731	0.4479
Trypanosoma cruzi	beta tubulin, putative	0.0249	0.3086	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0136	0.1364	0.2237
Loa Loa (eye worm)	hypothetical protein	0.0507	0.7024	1
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0249	0.3086	0.4823
Echinococcus multilocularis	tar DNA binding protein	0.0066	0.0294	0.0023
Echinococcus granulosus	Tubulin beta 2C chain	0.0249	0.3086	0.4823
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0226	0.2731	0.8733
Brugia malayi	hypothetical protein	0.0419	0.5681	0.9318
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0161	0.1733	0.5176
Schistosoma mansoni	tubulin subunit beta	0.0249	0.3086	0.4823
Plasmodium vivax	tubulin beta chain, putative	0.0249	0.3086	0.7206
Loa Loa (eye worm)	RNA binding protein	0.0066	0.0294	0.0325
Echinococcus granulosus	tubulin alpha chain	0.0226	0.2731	0.4212
Treponema pallidum	DNA gyrase, subunit A (gyrA)	0.032	0.4174	1
Echinococcus granulosus	tubulin alpha chain	0.0226	0.2731	0.4212
Entamoeba histolytica	tubulin family protein	0.0249	0.3086	1
Leishmania major	alpha tubulin	0.0226	0.2731	0.8733
Brugia malayi	follicle stimulating hormone receptor	0.0234	0.2847	0.4669
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0226	0.2731	0.8733
Echinococcus multilocularis	hypothetical protein	0.0226	0.2731	0.4212
Leishmania major	beta tubulin	0.0249	0.3086	1
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0151	0.1581	0.334
Leishmania major	epsilon tubulin, putative	0.0151	0.1581	0.4635
Trypanosoma brucei	tubulin gamma chain	0.0151	0.1581	0.4635
Echinococcus multilocularis	Tubulin beta 2C chain	0.0249	0.3086	0.4823
Toxoplasma gondii	beta-tubulin, putative	0.0249	0.3086	0.7206
Echinococcus granulosus	beta tubulin	0.0249	0.3086	0.4823
Plasmodium vivax	tubulin gamma chain, putative	0.0151	0.1581	0.334
Mycobacterium ulcerans	isocitrate lyase AceAb	0.0702	1	1
Loa Loa (eye worm)	hypothetical protein	0.0141	0.1431	0.1958
Giardia lamblia	Beta tubulin	0.0249	0.3086	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0249	0.3086	0.4823
Brugia malayi	Tubulin alpha chain	0.0065	0.0281	0.0461
Loa Loa (eye worm)	tubulin beta-4 chain	0.0249	0.3086	0.4338
Loa Loa (eye worm)	tubulin beta-2A chain	0.0249	0.3086	0.4338
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0447	0.6097	0.8667
Leishmania major	gamma-tubulin	0.0151	0.1581	0.4635
Echinococcus granulosus	tubulin beta 1 chain	0.0249	0.3086	0.4823
Loa Loa (eye worm)	tubulin alpha chain	0.0226	0.2731	0.3827
Echinococcus granulosus	tubulin alpha chain	0.0226	0.2731	0.4212
Echinococcus multilocularis	beta tubulin	0.0249	0.3086	0.4823
Leishmania major	alpha tubulin	0.0226	0.2731	0.8733
Leishmania major	beta tubulin	0.0249	0.3086	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0249	0.3086	1
Plasmodium vivax	tubulin epsilon chain, putative	0.0151	0.1581	0.334
Echinococcus multilocularis	Tubulin beta 2C chain	0.0249	0.3086	0.4823
Toxoplasma gondii	beta-1 tubulin, putative	0.0249	0.3086	0.7206
Trichomonas vaginalis	tubulin alpha chain, putative	0.0151	0.1581	0.4635
Trypanosoma brucei	epsilon tubulin	0.0151	0.1581	0.4635
Brugia malayi	Tubulin alpha-2 chain	0.0226	0.2731	0.4479
Mycobacterium tuberculosis	Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl)	0.0702	1	1
Giardia lamblia	Beta tubulin	0.0249	0.3086	1
Loa Loa (eye worm)	tubulin alpha 2	0.0161	0.1733	0.2393
Trichomonas vaginalis	tubulin beta chain, putative	0.0226	0.2731	0.8733
Trypanosoma brucei	alpha tubulin	0.0226	0.2731	0.8733
Echinococcus multilocularis	tubulin alpha chain	0.0226	0.2731	0.4212
Echinococcus multilocularis	Tubulin beta 2C chain	0.0249	0.3086	0.4823
Trichomonas vaginalis	tubulin beta chain, putative	0.0226	0.2731	0.8733
Loa Loa (eye worm)	hypothetical protein	0.0136	0.1364	0.1862
Trypanosoma cruzi	PAB1-binding protein , putative	0.0073	0.0393	0.0401
Trichomonas vaginalis	tubulin alpha chain, putative	0.0085	0.0584	0.1078
Plasmodium vivax	tubulin alpha chain, putative	0.0226	0.2731	0.6293
Trypanosoma cruzi	epsilon tubulin, putative	0.0151	0.1581	0.4635
Echinococcus multilocularis	tubulin alpha chain	0.0226	0.2731	0.4212
Trypanosoma cruzi	PAB1-binding protein , putative	0.0073	0.0393	0.0401
Trichomonas vaginalis	tubulin beta chain, putative	0.0226	0.2731	0.8733
Wolbachia endosymbiont of Brugia malayi	DNA gyrase subunit A	0.032	0.4174	1
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0294	0.0023
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0234	0.2847	0.3994
Mycobacterium leprae	Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase)	0.0153	0.1614	0.1372
Trichomonas vaginalis	tubulin beta chain, putative	0.0085	0.0584	0.1078
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0161	0.1733	0.2393
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0226	0.2731	0.4212
Loa Loa (eye worm)	hypothetical protein	0.0226	0.2731	0.3827
Trichomonas vaginalis	tubulin gamma chain, putative	0.0151	0.1581	0.4635
Echinococcus granulosus	geminin	0.0311	0.4027	0.6441
Giardia lamblia	Alpha-tubulin	0.0226	0.2731	0.8733
Echinococcus granulosus	tubulin alpha	0.0151	0.1581	0.2235
Leishmania major	beta tubulin	0.0249	0.3086	1
Loa Loa (eye worm)	BEN-1 protein	0.0249	0.3086	0.4338
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0447	0.6097	1
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0294	0.0023
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0066	0.0294	0.0325
Schistosoma mansoni	tubulin subunit alpha	0.0226	0.2731	0.4212
Echinococcus granulosus	peroxisome assembly protein 26	0.0226	0.2731	0.4212
Brugia malayi	latrophilin 2 splice variant baaae	0.0093	0.0705	0.1157
Trichomonas vaginalis	tubulin alpha chain, putative	0.0085	0.0584	0.1078
Toxoplasma gondii	alpha-tubulin I, putative	0.0226	0.2731	0.6293
Echinococcus granulosus	tubulin alpha 3 chain	0.0226	0.2731	0.4212
Loa Loa (eye worm)	BEN-1 protein	0.0249	0.3086	0.4338
Schistosoma mansoni	tubulin subunit alpha	0.0226	0.2731	0.4212
Plasmodium vivax	ataxin-2 like protein, putative	0.0073	0.0393	0.0289
Giardia lamblia	Gamma tubulin	0.0151	0.1581	0.4635
Trichomonas vaginalis	tubulin, putative	0.0085	0.0584	0.1078
Toxoplasma gondii	LsmAD domain-containing protein	0.0073	0.0393	0.0289
Echinococcus granulosus	Tubulin alpha 1 chain	0.0226	0.2731	0.4212
Echinococcus multilocularis	tubulin alpha	0.0151	0.1581	0.2235
Echinococcus granulosus	tubulin alpha chain	0.0226	0.2731	0.4212
Toxoplasma gondii	beta tubulin	0.0249	0.3086	0.7206
Mycobacterium ulcerans	DNA gyrase subunit A	0.032	0.4174	0.4005
Leishmania major	beta tubulin	0.0249	0.3086	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0226	0.2731	0.8733
Echinococcus granulosus	Tubulin beta 2C chain	0.0249	0.3086	0.4823
Trichomonas vaginalis	tubulin alpha chain, putative	0.0085	0.0584	0.1078
Echinococcus multilocularis	beta tubulin	0.0249	0.3086	0.4823
Leishmania major	beta tubulin	0.0249	0.3086	1
Trypanosoma brucei	alpha tubulin	0.0226	0.2731	0.8733
Plasmodium falciparum	tubulin gamma chain	0.0151	0.1581	0.334
Echinococcus multilocularis	tubulin beta 1 chain	0.0249	0.3086	0.4823
Schistosoma mansoni	alpha tubulin	0.0226	0.2731	0.4212
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0447	0.6097	1
Plasmodium vivax	DNA gyrase subunit A, putative	0.032	0.4174	1
Trypanosoma brucei	beta tubulin	0.0249	0.3086	1
Leishmania major	beta tubulin	0.0249	0.3086	1
Echinococcus multilocularis	tubulin alpha chain	0.0226	0.2731	0.4212
Chlamydia trachomatis	DNA gyrase subunit A	0.032	0.4174	0.5
Echinococcus granulosus	tubulin alpha 1C chain	0.0226	0.2731	0.4212
Loa Loa (eye worm)	tubulin beta chain	0.0249	0.3086	0.4338
Leishmania major	alpha tubulin	0.0226	0.2731	0.8733
Echinococcus granulosus	tubulin alpha 1C chain	0.0226	0.2731	0.4212
Trichomonas vaginalis	tubulin beta chain, putative	0.0226	0.2731	0.8733
Plasmodium falciparum	alpha tubulin 2	0.0226	0.2731	0.6293
Schistosoma mansoni	tubulin subunit gamma	0.0151	0.1581	0.2235
Echinococcus granulosus	Tubulin beta 2C chain	0.0249	0.3086	0.4823
Trichomonas vaginalis	tubulin, putative	0.0085	0.0584	0.1078

Activities

Activity type	Activity value	Assay description	Source	Reference
Kd (functional)	= 5.7	Antagonist potency against carbachol induced contractions of isolated guinea pig ileum Muscarinic acetylcholine receptor	ChEMBL.	2909747
Kd (functional)	= 7.23	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL.	2909747
pA2 (functional)	= 5.7	Antagonist potency against carbachol induced contractions of isolated guinea pig ileum Muscarinic acetylcholine receptor	ChEMBL.	2909747
pA2 (functional)	= 7.23	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL.	2909747
Ratio (functional)	= 34	Selectivity ratio between antagonistic potency in atria and ileum	ChEMBL.	2909747

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL168616

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 288966