TDR Targets

Basic information

Technical information

TDR Targets ID: 309570
Name: 6-chloro-N-ethyl-2,3,4,9-tetrahydro-1H-carbaz ole-1-carboxamide
MW: 276.761 | Formula: C15H17ClN2O
H donors: 2 H acceptors: 1 LogP: 3.26 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CCNC(=O)C1CCCc2c1[nH]c1c2cc(cc1)Cl
InChi: 1S/C15H17ClN2O/c1-2-17-15(19)11-5-3-4-10-12-8-9(16)6-7-13(12)18-14(10)11/h6-8,11,18H,2-5H2,1H3,(H,17,19)
InChiKey: CINDSJGTCCZHHM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

IDI1_021129
Oprea1_166042
ChemDiv3_003219
MLS000724132
SMR000305727

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ATPase family, AAA domain containing 5	Starlite/ChEMBL	No references
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	Starlite/ChEMBL	No references
Homo sapiens	parathyroid hormone 1 receptor	Starlite/ChEMBL	No references
Trypanosoma brucei gambiense	ATP-dependent phosphofructokinase,6-phospho-1-fructokinase		No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C)	Get druggable targets OG5_126758	All targets in OG5_126758
Candida albicans	phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C)	Get druggable targets OG5_126758	All targets in OG5_126758
Trichomonas vaginalis	phosphofructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Loa Loa (eye worm)	6-phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Brugia malayi	6-phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	Get druggable targets OG5_126758	All targets in OG5_126758
Entamoeba histolytica	phosphofructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Echinococcus granulosus	6 phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Schistosoma mansoni	6-phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Schistosoma japonicum	ko:K00850 6-phosphofructokinase [EC2.7.1.11], putative	Get druggable targets OG5_126758	All targets in OG5_126758
Leishmania major	ATP-dependent phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Trypanosoma congolense	ATP-dependent 6-phosphofructokinase, glycosomal	Get druggable targets OG5_126758	All targets in OG5_126758
Mycobacterium ulcerans	6-phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Entamoeba histolytica	phosphofructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Brugia malayi	6-phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	Get druggable targets OG5_126758	All targets in OG5_126758
Echinococcus multilocularis	6 phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Schistosoma japonicum	ko:K04588 secretin receptor, putative	Get druggable targets OG5_139196	All targets in OG5_139196
Schistosoma mansoni	6-phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	Get druggable targets OG5_139225	All targets in OG5_139225
Loa Loa (eye worm)	phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Entamoeba histolytica	phosphofructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	Get druggable targets OG5_126758	All targets in OG5_126758
Trichomonas vaginalis	phosphofructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	Get druggable targets OG5_126758	All targets in OG5_126758
Candida albicans	phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C)	Get druggable targets OG5_126758	All targets in OG5_126758
Leishmania infantum	ATP-dependent phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Trichomonas vaginalis	phosphofructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Leishmania braziliensis	ATP-dependent phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Candida albicans	phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C)	Get druggable targets OG5_126758	All targets in OG5_126758
Candida albicans	hypothetical protein	Get druggable targets OG5_126758	All targets in OG5_126758
Trypanosoma brucei gambiense	ATP-dependent phosphofructokinase,6-phospho-1-fructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Trichomonas vaginalis	phosphofructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Leishmania donovani	ATP-dependent 6-phosphofructokinase, glycosomal	Get druggable targets OG5_126758	All targets in OG5_126758
Loa Loa (eye worm)	6-phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Brugia malayi	phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	Get druggable targets OG5_126758	All targets in OG5_126758
Leishmania mexicana	6-phospho-1-fructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	H(+):Cl() exchange transporter 7	0.0074	0.0183	0.0183
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.0608	0.0608
Schistosoma mansoni	neuropeptide F-like receptor	0.0116	0.0437	0.0437
Schistosoma mansoni	survival motor neuron protein	0.0058	0.0089	0.0089
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.1244	0.7243	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0116	0.0437	0.0437
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0116	0.0437	0.0437
Echinococcus multilocularis	5' AMP activated protein kinase subunit gamma	0.0074	0.0183	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0183	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0437	0.0437
Trypanosoma cruzi	GMP reductase	0.1244	0.7243	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0116	0.0437	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0437	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0183	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0437	0.0437
Echinococcus granulosus	6 phosphofructokinase	0.0131	0.053	0.053
Schistosoma mansoni	biogenic amine receptor	0.0116	0.0437	0.0437
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0116	0.0437	0.0437
Loa Loa (eye worm)	G-protein coupled receptor	0.0116	0.0437	0.0437
Brugia malayi	neuropeptide F receptor	0.0116	0.0437	0.0498
Trypanosoma brucei	AMP-activated protein kinase, gamma regulatory subunit	0.0074	0.0183	0.0253
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0116	0.0437	0.0437
Echinococcus multilocularis	neuropeptide receptor	0.0116	0.0437	0.0437
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0116	0.0437	0.153
Brugia malayi	GnHR receptor homolog	0.0116	0.0437	0.0498
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0437	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0234	0.0234
Loa Loa (eye worm)	hypothetical protein	0.012	0.0464	0.0464
Mycobacterium tuberculosis	Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450)	0.0074	0.0183	0.0253
Brugia malayi	6-phosphofructokinase	0.0131	0.053	0.0603
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0199	0.0199
Echinococcus multilocularis	serotonin receptor	0.17	1	1
Giardia lamblia	Hypothetical protein	0.0074	0.0183	0.5
Loa Loa (eye worm)	6-phosphofructokinase	0.0131	0.053	0.053
Schistosoma mansoni	6-phosphofructokinase	0.0131	0.053	0.053
Trichomonas vaginalis	phosphofructokinase, putative	0.0131	0.053	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.0098	0.0098
Echinococcus multilocularis	g protein coupled receptor	0.0116	0.0437	0.0437
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0116	0.0437	0.0437
Echinococcus granulosus	inosine 5' monophosphate dehydrogenase 2	0.1244	0.7243	0.7243
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.1244	0.7243	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0278	0.1414	0.1952
Echinococcus granulosus	dro:myosuppressin receptor	0.0116	0.0437	0.0437
Schistosoma mansoni	6-phosphofructokinase	0.0131	0.053	0.053
Loa Loa (eye worm)	hypothetical protein	0.0682	0.3853	0.3853
Trypanosoma cruzi	AMP-activated protein kinase, gamma regulatory subunit	0.0074	0.0183	0.0253
Echinococcus multilocularis	dro:myosuppressin receptor	0.0116	0.0437	0.0437
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0116	0.0437	0.0437
Brugia malayi	Melatonin receptor type 1A	0.0116	0.0437	0.0498
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0116	0.0437	0.0437
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0116	0.0437	0.0437
Schistosoma mansoni	adenoreceptor	0.0116	0.0437	0.0437
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	0.0653	0.3678	0.5078
Schistosoma mansoni	biogenic amine (5HT) receptor	0.17	1	1
Schistosoma mansoni	neuropeptide receptor	0.0116	0.0437	0.0437
Onchocerca volvulus		0.0058	0.0089	0.0312
Echinococcus granulosus	rhodopsin orphan GPCR	0.0116	0.0437	0.0437
Schistosoma mansoni	hypothetical protein	0.0116	0.0437	0.0437
Brugia malayi	GMP reductase	0.0517	0.2857	0.3252
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0116	0.0437	0.0437
Brugia malayi	Serotonin receptor	0.0116	0.0437	0.0498
Echinococcus granulosus	tm gpcr rhodopsin	0.0116	0.0437	0.0437
Schistosoma mansoni	chloride channel protein	0.0074	0.0183	0.0183
Brugia malayi	TAR-binding protein	0.0076	0.0199	0.0227
Echinococcus granulosus	tar DNA binding protein	0.0076	0.0199	0.0199
Trypanosoma cruzi	chloride channel protein, putative	0.0074	0.0183	0.0253
Leishmania major	inosine-5-monophosphate dehydrogenase	0.1244	0.7243	1
Onchocerca volvulus		0.0116	0.0437	0.153
Echinococcus granulosus	somatostatin receptor	0.0116	0.0437	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0437	0.0437
Toxoplasma gondii	IMP dehydrogenas	0.1244	0.7243	1
Plasmodium falciparum	inosine-5'-monophosphate dehydrogenase	0.117	0.6798	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0116	0.0437	0.0437
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0116	0.0437	0.0437
Brugia malayi	Dopamine receptor	0.0116	0.0437	0.0498
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0116	0.0437	0.0437
Onchocerca volvulus		0.0116	0.0437	0.153
Loa Loa (eye worm)	phosphofructokinase	0.0131	0.053	0.053
Echinococcus multilocularis	g-protein coupled receptor	0.0116	0.0437	0.0437
Brugia malayi	hypothetical protein	0.0116	0.0437	0.0498
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	0.1244	0.7243	1
Echinococcus granulosus	neuropeptides capa receptor	0.0116	0.0437	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0286	0.1461	0.1461
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0116	0.0437	0.0437
Trypanosoma cruzi	polypeptide deformylase-like protein, putative	0.0184	0.085	0.1174
Brugia malayi	Voltage gated chloride channel family protein	0.0074	0.0183	0.0209
Toxoplasma gondii	chloride transporter, chloride channel (ClC) family protein	0.0074	0.0183	0.0253
Brugia malayi	latrophilin 2 splice variant baaae	0.0082	0.0234	0.0267
Plasmodium vivax	inosine-5'-monophosphate dehydrogenase, putative	0.117	0.6798	1
Schistosoma mansoni	biogenic amine receptor	0.0116	0.0437	0.0437
Brugia malayi	hypothetical protein	0.0116	0.0437	0.0498
Schistosoma mansoni	opsin-like receptor	0.0116	0.0437	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0437	0.0437
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0116	0.0437	0.0437
Echinococcus granulosus	H:Cl exchange transporter 7	0.0074	0.0183	0.0183
Brugia malayi	Dopamine receptor protein 2	0.0116	0.0437	0.0498
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0116	0.0437	0.0437
Toxoplasma gondii	hypothetical protein	0.0483	0.2653	0.3663
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0979	0.5648	0.5648
Schistosoma mansoni	biogenic amine receptor	0.0116	0.0437	0.0437
Brugia malayi	phosphofructokinase	0.0131	0.053	0.0603
Onchocerca volvulus		0.0074	0.0183	0.0642
Leishmania major	CBS domain protein, conserved	0.0074	0.0183	0.0253
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0058	0.0089	0.0101
Loa Loa (eye worm)	hypothetical protein	0.1499	0.8786	0.8786
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0437	0.0437
Echinococcus granulosus	neuropeptide receptor A26	0.0116	0.0437	0.0437
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0116	0.0437	0.0437
Brugia malayi	G protein-coupled receptor F59B2.13	0.0116	0.0437	0.0498
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0116	0.0437	0.0437
Loa Loa (eye worm)	chloride channel 3	0.0074	0.0183	0.0183
Trichomonas vaginalis	phosphofructokinase, putative	0.0131	0.053	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0116	0.0437	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0437	0.0437
Echinococcus granulosus	tumor protein p63	0.0408	0.22	0.22
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0116	0.0437	0.0437
Plasmodium falciparum	peptide deformylase	0.0483	0.2653	0.3734
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0116	0.0437	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0437	0.0437
Leishmania major	polypeptide deformylase-like protein, putative	0.0184	0.085	0.1174
Loa Loa (eye worm)	TYRA-2 protein	0.0116	0.0437	0.0437
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.0199	0.0199
Brugia malayi	hypothetical protein	0.0116	0.0437	0.0498
Entamoeba histolytica	phosphofructokinase, putative	0.0131	0.053	0.5
Loa Loa (eye worm)	IMP dehydrogenase 1	0.1244	0.7243	0.7243
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0116	0.0437	0.0437
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0116	0.0437	0.0437
Loa Loa (eye worm)	RNA binding protein	0.0076	0.0199	0.0199
Trypanosoma brucei	Voltage-gated Chloride channel Like 1	0.0074	0.0183	0.0253
Schistosoma mansoni	neuropeptide F-like receptor	0.0116	0.0437	0.0437
Giardia lamblia	Manganese-dependent inorganic pyrophosphatase, putative	0.0074	0.0183	0.5
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0116	0.0437	0.0437
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0116	0.0437	0.153
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0116	0.0437	0.0437
Trypanosoma cruzi	polypeptide deformylase-like protein, putative	0.0184	0.085	0.1174
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0116	0.0437	0.0437
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0116	0.0437	0.0437
Schistosoma mansoni	amine GPCR	0.0116	0.0437	0.0437
Brugia malayi	inosine-5'-monophosphate dehydrogenase	0.0517	0.2857	0.3252
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.0199	0.0199
Onchocerca volvulus		0.0116	0.0437	0.153
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0437	0.0437
Echinococcus granulosus	orexin receptor type 2	0.0116	0.0437	0.0437
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0116	0.0437	0.0437
Echinococcus multilocularis	6 phosphofructokinase	0.0131	0.053	0.053
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0199	0.0199
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0116	0.0437	0.0437
Trichomonas vaginalis	phosphofructokinase, putative	0.0131	0.053	1
Brugia malayi	AKH receptor	0.0116	0.0437	0.0498
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0437	0.0437
Leishmania major	ATP-dependent phosphofructokinase	0.0131	0.053	0.0731
Leishmania major	guanosine monophosphate reductase	0.1244	0.7243	1
Schistosoma mansoni	opsin-like receptor	0.0116	0.0437	0.0437
Mycobacterium tuberculosis	Conserved protein	0.0074	0.0183	0.0253
Brugia malayi	sulfakinin receptor protein	0.0116	0.0437	0.0498
Echinococcus multilocularis	neuropeptide Y receptor	0.0116	0.0437	0.0437
Brugia malayi	Dopamine receptor protein 1	0.1499	0.8786	1
Echinococcus granulosus	survival motor neuron protein 1	0.0286	0.1461	0.1461
Echinococcus multilocularis	inosine 5' monophosphate dehydrogenase 2	0.1244	0.7243	0.7243
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0437	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0437	0.0437
Schistosoma mansoni	amine GPCR	0.0116	0.0437	0.0437
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0116	0.0437	0.0498
Trypanosoma brucei	inosine-5'-monophosphate dehydrogenase	0.1244	0.7243	1
Onchocerca volvulus		0.0116	0.0437	0.153
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0437	0.0437
Trypanosoma cruzi	AMP-activated protein kinase, gamma regulatory subunit	0.0074	0.0183	0.0253
Echinococcus multilocularis	SNF4:AMP activated protein kinase gamma subunit	0.0074	0.0183	0.0183
Brugia malayi	inosine-5'-monophosphate dehydrogenase	0.0517	0.2857	0.3252
Brugia malayi	MH2 domain containing protein	0.0144	0.0608	0.0692
Echinococcus granulosus	fmrfamide receptor	0.0116	0.0437	0.0437
Brugia malayi	RNA binding protein	0.0076	0.0199	0.0227
Echinococcus granulosus	AMP activated protein kinase gamma regulatory	0.0074	0.0183	0.0183
Schistosoma mansoni	amine GPCR	0.0116	0.0437	0.0437
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.012	0.0464	0.0464
Brugia malayi	hypothetical protein	0.0116	0.0437	0.0498
Onchocerca volvulus		0.0116	0.0437	0.153
Trypanosoma cruzi	chloride channel protein, putative	0.0074	0.0183	0.0253
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0116	0.0437	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0437	0.0437
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0116	0.0437	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0437	0.0437
Brugia malayi	neuropeptide F receptor	0.0116	0.0437	0.0498
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0437	0.0437
Schistosoma mansoni	AMP-activated protein kinase gamma regulatory subunit	0.0074	0.0183	0.0183
Onchocerca volvulus		0.0116	0.0437	0.153
Echinococcus granulosus	hypothetical protein	0.0116	0.0437	0.0437
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.012	0.0464	0.0528
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.1244	0.7243	1
Schistosoma mansoni	chloride channel protein	0.0074	0.0183	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0437	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0437	0.0437
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0116	0.0437	0.0437
Onchocerca volvulus		0.0116	0.0437	0.153
Loa Loa (eye worm)	chloride channel protein 7	0.0074	0.0183	0.0183
Echinococcus multilocularis	G protein coupled receptor 139	0.0116	0.0437	0.0437
Trypanosoma cruzi	chloride channel protein, putative	0.0074	0.0183	0.0253
Brugia malayi	hypothetical protein	0.0116	0.0437	0.0498
Mycobacterium ulcerans	inosine 5-monophosphate dehydrogenase	0.117	0.6798	0.9385
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0116	0.0437	0.0437
Echinococcus granulosus	rhodopsin orphan GPCR	0.0116	0.0437	0.0437
Schistosoma mansoni	AMP-activated protein kinase gamma regulatory subunit	0.0074	0.0183	0.0183
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0131	0.053	0.0731
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0116	0.0437	0.0437
Toxoplasma gondii	CBS domain-containing protein	0.0074	0.0183	0.0253
Mycobacterium ulcerans	inosine 5'-monophosphate dehydrogenase	0.1244	0.7243	1
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0437	0.0437
Schistosoma mansoni	inosine-5-monophosphate dehydrogenase	0.1244	0.7243	0.7243
Echinococcus multilocularis	allatostatin A receptor	0.0116	0.0437	0.0437
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0116	0.0437	0.0437
Echinococcus granulosus	neuropeptide s receptor	0.0116	0.0437	0.0437
Schistosoma mansoni	AMP-activated protein kinase gamma regulatory subunit	0.0074	0.0183	0.0183
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0116	0.0437	0.0437
Echinococcus multilocularis	g protein coupled receptor	0.0116	0.0437	0.0437
Trypanosoma cruzi	Domain of unknown function DUF21, putative	0.0074	0.0183	0.0253
Trypanosoma cruzi	Peptide deformylase 2, putative	0.0184	0.085	0.1174
Schistosoma mansoni	cellular tumor antigen P53	0.006	0.0098	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0183	0.0183
Mycobacterium tuberculosis	Probable conserved transmembrane protein	0.0074	0.0183	0.0253
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0116	0.0437	0.0437
Schistosoma mansoni	opsin-like receptor	0.0116	0.0437	0.0437
Echinococcus granulosus	neuropeptide Y receptor	0.0116	0.0437	0.0437
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0116	0.0437	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0437	0.0437
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0116	0.0437	0.0437
Echinococcus granulosus	allatostatin A receptor	0.0116	0.0437	0.0437
Trypanosoma cruzi	GMP reductase	0.1244	0.7243	1
Loa Loa (eye worm)	hypothetical protein	0.17	1	1
Brugia malayi	ancient conserved domain protein 4	0.0074	0.0183	0.0209
Schistosoma mansoni	neuropeptide f receptor 76f	0.0116	0.0437	0.0437
Trypanosoma brucei	Voltage-gated Chloride channel Like 3	0.0074	0.0183	0.0253
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.0199	0.0227
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0437	0.0437
Brugia malayi	hypothetical protein	0.0286	0.1461	0.1663
Schistosoma mansoni	amine GPCR	0.0116	0.0437	0.0437
Mycobacterium tuberculosis	Conserved protein	0.0074	0.0183	0.0253
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0116	0.0437	0.0437
Echinococcus multilocularis	serotonin receptor	0.17	1	1
Brugia malayi	chloride channel protein 7	0.0074	0.0183	0.0209
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0116	0.0437	0.0437
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0131	0.053	0.1403
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0116	0.0437	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0437	0.0437
Mycobacterium leprae	Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450)	0.0074	0.0183	0.0253
Echinococcus granulosus	7tm_1 domain containing protein	0.0116	0.0437	0.0437
Echinococcus multilocularis	neuropeptide Y receptor	0.0116	0.0437	0.0437
Echinococcus multilocularis	neuropeptide receptor A26	0.0116	0.0437	0.0437
Echinococcus granulosus	g protein coupled receptor	0.0116	0.0437	0.0437
Onchocerca volvulus		0.0116	0.0437	0.153
Mycobacterium tuberculosis	Probable conserved transmembrane alanine and leucine rich protein	0.0074	0.0183	0.0253
Brugia malayi	CLC chloride channel protein	0.0074	0.0183	0.0209
Brugia malayi	6-phosphofructokinase	0.0131	0.053	0.0603
Echinococcus multilocularis	fmrfamide receptor	0.0116	0.0437	0.0437
Leishmania major	chloride channel protein, putative	0.0074	0.0183	0.0253
Onchocerca volvulus	Putative GMP reductase	0.0517	0.2857	1
Giardia lamblia	Manganese-dependent inorganic pyrophosphatase, putative	0.0074	0.0183	0.5
Treponema pallidum	polypeptide deformylase (def)	0.0483	0.2653	1
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0437	0.0437
Onchocerca volvulus		0.0116	0.0437	0.153
Echinococcus multilocularis	g protein coupled receptor	0.0116	0.0437	0.0437
Onchocerca volvulus		0.0116	0.0437	0.153
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.0199	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0437	0.0437
Echinococcus granulosus	g-protein coupled receptor	0.0116	0.0437	0.0437
Brugia malayi	hypothetical protein	0.0116	0.0437	0.0498
Onchocerca volvulus		0.0116	0.0437	0.153
Echinococcus granulosus	rhodopsin orphan GPCR	0.0116	0.0437	0.0437
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0116	0.0437	0.0437
Schistosoma mansoni	myosin xvIII	0.0116	0.0437	0.0437
Chlamydia trachomatis	peptide deformylase	0.0483	0.2653	1
Brugia malayi	Serotonin receptor	0.0116	0.0437	0.0498
Loa Loa (eye worm)	GMP reductase	0.0517	0.2857	0.2857
Brugia malayi	putative neuropeptide receptor NPR1	0.0116	0.0437	0.0498
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0116	0.0437	0.0437
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0116	0.0437	0.0437
Schistosoma mansoni	amine GPCR	0.0116	0.0437	0.0437
Echinococcus granulosus	neuropeptides capa receptor	0.0116	0.0437	0.0437
Mycobacterium ulcerans	hypothetical protein	0.0074	0.0183	0.0253
Brugia malayi	CBS domain containing protein	0.0074	0.0183	0.0209
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0116	0.0437	0.0437
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0116	0.0437	0.0437
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0116	0.0437	0.0437
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0116	0.0437	0.0498
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0116	0.0437	0.0437
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0116	0.0437	0.0437
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0199	0.0199
Schistosoma mansoni	hypothetical protein	0.0116	0.0437	0.0437
Echinococcus multilocularis	orexin receptor type 2	0.0116	0.0437	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0437	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0437	0.0437
Echinococcus multilocularis	neuropeptide s receptor	0.0116	0.0437	0.0437
Loa Loa (eye worm)	neuropeptide F receptor	0.0116	0.0437	0.0437
Brugia malayi	G-protein coupled receptor	0.0116	0.0437	0.0498
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0116	0.0437	0.0498
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD)	0.1244	0.7243	1
Echinococcus granulosus	sex peptide receptor	0.0116	0.0437	0.0437
Brugia malayi	hypothetical protein	0.0116	0.0437	0.0498
Mycobacterium tuberculosis	Conserved hypothetical membrane protein	0.0074	0.0183	0.0253
Entamoeba histolytica	phosphofructokinase, putative	0.0131	0.053	0.5
Trypanosoma cruzi	chloride channel protein, putative	0.0074	0.0183	0.0253
Schistosoma mansoni	protein kinase subunit gamma	0.0074	0.0183	0.0183
Echinococcus multilocularis	neuropeptides capa receptor	0.0116	0.0437	0.0437
Mycobacterium ulcerans	peptide deformylase	0.0483	0.2653	0.3663
Brugia malayi	G protein-coupled receptor	0.0116	0.0437	0.0498
Mycobacterium ulcerans	hypothetical protein	0.0074	0.0183	0.0253
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0116	0.0437	0.0437
Echinococcus multilocularis	sex peptide receptor	0.0116	0.0437	0.0437
Echinococcus granulosus	tm gpcr rhodopsin	0.0116	0.0437	0.0437
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0116	0.0437	0.0437
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0131	0.053	0.0731
Loa Loa (eye worm)	hypothetical protein	0.17	1	1
Schistosoma mansoni	histamine h1 receptor	0.0116	0.0437	0.0437
Loa Loa (eye worm)	6-phosphofructokinase	0.0131	0.053	0.053
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0116	0.0437	0.0498
Toxoplasma gondii	CBS family protein	0.0074	0.0183	0.0253
Brugia malayi	hypothetical protein	0.0116	0.0437	0.0498
Onchocerca volvulus		0.0116	0.0437	0.153
Schistosoma mansoni	chloride channel protein	0.0074	0.0183	0.0183
Mycobacterium ulcerans	inosine 5-monophosphate dehydrogenase	0.0591	0.3302	0.4559
Schistosoma mansoni	hypothetical protein	0.0116	0.0437	0.0437
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0116	0.0437	0.0437
Echinococcus granulosus	H:Cl exchange transporter 3	0.0074	0.0183	0.0183
Echinococcus granulosus	5' AMP activated protein kinase subunit gamma	0.0074	0.0183	0.0183
Loa Loa (eye worm)	loechrig isoform VII	0.0074	0.0183	0.0183
Onchocerca volvulus		0.0116	0.0437	0.153
Mycobacterium ulcerans	hypothetical protein	0.0074	0.0183	0.0253
Echinococcus multilocularis	neuropeptides capa receptor	0.0116	0.0437	0.0437
Wolbachia endosymbiont of Brugia malayi	peptide deformylase	0.0483	0.2653	0.3498
Echinococcus granulosus	rhodopsin orphan GPCR	0.0116	0.0437	0.0437
Loa Loa (eye worm)	melatonin receptor type 1A	0.0116	0.0437	0.0437
Schistosoma mansoni	hypothetical protein	0.0082	0.0234	0.0234
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0437	0.0437
Leishmania major	hypothetical protein, conserved	0.0074	0.0183	0.0253
Brugia malayi	larval opioid receptor	0.0116	0.0437	0.0498
Trypanosoma brucei	GMP reductase	0.1244	0.7243	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0116	0.0437	0.0498
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.0608	0.0608
Wolbachia endosymbiont of Brugia malayi	IMP dehydrogenase	0.1244	0.7243	1
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0437	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0437	0.0437
Echinococcus granulosus	H:Cl exchange transporter 4	0.0074	0.0183	0.0183
Brugia malayi	ancient conserved domain protein 2	0.0074	0.0183	0.0209
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0199	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0437	0.0437
Mycobacterium tuberculosis	Conserved hypothetical membrane protein	0.0074	0.0183	0.0253
Trypanosoma brucei	Polypeptide deformylase 1	0.0184	0.085	0.1174
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0437	0.0437
Trypanosoma cruzi	Peptide deformylase 2, putative	0.0184	0.085	0.1174
Echinococcus multilocularis	somatostatin receptor	0.0116	0.0437	0.0437
Mycobacterium leprae	conserved hypothetical protein	0.0074	0.0183	0.0253
Schistosoma mansoni	neuropeptide receptor	0.0116	0.0437	0.0437
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0116	0.0437	0.0437
Echinococcus granulosus	SNF4:AMP activated protein kinase gamma subunit	0.0074	0.0183	0.0183
Mycobacterium tuberculosis	Hypoxic response protein 1 Hrp1	0.0074	0.0183	0.0253
Onchocerca volvulus		0.0116	0.0437	0.153
Echinococcus multilocularis	neuropeptide receptor	0.0116	0.0437	0.0437
Mycobacterium tuberculosis	Conserved protein	0.0074	0.0183	0.0253
Onchocerca volvulus		0.0116	0.0437	0.153
Echinococcus granulosus	neuropeptide FF receptor 2	0.0116	0.0437	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0437	0.0437
Echinococcus granulosus	tm gpcr rhodopsin	0.0116	0.0437	0.0437
Leishmania major	chloride channel protein, putative	0.0074	0.0183	0.0253
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0116	0.0437	0.0437
Brugia malayi	G-protein coupled receptor	0.0116	0.0437	0.0498
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0437	0.0437
Onchocerca volvulus		0.0116	0.0437	0.153
Mycobacterium ulcerans	transcriptional regulator	0.0074	0.0183	0.0253
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0116	0.0437	0.0437
Brugia malayi	ORL1-like opioid receptor	0.0116	0.0437	0.0498
Echinococcus multilocularis	fmrfamide receptor	0.0116	0.0437	0.0437
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0116	0.0437	0.0437
Brugia malayi	RE15519p	0.0116	0.0437	0.0498
Mycobacterium tuberculosis	Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase)	0.0483	0.2653	0.3663
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0131	0.053	0.0731
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0116	0.0437	0.0437
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0131	0.053	0.0731
Echinococcus granulosus	g protein coupled receptor	0.0116	0.0437	0.0437
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena	0.0653	0.3678	0.5078
Brugia malayi	hypothetical protein	0.0116	0.0437	0.0498
Trypanosoma brucei	Peptide deformylase 2	0.0184	0.085	0.1174
Schistosoma mansoni	neuropeptide receptor	0.0116	0.0437	0.0437
Echinococcus multilocularis	tumor protein p63	0.0408	0.22	0.22
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0437	0.0437
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0116	0.0437	0.0437
Loa Loa (eye worm)	neuropeptide F receptor	0.0116	0.0437	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0437	0.0437
Mycobacterium ulcerans	cystathionine beta-synthase	0.0074	0.0183	0.0253
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0437	0.0437
Schistosoma mansoni	hypothetical protein	0.0058	0.0089	0.0089
Echinococcus granulosus	neuropeptide receptor	0.0116	0.0437	0.0437
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0116	0.0437	0.0498
Echinococcus multilocularis	H(+):Cl() exchange transporter 3	0.0074	0.0183	0.0183
Schistosoma mansoni	neuropeptide receptor	0.0116	0.0437	0.0437
Echinococcus granulosus	neuropeptide receptor	0.0116	0.0437	0.0437
Schistosoma mansoni	hypothetical protein	0.0116	0.0437	0.0437
Echinococcus granulosus	g protein coupled receptor	0.0116	0.0437	0.0437
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0116	0.0437	0.0437
Onchocerca volvulus		0.006	0.0098	0.0343
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0437	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0183	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0437	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0437	0.0437
Brugia malayi	loechrig isoform VII	0.0074	0.0183	0.0209
Trichomonas vaginalis	phosphofructokinase, putative	0.0131	0.053	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0116	0.0437	0.0437
Echinococcus granulosus	G protein coupled receptor 139	0.0116	0.0437	0.0437
Giardia lamblia	5-AMP-activated protein kinase, gamma-1 subunit	0.0074	0.0183	0.5
Brugia malayi	Calcitonin receptor-like protein seb-1	0.012	0.0464	0.0528
Echinococcus granulosus	serotonin receptor	0.0116	0.0437	0.0437
Entamoeba histolytica	phosphofructokinase, putative	0.0131	0.053	0.5
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0116	0.0437	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0437	0.0437
Onchocerca volvulus		0.0116	0.0437	0.153
Mycobacterium ulcerans	6-phosphofructokinase	0.0131	0.053	0.0731
Plasmodium vivax	peptide deformylase, putative	0.0483	0.2653	0.3903
Echinococcus multilocularis	H(+):Cl() exchange transporter 4	0.0074	0.0183	0.0183
Schistosoma mansoni	growth hormone secretagogue receptor	0.0116	0.0437	0.0437
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0116	0.0437	0.0437
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0116	0.0437	0.0437
Mycobacterium leprae	PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD)	0.0591	0.3302	0.4559
Brugia malayi	follicle stimulating hormone receptor	0.0116	0.0437	0.0498
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0116	0.0437	0.0437
Echinococcus granulosus	neuropeptide Y receptor	0.0116	0.0437	0.0437
Brugia malayi	inosine-5'-monophosphate dehydrogenase family protein	0.1244	0.7243	0.8245
Brugia malayi	putative neuropeptide receptor	0.0116	0.0437	0.0498
Echinococcus granulosus	rhodopsin orphan GPCR	0.0116	0.0437	0.0437
Brugia malayi	hypothetical protein	0.0116	0.0437	0.0498
Mycobacterium leprae	PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE)	0.0483	0.2653	0.3663
Toxoplasma gondii	CBS domain-containing protein	0.0074	0.0183	0.0253
Echinococcus multilocularis	survival motor neuron protein 1	0.0286	0.1461	0.1461
Echinococcus granulosus	7TM GPCR rhodopsin	0.0116	0.0437	0.0437
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0199	0.0199
Echinococcus granulosus	rhodopsin orphan GPCR	0.0116	0.0437	0.0437

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 100 uM	Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assay	ChEMBL.	16335928
IC50 (binding)	> 100 uM	Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assay	ChEMBL.	16335928
Potency (functional)	7.9433 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	10.691 uM	PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961]	ChEMBL.	No reference
Potency (functional)	11.9955 uM	PUBCHEM_BIOASSAY: Tb PFK orthogonal confirmatory assay using ATP depletion (Kinase-Glo Plus) as an alternative measure of Tb PFK activity: Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768]	ChEMBL.	No reference
Potency (functional)	18.3489 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (functional)	21.3313 uM	PUBCHEM_BIOASSAY: Inhibitors of T. brucei phosphofructokinase: Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768]	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	79.4328 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL177487
PubChem: 2858149
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Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 309570