TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 411.881 | Formula: C22H22ClN3O3
H donors: 3 H acceptors: 3 LogP: 3.05 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: OCCN(C1CCc2c1cccc2)C(=O)CNC(=O)c1[nH]c2c(c1)cc(cc2)Cl
InChi: 1S/C22H22ClN3O3/c23-16-6-7-18-15(11-16)12-19(25-18)22(29)24-13-21(28)26(9-10-27)20-8-5-14-3-1-2-4-17(14)20/h1-4,6-7,11-12,20,25,27H,5,8-10,13H2,(H,24,29)
InChiKey: DCXVGEYRPVWNSA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphorylase, glycogen, liver	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	Glycosyl transferase family 35	Get druggable targets OG5_126999	All targets in OG5_126999
Candida albicans	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Neospora caninum	hypothetical protein	Get druggable targets OG5_126999	All targets in OG5_126999
Chlamydia trachomatis	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Entamoeba histolytica	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Giardia lamblia	Glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Candida albicans	hypothetical protein	Get druggable targets OG5_126999	All targets in OG5_126999
Brugia malayi	carbohydrate phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Trichomonas vaginalis	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma mansoni	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus multilocularis	Glycosyl transferase, family 35	Get druggable targets OG5_126999	All targets in OG5_126999
Entamoeba histolytica	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Onchocerca volvulus	Glycogen phosphorylase homolog	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma mansoni	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus granulosus	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma japonicum	ko:K00688 starch phosphorylase [EC2.4.1.1], putative	Get druggable targets OG5_126999	All targets in OG5_126999
Cryptosporidium parvum	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Trichomonas vaginalis	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus multilocularis	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Cryptosporidium hominis	glycogen phosphorylase 1	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus granulosus	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Loa Loa (eye worm)	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma japonicum	Glycogen phosphorylase, brain form, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma japonicum	ko:K00688 starch phosphorylase [EC2.4.1.1], putative	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus multilocularis	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	casein kinase, putative	0.0117	0.1546	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0111	0.1384	0.2282
Schistosoma mansoni	nephrin	0.0224	0.4437	0.9476
Echinococcus multilocularis	hemicentin 1	0.0111	0.1384	0.2282
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1384	0.1384
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0173	0.3053	0.652
Echinococcus granulosus	hemicentin 1	0.0111	0.1384	0.2282
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0245	0.4994	0.8232
Echinococcus multilocularis	Immunoglobulin	0.0173	0.3053	0.5032
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0096	0.097	0.1599
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0111	0.1384	0.2282
Schistosoma mansoni	cell adhesion molecule	0.0111	0.1384	0.2956
Schistosoma mansoni	serine/threonine protein kinase	0.0124	0.1726	0.3685
Toxoplasma gondii	casein kinase I	0.0117	0.1546	1
Brugia malayi	Fibronectin type III domain containing protein	0.0173	0.3053	0.3053
Schistosoma mansoni	tyrosine kinase	0.0172	0.3029	0.6468
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0096	0.097	0.1599
Echinococcus granulosus	Immunoglobulin	0.0173	0.3053	0.5032
Echinococcus granulosus	casein kinase I delta	0.0117	0.1546	0.2549
Loa Loa (eye worm)	hypothetical protein	0.0284	0.6067	0.6067
Schistosoma mansoni	serine/threonine protein kinase	0.0117	0.1546	0.3302
Leishmania major	casein kinase, putative	0.0117	0.1546	1
Echinococcus multilocularis	insulin receptor	0.007	0.0268	0.0442
Giardia lamblia	Kinase, CK1 Casein kinase	0.0117	0.1546	0.5782
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.011	0.135	0.2225
Loa Loa (eye worm)	TK protein kinase	0.0082	0.0581	0.0581
Brugia malayi	hypothetical protein	0.0173	0.3053	0.3053
Echinococcus granulosus	tyrosine protein kinase Fyn	0.011	0.135	0.2225
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0096	0.097	0.1599
Echinococcus multilocularis	peroxidasin	0.0111	0.1384	0.2282
Echinococcus granulosus	tyrosine protein kinase otk	0.0111	0.1384	0.2282
Schistosoma mansoni	tyrosine kinase	0.007	0.0268	0.0573
Loa Loa (eye worm)	hypothetical protein	0.0173	0.3053	0.3053
Brugia malayi	PAS domain containing protein	0.0095	0.0928	0.0928
Echinococcus multilocularis	roundabout 2	0.0111	0.1384	0.2282
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0111	0.1384	0.1384
Echinococcus granulosus	tyrosine protein kinase Src64B	0.011	0.135	0.2225
Trypanosoma cruzi	casein kinase, putative	0.0117	0.1546	1
Loa Loa (eye worm)	TK/INSR protein kinase	0.007	0.0268	0.0268
Schistosoma mansoni	tyrosine kinase	0.011	0.135	0.2882
Schistosoma mansoni	nephrin	0.0111	0.1384	0.2956
Schistosoma mansoni	protein kinase	0.0117	0.1546	0.3302
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0073	0.0346	0.057
Echinococcus multilocularis	casein kinase i	0.0117	0.1546	0.2549
Loa Loa (eye worm)	TK/ABL protein kinase	0.0245	0.4994	0.4994
Schistosoma mansoni	glycogen phosphorylase	0.013	0.1898	0.4054
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0111	0.1384	0.2282
Echinococcus multilocularis	neuroglian	0.0224	0.4437	0.7314
Brugia malayi	Protein kinase domain containing protein	0.007	0.0268	0.0268
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.011	0.135	0.2225
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0111	0.1384	0.1384
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0111	0.1384	0.2282
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.011	0.135	0.2225
Brugia malayi	intracellular kinase	0.01	0.1064	0.1064
Entamoeba histolytica	protein kinase domain containing protein	0.01	0.1064	0.3664
Echinococcus multilocularis	casein kinase I alpha	0.0117	0.1546	0.2549
Echinococcus granulosus	casein kinase i	0.0117	0.1546	0.2549
Echinococcus multilocularis	hemicentin 1	0.0111	0.1384	0.2282
Loa Loa (eye worm)	hypothetical protein	0.0173	0.3053	0.3053
Schistosoma mansoni	cell adhesion molecule	0.0233	0.4683	1
Giardia lamblia	Glycogen phosphorylase	0.013	0.1898	1
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1384	0.1384
Echinococcus multilocularis	neurotracting:lsamp:neurotrimin:obcam	0.0111	0.1384	0.2282
Trypanosoma brucei	casein kinase I, isoform 2	0.0117	0.1546	1
Echinococcus granulosus	glycogen phosphorylase	0.013	0.1898	0.3129
Chlamydia trachomatis	glycogen phosphorylase	0.013	0.1898	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.011	0.135	0.2225
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.011	0.135	0.2225
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.011	0.135	0.2225
Echinococcus granulosus	casein kinase I delta	0.0117	0.1546	0.2549
Loa Loa (eye worm)	SRC-1	0.011	0.135	0.135
Loa Loa (eye worm)	hypothetical protein	0.0102	0.114	0.114
Schistosoma mansoni	serine/threonine protein kinase	0.0081	0.0557	0.1189
Brugia malayi	hypoxia-induced factor 1	0.0293	0.6288	0.6288
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.043	1	1
Echinococcus multilocularis	casein kinase I alpha	0.0117	0.1546	0.2549
Trichomonas vaginalis	glycogen phosphorylase, putative	0.013	0.1898	1
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1384	0.1384
Entamoeba histolytica	casein kinase, putative	0.0117	0.1546	0.7327
Echinococcus multilocularis	casein kinase I delta	0.0117	0.1546	0.2549
Loa Loa (eye worm)	hypothetical protein	0.0173	0.3053	0.3053
Echinococcus granulosus	roundabout 2	0.0111	0.1384	0.2282
Echinococcus granulosus	tyrosine protein kinase Src42A	0.011	0.135	0.2225
Loa Loa (eye worm)	hypothetical protein	0.0173	0.3053	0.3053
Schistosoma mansoni	cell adhesion molecule	0.0111	0.1384	0.2956
Brugia malayi	Peroxidasin	0.0111	0.1384	0.1384
Loa Loa (eye worm)	casein kinase	0.012	0.1621	0.1621
Loa Loa (eye worm)	CK1/CK1/CK1-D protein kinase	0.0117	0.1546	0.1546
Echinococcus multilocularis	tyrosine protein kinase otk	0.0111	0.1384	0.2282
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0124	0.1726	0.1726
Entamoeba histolytica	glycogen phosphorylase, putative	0.013	0.1898	1
Brugia malayi	casein kinase 1, delta	0.0117	0.1546	0.1546
Echinococcus multilocularis	neuroglian	0.0111	0.1384	0.2282
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0111	0.1384	0.1384
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1384	0.1384
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0111	0.1384	0.2956
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.007	0.0268	0.0442
Schistosoma mansoni	aryl hydrocarbon receptor	0.0095	0.0928	0.1983
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0111	0.1384	0.1384
Loa Loa (eye worm)	CK1/CK1/CK1-A protein kinase	0.0117	0.1546	0.1546
Echinococcus multilocularis	transfer RNA-Lys	0.007	0.0264	0.0435
Schistosoma mansoni	neuroglian	0.0111	0.1384	0.2956
Echinococcus multilocularis	Immunoglobulin	0.0173	0.3053	0.5032
Schistosoma mansoni	neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule	0.0111	0.1384	0.2956
Echinococcus multilocularis	epidermal growth factor receptor	0.0103	0.1152	0.1898
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0111	0.1384	0.1384
Echinococcus granulosus	neuroglian	0.0224	0.4437	0.7314
Echinococcus granulosus	epidermal growth factor receptor	0.0172	0.3029	0.4992
Brugia malayi	Prion-like-	0.0111	0.1384	0.1384
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0111	0.1384	0.1384
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0173	0.3053	0.652
Schistosoma mansoni	septate junction protein	0.0111	0.1384	0.2956
Schistosoma mansoni	serine/threonine protein kinase	0.0081	0.0557	0.1189
Loa Loa (eye worm)	CK1/CK1/CK1-A protein kinase	0.0117	0.1546	0.1546
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0074	0.0379	0.0625
Echinococcus granulosus	roundabout 2	0.0284	0.6067	1
Trypanosoma cruzi	casein kinase, delta isoform, putative	0.0117	0.1546	1
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.011	0.135	0.2225
Echinococcus multilocularis	roundabout 2	0.0284	0.6067	1
Brugia malayi	Protein kinase domain containing protein	0.0124	0.1726	0.1726
Loa Loa (eye worm)	hypothetical protein	0.0284	0.6067	0.6067
Mycobacterium ulcerans	putative regulatory protein	0.007	0.0264	0.5
Echinococcus granulosus	lachesin	0.0111	0.1384	0.2282
Echinococcus granulosus	tyrosine protein kinase Blk	0.0096	0.097	0.1599
Trypanosoma cruzi	casein kinase, putative	0.0117	0.1546	1
Echinococcus granulosus	neuroglian	0.0111	0.1384	0.2282
Echinococcus multilocularis	protein kinase shaggy	0.01	0.1064	0.1753
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.011	0.135	0.2225
Echinococcus granulosus	defective proboscis extension response	0.0173	0.3053	0.5032
Trypanosoma cruzi	casein kinase, putative	0.0117	0.1546	1
Plasmodium falciparum	casein kinase 1	0.0117	0.1546	1
Echinococcus multilocularis	casein kinase I alpha	0.0117	0.1546	0.2549
Entamoeba histolytica	glycogen phosphorylase, putative	0.013	0.1898	1
Loa Loa (eye worm)	hypothetical protein	0.0173	0.3053	0.3053
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.01	0.1064	0.1753
Echinococcus multilocularis	casein kinase I gamma	0.0124	0.1726	0.2844
Echinococcus granulosus	insulin receptor	0.007	0.0268	0.0442
Entamoeba histolytica	protein kinase, putative	0.01	0.1064	0.3664
Echinococcus multilocularis	epidermal growth factor receptor	0.0172	0.3029	0.4992
Schistosoma mansoni	titin	0.0111	0.1384	0.2956
Schistosoma mansoni	glycogen phosphorylase	0.013	0.1898	0.4054
Echinococcus granulosus	single minded 2	0.007	0.0264	0.0435
Onchocerca volvulus	Tyrosine kinase homolog	0.0248	0.5072	1
Echinococcus granulosus	protein kinase shaggy	0.01	0.1064	0.1753
Echinococcus multilocularis	casein kinase I delta	0.0117	0.1546	0.2549
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1384	0.1384
Entamoeba histolytica	protein kinase domain containing protein	0.01	0.1064	0.3664
Echinococcus multilocularis	lachesin	0.0111	0.1384	0.2282
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0111	0.1384	0.1384
Trichomonas vaginalis	CK1 family protein kinase	0.0117	0.1546	0.5782
Trichomonas vaginalis	CK1 family protein kinase	0.0117	0.1546	0.5782
Entamoeba histolytica	casein kinase 1, putative	0.0117	0.1546	0.7327
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0173	0.3053	0.5032
Loa Loa (eye worm)	glycogen phosphorylase	0.013	0.1898	0.1898
Brugia malayi	Furin-like cysteine rich region family protein	0.0172	0.3029	0.3029
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.01	0.1064	0.1064
Echinococcus granulosus	tyrosine kinase	0.0096	0.097	0.1599
Brugia malayi	Tyrosine-protein kinase abl-1	0.0131	0.1909	0.1909
Loa Loa (eye worm)	hypothetical protein	0.0173	0.3053	0.3053
Echinococcus granulosus	epidermal growth factor receptor	0.0103	0.1152	0.1898
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0293	0.6288	0.6288
Loa Loa (eye worm)	hypothetical protein	0.0233	0.4683	0.4683
Schistosoma mansoni	vesicular amine transporter	0.0173	0.3053	0.652
Schistosoma mansoni	tyrosine kinase	0.0103	0.1152	0.2459
Echinococcus granulosus	tyrosine protein kinase HCK	0.0082	0.0581	0.0958
Schistosoma mansoni	tyrosine kinase	0.008	0.0527	0.1125
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.007	0.0268	0.0442
Echinococcus granulosus	Glycosyl transferase family 35	0.013	0.1898	0.3129
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0172	0.3029	0.3029
Echinococcus granulosus	casein kinase I alpha	0.0117	0.1546	0.2549
Trypanosoma cruzi	casein kinase, putative	0.0117	0.1546	1
Echinococcus multilocularis	roundabout 2	0.0111	0.1384	0.2282
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0111	0.1384	0.1384
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0074	0.0379	0.0379
Echinococcus granulosus	contactin	0.0111	0.1384	0.2282
Onchocerca volvulus		0.0173	0.3063	0.5821
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0131	0.1909	0.3146
Trichomonas vaginalis	glycogen phosphorylase, putative	0.013	0.1898	1
Echinococcus granulosus	roundabout 2	0.0111	0.1384	0.2282
Brugia malayi	hypothetical protein	0.0317	0.6953	0.6953
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.011	0.135	0.2225
Echinococcus multilocularis	Glycosyl transferase, family 35	0.013	0.1898	0.3129
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0103	0.1152	0.1898
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0111	0.1384	0.1384
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0074	0.0379	0.0625
Echinococcus granulosus	casein kinase I alpha	0.0117	0.1546	0.2549
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0111	0.1384	0.1384
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.01	0.1064	0.1753
Echinococcus granulosus	peroxidasin	0.0111	0.1384	0.2282
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0111	0.1384	0.2282
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0233	0.4683	0.7718
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0115	0.1489	0.1489
Echinococcus granulosus	tyrosine protein kinase Fyn	0.011	0.135	0.2225
Schistosoma mansoni	tyrosine kinase	0.008	0.0527	0.1125
Brugia malayi	cyclin-dependent kinase 7 homolog	0.0081	0.0557	0.0557
Brugia malayi	carbohydrate phosphorylase	0.013	0.1898	0.1898
Brugia malayi	casein kinase I	0.0117	0.1546	0.1546
Brugia malayi	bHLH-PAS transcription factor	0.007	0.0264	0.0264
Onchocerca volvulus	Glycogen phosphorylase homolog	0.013	0.1898	0.3399
Loa Loa (eye worm)	TK protein kinase	0.0074	0.0379	0.0379
Trichomonas vaginalis	CK1 family protein kinase	0.0117	0.1546	0.5782
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.011	0.135	0.2225
Brugia malayi	Tyrosine-protein kinase abl-1	0.0128	0.1836	0.1836
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0096	0.097	0.1599
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.011	0.135	0.2225
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1384	0.1384
Schistosoma mansoni	roundabout	0.0111	0.1384	0.2956
Echinococcus granulosus	glycogen phosphorylase	0.013	0.1898	0.3129
Schistosoma mansoni	tyrosine kinase	0.0103	0.1152	0.2459
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1384	0.1384
Schistosoma mansoni	septate junction protein	0.0111	0.1384	0.2956
Schistosoma mansoni	cell adhesion molecule	0.0111	0.1384	0.2956
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0173	0.3053	0.3053
Echinococcus granulosus	casein kinase I gamma	0.0124	0.1726	0.2844
Loa Loa (eye worm)	TK protein kinase	0.0096	0.097	0.097
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.01	0.1064	0.1064
Schistosoma mansoni	tyrosine kinase	0.011	0.135	0.2882
Loa Loa (eye worm)	hypothetical protein	0.0317	0.6953	0.6953
Schistosoma mansoni	tyrosine kinase	0.007	0.0268	0.0573
Onchocerca volvulus		0.0117	0.1546	0.2667
Onchocerca volvulus		0.0114	0.1442	0.245
Schistosoma mansoni	tyrosine kinase	0.008	0.0527	0.1125
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.01	0.1064	0.2272
Echinococcus multilocularis	glycogen phosphorylase	0.013	0.1898	0.3129
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0111	0.1384	0.1384
Echinococcus granulosus	cyclin dependent kinase 7	0.0081	0.0557	0.0918
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.011	0.135	0.2225
Echinococcus multilocularis	cyclin dependent kinase 7	0.0081	0.0557	0.0918
Loa Loa (eye worm)	TK/ROR protein kinase	0.0074	0.0379	0.0379
Schistosoma mansoni	tyrosine kinase	0.0134	0.2009	0.4291
Onchocerca volvulus		0.01	0.1064	0.1664
Trypanosoma cruzi	casein kinase, delta isoform, putative	0.0114	0.1442	0.7834
Loa Loa (eye worm)	CMGC/CDK/CDK7 protein kinase	0.0081	0.0557	0.0557
Brugia malayi	SRC-1	0.011	0.135	0.135
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0073	0.0346	0.057
Echinococcus multilocularis	glycogen phosphorylase	0.013	0.1898	0.3129
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0245	0.4994	0.8232
Echinococcus granulosus	twitchin	0.0228	0.4542	0.7486
Onchocerca volvulus	Basement membrane proteoglycan homolog	0.0111	0.1384	0.2331
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0111	0.1384	0.1384
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0114	0.1454	0.2397
Plasmodium vivax	casein kinase 1, putative	0.0117	0.1546	1
Echinococcus granulosus	casein kinase I alpha	0.0117	0.1546	0.2549
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1384	0.1384
Schistosoma mansoni	tyrosine kinase	0.023	0.4605	0.9835
Schistosoma mansoni	single-minded	0.0095	0.0928	0.1983
Brugia malayi	protein-tyrosine kinase	0.0096	0.097	0.097
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0082	0.0581	0.0958

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.049 uM	Inhibitory concentration against glycogen phosphorylase	ChEMBL.	15603973
IC50 (binding)	= 0.049 uM	Inhibitory concentration against glycogen phosphorylase	ChEMBL.	15603973
IC50 (functional)	= 1.8 uM	Inhibitory concentration against human SK-Hep-1 cells (hepatoma cell line)	ChEMBL.	15603973
IC50 (functional)	= 1.8 uM	Inhibitory concentration against human SK-Hep-1 cells (hepatoma cell line)	ChEMBL.	15603973

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	15603973

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL181876

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 317054