Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0003 | 0.0009 | 0.0024 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0008 | 0.0195 | 1 |
Trypanosoma brucei | serine peptidase, clan SB, family S8-like protein | 0.0008 | 0.0195 | 1 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0003 | 0.0009 | 0.0024 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0003 | 0.000000060518 | 0.00000016487 |
Echinococcus granulosus | membrane bound transcription factor site 1 | 0.0008 | 0.0195 | 0.0531 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0008 | 0.0195 | 1 |
Brugia malayi | endoprotease bli-4 precursor | 0.0008 | 0.0195 | 0.0195 |
Toxoplasma gondii | subtilisin SUB9 | 0.0008 | 0.0195 | 1 |
Mycobacterium ulcerans | membrane-anchored serine protease (mycosin), MycP4 | 0.0008 | 0.0195 | 0.5 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0008 | 0.0195 | 1 |
Schistosoma mansoni | site-1 peptidase (S08 family) | 0.0008 | 0.0195 | 0.0195 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0008 | 0.0195 | 1 |
Echinococcus granulosus | proprotein convertase subtilisin:kexin type 5 | 0.0008 | 0.0195 | 0.0531 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0003 | 0.0009 | 0.0024 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0008 | 0.0195 | 1 |
Plasmodium falciparum | subtilisin-like protease 2 | 0.0008 | 0.0195 | 0.5 |
Mycobacterium leprae | PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) | 0.0008 | 0.0195 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0003 | 0.0009 | 0.0009 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0008 | 0.0195 | 1 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0008 | 0.0195 | 1 |
Plasmodium falciparum | subtilisin-like protease 3 | 0.0008 | 0.0195 | 0.5 |
Toxoplasma gondii | subtilisin SUB12 | 0.0008 | 0.0195 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0003 | 0.000000060518 | 0.000000060518 |
Schistosoma mansoni | subfamily S8B non-peptidase homologue (S08 family) | 0.0008 | 0.0195 | 0.0195 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0008 | 0.0195 | 1 |
Trypanosoma cruzi | subtilisin-like serine peptidase, putative | 0.0008 | 0.0195 | 0.239 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0003 | 0.000000060518 | 0.00000016487 |
Brugia malayi | POT family protein | 0.0218 | 0.8014 | 0.8014 |
Trypanosoma brucei | subtilisin peptidase | 0.0008 | 0.0195 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0195 | 0.0195 |
Brugia malayi | Hypothetical subtilase-type proteinase F21H12.6 in chromosome II | 0.0008 | 0.0195 | 0.0195 |
Schistosoma mansoni | furin-1 (S08 family) | 0.0008 | 0.0195 | 0.0195 |
Mycobacterium ulcerans | membrane-anchored mycosin MycP3 | 0.0008 | 0.0195 | 0.5 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0008 | 0.0195 | 1 |
Brugia malayi | olfactory channel protein osm-9 | 0.0003 | 0.0009 | 0.0009 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0008 | 0.0195 | 1 |
Brugia malayi | Membrane-bound transcription factor site-1 protease precursor | 0.0008 | 0.0195 | 0.0195 |
Plasmodium vivax | subtilisin-like protease 1 | 0.0008 | 0.0195 | 0.5 |
Echinococcus multilocularis | Furin 1 | 0.0008 | 0.0195 | 0.0531 |
Brugia malayi | proprotein convertase 2 | 0.0008 | 0.0195 | 0.0195 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0025 | 0.0816 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0195 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0003 | 0.000000060518 | 0.000000060518 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0008 | 0.0195 | 1 |
Echinococcus multilocularis | proprotein convertase subtilisin:kexin type 5 | 0.0008 | 0.0195 | 0.0531 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0003 | 0.0009 | 0.0024 |
Brugia malayi | celfurPC protein | 0.0008 | 0.0195 | 0.0195 |
Brugia malayi | neuroendocrine convertase 1 precursor | 0.0008 | 0.0195 | 0.0195 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0008 | 0.0195 | 1 |
Leishmania major | subtilisin-like serine peptidase | 0.0008 | 0.0195 | 0.239 |
Echinococcus multilocularis | neuroendocrine convertase 2 | 0.0008 | 0.0195 | 0.0531 |
Mycobacterium tuberculosis | Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) | 0.0008 | 0.0195 | 0.5 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0008 | 0.0195 | 1 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0008 | 0.0195 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0195 | 1 |
Mycobacterium ulcerans | proline rich membrane-anchored mycosin MycP5 | 0.0008 | 0.0195 | 0.5 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0008 | 0.0195 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0195 | 0.0195 |
Loa Loa (eye worm) | subtilase | 0.0271 | 1 | 1 |
Toxoplasma gondii | subtilisin SUB2 | 0.0008 | 0.0195 | 1 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0003 | 0.0009 | 0.0024 |
Loa Loa (eye worm) | endoprotease bli-4 | 0.0008 | 0.0195 | 0.0195 |
Mycobacterium tuberculosis | Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) | 0.0008 | 0.0195 | 0.5 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0008 | 0.0195 | 1 |
Toxoplasma gondii | subtilisin SUB10 | 0.0008 | 0.0195 | 1 |
Toxoplasma gondii | subtilisin SUB1 | 0.0008 | 0.0195 | 1 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0008 | 0.0195 | 1 |
Toxoplasma gondii | subtilisin SUB7 | 0.0008 | 0.0195 | 1 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0008 | 0.0195 | 1 |
Mycobacterium tuberculosis | Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) | 0.0008 | 0.0195 | 0.5 |
Schistosoma mansoni | subfamily S8B unassigned peptidase (S08 family) | 0.0008 | 0.0195 | 0.0195 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0816 | 1 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0008 | 0.0195 | 1 |
Echinococcus granulosus | furin | 0.0008 | 0.0195 | 0.0531 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0008 | 0.0195 | 1 |
Echinococcus granulosus | neuroendocrine convertase 2 | 0.0008 | 0.0195 | 0.0531 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0008 | 0.0195 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0195 | 1 |
Echinococcus granulosus | peptidase s8 s53 subtilisin kexin sedolisin | 0.0101 | 0.3671 | 1 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0008 | 0.0195 | 1 |
Echinococcus granulosus | Furin 1 | 0.0008 | 0.0195 | 0.0531 |
Mycobacterium leprae | Possible secreted protease | 0.0008 | 0.0195 | 0.5 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0008 | 0.0195 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.0003 | 0.000000060518 | 0.000000060518 |
Toxoplasma gondii | subtilisin SUB8 | 0.0008 | 0.0195 | 1 |
Mycobacterium tuberculosis | Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) | 0.0008 | 0.0195 | 0.5 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0008 | 0.0195 | 1 |
Plasmodium vivax | subtilisin-like serine protease, putative | 0.0008 | 0.0195 | 0.5 |
Toxoplasma gondii | subtilisin SUB5 | 0.0008 | 0.0195 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.0003 | 0.0009 | 0.0009 |
Schistosoma mansoni | tripeptidyl-peptidase II (S08 family) | 0.0271 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0195 | 1 |
Echinococcus multilocularis | Peptidase S8 S53, subtilisin kexin sedolisin | 0.0101 | 0.3671 | 1 |
Brugia malayi | follicle stimulating hormone receptor | 0.0244 | 0.8989 | 0.8989 |
Onchocerca volvulus | 0.0008 | 0.0195 | 1 | |
Schistosoma mansoni | subfamily S8B unassigned peptidase (S08 family) | 0.0008 | 0.0195 | 0.0195 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0008 | 0.0195 | 1 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0008 | 0.0195 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.0003 | 0.000000060518 | 0.000000060518 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0025 | 0.0816 | 1 |
Toxoplasma gondii | subtilisin SUB11 | 0.0008 | 0.0195 | 1 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0008 | 0.0195 | 1 |
Loa Loa (eye worm) | proprotein convertase 2 | 0.0008 | 0.0195 | 0.0195 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0003 | 0.000000060518 | 0.00000016487 |
Plasmodium falciparum | subtilisin-like protease 1 | 0.0008 | 0.0195 | 0.5 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0008 | 0.0195 | 1 |
Toxoplasma gondii | subtilisin SUB4 | 0.0008 | 0.0195 | 1 |
Echinococcus multilocularis | membrane bound transcription factor site 1 | 0.0008 | 0.0195 | 0.0531 |
Loa Loa (eye worm) | POT family protein | 0.0218 | 0.8014 | 0.8014 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0195 | 1 |
Schistosoma mansoni | site-1 peptidase (S08 family) | 0.0008 | 0.0195 | 0.0195 |
Trypanosoma cruzi | subtilisin peptidase | 0.0008 | 0.0195 | 0.239 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0008 | 0.0195 | 1 |
Toxoplasma gondii | subtilisin SUB6 | 0.0008 | 0.0195 | 1 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0008 | 0.0195 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0244 | 0.8989 | 0.8989 |
Plasmodium vivax | subtilisin-like protease 2, putative | 0.0008 | 0.0195 | 0.5 |
Echinococcus multilocularis | 0.0008 | 0.0195 | 0.0531 | |
Trypanosoma cruzi | subtilisin-like serine peptidase, putative | 0.0008 | 0.0195 | 0.239 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0008 | 0.0195 | 1 |
Mycobacterium leprae | PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) | 0.0008 | 0.0195 | 0.5 |
Trypanosoma cruzi | serine peptidase, clan SB, family S8-like protein | 0.0008 | 0.0195 | 0.239 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0008 | 0.0195 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Phototoxicity (functional) | Phototoxicity of the compound was evaluated at a concentration of 1.4 mM and with an irradiation dose of 6 J/cm**2 in mouse ear-swelling test; non-phototoxic | ChEMBL. | No reference | |
Phototoxicity (functional) | Phototoxicity of the compound was evaluated at a concentration of 27.7 mM at a UVA dose of 12 J/cm**2 in mouse ear-swelling test; non-phototoxic | ChEMBL. | No reference | |
Phototoxicity (functional) | 0 | Phototoxicity of the compound was evaluated at a concentration of 1.4 mM and with an irradiation dose of 6 J/cm**2 in mouse ear-swelling test; non-phototoxic | ChEMBL. | No reference |
Phototoxicity (functional) | 0 | Phototoxicity of the compound was evaluated at a concentration of 27.7 mM at a UVA dose of 12 J/cm**2 in mouse ear-swelling test; non-phototoxic | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.