Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dopamine transporter | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.082 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.082 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.082 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.082 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.082 | 1 | 1 |
Onchocerca volvulus | 0.082 | 1 | 1 | |
Onchocerca volvulus | 0.082 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.082 | 1 | 1 |
Echinococcus granulosus | peroxidasin | 0.082 | 1 | 1 |
Onchocerca volvulus | 0.082 | 1 | 1 | |
Schistosoma mansoni | peroxidasin | 0.082 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.082 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.082 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.082 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.082 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.082 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.082 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.082 | 1 | 1 |
Echinococcus multilocularis | peroxidasin | 0.082 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.082 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.082 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.082 | 1 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.082 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.082 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.082 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.082 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.082 | 1 | 1 |
Giardia lamblia | High cysteine protein | 0.0265 | 0 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.082 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.082 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.082 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.082 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.082 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.082 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.082 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.082 | 1 | 1 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0265 | 0 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.082 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.082 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.082 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.082 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Discrimination ratio (binding) | = 4.4 | Discrimination ratio of compound is the ratio of inhibitory activity against [3H]-dopamine uptake over [3H]WIN35,248 binding | ChEMBL. | 10072685 |
Discrimination ratio (binding) | = 4.4 | Discrimination ratio of compound is the ratio of inhibitory activity against [3H]-dopamine uptake over [3H]WIN35,248 binding | ChEMBL. | 10072685 |
IC50 (binding) | = 160 nM | Inhibitory binding activity against rat striatal tissue, using [3H]- WIN35,248 as the radioligand. | ChEMBL. | 10072685 |
IC50 (binding) | = 160 nM | Inhibitory binding activity against rat striatal tissue, using [3H]- WIN35,248 as the radioligand. | ChEMBL. | 10072685 |
IC50 (binding) | = 704 nM | Inhibition of dopamine uptake into rat striatal tissue, using [3H]- dopamine as the radioligand. | ChEMBL. | 10072685 |
IC50 (binding) | = 704 nM | Inhibition of dopamine uptake into rat striatal tissue, using [3H]- dopamine as the radioligand. | ChEMBL. | 10072685 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.