Detailed information for compound 305013

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 345.351 | Formula: C20H15N3O3
  • H donors: 2 H acceptors: 2 LogP: 3.87 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=Cc1ccc2c(c1)[nH]c(c2C1=Nc2c(/C/1=N\OC(=O)C)cccc2)O
  • InChi: 1S/C20H15N3O3/c1-3-12-8-9-13-16(10-12)22-20(25)17(13)19-18(23-26-11(2)24)14-6-4-5-7-15(14)21-19/h3-10,22,25H,1H2,2H3/b23-18+
  • InChiKey: BMKAEDSPKKTWID-PTGBLXJZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL References
Homo sapiens cyclin B2 Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 5 Starlite/ChEMBL References
Homo sapiens cyclin B3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium hominis mitotic cyclin-CYC2 Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia G2/mitotic-specific cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis cyclin A, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_134175 All targets in OG5_134175
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis G2:mitotic specific cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum IPR002155,Thiolase,domain-containing Get druggable targets OG5_134175 All targets in OG5_134175
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense cyclin 6,mitotic cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus G2:mitotic specific cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium parvum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) cyclin domain-containing protein Get druggable targets OG5_134175 All targets in OG5_134175
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_134175 All targets in OG5_134175
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 5 260 aa 307 aa 28.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.023 1 1
Brugia malayi Dopamine receptor 0.023 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.023 1 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.1887 0.1328
Brugia malayi Tachykinin-like peptides receptor 99D 0.023 1 1
Trypanosoma cruzi cdc2-related kinase 1 0.0053 0.1136 0.1094
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.023 1 1
Trichomonas vaginalis cyclins, putative 0.0073 0.2147 1
Trypanosoma brucei mitotic cyclin 6 0.0073 0.2147 1
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0177 0.7374 0.7248
Echinococcus multilocularis rhodopsin orphan GPCR 0.023 1 1
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.023 1 1
Brugia malayi Dopamine receptor protein 1 0.023 1 1
Schistosoma mansoni neuropeptide f receptor 76f 0.023 1 1
Onchocerca volvulus 0.023 1 1
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0177 0.7374 0.7248
Echinococcus granulosus tm gpcr rhodopsin 0.023 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.023 1 1
Schistosoma mansoni myosin xvIII 0.023 1 1
Echinococcus granulosus protein kinase shaggy 0.0059 0.1433 0.102
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.023 1 1
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Giardia lamblia Kinase, CMGC CDK 0.0053 0.1136 0.3267
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.023 1 1
Schistosoma mansoni neuropeptide receptor 0.023 1 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.1887 0.1887
Schistosoma mansoni cyclin B3 0.0177 0.7374 0.7193
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Brugia malayi neuropeptide F receptor 0.023 1 1
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Echinococcus granulosus neuropeptide receptor 0.023 1 1
Echinococcus multilocularis sex peptide receptor 0.023 1 1
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.023 1 1
Echinococcus granulosus neuropeptide receptor A26 0.023 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.023 1 1
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0059 0.1433 0.0842
Schistosoma mansoni histamine h1 receptor 0.023 1 1
Plasmodium vivax protein kinase Crk2 0.0053 0.1136 0.2951
Echinococcus multilocularis rhodopsin orphan GPCR 0.023 1 1
Plasmodium falciparum glycogen synthase kinase 3 0.0059 0.1433 1
Trypanosoma cruzi cyclin 6, putative 0.0073 0.2147 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0127 0.4871 1
Plasmodium vivax glycogen synthase kinase 3, putative 0.0059 0.1433 1
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Brugia malayi neuropeptide F receptor 0.023 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.023 1 1
Onchocerca volvulus 0.0085 0.2767 0.1557
Loa Loa (eye worm) hypothetical protein 0.0073 0.2147 0.2147
Schistosoma mansoni biogenic amine receptor 0.023 1 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0114 0.4231 0.8342
Brugia malayi hypothetical protein 0.023 1 1
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Brugia malayi hypothetical protein 0.023 1 1
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Echinococcus granulosus L aminoadipate semialdehyde 0.0085 0.2767 0.2418
Brugia malayi G protein-coupled receptor 0.023 1 1
Trypanosoma cruzi cdc2-related kinase 3 0.0053 0.1136 0.1094
Echinococcus granulosus cyclins 0.0043 0.0645 0.0194
Echinococcus granulosus biogenic amine 5HT receptor 0.023 1 1
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.1136 0.3267
Echinococcus granulosus hypothetical protein 0.023 1 1
Echinococcus granulosus neuropeptides capa receptor 0.023 1 1
Onchocerca volvulus 0.023 1 1
Trichomonas vaginalis cyclin D, putative 0.0043 0.0645 0.078
Brugia malayi hypothetical protein 0.023 1 1
Brugia malayi Thioredoxin reductase 0.005 0.1012 0.001
Echinococcus granulosus sex peptide receptor 0.023 1 1
Echinococcus multilocularis cyclin dependent kinase 0.0053 0.1136 0.0709
Schistosoma mansoni amine GPCR 0.023 1 1
Schistosoma mansoni amine GPCR 0.023 1 1
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Giardia lamblia G2/mitotic-specific cyclin B 0.0073 0.2147 1
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Loa Loa (eye worm) thioredoxin reductase 0.005 0.1012 0.1012
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0073 0.2147 1
Brugia malayi hypothetical protein 0.023 1 1
Echinococcus multilocularis neuropeptide receptor 0.023 1 1
Schistosoma mansoni hypothetical protein 0.023 1 1
Echinococcus multilocularis cyclins 0.0043 0.0645 0.0194
Echinococcus multilocularis g protein coupled receptor 0.023 1 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.023 1 1
Trichomonas vaginalis cyclin B3, putative 0.0043 0.0645 0.078
Echinococcus multilocularis protein kinase shaggy 0.0059 0.1433 0.102
Echinococcus multilocularis cyclins 0.0043 0.0645 0.0194
Trichomonas vaginalis cyclins, putative 0.0073 0.2147 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.023 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.023 1 1
Onchocerca volvulus 0.023 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.023 1 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.023 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.023 1 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.023 1 1
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0059 0.1433 0.1433
Schistosoma mansoni rhodopsin-like orphan GPCR 0.023 1 1
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Echinococcus multilocularis g-protein coupled receptor 0.023 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.023 1 1
Onchocerca volvulus 0.023 1 1
Loa Loa (eye worm) TYRA-2 protein 0.023 1 1
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0053 0.1136 0.1136
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.023 1 1
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0085 0.2767 0.1961
Schistosoma mansoni amine GPCR 0.023 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.023 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.023 1 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.023 1 1
Echinococcus granulosus G protein coupled receptor 139 0.023 1 1
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0059 0.1433 0.3708
Brugia malayi GnHR receptor homolog 0.023 1 1
Brugia malayi Dopamine receptor protein 2 0.023 1 1
Echinococcus granulosus cyclin dependent kinase 1 0.0053 0.1136 0.0709
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0059 0.1433 1
Echinococcus granulosus g protein coupled receptor 0.023 1 1
Echinococcus multilocularis g protein coupled receptor 0.023 1 1
Trichomonas vaginalis cyclins, putative 0.0073 0.2147 1
Brugia malayi glutathione reductase 0.005 0.1012 0.001
Mycobacterium tuberculosis Probable oxidoreductase 0.0127 0.4871 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.023 1 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.023 1 1
Entamoeba histolytica cyclin, putative 0.0073 0.2147 1
Schistosoma mansoni biogenic amine receptor 0.023 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1136 0.3793
Echinococcus multilocularis neuropeptides capa receptor 0.023 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.023 1 1
Echinococcus granulosus cyclins 0.0043 0.0645 0.0194
Echinococcus granulosus neuropeptide Y receptor 0.023 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.1433 0.5614
Onchocerca volvulus 0.023 1 1
Trichomonas vaginalis cyclin B, putative 0.0043 0.0645 0.078
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.023 1 1
Echinococcus granulosus neuropeptide receptor 0.023 1 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.1136 0.1136
Trichomonas vaginalis cyclin D, putative 0.0043 0.0645 0.078
Schistosoma mansoni amine GPCR 0.023 1 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.023 1 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0114 0.4231 0.8342
Schistosoma mansoni rhodopsin-like orphan GPCR 0.023 1 1
Schistosoma mansoni biogenic amine receptor 0.023 1 1
Trypanosoma cruzi cdc2-related kinase 3 0.0053 0.1136 0.1094
Loa Loa (eye worm) hypothetical protein 0.0085 0.2767 0.2767
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.1887 0.1496
Echinococcus multilocularis tachykinin peptides receptor 99D 0.023 1 1
Echinococcus multilocularis neuropeptide receptor A26 0.023 1 1
Onchocerca volvulus 0.023 1 1
Leishmania major cyclin 0.0073 0.2147 1
Echinococcus granulosus fmrfamide receptor 0.023 1 1
Onchocerca volvulus 0.023 1 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.1887 0.1496
Trichomonas vaginalis cyclin A, putative 0.0073 0.2147 1
Onchocerca volvulus 0.023 1 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.023 1 1
Onchocerca volvulus 0.023 1 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.023 1 1
Schistosoma mansoni opsin-like receptor 0.023 1 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.023 1 1
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0059 0.1433 0.102
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.023 1 1
Echinococcus granulosus cyclin dependent kinase 0.0053 0.1136 0.0709
Brugia malayi G-protein coupled receptor 0.023 1 1
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Echinococcus multilocularis cyclin dependent kinase 5 0.0053 0.1136 0.0709
Trypanosoma brucei protein kinase, putative 0.0059 0.1433 0.3708
Echinococcus granulosus cyclins 0.0043 0.0645 0.0194
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0645 0.078
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Echinococcus granulosus g protein coupled receptor 0.023 1 1
Echinococcus granulosus cyclin b3 0.0043 0.0645 0.0194
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.023 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1136 0.3793
Brugia malayi intracellular kinase 0.0059 0.1433 0.0478
Loa Loa (eye worm) cyclin domain-containing protein 0.0177 0.7374 0.7374
Plasmodium falciparum thioredoxin reductase 0.005 0.1012 0.4653
Echinococcus multilocularis cyclin b3 0.0043 0.0645 0.0194
Echinococcus granulosus rhodopsin orphan GPCR 0.023 1 1
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0059 0.1433 0.102
Echinococcus multilocularis cyclin B3 1 0.0043 0.0645 0.0194
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.1887 0.7712
Brugia malayi larval opioid receptor 0.023 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.023 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.023 1 1
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0059 0.1433 0.3708
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.1887 0.7712
Brugia malayi Cyclin, N-terminal domain containing protein 0.0073 0.2147 0.1272
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.1887 0.827
Schistosoma mansoni opsin-like receptor 0.023 1 1
Echinococcus granulosus neuropeptides capa receptor 0.023 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.023 1 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.023 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.023 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.1433 0.5243
Echinococcus multilocularis serotonin receptor 0.023 1 1
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Echinococcus granulosus serotonin receptor 0.023 1 1
Echinococcus multilocularis neuropeptide receptor 0.023 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.023 1 1
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Plasmodium falciparum glutathione reductase 0.005 0.1012 0.4653
Trypanosoma brucei cdc2-related kinase 1 0.0053 0.1136 0.1094
Brugia malayi sulfakinin receptor protein 0.023 1 1
Echinococcus granulosus orexin receptor type 2 0.023 1 1
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Echinococcus multilocularis cyclins 0.0043 0.0645 0.0194
Echinococcus multilocularis serotonin receptor 0.023 1 1
Echinococcus multilocularis cyclin B 0.0073 0.2147 0.1768
Schistosoma mansoni biogenic amine (5HT) receptor 0.023 1 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.1332 0.0915
Onchocerca volvulus 0.0073 0.2147 0.0834
Loa Loa (eye worm) G-protein coupled receptor 0.023 1 1
Echinococcus multilocularis somatostatin receptor 0.023 1 1
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.023 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.023 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.023 1 1
Trypanosoma cruzi cdc2-related kinase 1 0.0053 0.1136 0.1094
Schistosoma mansoni biogenic amine (dopamine) receptor 0.023 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.023 1 1
Schistosoma mansoni neuropeptide receptor 0.023 1 1
Echinococcus multilocularis dro:myosuppressin receptor 0.023 1 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.023 1 1
Brugia malayi AKH receptor 0.023 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.1433 0.5614
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0085 0.2767 0.2268
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1136 0.3793
Echinococcus granulosus neuropeptide Y receptor 0.023 1 1
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Onchocerca volvulus 0.023 1 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.023 1 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.023 1 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.023 1 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0177 0.7374 0.7082
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.023 1 1
Schistosoma mansoni adenoreceptor 0.023 1 1
Echinococcus multilocularis fmrfamide receptor 0.023 1 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0127 0.4871 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.023 1 1
Onchocerca volvulus 0.023 1 1
Echinococcus multilocularis orexin receptor type 2 0.023 1 1
Echinococcus multilocularis g protein coupled receptor 0.023 1 1
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0059 0.1433 0.1433
Onchocerca volvulus 0.023 1 1
Onchocerca volvulus 0.023 1 1
Brugia malayi Protein kinase domain containing protein 0.0053 0.1136 0.0148
Echinococcus granulosus cyclin B3 1 0.0043 0.0645 0.0194
Loa Loa (eye worm) melatonin receptor type 1A 0.023 1 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.1887 0.7712
Brugia malayi ORL1-like opioid receptor 0.023 1 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.023 1 1
Echinococcus granulosus g protein coupled receptor 0.023 1 1
Schistosoma mansoni lipoxygenase 0.0057 0.1332 0.0735
Loa Loa (eye worm) glutathione reductase 0.005 0.1012 0.1012
Trypanosoma cruzi CYC2-like cyclin, putative 0.0073 0.2147 1
Echinococcus granulosus tm gpcr rhodopsin 0.023 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.023 1 1
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.023 1 1
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0053 0.1136 0.1094
Onchocerca volvulus 0.023 1 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.023 1 1
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.023 1 1
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0053 0.1136 0.0709
Schistosoma mansoni rhodopsin-like orphan GPCR 0.023 1 1
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.005 0.1002 0.1002
Echinococcus multilocularis neuropeptide Y receptor 0.023 1 1
Brugia malayi G protein-coupled receptor F59B2.13 0.023 1 1
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.1887 0.0983
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.1136 0.0524
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Entamoeba histolytica protein kinase, putative 0.0059 0.1433 0.5243
Giardia lamblia Kinase, CMGC CDK 0.0053 0.1136 0.3267
Onchocerca volvulus 0.023 1 1
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.1136 0.3267
Schistosoma mansoni growth hormone secretagogue receptor 0.023 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.023 1 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.1332 0.0915
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0053 0.1136 0.7727
Brugia malayi RE15519p 0.023 1 1
Onchocerca volvulus 0.023 1 1
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.1136 0.0709
Schistosoma mansoni hypothetical protein 0.023 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.1433 0.5243
Giardia lamblia Kinase, CMGC GSK 0.0059 0.1433 0.5243
Echinococcus multilocularis neuropeptide FF receptor 2 0.023 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.023 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.023 1 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.1887 0.7712
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.023 1 1
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0053 0.1136 0.1094
Toxoplasma gondii thioredoxin reductase 0.005 0.1012 0.6775
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0127 0.4871 1
Echinococcus granulosus dro:myosuppressin receptor 0.023 1 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.023 1 1
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Brugia malayi cell division control protein 2 homolog 0.0053 0.1136 0.0148
Schistosoma mansoni neuropeptide receptor 0.023 1 1
Echinococcus multilocularis cyclins 0.0043 0.0645 0.0194
Echinococcus granulosus cyclin dependent kinase 5 0.0053 0.1136 0.0709
Schistosoma mansoni hypothetical protein 0.023 1 1
Schistosoma mansoni opsin-like receptor 0.023 1 1
Trichomonas vaginalis cyclin B, putative 0.0073 0.2147 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.023 1 1
Trypanosoma cruzi cyclin, putative 0.0073 0.2147 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.108 0.108
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.1136 0.0524
Schistosoma mansoni cyclin B 0.0073 0.2147 0.1605
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Giardia lamblia Kinase, CMGC GSK 0.0059 0.1433 0.5243
Echinococcus granulosus g-protein coupled receptor 0.023 1 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0114 0.4231 0.8342
Mycobacterium tuberculosis Probable reductase 0.0114 0.4231 0.8342
Brugia malayi hypothetical protein 0.023 1 1
Schistosoma mansoni amine GPCR 0.023 1 1
Schistosoma mansoni neuropeptide receptor 0.023 1 1
Brugia malayi hypothetical protein 0.023 1 1
Plasmodium falciparum protein kinase 5 0.0053 0.1136 0.6231
Brugia malayi putative neuropeptide receptor NPR1 0.023 1 1
Brugia malayi Melatonin receptor type 1A 0.023 1 1
Echinococcus multilocularis cyclins 0.0043 0.0645 0.0194
Echinococcus multilocularis G protein coupled receptor 139 0.023 1 1
Echinococcus granulosus neuropeptide FF receptor 2 0.023 1 1
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.1136 0.0709
Echinococcus granulosus somatostatin receptor 0.023 1 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.023 1 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.1012 0.0578
Brugia malayi Cyclin, N-terminal domain containing protein 0.0073 0.2147 0.1272
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.023 1 1
Trichomonas vaginalis cyclins, putative 0.0073 0.2147 1
Echinococcus granulosus cyclin B 0.0073 0.2147 0.1768
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.023 1 1
Echinococcus multilocularis neuropeptide s receptor 0.023 1 1
Brugia malayi hypothetical protein 0.023 1 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.1136 0.1136
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.023 1 1
Echinococcus multilocularis fmrfamide receptor 0.023 1 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.023 1 1
Brugia malayi putative neuropeptide receptor 0.023 1 1
Schistosoma mansoni hypothetical protein 0.023 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.023 1 1
Brugia malayi Serotonin receptor 0.023 1 1
Echinococcus multilocularis allatostatin A receptor 0.023 1 1
Echinococcus multilocularis cyclins 0.0043 0.0645 0.0194
Trichomonas vaginalis cyclin B, putative 0.0073 0.2147 1
Echinococcus granulosus biogenic amine 5HT receptor 0.023 1 1
Onchocerca volvulus 0.023 1 1
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.023 1 1
Echinococcus granulosus allatostatin A receptor 0.023 1 1
Trichomonas vaginalis cyclins, putative 0.0043 0.0645 0.078
Brugia malayi Serotonin receptor 0.023 1 1
Echinococcus granulosus cyclins 0.0043 0.0645 0.0194
Echinococcus granulosus cyclins 0.0043 0.0645 0.0194
Trypanosoma brucei cdc2-related kinase 3 0.0053 0.1136 0.1094
Echinococcus multilocularis alpha 1A adrenergic receptor 0.023 1 1
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Trypanosoma cruzi cyclin, putative 0.0073 0.2147 1
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.023 1 1
Brugia malayi G-protein coupled receptor 0.023 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.023 1 1
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.1012 0.0578
Echinococcus multilocularis rhodopsin orphan GPCR 0.023 1 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.023 1 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0114 0.4231 0.8342
Loa Loa (eye worm) neuropeptide F receptor 0.023 1 1
Brugia malayi follicle stimulating hormone receptor 0.023 1 1
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.2147 0.2147
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Echinococcus multilocularis L aminoadipate semialdehyde 0.0085 0.2767 0.2418
Brugia malayi hypothetical protein 0.023 1 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0114 0.4231 0.8342
Schistosoma mansoni peptide (allatostatin)-like receptor 0.023 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.023 1 1
Echinococcus granulosus 7tm_1 domain containing protein 0.023 1 1
Trichomonas vaginalis cyclin B, putative 0.0073 0.2147 1
Loa Loa (eye worm) hypothetical protein 0.023 1 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.023 1 1
Brugia malayi hypothetical protein 0.023 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.023 1 1
Echinococcus granulosus neuropeptide s receptor 0.023 1 1
Echinococcus multilocularis cyclins 0.0043 0.0645 0.0194
Trichomonas vaginalis cyclin B, putative 0.0073 0.2147 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.065 uM Inhibitory activity against GSK-3alpha/beta from porcine brain ChEMBL. 14761195
IC50 (binding) = 0.065 uM Inhibitory activity against GSK-3alpha/beta from porcine brain ChEMBL. 14761195
IC50 (binding) = 0.4 uM Inhibitory activity against Cyclin-dependent kinase 5-p35nck5a ChEMBL. 14761195
IC50 (binding) = 0.4 uM Inhibitory activity against Cyclin-dependent kinase 5-p35nck5a ChEMBL. 14761195
IC50 (binding) = 1.6 uM Inhibitory activity against cyclin dependent kinase 1-cyclinB from starfish (Marthasterias glacialis) oocytes ChEMBL. 14761195
IC50 (binding) = 1.6 uM Inhibitory activity against cyclin dependent kinase 1-cyclinB from starfish (Marthasterias glacialis) oocytes ChEMBL. 14761195

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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