Detailed information for compound 306917

Basic information

Technical information
  • TDR Targets ID: 306917
  • Name: (E)-3-(5-methyl-2,4-dioxopyrimidin-1-yl)prop- 2-enal
  • MW: 180.161 | Formula: C8H8N2O3
  • H donors: 1 H acceptors: 3 LogP: -0.81 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C/C=C/n1cc(C)c(=O)[nH]c1=O
  • InChi: 1S/C8H8N2O3/c1-6-5-10(3-2-4-11)8(13)9-7(6)12/h2-5H,1H3,(H,9,12,13)/b3-2+
  • InChiKey: CDPXAPVOBNKPPD-NSCUHMNNSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-3-(5-methyl-2,4-dioxo-pyrimidin-1-yl)prop-2-enal
  • (E)-3-(5-methyl-2,4-dioxo-1-pyrimidinyl)-2-propenal
  • (E)-3-(2,4-diketo-5-methyl-pyrimidin-1-yl)acrolein
  • 3-(thymin-1'-yl)-2-propenal
  • (E)-3-(5-methyl-2,4-dioxo-1-pyrimidinyl)prop-2-enal
  • 85394-19-0
  • Thymine propenal
  • Thymine-N(1)-2-propenal
  • 2-Propenal, 3-(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)-
  • TNPP

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus rhodopsin orphan GPCR 0.0174 0.0668 0.0871
Loa Loa (eye worm) hypothetical protein 0.0131 0.0464 0.1396
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0174 0.0668 0.1399
Schistosoma mansoni hypothetical protein 0.0174 0.0668 0.1399
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0131 0.0464 0.0459
Brugia malayi hypothetical protein 0.0174 0.0668 0.0663
Echinococcus multilocularis g-protein coupled receptor 0.0174 0.0668 0.0966
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0174 0.0668 0.0966
Echinococcus granulosus sex peptide receptor 0.0174 0.0668 0.0871
Schistosoma mansoni acetylcholine receptor subunit beta 0.0055 0.0115 0.0231
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0618 0.2725 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0049 0.0088 0.261
Loa Loa (eye worm) hypothetical protein 0.0174 0.0668 0.2015
Leishmania major calcium channel protein, putative,ion transporter, putative 0.004 0.0043 0.0604
Onchocerca volvulus 0.0174 0.0668 0.257
Brugia malayi Pre-SET motif family protein 0.0221 0.0884 0.0879
Schistosoma mansoni amine GPCR 0.0174 0.0668 0.1399
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.01 0.0321 1
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.01 0.0321 0.0959
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0131 0.0464 0.1396
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0049 0.0088 0.0389
Plasmodium falciparum amino acid transporter, putative 0.01 0.0321 1
Echinococcus multilocularis g protein coupled receptor 0.0174 0.0668 0.0966
Schistosoma mansoni nAChR subunit 0.0131 0.0464 0.0969
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0089 0.0272 0.0355
Loa Loa (eye worm) hypothetical protein 0.0337 0.1421 0.4308
Loa Loa (eye worm) hypothetical protein 0.0075 0.0208 0.0616
Echinococcus multilocularis L aminoadipate semialdehyde 0.0176 0.0674 0.0976
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.01 0.0321 0.046
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0049 0.0088 0.261
Brugia malayi Dopamine receptor protein 2 0.0174 0.0668 0.0663
Loa Loa (eye worm) hypothetical protein 0.0055 0.0115 0.0333
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0041 0.0001
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0075 0.0208 0.0202
Loa Loa (eye worm) hypothetical protein 0.057 0.2503 0.7598
Loa Loa (eye worm) hypothetical protein 0.0131 0.0464 0.1396
Schistosoma mansoni acetylcholine receptor-related 0.0055 0.0115 0.0231
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0174 0.0668 0.1399
Loa Loa (eye worm) hypothetical protein 0.01 0.0321 0.0959
Schistosoma mansoni hypothetical protein 0.0174 0.0668 0.1399
Loa Loa (eye worm) hypothetical protein 0.0174 0.0668 0.2015
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.01 0.0321 0.0666
Schistosoma mansoni neuropeptide receptor 0.0174 0.0668 0.1399
Loa Loa (eye worm) hypothetical protein 0.01 0.0321 0.0959
Schistosoma mansoni amine GPCR 0.0174 0.0668 0.1399
Brugia malayi hypothetical protein 0.0174 0.0668 0.0663
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0041 0.0053
Loa Loa (eye worm) hypothetical protein 0.0055 0.0115 0.0333
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0055 0.0115 0.011
Schistosoma mansoni nAChR subunit 0.0055 0.0115 0.0231
Loa Loa (eye worm) hypothetical protein 0.0075 0.0208 0.0616
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0055 0.0115 0.011
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0131 0.0464 0.0459
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.01 0.0321 0.0666
Loa Loa (eye worm) hypothetical protein 0.0174 0.0668 0.2015
Echinococcus multilocularis fmrfamide receptor 0.0174 0.0668 0.0966
Brugia malayi hypothetical protein 0.0174 0.0668 0.0663
Trypanosoma brucei hypothetical protein, conserved 0.0049 0.0088 1
Loa Loa (eye worm) hypothetical protein 0.0489 0.2125 0.6448
Echinococcus multilocularis nAChR subunit 0.0075 0.0208 0.0295
Loa Loa (eye worm) hypothetical protein 0.0174 0.0668 0.2015
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0174 0.0668 0.1399
Echinococcus granulosus glycine receptor subunit beta 0.0131 0.0464 0.0606
Toxoplasma gondii hypothetical protein 0.01 0.0321 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0974 0.4377 0.638
Brugia malayi Cytochrome P450 family protein 0.0059 0.0134 0.0128
Echinococcus granulosus g protein coupled receptor 0.0174 0.0668 0.0871
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0131 0.0464 0.067
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0174 0.0668 0.257
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0489 0.2125 0.2121
Plasmodium vivax hypothetical protein, conserved 0.01 0.0321 1
Onchocerca volvulus 0.01 0.0321 0.1224
Schistosoma mansoni biogenic amine receptor 0.0174 0.0668 0.1399
Echinococcus granulosus peptide allatostatin:somatostatin 0.0174 0.0668 0.0871
Brugia malayi hypothetical protein 0.0129 0.0458 0.0453
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0174 0.0668 0.2015
Echinococcus multilocularis neuropeptide FF receptor 2 0.0174 0.0668 0.0966
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.01 0.0321 0.0666
Schistosoma mansoni biogenic amine (5HT) receptor 0.0974 0.4377 0.9232
Loa Loa (eye worm) acetylcholine receptor protein 0.0055 0.0115 0.0333
Echinococcus granulosus lysine specific demethylase 5A 0.0062 0.0148 0.0193
Brugia malayi Cation transporter family protein 0.0131 0.0464 0.0459
Brugia malayi hypothetical protein 0.01 0.0321 0.0316
Loa Loa (eye worm) hypothetical protein 0.0174 0.0668 0.2015
Loa Loa (eye worm) hypothetical protein 0.0131 0.0464 0.1396
Schistosoma mansoni amine GPCR 0.1052 0.4741 1
Echinococcus granulosus tumor protein p63 0.0359 0.1523 0.1987
Brugia malayi hypothetical protein 0.0174 0.0668 0.0663
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.01 0.0321 0.0418
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0174 0.0668 0.0966
Loa Loa (eye worm) hypothetical protein 0.0174 0.0668 0.2015
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0131 0.0464 0.0606
Loa Loa (eye worm) hypothetical protein 0.01 0.0321 0.0959
Loa Loa (eye worm) hypothetical protein 0.0174 0.0668 0.2015
Echinococcus granulosus hypothetical protein 0.1683 0.7667 1
Loa Loa (eye worm) hypothetical protein 0.0174 0.0668 0.2015
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0049 0.0088 0.261
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0131 0.0464 0.0459
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0055 0.0115 0.016
Onchocerca volvulus 0.0131 0.0464 0.1781
Brugia malayi putative neuropeptide receptor 0.0174 0.0668 0.0663
Brugia malayi hypothetical protein 0.0055 0.0115 0.011
Loa Loa (eye worm) hypothetical protein 0.0174 0.0668 0.2015
Loa Loa (eye worm) hypothetical protein 0.0075 0.0208 0.0616
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.01 0.0321 0.0666
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0131 0.0464 0.0459
Echinococcus multilocularis sodium and chloride dependent glycine 0.01 0.0321 0.046
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0131 0.0464 0.067
Loa Loa (eye worm) hypothetical protein 0.0055 0.0115 0.0333
Loa Loa (eye worm) neuropeptide F receptor 0.0174 0.0668 0.2015
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0174 0.0668 0.0663
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0131 0.0464 0.0969
Echinococcus granulosus rhodopsin orphan GPCR 0.0174 0.0668 0.0871
Loa Loa (eye worm) hypothetical protein 0.0131 0.0464 0.1396
Echinococcus granulosus neuropeptide receptor A26 0.0174 0.0668 0.0871
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0055 0.0115 0.016
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0618 0.2725 1
Echinococcus multilocularis neuropeptide receptor A26 0.0174 0.0668 0.0966
Schistosoma mansoni neuropeptide receptor 0.0174 0.0668 0.1399
Schistosoma mansoni sodium-dependent amino acid transporter 0.01 0.0321 0.0666
Schistosoma mansoni nAChR subunit 0.0131 0.0464 0.0969
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0131 0.0464 0.0969
Loa Loa (eye worm) serotonin transporter b 0.0587 0.2583 0.784
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.01 0.0321 0.0418
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0174 0.0668 0.0871
Loa Loa (eye worm) hypothetical protein 0.0131 0.0464 0.1396
Loa Loa (eye worm) hypothetical protein 0.074 0.3292 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0115 0.0333
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0587 0.2583 0.2579
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0041 0.0046
Echinococcus multilocularis dro:myosuppressin receptor 0.0174 0.0668 0.0966
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0489 0.2125 0.4476
Brugia malayi hypothetical protein 0.0174 0.0668 0.0663
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.004 0.1107
Brugia malayi ORL1-like opioid receptor 0.0174 0.0668 0.0663
Loa Loa (eye worm) hypothetical protein 0.0174 0.0668 0.2015
Brugia malayi Dopamine receptor protein 1 0.0174 0.0668 0.0663
Schistosoma mansoni neurotransmitter gated ion channel 0.0075 0.0208 0.0427
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0131 0.0464 0.0969
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.01 0.0321 0.0316
Onchocerca volvulus 0.0131 0.0464 0.1781
Loa Loa (eye worm) hypothetical protein 0.0174 0.0668 0.2015
Echinococcus multilocularis neuropeptides capa receptor 0.0174 0.0668 0.0966
Loa Loa (eye worm) hypothetical protein 0.01 0.0321 0.0959
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0131 0.0464 0.067
Loa Loa (eye worm) hypothetical protein 0.0055 0.0115 0.0333
Schistosoma mansoni neurotransmitter gated ion channel 0.0055 0.0115 0.0231
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0618 0.2725 1
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0176 0.0674 0.1412
Schistosoma mansoni neuropeptide f receptor 76f 0.0174 0.0668 0.1399
Loa Loa (eye worm) hypothetical protein 0.0174 0.0668 0.2015
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0174 0.0668 0.0871
Echinococcus granulosus jun protein 0.0089 0.0272 0.0355
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0174 0.0668 0.1399
Brugia malayi Tachykinin-like peptides receptor 99D 0.0174 0.0668 0.0663
Brugia malayi neuropeptide F receptor 0.0174 0.0668 0.0663
Loa Loa (eye worm) hypothetical protein 0.0174 0.0668 0.2015
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0131 0.0464 0.067
Brugia malayi hypothetical protein 0.007 0.0183 0.0178
Echinococcus granulosus geminin 0.0358 0.1521 0.1983
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0055 0.0115 0.011
Brugia malayi hypothetical protein 0.0174 0.0668 0.0663
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0131 0.0464 0.067
Echinococcus granulosus neuropeptide Y receptor 0.0174 0.0668 0.0871
Schistosoma mansoni sodium/chloride dependent transporter 0.01 0.0321 0.0666
Echinococcus granulosus sodium channel protein 0.004 0.0043 0.0056
Onchocerca volvulus 0.0174 0.0668 0.257
Brugia malayi G-protein coupled receptor 0.0174 0.0668 0.0663
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0055 0.0115 0.016
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0419 0.1801 0.5463
Echinococcus multilocularis tumor protein p63 0.0359 0.1523 0.2215
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0174 0.0668 0.1399
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0055 0.0115 0.0333
Brugia malayi hypothetical protein 0.0174 0.0668 0.0663
Loa Loa (eye worm) hypothetical protein 0.0131 0.0464 0.1396
Echinococcus multilocularis serotonin receptor 0.057 0.2503 0.3645
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0174 0.0668 0.0966
Echinococcus multilocularis rhodopsin orphan GPCR 0.0174 0.0668 0.0966
Onchocerca volvulus 0.0131 0.0464 0.1781
Echinococcus granulosus tachykinin peptides receptor 99D 0.0174 0.0668 0.0871
Echinococcus multilocularis rhodopsin orphan GPCR 0.0174 0.0668 0.0966
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0131 0.0464 0.0459
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0131 0.0464 0.067
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0131 0.0464 0.0969
Echinococcus multilocularis fmrfamide receptor 0.0174 0.0668 0.0966
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0618 0.2725 1
Onchocerca volvulus 0.0174 0.0668 0.257
Echinococcus multilocularis lysine specific demethylase 5A 0.0062 0.0148 0.0208
Loa Loa (eye worm) hypothetical protein 0.01 0.0321 0.0959
Loa Loa (eye worm) hypothetical protein 0.0587 0.2583 0.784
Echinococcus multilocularis glycine receptor subunit beta 0.0131 0.0464 0.067
Loa Loa (eye worm) hypothetical protein 0.0174 0.0668 0.2015
Echinococcus granulosus neuropeptide receptor 0.0174 0.0668 0.0871
Echinococcus multilocularis serotonin transporter 0.0587 0.2583 0.3761
Schistosoma mansoni alpha-1 adrenergic receptor 0.0174 0.0668 0.1399
Onchocerca volvulus 0.01 0.0321 0.1224
Echinococcus granulosus nAChR subunit 0.0075 0.0208 0.0271
Brugia malayi Dopamine receptor 0.0174 0.0668 0.0663
Brugia malayi bZIP transcription factor family protein 0.0089 0.0272 0.0267
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1054 0.4748 0.6921
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.01 0.0321 0.046
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0131 0.0464 0.0459
Loa Loa (eye worm) hypothetical protein 0.0174 0.0668 0.2015
Echinococcus granulosus dro:myosuppressin receptor 0.0174 0.0668 0.0871
Echinococcus granulosus rhodopsin orphan GPCR 0.0174 0.0668 0.0871
Loa Loa (eye worm) hypothetical protein 0.0131 0.0464 0.1396
Loa Loa (eye worm) hypothetical protein 0.0075 0.0208 0.0616
Echinococcus multilocularis g protein coupled receptor 0.0174 0.0668 0.0966
Echinococcus granulosus rhodopsin orphan GPCR 0.0174 0.0668 0.0871
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0055 0.0115 0.015
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0131 0.0464 0.0606
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0055 0.0115 0.015
Loa Loa (eye worm) hypothetical protein 0.0131 0.0464 0.1396
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0174 0.0668 0.0966
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0041 0.0053
Loa Loa (eye worm) hypothetical protein 0.0055 0.0115 0.0333
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0131 0.0464 0.0606
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0131 0.0464 0.0459
Loa Loa (eye worm) hypothetical protein 0.0055 0.0115 0.0333
Loa Loa (eye worm) hypothetical protein 0.0174 0.0668 0.2015
Schistosoma mansoni nAChR subunit 0.0131 0.0464 0.0969
Loa Loa (eye worm) hypothetical protein 0.0174 0.0668 0.2015
Onchocerca volvulus Neuropeptide F receptor homolog 0.0174 0.0668 0.257
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0131 0.0464 0.0459
Echinococcus granulosus neuropeptides capa receptor 0.0174 0.0668 0.0871
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.01 0.0321 0.0666
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0174 0.0668 0.1399
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0174 0.0668 0.0871
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0131 0.0464 0.0459
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0131 0.0464 0.0606
Echinococcus granulosus glycine receptor subunit beta 0.0131 0.0464 0.0606
Echinococcus granulosus glycine receptor subunit alpha 1 0.0131 0.0464 0.0606
Brugia malayi follicle stimulating hormone receptor 0.0419 0.1801 0.1797
Echinococcus granulosus neuropeptides capa receptor 0.0174 0.0668 0.0871
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0131 0.0464 0.067
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0005 0.0007
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0174 0.0668 0.2015
Onchocerca volvulus 0.0174 0.0668 0.257
Loa Loa (eye worm) hypothetical protein 0.01 0.0321 0.0959
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0176 0.0674 0.0669
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0131 0.0464 0.1396
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0049 0.0088 0.0389
Loa Loa (eye worm) hypothetical protein 0.0055 0.0115 0.0333
Onchocerca volvulus 0.0174 0.0668 0.257
Onchocerca volvulus 0.0055 0.0115 0.0425
Loa Loa (eye worm) hypothetical protein 0.0174 0.0668 0.2015
Loa Loa (eye worm) hypothetical protein 0.0174 0.0668 0.2015
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0174 0.0668 0.0966
Brugia malayi Sodium:neurotransmitter symporter family protein 0.01 0.0321 0.0316
Brugia malayi sulfakinin receptor protein 0.0174 0.0668 0.0663
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0174 0.0668 0.1399
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0075 0.0208 0.0202
Loa Loa (eye worm) hypothetical protein 0.0055 0.0115 0.0333
Echinococcus granulosus g protein coupled receptor 0.0174 0.0668 0.0871
Onchocerca volvulus 0.0174 0.0668 0.257
Loa Loa (eye worm) hypothetical protein 0.0174 0.0668 0.2015
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0041 0.0001
Schistosoma mansoni amine GPCR 0.0174 0.0668 0.1399
Echinococcus multilocularis rhodopsin orphan GPCR 0.0174 0.0668 0.0966
Schistosoma mansoni growth hormone secretagogue receptor 0.0174 0.0668 0.1399
Echinococcus multilocularis sodium channel protein 0.004 0.0043 0.0055
Loa Loa (eye worm) hypothetical protein 0.0174 0.0668 0.2015
Loa Loa (eye worm) hypothetical protein 0.0055 0.0115 0.0333
Echinococcus granulosus alpha 1A adrenergic receptor 0.0174 0.0668 0.0871
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0618 0.2725 1
Loa Loa (eye worm) hypothetical protein 0.0174 0.0668 0.2015
Schistosoma mansoni nAChR subunit 0.0131 0.0464 0.0969
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0075 0.0208 0.0427
Echinococcus granulosus uncharacterized sodium dependent transporter 0.01 0.0321 0.0418
Echinococcus granulosus 7tm_1 domain containing protein 0.0174 0.0668 0.0871
Echinococcus granulosus rhodopsin orphan GPCR 0.0174 0.0668 0.0871
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0131 0.0464 0.1396
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0055 0.0115 0.011
Loa Loa (eye worm) hypothetical protein 0.0131 0.0464 0.1396
Schistosoma mansoni biogenic amine (5HT) receptor 0.057 0.2503 0.5274
Onchocerca volvulus 0.0176 0.0674 0.2594
Loa Loa (eye worm) GABA receptor subunit 0.0075 0.0208 0.0616
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0049 0.0088 0.0537
Echinococcus multilocularis G protein coupled receptor 139 0.0174 0.0668 0.0966
Mycobacterium leprae conserved hypothetical protein 0.0049 0.0088 0.0537
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0131 0.0464 0.0606
Echinococcus multilocularis jun protein 0.0089 0.0272 0.0389
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0041 0.0001
Echinococcus granulosus orexin receptor type 2 0.0174 0.0668 0.0871
Onchocerca volvulus 0.0174 0.0668 0.257
Schistosoma mansoni amine GPCR 0.0174 0.0668 0.1399
Loa Loa (eye worm) TYRA-2 protein 0.0174 0.0668 0.2015
Loa Loa (eye worm) ACC-1 protein 0.0131 0.0464 0.1396
Schistosoma mansoni hypothetical protein 0.0174 0.0668 0.1399
Onchocerca volvulus 0.0587 0.2583 1
Loa Loa (eye worm) hypothetical protein 0.0131 0.0464 0.1396
Schistosoma mansoni nAChR subunit 0.0055 0.0115 0.0231
Echinococcus multilocularis sodium and chloride dependent glycine 0.01 0.0321 0.046
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0075 0.0208 0.0427
Onchocerca volvulus 0.0174 0.0668 0.257
Schistosoma mansoni neuropeptide receptor 0.0174 0.0668 0.1399
Trichomonas vaginalis set domain proteins, putative 0.0252 0.1025 0.3669
Loa Loa (eye worm) hypothetical protein 0.0055 0.0115 0.0333
Schistosoma mansoni opsin-like receptor 0.0174 0.0668 0.1399
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0049 0.0088 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0174 0.0668 0.1399
Onchocerca volvulus 0.0131 0.0464 0.1781
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0174 0.0668 0.1399
Echinococcus granulosus neuropeptide FF receptor 2 0.0174 0.0668 0.0871
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.0041 0.0051
Loa Loa (eye worm) hypothetical protein 0.0174 0.0668 0.2015
Echinococcus multilocularis neuropeptide s receptor 0.0174 0.0668 0.0966
Echinococcus granulosus sodium and chloride dependent glycine 0.01 0.0321 0.0418
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0075 0.0208 0.0202
Loa Loa (eye worm) hypothetical protein 0.0174 0.0668 0.2015
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0131 0.0464 0.0969
Brugia malayi RE15519p 0.0174 0.0668 0.0663
Schistosoma mansoni biogenic amine receptor 0.0174 0.0668 0.1399
Onchocerca volvulus 0.01 0.0321 0.1224
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.01 0.0321 0.0666
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0148 0.0301
Loa Loa (eye worm) hypothetical protein 0.0174 0.0668 0.2015
Entamoeba histolytica hypothetical protein 0.0075 0.0208 0.0623
Onchocerca volvulus 0.0174 0.0668 0.257
Brugia malayi hypothetical protein 0.0055 0.0115 0.011
Loa Loa (eye worm) hypothetical protein 0.0587 0.2583 0.784
Echinococcus granulosus serotonin receptor 0.0174 0.0668 0.0871
Echinococcus granulosus rhodopsin orphan GPCR 0.0174 0.0668 0.0871
Loa Loa (eye worm) hypothetical protein 0.0174 0.0668 0.2015
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.01 0.0321 0.046
Onchocerca volvulus 0.007 0.0183 0.069
Schistosoma mansoni jun-related protein 0.0072 0.0195 0.04
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0174 0.0668 0.0871
Loa Loa (eye worm) LGC-31 protein 0.0131 0.0464 0.1396
Brugia malayi Serotonin receptor 0.0174 0.0668 0.0663
Brugia malayi putative neuropeptide receptor NPR1 0.0174 0.0668 0.0663
Loa Loa (eye worm) hypothetical protein 0.0055 0.0115 0.0333
Echinococcus multilocularis rhodopsin orphan GPCR 0.0174 0.0668 0.0966
Schistosoma mansoni neurotransmitter gated ion channel 0.0055 0.0115 0.0231
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.01 0.0321 1
Loa Loa (eye worm) hypothetical protein 0.0174 0.0668 0.2015
Echinococcus granulosus tm gpcr rhodopsin 0.1054 0.4748 0.6193
Onchocerca volvulus 0.0174 0.0668 0.257
Loa Loa (eye worm) hypothetical protein 0.0075 0.0208 0.0616
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0174 0.0668 0.0966
Onchocerca volvulus 0.0055 0.0115 0.0425
Loa Loa (eye worm) hypothetical protein 0.0176 0.0674 0.2034
Loa Loa (eye worm) hypothetical protein 0.0055 0.0115 0.0333
Loa Loa (eye worm) G-protein coupled receptor 0.0174 0.0668 0.2015
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0302 0.1259 1
Echinococcus multilocularis allatostatin A receptor 0.0174 0.0668 0.0966
Schistosoma mansoni nAChR subunit 0.0131 0.0464 0.0969
Loa Loa (eye worm) hypothetical protein 0.0489 0.2125 0.6448
Brugia malayi AKH receptor 0.0174 0.0668 0.0663
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0221 0.0884 0.2672
Loa Loa (eye worm) G-protein coupled receptor 0.0174 0.0668 0.2015
Loa Loa (eye worm) solute carrier family 6 member 4 0.0587 0.2583 0.784
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0618 0.2725 1
Onchocerca volvulus 0.0174 0.0668 0.257
Echinococcus multilocularis neuropeptide Y receptor 0.0174 0.0668 0.0966
Loa Loa (eye worm) hypothetical protein 0.0174 0.0668 0.2015
Echinococcus granulosus serotonin transporter 0.0587 0.2583 0.3368
Brugia malayi G protein-coupled receptor 0.0174 0.0668 0.0663
Schistosoma mansoni neuropeptide receptor 0.0174 0.0668 0.1399
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0148 0.0434
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0131 0.0464 0.1396
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0055 0.0115 0.0333
Echinococcus granulosus biogenic amine 5HT receptor 0.0974 0.4377 0.5709
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0131 0.0464 0.1396
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0041 1
Loa Loa (eye worm) hypothetical protein 0.0131 0.0464 0.1396
Echinococcus granulosus glycine receptor subunit alpha 1 0.0131 0.0464 0.0606
Onchocerca volvulus 0.0131 0.0464 0.1781
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0131 0.0464 0.0459
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0174 0.0668 0.1399
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0148 0.0301
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.004 0.0051
Onchocerca volvulus 0.0131 0.0464 0.1781
Loa Loa (eye worm) hypothetical protein 0.0174 0.0668 0.2015
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0062 0.0148 0.0208
Loa Loa (eye worm) hypothetical protein 0.0174 0.0668 0.2015
Brugia malayi G protein-coupled receptor F59B2.13 0.0174 0.0668 0.0663
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0131 0.0464 0.0606
Onchocerca volvulus 0.0075 0.0208 0.0785
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0174 0.0668 0.0966
Loa Loa (eye worm) hypothetical protein 0.0131 0.0464 0.1396
Schistosoma mansoni opsin-like receptor 0.0174 0.0668 0.1399
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0174 0.0668 0.2015
Loa Loa (eye worm) hypothetical protein 0.0039 0.0041 0.0107
Schistosoma mansoni hypothetical protein 0.0358 0.1521 0.32
Loa Loa (eye worm) hypothetical protein 0.01 0.0321 0.0959
Schistosoma mansoni nAChR subunit 0.0131 0.0464 0.0969
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.0041 0.0074
Schistosoma mansoni myosin xvIII 0.0174 0.0668 0.1399
Loa Loa (eye worm) hypothetical protein 0.0174 0.0668 0.2015
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0174 0.0668 0.0966
Schistosoma mansoni opsin-like receptor 0.0174 0.0668 0.1399
Loa Loa (eye worm) hypothetical protein 0.0614 0.2708 0.8222
Onchocerca volvulus 0.0055 0.0115 0.0425
Echinococcus multilocularis sex peptide receptor 0.0174 0.0668 0.0966
Schistosoma mansoni biogenic amine receptor 0.0174 0.0668 0.1399
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0131 0.0464 0.0606
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.0041 0.0074
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0131 0.0464 0.0459
Brugia malayi hypothetical protein 0.0174 0.0668 0.0663
Schistosoma mansoni neuropeptide F-like receptor 0.0174 0.0668 0.1399
Brugia malayi hypothetical protein 0.0055 0.0115 0.011
Onchocerca volvulus 0.0075 0.0208 0.0785
Echinococcus granulosus neuropeptide Y receptor 0.0174 0.0668 0.0871
Echinococcus multilocularis glycine receptor subunit beta 0.0131 0.0464 0.067
Loa Loa (eye worm) hypothetical protein 0.0174 0.0668 0.2015
Echinococcus multilocularis g protein coupled receptor 0.0174 0.0668 0.0966
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0174 0.0668 0.0966
Echinococcus granulosus tm gpcr rhodopsin 0.0174 0.0668 0.0871
Echinococcus multilocularis nAChR subunit 0.0131 0.0464 0.067
Loa Loa (eye worm) hypothetical protein 0.0131 0.0464 0.1396
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0174 0.0668 0.1399
Onchocerca volvulus 0.0174 0.0668 0.257
Echinococcus multilocularis neuropeptide receptor 0.0174 0.0668 0.0966
Schistosoma mansoni hypothetical protein 0.0174 0.0668 0.1399
Loa Loa (eye worm) hypothetical protein 0.0075 0.0208 0.0616
Giardia lamblia Fructose-bisphosphate aldolase 0.0618 0.2725 1
Onchocerca volvulus 0.0174 0.0668 0.257
Loa Loa (eye worm) hypothetical protein 0.0055 0.0115 0.0333
Loa Loa (eye worm) hypothetical protein 0.0131 0.0464 0.1396
Brugia malayi Melatonin receptor type 1A 0.0174 0.0668 0.0663
Loa Loa (eye worm) hypothetical protein 0.057 0.2503 0.7598
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.01 0.0321 0.0666
Loa Loa (eye worm) hypothetical protein 0.0087 0.0261 0.0777
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0618 0.2725 1
Echinococcus granulosus g-protein coupled receptor 0.0174 0.0668 0.0871
Brugia malayi hypothetical protein 0.0174 0.0668 0.0663
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0174 0.0668 0.0871
Loa Loa (eye worm) hypothetical protein 0.0174 0.0668 0.2015
Onchocerca volvulus 0.0174 0.0668 0.257
Loa Loa (eye worm) hypothetical protein 0.0174 0.0668 0.2015
Loa Loa (eye worm) hypothetical protein 0.0174 0.0668 0.2015
Echinococcus multilocularis serotonin receptor 0.057 0.2503 0.3645
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0131 0.0464 0.0459
Echinococcus granulosus G protein coupled receptor 139 0.0174 0.0668 0.0871
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0131 0.0464 0.0459
Brugia malayi hypothetical protein 0.0174 0.0668 0.0663
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.01 0.0321 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.0134 0.039
Echinococcus granulosus fmrfamide receptor 0.0174 0.0668 0.0871
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0302 0.1259 1
Loa Loa (eye worm) hypothetical protein 0.0131 0.0464 0.1396
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0174 0.0668 0.1399
Echinococcus granulosus somatostatin receptor 0.0174 0.0668 0.0871
Plasmodium falciparum transporter, putative 0.01 0.0321 1
Echinococcus granulosus allatostatin A receptor 0.0174 0.0668 0.0871
Echinococcus granulosus g protein coupled receptor 0.0174 0.0668 0.0871
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0131 0.0464 0.067
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0174 0.0668 0.1399
Treponema pallidum fructose-bisphosphate aldolase 0.0618 0.2725 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0174 0.0668 0.1399
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0131 0.0464 0.0459
Loa Loa (eye worm) neuropeptide F receptor 0.0174 0.0668 0.2015
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0174 0.0668 0.1399
Brugia malayi hypothetical protein 0.0055 0.0115 0.011
Loa Loa (eye worm) hypothetical protein 0.0174 0.0668 0.2015
Echinococcus granulosus glycine receptor subunit alpha 1 0.0131 0.0464 0.0606
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0618 0.2725 1
Echinococcus multilocularis somatostatin receptor 0.0174 0.0668 0.0966
Echinococcus granulosus sodium and chloride dependent glycine 0.01 0.0321 0.0418
Echinococcus multilocularis conserved hypothetical protein 0.1509 0.6858 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.01 0.0321 0.0418
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0174 0.0668 0.1399
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0174 0.0668 0.0966
Loa Loa (eye worm) hypothetical protein 0.0055 0.0115 0.0333
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0102 0.0204
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0089 0.0272 0.0389
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0041 0.0051
Echinococcus multilocularis rhodopsin orphan GPCR 0.0174 0.0668 0.0966
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0174 0.0668 0.0966
Leishmania major phosphopantetheinyl transferase-like protein 0.0049 0.0088 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.01 0.0321 0.0666
Brugia malayi Sodium:neurotransmitter symporter family protein 0.01 0.0321 0.0316
Loa Loa (eye worm) hypothetical protein 0.0131 0.0464 0.1396
Echinococcus granulosus rhodopsin orphan GPCR 0.0174 0.0668 0.0871
Loa Loa (eye worm) ACC-1 protein 0.0131 0.0464 0.1396
Loa Loa (eye worm) hypothetical protein 0.0131 0.0464 0.1396
Onchocerca volvulus 0.0174 0.0668 0.257
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0062 0.0148 0.0193
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0302 0.1259 1
Echinococcus multilocularis expressed protein 0.0396 0.1698 0.2469
Entamoeba histolytica hypothetical protein 0.0049 0.0088 0.0176
Echinococcus granulosus biogenic amine 5HT receptor 0.057 0.2503 0.3265
Echinococcus granulosus tm gpcr rhodopsin 0.0174 0.0668 0.0871
Echinococcus multilocularis geminin 0.0358 0.1521 0.2211
Brugia malayi G-protein coupled receptor 0.0174 0.0668 0.0663
Toxoplasma gondii hypothetical protein 0.01 0.0321 1
Plasmodium vivax amine transporter, putative 0.01 0.0321 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0174 0.0668 0.1399
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0174 0.0668 0.2015
Schistosoma mansoni jumonji domain containing protein 0.0062 0.0148 0.0301
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0174 0.0668 0.1399
Echinococcus granulosus 7TM GPCR rhodopsin 0.0174 0.0668 0.0871
Echinococcus granulosus nAChR subunit 0.0131 0.0464 0.0606
Schistosoma mansoni nAChR subunit 0.0131 0.0464 0.0969
Onchocerca volvulus Putative nachr subunit 0.0131 0.0464 0.1781
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0131 0.0464 0.0969
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0587 0.2583 0.5443
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0055 0.0115 0.011
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.01 0.0321 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0174 0.0668 0.1399
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0174 0.0668 0.1399
Loa Loa (eye worm) norepinephrine transporter 0.0587 0.2583 0.784
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0174 0.0668 0.0966
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0131 0.0464 0.0459
Echinococcus multilocularis G-protein coupled receptor, putative 0.0174 0.0668 0.0966
Loa Loa (eye worm) melatonin receptor type 1A 0.0174 0.0668 0.2015
Brugia malayi Cation transporter family protein 0.0131 0.0464 0.0459
Echinococcus multilocularis rhodopsin orphan GPCR 0.0174 0.0668 0.0966
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.004 0.0043 0.0056
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0174 0.0668 0.0663
Loa Loa (eye worm) hypothetical protein 0.0131 0.0464 0.1396
Loa Loa (eye worm) hypothetical protein 0.0075 0.0208 0.0616
Schistosoma mansoni sodium/chloride dependent transporter 0.0587 0.2583 0.5443
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0041 0.0046
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0618 0.2725 1
Loa Loa (eye worm) hypothetical protein 0.0174 0.0668 0.2015
Schistosoma mansoni neuropeptide F-like receptor 0.0174 0.0668 0.1399
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0041 0.0001
Loa Loa (eye worm) hypothetical protein 0.0174 0.0668 0.2015
Echinococcus granulosus L aminoadipate semialdehyde 0.0176 0.0674 0.0879
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0041 0.0035
Brugia malayi Inositol-1 0.0039 0.004 0.0035
Schistosoma mansoni inositol monophosphatase 0.0039 0.004 0.0074
Schistosoma mansoni histamine h1 receptor 0.0174 0.0668 0.1399
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0174 0.0668 0.0663
Brugia malayi Sodium:neurotransmitter symporter family protein 0.01 0.0321 0.0316
Brugia malayi hypothetical protein 0.0055 0.0115 0.011
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0131 0.0464 0.067
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0174 0.0668 0.0663
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0131 0.0464 0.1396
Loa Loa (eye worm) hypothetical protein 0.0053 0.0102 0.0294
Brugia malayi GnHR receptor homolog 0.0174 0.0668 0.0663
Schistosoma mansoni hypothetical protein 0.0358 0.1521 0.32
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0174 0.0668 0.0871
Schistosoma mansoni sodium/chloride dependent transporter 0.01 0.0321 0.0666
Brugia malayi larval opioid receptor 0.0174 0.0668 0.0663
Schistosoma mansoni hypothetical protein 0.0072 0.0195 0.04
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0041 0.0051
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0174 0.0668 0.1399
Echinococcus multilocularis neuropeptides capa receptor 0.0174 0.0668 0.0966
Echinococcus granulosus expressed protein 0.0396 0.1698 0.2214
Echinococcus granulosus neuropeptide s receptor 0.0174 0.0668 0.0871
Brugia malayi Cation transporter family protein 0.0131 0.0464 0.0459
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.004 0.0053
Loa Loa (eye worm) hypothetical protein 0.0075 0.0208 0.0616
Loa Loa (eye worm) hypothetical protein 0.0075 0.0208 0.0616
Echinococcus multilocularis rhodopsin orphan GPCR 0.0174 0.0668 0.0966
Loa Loa (eye worm) hypothetical protein 0.0614 0.2708 0.8222
Onchocerca volvulus 0.0174 0.0668 0.257
Echinococcus multilocularis rhodopsin orphan GPCR 0.0174 0.0668 0.0966
Echinococcus multilocularis orexin receptor type 2 0.0174 0.0668 0.0966
Treponema pallidum sodium- and chloride- dependent transporter 0.0587 0.2583 0.9458
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0055 0.0115 0.011
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.0041 0.0053
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.01 0.0321 0.0959
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0618 0.2725 1
Brugia malayi jmjC domain containing protein 0.0062 0.0148 0.0143
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0131 0.0464 0.0459
Onchocerca volvulus 0.0252 0.1025 0.3958
Brugia malayi jmjC domain containing protein 0.0062 0.0148 0.0143
Onchocerca volvulus 0.0053 0.0102 0.0375
Schistosoma mansoni adenoreceptor 0.0174 0.0668 0.1399
Loa Loa (eye worm) hypothetical protein 0.0131 0.0464 0.1396
Echinococcus multilocularis neuropeptide Y receptor 0.0174 0.0668 0.0966
Brugia malayi excitatory GABA receptor EXP-1A 0.0131 0.0464 0.0459
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0131 0.0464 0.0606
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0075 0.0208 0.0202
Echinococcus multilocularis neuropeptide receptor 0.0174 0.0668 0.0966
Brugia malayi neuropeptide F receptor 0.0174 0.0668 0.0663
Onchocerca volvulus 0.0174 0.0668 0.257
Loa Loa (eye worm) hypothetical protein 0.0587 0.2583 0.784
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0131 0.0464 0.067
Schistosoma mansoni inositol monophosphatase 0.0039 0.004 0.0074
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0041 1
Loa Loa (eye worm) inositol-1 0.0039 0.004 0.0106
Echinococcus granulosus neuropeptide receptor 0.0174 0.0668 0.0871

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 23 uM Inhibition of macromolecular synthesis in HeLa cells asayed by the incorporation of radioactive thymidine into DNA ChEMBL. 6205151
IC50 (functional) = 23 uM Inhibition of macromolecular synthesis in HeLa cells asayed by the incorporation of radioactive thymidine into DNA ChEMBL. 6205151
IC50 (functional) = 25 uM Inhibition of macromolecular synthesis in HeLa cells assayed by the incorporation of radioactive leucine into protein ChEMBL. 6205151
IC50 (functional) = 25 uM Inhibition of macromolecular synthesis in HeLa cells assayed by the incorporation of radioactive leucine into protein ChEMBL. 6205151
IC50 (functional) = 100 uM Inhibition of macromolecular synthesis in HeLa cells assayed by the incorporation of radioactive uridine into RNA ChEMBL. 6205151
IC50 (functional) = 100 uM Inhibition of macromolecular synthesis in HeLa cells assayed by the incorporation of radioactive uridine into RNA ChEMBL. 6205151
ID50 (functional) = 1 uM Inhibition of HeLa cells growth (cytotoxicity) ChEMBL. 6205151
ID50 (functional) = 1 uM Inhibition of HeLa cells growth (cytotoxicity) ChEMBL. 6205151
T1/2 (ADMET) = 18 hr Compound was evaluated for its half-life when nucleophile was added in solution buffered at pH 7.2 in the presence of aminoethanol ChEMBL. 6205151
T1/2 (ADMET) = 3.5 min Compound was evaluated for its half-life when nucleophile was added in solution buffered at pH 7.2 in the presence of glutathione ChEMBL. 6205151

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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