TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 337.399 | Formula: C8H11N5O4S3
H donors: 4 H acceptors: 4 LogP: 0.06 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Nc1ccc(cc1)S(=O)(=O)NC1NN=C(S1)S(=O)(=O)N
InChi: 1S/C8H11N5O4S3/c9-5-1-3-6(4-2-5)20(16,17)13-7-11-12-8(18-7)19(10,14)15/h1-4,7,11,13H,9H2,(H2,10,14,15)
InChiKey: VTGCXQMCXKWQQC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	carbonic anhydrase II	Starlite/ChEMBL	References
Homo sapiens	carbonic anhydrase VII	Starlite/ChEMBL	References
Homo sapiens	carbonic anhydrase I	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	carbonic anhydrase II	Get druggable targets OG5_127628	All targets in OG5_127628
Schistosoma japonicum	ko:K01672 carbonic anhydrase [EC4.2.1.1], putative	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania infantum	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania braziliensis	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma congolense	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania major	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Echinococcus granulosus	carbonic anhydrase II	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	Get druggable targets OG5_127628	All targets in OG5_127628
Loa Loa (eye worm)	carbonic anhydrase 3	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania mexicana	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania donovani	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma congolense	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	Get druggable targets OG5_127628	All targets in OG5_127628
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	Get druggable targets OG5_127628	All targets in OG5_127628
Brugia malayi	Putative carbonic anhydrase 5 precursor	Get druggable targets OG5_127628	All targets in OG5_127628
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma brucei gambiense	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma brucei	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Carbonic anhydrase like protein 2 precursor	carbonic anhydrase II	260 aa	259 aa	32.0 %
Brugia malayi	Carbonic anhydrase like protein 2 precursor	carbonic anhydrase VII	208 aa	212 aa	33.0 %
Trypanosoma brucei	carbonic anhydrase-like protein	carbonic anhydrase I	261 aa	281 aa	25.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Death domain containing protein	0.0061	0.000000044942	0.000000044942
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.008	0.0245	0.0216
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0114	0.0683	0.0655
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0657	0.0657
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0711	0.8319	0.8314
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0349	0.3693	0.3693
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0131	0.0906	0.0906
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.013	0.0886	0.0886
Giardia lamblia	GTOR	0.0842	1	1
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0513	0.0513
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0173	0.1437	0.1411
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0175	0.1462	0.1462
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0677	0.7889	0.7883
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0112	0.0657	0.0629
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0392	0.4243	0.4226
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0121	0.0777	0.0749
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.013	0.0886	0.0886
Schistosoma mansoni	hypothetical protein	0.0101	0.0513	0.0513
Schistosoma mansoni	voltage-gated potassium channel	0.0142	0.1039	0.1039
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0842	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0636	0.7356	0.7349
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0471	0.5254	0.524
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0175	0.1462	0.1462
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0315	0.3261	0.324
Echinococcus granulosus	carbonic anhydrase	0.0101	0.0513	0.0513
Echinococcus granulosus	nuclear factor of activated T cells 5	0.031	0.3195	0.3195
Schistosoma mansoni	carbonic anhydrase	0.0101	0.0513	0.0513
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0114	0.0683	0.0655
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0677	0.7889	0.7883
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0225	0.2108	0.2108
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0471	0.5254	0.524
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0139	0.1	0.0973
Onchocerca volvulus		0.0063	0.003	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0306	0.3143	0.3123
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.008	0.0245	0.0216
Loa Loa (eye worm)	phosphatidylinositol 3	0.0339	0.3556	0.3556
Loa Loa (eye worm)	phosphatidylinositol 3	0.0063	0.003	0.003
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0504	0.5676	0.5663
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.008	0.0245	0.0245
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0328	0.342	0.3401
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0114	0.0683	0.0655
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0175	0.1462	0.1437
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0063	0.003	0.5
Leishmania major	carbonic anhydrase-like protein	0.0328	0.342	0.3401
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0191	0.167	0.1645
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0063	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0667	0.0667
Plasmodium falciparum	carbonic anhydrase	0.0101	0.0513	1
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0328	0.342	0.342
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0175	0.1462	0.1437
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0546	0.6208	0.6197
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0842	1	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0315	0.3261	0.3261
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0349	0.3693	0.3674
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0162	0.1302	0.1276
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0906	0.0906
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0842	1	1
Loa Loa (eye worm)	carbonic anhydrase 3	0.0328	0.342	0.342
Mycobacterium leprae	conserved hypothetical protein	0.0063	0.003	0.5
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0842	1	1
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0063	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0166	0.1353	0.1353
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0513	0.0513
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0175	0.1462	0.1462
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0842	1	1
Leishmania major	hypothetical protein, conserved	0.0141	0.1022	0.0995
Schistosoma mansoni	voltage-gated potassium channel	0.0142	0.1039	0.1039
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0306	0.3143	0.3123
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0328	0.342	0.3401
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0513	0.5787	0.5774
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0349	0.3693	0.3693
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0061	0.0007	0.0007
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0063	0.003	0.003
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0373	0.3993	0.3993
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0306	0.3143	0.3123
Echinococcus multilocularis	Zinc finger, PHD finger	0.008	0.0245	0.0245
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0349	0.3693	0.3693
Echinococcus granulosus	Ankyrin	0.0061	0.0007	0.0007
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0101	0.0513	0.0513
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0677	0.7889	0.7883
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.031	0.3195	0.3195
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0842	1	1
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0328	0.342	0.342
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0359	0.3822	0.3803
Trichomonas vaginalis	conserved hypothetical protein	0.0194	0.1711	0.1686
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0114	0.0683	0.0683
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0166	0.1353	0.1353
Echinococcus multilocularis	carbonic anhydrase	0.0101	0.0513	0.0513
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0349	0.3693	0.3693
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0677	0.7889	0.7883
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.008	0.0245	0.0245
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.008	0.0245	0.0294
Brugia malayi	Protein kinase domain containing protein	0.0061	0.000000044942	0.000000044942
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0147	0.1111	0.1111
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0225	0.2108	0.2084
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0175	0.1462	0.1462
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0101	0.0513	0.0513
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0306	0.3143	0.3123
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0097	0.0467	0.0439
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0636	0.7356	0.7349
Entamoeba histolytica	hypothetical protein	0.0175	0.1462	0.1437
Echinococcus multilocularis		0.0063	0.003	0.003
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0063	0.003	0.003
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0842	1	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.013	0.0886	0.0886
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0471	0.5246	0.5231
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.008	0.0245	0.0245
Entamoeba histolytica	protein kinase rad3, putative	0.0175	0.1462	0.1437
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0282	0.2829	0.2829
Toxoplasma gondii	FATC domain-containing protein	0.0175	0.1462	0.1955
Loa Loa (eye worm)	hypothetical protein	0.0175	0.1462	0.1462
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0007	0.0007
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0471	0.5254	0.524
Onchocerca volvulus		0.0063	0.003	1
Schistosoma mansoni	hypothetical protein	0.0063	0.003	0.003
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0504	0.5676	0.5663
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.008	0.0245	0.0245
Schistosoma mansoni	carbonic anhydrase-related	0.0101	0.0513	0.0513
Brugia malayi	Uncoordinated protein 44	0.0061	0.000000044942	0.000000044942
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0132	0.0916	0.0889
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0175	0.1462	0.1437
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0678	0.7898	0.7891
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0194	0.1711	0.2294
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0112	0.0657	0.0629
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0114	0.0683	0.0655
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0225	0.2108	0.2084
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0504	0.5676	0.5663
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0315	0.3261	0.324
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0175	0.1462	0.1462
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0101	0.0513	0.0513
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.008	0.0245	0.4464
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.008	0.0245	0.0245
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0225	0.2108	0.2084
Loa Loa (eye worm)	phosphatidylinositol 3	0.0063	0.003	0.003
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0328	0.342	0.342
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0842	1	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0842	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0842	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0112	0.0657	0.0629
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0063	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0164	0.1327	0.1327
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0173	0.1437	0.1411
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0513	0.0513
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.008	0.0245	0.0216
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0063	0.003	0.003
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0636	0.7356	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.003	0.003
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0227	0.2132	0.2109
Trypanosoma cruzi	hypothetical protein, conserved	0.0078	0.0217	0.0188
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0565	0.6457	0.6446
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0636	0.7356	0.7349
Leishmania major	phosphatidylinositol 3-kinase, putative	0.008	0.0245	0.0216
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0063	0.003	0.003
Trypanosoma cruzi	target of rapamycin kinase 3	0.0678	0.7898	0.7891
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0225	0.2108	0.2084
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0636	0.7356	0.7349
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.008	0.0245	0.0245
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0471	0.5254	0.524
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.008	0.0245	0.0216
Echinococcus multilocularis	carbonic anhydrase	0.0101	0.0513	0.0513
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0636	0.7356	0.7349
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0513	0.5787	0.5774
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0636	0.7356	0.7349
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0225	0.2108	0.2084
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0101	0.0513	0.0513
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0373	0.3993	0.3993
Trichomonas vaginalis	conserved hypothetical protein	0.0131	0.0906	0.0878
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0842	1	1
Echinococcus granulosus	carbonic anhydrase	0.0101	0.0513	0.0513
Schistosoma mansoni	hypothetical protein	0.0131	0.0906	0.0906
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0114	0.0683	0.0655
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0121	0.0777	0.0749
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.008	0.0245	0.0245
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0063	0.003	0.003
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0175	0.1462	0.1462
Echinococcus granulosus	carbonic anhydrase	0.0101	0.0513	0.0513
Entamoeba histolytica	hypothetical protein	0.0191	0.167	0.1645
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.008	0.0245	0.0216
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0315	0.3261	0.324
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0175	0.1462	0.1437
Echinococcus multilocularis	carbonic anhydrase II	0.0328	0.342	0.342
Loa Loa (eye worm)	phosphatidylinositol 3	0.0842	1	1
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0678	0.7898	0.7891
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0061	0.000000044942	0.000000044942
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0063	0.003	0.003
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0328	0.342	0.342
Echinococcus granulosus	carbonic anhydrase II	0.0328	0.342	0.342
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0114	0.0683	0.0683
Loa Loa (eye worm)	hypothetical protein	0.0194	0.1711	0.1711
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0373	0.3993	0.3993
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0101	0.0513	0.0513
Echinococcus granulosus	serine protein kinase ATM	0.0175	0.1462	0.1462
Echinococcus multilocularis	Ankyrin	0.0061	0.0007	0.0007
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0114	0.0683	0.0655
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0842	1	1
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0131	0.0906	0.0906
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0101	0.0513	0.0513
Toxoplasma gondii	hypothetical protein	0.0101	0.0513	0.0659
Brugia malayi	FAT domain containing protein	0.0131	0.0906	0.0906
Trypanosoma brucei	carbonic anhydrase-like protein	0.0328	0.342	0.3401
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0842	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0184	0.158	0.1554
Schistosoma mansoni	carbonic anhydrase-related	0.0101	0.0513	0.0513
Schistosoma mansoni	ankyrin 23/unc44	0.0061	0.000000044942	0.000000044942
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0061	0.000000044942	0.000000044942
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.008	0.0245	0.0294
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0166	0.1353	0.1353
Echinococcus multilocularis	serine protein kinase ATM	0.0175	0.1462	0.1462
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0063	0.003	0.003
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0166	0.1353	0.1353
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0063	0.003	0.003
Loa Loa (eye worm)	phosphatidylinositol 3	0.0063	0.003	0.003
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0306	0.3143	0.3123
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.013	0.0886	0.0886
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0175	0.1462	0.1437
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0225	0.2108	0.2084
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0636	0.7356	0.7349
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0114	0.0683	0.0655
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0063	0.003	0.003
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0282	0.2829	0.2829
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0349	0.3693	0.3674
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0306	0.3143	0.3123
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.008	0.0245	0.0216
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.008	0.0245	0.0216
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.008	0.0245	1
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0328	0.342	0.342
Loa Loa (eye worm)	phosphatidylinositol 3	0.0063	0.003	0.003
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0471	0.5246	0.5231
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.008	0.0245	0.0216
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0677	0.7889	0.7883
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0184	0.158	0.1554
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.008	0.0245	0.0216
Echinococcus multilocularis	carbonic anhydrase	0.0101	0.0513	0.0513
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0842	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0471	0.5246	0.5231
Schistosoma mansoni	carbonic anhydrase-related	0.0101	0.0513	0.0513

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	nM	Ki value against murine carbonic anhydrase XIII was determined; (not tested)	ChEMBL.	15686895
Ki (binding)	0 nM	Ki value against murine carbonic anhydrase XIII was determined; (not tested)	ChEMBL.	15686895
Ki (binding)	= 2 nM	Ki value against human carbonic anhydrase II	ChEMBL.	15686895
Ki (binding)	= 2 nM	Ki value against human carbonic anhydrase II	ChEMBL.	15686895
Ki (binding)	= 6 nM	Ki value against human carbonic anhydrase I	ChEMBL.	15686895
Ki (binding)	= 6 nM	Ki value against human carbonic anhydrase I	ChEMBL.	15686895
Ki (binding)	= 7 nM	Ki value against human carbonic anhydrase VII	ChEMBL.	15686895
Ki (binding)	= 7 nM	Ki value against human carbonic anhydrase VII	ChEMBL.	15686895

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL427312

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 315615