Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0118 | 0.2829 | 0.4913 |
Schistosoma mansoni | regulator of G protein signaling | 0.0019 | 0.0127 | 0.0075 |
Echinococcus granulosus | axis inhibition protein axin | 0.0019 | 0.0127 | 0.0075 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0029 | 0.04 | 0.0846 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0107 | 0.2506 | 0.4342 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0127 | 0.0127 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0047 | 0.0881 | 0.3347 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0566 | 0.0909 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0118 | 0.2829 | 1 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0029 | 0.04 | 0.4201 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0127 | 0.0127 |
Echinococcus granulosus | 6 phosphofructokinase | 0.0107 | 0.2528 | 0.2489 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0019 | 0.0127 | 0.0075 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.0566 | 0.0517 |
Mycobacterium leprae | PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) | 0.0107 | 0.2528 | 0.8672 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0224 | 0.5704 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0566 | 0.2075 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0019 | 0.0127 | 0.0075 |
Toxoplasma gondii | phosphofructokinase domain-containing protein | 0.0029 | 0.04 | 0.4201 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0047 | 0.0881 | 0.0833 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0336 | 0.0336 |
Brugia malayi | 6-phosphofructokinase | 0.0107 | 0.2528 | 0.2528 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0107 | 0.2528 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0019 | 0.0127 | 0.0181 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0019 | 0.0127 | 0.0075 |
Trichomonas vaginalis | 6-phosphofructokinase, putative | 0.0029 | 0.04 | 0.0846 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0566 | 0.0517 |
Echinococcus granulosus | Regulator of G protein signaling 20 | 0.0019 | 0.0127 | 0.0075 |
Echinococcus granulosus | A kinase anchor protein 10 mitochondrial | 0.0019 | 0.0127 | 0.0075 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0336 | 0.0285 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0035 | 0.0566 | 0.0909 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0029 | 0.04 | 1 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0566 | 0.0566 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0566 | 0.0566 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0566 | 0.0909 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0019 | 0.0127 | 0.0075 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0566 | 0.1248 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0019 | 0.0127 | 0.0127 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.0336 | 0.0285 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0019 | 0.0127 | 0.0075 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0168 | 0.4169 | 1 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0336 | 0.0336 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0035 | 0.0566 | 0.0909 |
Loa Loa (eye worm) | PXA domain-containing protein | 0.0019 | 0.0127 | 0.0127 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0035 | 0.0566 | 0.0909 |
Trichomonas vaginalis | regulator of G protein signaling 5, rgs5, putative | 0.0019 | 0.0127 | 0.0181 |
Echinococcus multilocularis | expressed protein | 0.0369 | 0.9625 | 0.9623 |
Plasmodium vivax | glutathione reductase, putative | 0.0047 | 0.0881 | 1 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0029 | 0.04 | 0.4201 |
Trypanosoma brucei | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0107 | 0.2528 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.0566 | 0.62 |
Echinococcus granulosus | fucosidase alpha L 1 tissue | 0.0383 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0019 | 0.0127 | 0.0181 |
Mycobacterium ulcerans | alpha-L-fucosidase | 0.0383 | 1 | 1 |
Brugia malayi | glutathione reductase | 0.0047 | 0.0881 | 0.0881 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0127 | 0.0127 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0566 | 0.1248 |
Echinococcus multilocularis | regulator of G protein signaling | 0.0019 | 0.0127 | 0.0075 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0107 | 0.2506 | 0.8573 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0127 | 0.0127 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0019 | 0.0127 | 0.0075 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0336 | 0.0336 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0336 | 0.0285 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0029 | 0.04 | 0.4201 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0566 | 0.0566 |
Giardia lamblia | Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit | 0.0029 | 0.04 | 1 |
Entamoeba histolytica | pyrophosphate-dependent phosphofructokinase | 0.0029 | 0.04 | 0.1139 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0127 | 0.0127 |
Brugia malayi | Thioredoxin reductase | 0.0047 | 0.0881 | 0.0881 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0336 | 0.0285 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0029 | 0.04 | 0.0846 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0336 | 0.0336 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0019 | 0.0127 | 0.0181 |
Brugia malayi | PXA domain containing protein | 0.0019 | 0.0127 | 0.0127 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0047 | 0.0881 | 0.0833 |
Toxoplasma gondii | phosphofructokinase PFKII | 0.0029 | 0.04 | 0.4201 |
Schistosoma mansoni | lamin | 0.0027 | 0.0336 | 0.0285 |
Leishmania major | trypanothione reductase | 0.0047 | 0.0881 | 0.3347 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0029 | 0.04 | 0.0846 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0107 | 0.2528 | 1 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0107 | 0.2528 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0029 | 0.04 | 0.0846 |
Mycobacterium tuberculosis | Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) | 0.0107 | 0.2528 | 0.4381 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0566 | 0.0566 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0566 | 0.0566 |
Toxoplasma gondii | thioredoxin reductase | 0.0047 | 0.0881 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0019 | 0.0127 | 0.0181 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0566 | 0.0566 |
Brugia malayi | phosphofructokinase | 0.0107 | 0.2528 | 0.2528 |
Brugia malayi | PXA domain containing protein | 0.0019 | 0.0127 | 0.0127 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0566 | 0.0517 |
Loa Loa (eye worm) | phosphofructokinase | 0.0107 | 0.2528 | 0.2528 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0019 | 0.0127 | 0.0075 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0107 | 0.2506 | 0.4342 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0019 | 0.0127 | 0.0127 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0566 | 0.2075 |
Loa Loa (eye worm) | glutathione reductase | 0.0047 | 0.0881 | 0.0881 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0336 | 0.0285 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0035 | 0.0566 | 0.0909 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0107 | 0.2528 | 0.6014 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0566 | 0.62 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0107 | 0.2528 | 0.2489 |
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.0019 | 0.0127 | 0.0075 |
Echinococcus granulosus | beta-adrenergic receptor kinase | 0.0019 | 0.0127 | 0.0075 |
Schistosoma mansoni | alpha-l-fucosidase | 0.0383 | 1 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0107 | 0.2506 | 0.4342 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.0019 | 0.0127 | 0.0127 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0035 | 0.0566 | 0.0909 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0107 | 0.2506 | 0.4342 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0323 | 0.0323 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0016 | 0.0052 | 0.5 |
Echinococcus multilocularis | A kinase anchor protein 10, mitochondrial | 0.0019 | 0.0127 | 0.0075 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0019 | 0.0127 | 0.0075 |
Loa Loa (eye worm) | RGS-3 protein | 0.0019 | 0.0127 | 0.0127 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0107 | 0.2528 | 0.2489 |
Echinococcus granulosus | lamin | 0.0027 | 0.0336 | 0.0285 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0566 | 0.1248 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0336 | 0.0336 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0019 | 0.0127 | 0.0075 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.0566 | 0.1248 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.0566 | 0.0517 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0566 | 0.0566 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0019 | 0.0127 | 0.0075 |
Schistosoma mansoni | axis inhibition protein axin | 0.0019 | 0.0127 | 0.0075 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0127 | 0.0127 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.0107 | 0.2528 | 0.2489 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0107 | 0.2528 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0047 | 0.0881 | 0.0881 |
Plasmodium falciparum | glutathione reductase | 0.0047 | 0.0881 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0566 | 0.0566 |
Brugia malayi | regulator of G-protein signaling rgs-7 | 0.0019 | 0.0127 | 0.0127 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0019 | 0.0127 | 0.0075 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.0566 | 0.2075 |
Schistosoma mansoni | regulator of G protein signaling | 0.0019 | 0.0127 | 0.0075 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0107 | 0.2506 | 0.4342 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0029 | 0.04 | 0.1406 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.0019 | 0.0127 | 0.0127 |
Plasmodium falciparum | thioredoxin reductase | 0.0047 | 0.0881 | 1 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0019 | 0.0127 | 0.0127 |
Loa Loa (eye worm) | alpha-L-fucosidase | 0.0383 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0019 | 0.0127 | 0.0181 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0168 | 0.4169 | 1 |
Brugia malayi | 6-phosphofructokinase | 0.0107 | 0.2528 | 0.2528 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0566 | 0.0566 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0107 | 0.2528 | 0.2528 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0019 | 0.0127 | 0.0075 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0107 | 0.2528 | 0.6014 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.0566 | 0.0517 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0019 | 0.0127 | 0.0075 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0566 | 0.0909 |
Schistosoma mansoni | axis inhibition protein axin | 0.0019 | 0.0127 | 0.0075 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0029 | 0.04 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0566 | 0.2075 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0566 | 0.1248 |
Schistosoma mansoni | regulator of G protein signaling | 0.0019 | 0.0127 | 0.0075 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0029 | 0.04 | 0.4201 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0336 | 0.0285 |
Echinococcus granulosus | expressed protein | 0.0369 | 0.9625 | 0.9623 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0047 | 0.0881 | 0.1467 |
Echinococcus granulosus | axis inhibition protein axin | 0.0019 | 0.0127 | 0.0075 |
Schistosoma mansoni | regulator of G protein signaling 3 rgs3 | 0.0019 | 0.0127 | 0.0075 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0019 | 0.0127 | 0.0075 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0107 | 0.2528 | 0.2528 |
Schistosoma mansoni | regulator of G protein signaling | 0.0019 | 0.0127 | 0.0075 |
Schistosoma mansoni | lamin | 0.0027 | 0.0336 | 0.0285 |
Trypanosoma cruzi | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0107 | 0.2528 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0047 | 0.0881 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0118 | 0.2829 | 0.4913 |
Schistosoma mansoni | regulator of G protein signaling | 0.0019 | 0.0127 | 0.0075 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0016 | 0.0052 | 0.0052 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.0566 | 0.0517 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0566 | 0.0517 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0127 | 0.0127 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0107 | 0.2528 | 0.2489 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0016 | 0.0052 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0566 | 0.0566 |
Leishmania major | ATP-dependent phosphofructokinase | 0.0107 | 0.2528 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0029 | 0.04 | 0.0846 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0035 | 0.0566 | 0.0909 |
Trypanosoma brucei | trypanothione reductase | 0.0047 | 0.0881 | 0.3347 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0566 | 0.0517 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0107 | 0.2528 | 0.6014 |
Onchocerca volvulus | 0.0035 | 0.0566 | 1 | |
Toxoplasma gondii | 6-phosphofructokinase | 0.0029 | 0.04 | 0.4201 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0566 | 0.0566 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0566 | 0.1248 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0107 | 0.2528 | 0.6014 |
Onchocerca volvulus | 0.0035 | 0.0566 | 1 | |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0566 | 0.0517 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0566 | 0.0566 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0127 | 0.0127 |
Onchocerca volvulus | 0.0035 | 0.0566 | 1 | |
Loa Loa (eye worm) | AGC/GRK/BARK protein kinase | 0.0019 | 0.0127 | 0.0127 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0029 | 0.04 | 0.0846 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0035 | 0.0566 | 0.0909 |
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 0.0383 | 1 | 1 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0019 | 0.0127 | 0.0075 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0118 | 0.2829 | 0.4913 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0019 | 0.0127 | 0.0075 |
Echinococcus multilocularis | Regulator of G protein signaling 20 | 0.0019 | 0.0127 | 0.0075 |
Brugia malayi | A-kinase anchor protein 10, precursor | 0.0019 | 0.0127 | 0.0127 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0107 | 0.2506 | 0.4342 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0019 | 0.0127 | 0.0181 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0019 | 0.0127 | 0.0127 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
HI (functional) | = 5 | Hypotensive index (HI) measured as the area under the time-hypotensive response curve for 6-h period at 30mg/kg,po | ChEMBL. | 7401118 |
IVP (functional) | = 0 | Integrated vasodilating potency (IVP) (the product of compound-induced maximum percent decrease in the perfusion pressure and the duration of the effect in minutes at 100 ug (ia)) | ChEMBL. | 7401118 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.