Detailed information for compound 317099

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 208.323 | Formula: C11H16N2S
  • H donors: 1 H acceptors: 0 LogP: 2.95 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCS/C(=N\C)/Nc1ccccc1C
  • InChi: 1S/C11H16N2S/c1-4-14-11(12-3)13-10-8-6-5-7-9(10)2/h5-8H,4H2,1-3H3,(H,12,13)
  • InChiKey: JGXUKDGDTZFCTP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0098 0.037 0.037
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 24 0.0087 0.0317 0.0876
Trypanosoma brucei hypothetical protein, conserved 0.0134 0.0541 0.3186
Loa Loa (eye worm) hypothetical protein 0.0087 0.0317 0.0317
Echinococcus granulosus para nitrobenzyl esterase 0.0132 0.0532 0.0513
Loa Loa (eye worm) hypothetical protein 0.0087 0.0317 0.0317
Brugia malayi Choline/ethanolamine kinase family protein 0.0071 0.0242 0.067
Trypanosoma cruzi ion transport protein, putative 0.0087 0.0317 0.1908
Echinococcus granulosus neuroligin 0.0132 0.0532 0.0513
Leishmania major farnesyltransferase beta subunit 0.036 0.1617 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.0532 0.0532
Loa Loa (eye worm) hypothetical protein 0.0087 0.0317 0.0317
Echinococcus multilocularis potassium channel subfamily K 8 0.0087 0.0317 0.0297
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0516 0.2359 1
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.036 0.1617 0.9285
Loa Loa (eye worm) hypothetical protein 0.0087 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0087 0.0317 0.0317
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0134 0.0541 0.3186
Trypanosoma cruzi lanosterol synthase, putative 0.0098 0.037 0.2237
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0134 0.0541 0.3186
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.0087 0.0317 0.0876
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 28 0.0087 0.0317 0.0876
Loa Loa (eye worm) hypothetical protein 0.0087 0.0317 0.0317
Trypanosoma brucei protein farnesyltransferase beta subunit 0.036 0.1617 1
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0087 0.0317 0.1908
Loa Loa (eye worm) carboxylesterase 0.0132 0.0532 0.0532
Schistosoma mansoni calcium-activated potassium channel 0.0087 0.0317 0.0297
Loa Loa (eye worm) hypothetical protein 0.0132 0.0532 0.0532
Trypanosoma cruzi cysteine peptidase, putative 0.0028 0.0039 0.0178
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0098 0.037 0.035
Brugia malayi hypothetical protein 0.0087 0.0317 0.0876
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0134 0.0541 0.3186
Leishmania major potassium channel subunit-like protein 0.0087 0.0317 0.1762
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0098 0.037 0.0603
Brugia malayi Carboxylesterase family protein 0.0132 0.0532 0.1472
Trypanosoma cruzi protein farnesyltransferase, putative 0.036 0.1617 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.0532 0.0532
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0098 0.037 0.2455
Loa Loa (eye worm) hypothetical protein 0.0087 0.0317 0.0317
Schistosoma mansoni acetylcholinesterase 0.0132 0.0532 0.0513
Leishmania major ion transport protein-like protein 0.0087 0.0317 0.1762
Echinococcus granulosus acetylcholinesterase 0.078 0.3616 0.3602
Leishmania major geranylgeranyltransferase, putative 0.0098 0.037 0.2097
Loa Loa (eye worm) hypothetical protein 0.0087 0.0317 0.0317
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 35 0.0087 0.0317 0.0876
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0098 0.037 0.035
Trypanosoma brucei calcium-activated potassium channel, putative 0.0087 0.0317 0.1762
Loa Loa (eye worm) hypothetical protein 0.078 0.3616 0.3616
Loa Loa (eye worm) hypothetical protein 0.0098 0.037 0.037
Loa Loa (eye worm) hypothetical protein 0.0087 0.0317 0.0317
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0087 0.0317 0.1908
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.036 0.1617 0.4472
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0132 0.0532 0.0513
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0028 0.0028
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0087 0.0317 0.0317
Echinococcus multilocularis potassium channel subfamily K 0.0087 0.0317 0.0297
Echinococcus multilocularis acetylcholinesterase 0.078 0.3616 0.3602
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0262 0.1153 0.4301
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 21 0.0087 0.0317 0.0876
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0516 0.2359 0.2343
Echinococcus multilocularis BC026374 protein (S09 family) 0.0132 0.0532 0.0513
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0132 0.0532 0.0513
Brugia malayi Carboxylesterase family protein 0.078 0.3616 1
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0516 0.2359 0.2359
Loa Loa (eye worm) hypothetical protein 0.0132 0.0532 0.0532
Loa Loa (eye worm) hypothetical protein 0.0087 0.0317 0.0317
Trypanosoma cruzi hypothetical protein, conserved 0.0087 0.0317 0.1908
Leishmania major hypothetical protein, conserved 0.0087 0.0317 0.1762
Echinococcus multilocularis twik family of potassium channels 0.0087 0.0317 0.0297
Loa Loa (eye worm) hypothetical protein 0.0349 0.1563 0.1563
Echinococcus granulosus BC026374 protein S09 family 0.0132 0.0532 0.0513
Plasmodium falciparum potassium channel 0.0087 0.0317 0.0353
Echinococcus granulosus microtubule associated protein 2 0.0303 0.1348 0.133
Loa Loa (eye worm) hypothetical protein 0.0087 0.0317 0.0317
Loa Loa (eye worm) carboxylesterase 0.0132 0.0532 0.0532
Mycobacterium tuberculosis Carboxylesterase LipT 0.0132 0.0532 1
Loa Loa (eye worm) TWK-28 protein 0.0087 0.0317 0.0317
Echinococcus multilocularis calcium activated potassium channel variant 0.0087 0.0317 0.0297
Onchocerca volvulus 0.0132 0.0532 0.9594
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0134 0.0541 0.1498
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0132 0.0532 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0087 0.0317 0.0876
Brugia malayi jmjC domain containing protein 0.0026 0.0028 0.0078
Schistosoma mansoni jumonji domain containing protein 0.0026 0.0028 0.0008
Loa Loa (eye worm) hypothetical protein 0.0087 0.0317 0.0317
Echinococcus granulosus calcium activated potassium channel variant 0.0087 0.0317 0.0297
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0132 0.0532 0.0513
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0098 0.037 0.035
Echinococcus granulosus Two pore potassium channel protein sup 9 0.0087 0.0317 0.0297
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0087 0.0317 0.1908
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.0087 0.0317 0.0297
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 45 0.0087 0.0317 0.0876
Plasmodium falciparum protein farnesyltransferase subunit beta 0.036 0.1617 0.6495
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0087 0.0317 0.1908
Loa Loa (eye worm) hypothetical protein 0.0087 0.0317 0.0317
Plasmodium falciparum potassium channel 0.0087 0.0317 0.0353
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0516 0.2359 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0026 0.0028 0.0008
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0132 0.0532 0.0513
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0098 0.037 0.2237
Echinococcus multilocularis TWiK family of potassium channels protein 7 0.0087 0.0317 0.0297
Schistosoma mansoni twik family of potassium channels-related 0.0087 0.0317 0.0297
Echinococcus granulosus carboxylesterase 5A 0.078 0.3616 0.3602
Echinococcus granulosus acetylcholinesterase 0.078 0.3616 0.3602
Brugia malayi jmjC domain containing protein 0.0026 0.0028 0.0078
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.078 0.3616 0.3602
Schistosoma mansoni protein farnesyltransferase subunit beta 0.036 0.1617 0.1599
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0098 0.037 0.0862
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 17 0.0087 0.0317 0.0876
Trypanosoma brucei lanosterol synthase 0.0098 0.037 0.2097
Schistosoma mansoni calcium-activated potassium channel 0.2123 1 1
Echinococcus granulosus potassium channel subfamily K 8 0.0087 0.0317 0.0297
Trypanosoma cruzi cysteine peptidase, putative 0.0028 0.0039 0.0178
Loa Loa (eye worm) hypothetical protein 0.0516 0.2359 0.2359
Schistosoma mansoni twik family of potassium channels-related 0.0087 0.0317 0.0297
Echinococcus granulosus lysine specific demethylase 5A 0.0026 0.0028 0.0008
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.036 0.1617 0.6367
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0516 0.2359 0.6523
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0134 0.0541 0.1414
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0134 0.0541 0.0522
Echinococcus granulosus twik family of potassium channels 0.0087 0.0317 0.0297
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0098 0.037 0.0862
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0098 0.037 0.037
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0098 0.037 0.035
Echinococcus granulosus TWiK family of potassium channels protein 7 0.0087 0.0317 0.0297
Echinococcus multilocularis lysine specific demethylase 5A 0.0026 0.0028 0.0008
Brugia malayi Carboxylesterase family protein 0.0132 0.0532 0.1472
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0134 0.0541 0.0522
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0134 0.0541 0.3307
Echinococcus granulosus potassium channel subfamily K 0.0087 0.0317 0.0297
Schistosoma mansoni twik family of potassium channels-related 0.0087 0.0317 0.0297
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0132 0.0532 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.0317 0.0317
Loa Loa (eye worm) uncoordinated protein 58 0.0087 0.0317 0.0317
Schistosoma mansoni twik family of potassium channels-related 0.0087 0.0317 0.0297
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0098 0.037 0.0259
Giardia lamblia Prenyltransferase 0.036 0.1617 0.6367
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0134 0.0541 0.3186
Loa Loa (eye worm) hypothetical protein 0.0087 0.0317 0.0317
Brugia malayi hypothetical protein 0.0132 0.0532 0.1472
Schistosoma mansoni calcium-activated potassium channel 0.0087 0.0317 0.0297
Schistosoma mansoni gliotactin 0.0132 0.0532 0.0513
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0134 0.0541 0.0522
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0134 0.0541 0.3307
Plasmodium vivax geranylgeranyltransferase, putative 0.0098 0.037 0.0603
Loa Loa (eye worm) hypothetical protein 0.0087 0.0317 0.0317
Trypanosoma brucei calcium/potassium channel (CAKC), putative 0.0087 0.0317 0.1762
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0098 0.037 0.0259
Onchocerca volvulus 0.0132 0.0532 0.9594
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.036 0.1617 0.6367
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0026 0.0027 0.0106
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0098 0.037 0.0259
Loa Loa (eye worm) hypothetical protein 0.078 0.3616 0.3616
Trypanosoma cruzi hypothetical protein, conserved 0.0087 0.0317 0.1908
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0098 0.037 0.1022
Loa Loa (eye worm) hypothetical protein 0.0087 0.0317 0.0317
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0516 0.2359 0.2343
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0098 0.037 0.0259
Echinococcus multilocularis choline:ethanolamine kinase 0.0071 0.0242 0.0222
Echinococcus multilocularis para nitrobenzyl esterase 0.0132 0.0532 0.0513
Echinococcus granulosus protein farnesyltransferase subunit beta 0.036 0.1617 0.1599
Trypanosoma cruzi hypothetical protein, conserved 0.0134 0.0541 0.3307
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 5 0.0087 0.0317 0.0876
Loa Loa (eye worm) acetylcholinesterase 1 0.078 0.3616 0.3616
Loa Loa (eye worm) hypothetical protein 0.0087 0.0317 0.0317
Toxoplasma gondii ion channel protein 0.0087 0.0317 0.0504
Loa Loa (eye worm) hypothetical protein 0.0798 0.3701 0.3701
Schistosoma mansoni twik family of potassium channels-related 0.0087 0.0317 0.0297
Leishmania major hypothetical protein, conserved 0.0087 0.0317 0.1762
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.036 0.1617 0.1599
Plasmodium vivax potassium channel, putative 0.0087 0.0317 0.0353
Trichomonas vaginalis spcc417.12 protein, putative 0.0132 0.0532 0.1056
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0134 0.0541 0.11
Onchocerca volvulus 0.0132 0.0532 0.9594
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0098 0.037 0.0603
Echinococcus granulosus choline:ethanolamine kinase 0.0071 0.0242 0.0222
Trypanosoma cruzi protein farnesyltransferase, putative 0.036 0.1617 1
Trypanosoma cruzi hypothetical protein, conserved 0.0098 0.037 0.2237
Trypanosoma cruzi hypothetical protein, conserved 0.0098 0.037 0.2237
Echinococcus multilocularis neuroligin 0.0132 0.0532 0.0513
Toxoplasma gondii ion channel protein 0.0087 0.0317 0.0504
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.036 0.1617 0.1617
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0516 0.2359 1
Onchocerca volvulus 0.0134 0.0541 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.0317 0.0317
Mycobacterium ulcerans carboxylesterase, LipT 0.0132 0.0532 1
Brugia malayi Carboxylesterase family protein 0.0132 0.0532 0.1472
Schistosoma mansoni twik family of potassium channels-related 0.0087 0.0317 0.0297
Onchocerca volvulus 0.0132 0.0532 0.9594
Trypanosoma cruzi hypothetical protein, conserved 0.0134 0.0541 0.3307
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0134 0.0541 0.0541
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0132 0.0532 0.1056
Loa Loa (eye worm) hypothetical protein 0.0087 0.0317 0.0317
Onchocerca volvulus 0.0132 0.0532 0.9594
Schistosoma mansoni hypothetical protein 0.0087 0.0317 0.0297
Giardia lamblia Rab geranylgeranyltransferase 0.0098 0.037 0.0259
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0134 0.0541 0.0522
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0098 0.037 0.035
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0098 0.037 0.035
Loa Loa (eye worm) S-phase kinase-associated protein 1A 0.0087 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0087 0.0317 0.0317
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39B 0.0087 0.0317 0.0876
Leishmania major calcium/potassium channel (CAKC), putative 0.0087 0.0317 0.1762
Loa Loa (eye worm) hypothetical protein 0.0087 0.0317 0.0317
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0516 0.2359 1
Schistosoma mansoni hypothetical protein 0.2123 1 1
Toxoplasma gondii hypothetical protein 0.0382 0.1723 1
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0516 0.2359 0.2343
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.036 0.1617 0.6367
Schistosoma mansoni calcium-activated potassium channel 0.1688 0.7931 0.7927
Plasmodium vivax farnesyltransferase beta subunit, putative 0.036 0.1617 0.6495
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.036 0.1617 0.6367
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0132 0.0532 0.0513
Schistosoma mansoni twik family of potassium channels-related 0.0087 0.0317 0.0297
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0098 0.037 0.0259
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0087 0.0317 0.0876
Loa Loa (eye worm) hypothetical protein 0.0132 0.0532 0.0532
Echinococcus multilocularis acetylcholinesterase 0.078 0.3616 0.3602
Loa Loa (eye worm) TWK-7 protein 0.0087 0.0317 0.0317
Brugia malayi Carboxylesterase family protein 0.078 0.3616 1
Trypanosoma cruzi ion transport protein, putative 0.0087 0.0317 0.1908
Echinococcus multilocularis carboxylesterase 5A 0.078 0.3616 0.3602
Loa Loa (eye worm) hypothetical protein 0.0087 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.2123 1 1
Echinococcus multilocularis small conductance calcium activated potassium 0.2123 1 1
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0134 0.0541 0.11
Trypanosoma cruzi cruzipain precursor, putative 0.0028 0.0039 0.0178
Loa Loa (eye worm) hypothetical protein 0.0087 0.0317 0.0317
Schistosoma mansoni jumonji/arid domain-containing protein 0.0026 0.0028 0.0008
Loa Loa (eye worm) choline/ethanolamine kinase 0.0071 0.0242 0.0242
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0026 0.0028 0.0008
Loa Loa (eye worm) hypothetical protein 0.0087 0.0317 0.0317
Brugia malayi Carboxylesterase family protein 0.0132 0.0532 0.1472
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0098 0.037 0.1022
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 13 0.0087 0.0317 0.0876
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 12 0.0087 0.0317 0.0876
Echinococcus multilocularis twik family of potassium channels 0.0087 0.0317 0.0297
Loa Loa (eye worm) hypothetical protein 0.0087 0.0317 0.0317
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39A 0.0087 0.0317 0.0876
Echinococcus granulosus twik family of potassium channels 0.0087 0.0317 0.0297
Loa Loa (eye worm) hypothetical protein 0.0087 0.0317 0.0317
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0516 0.2359 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.0317 0.0317
Brugia malayi Twik (KCNK-like) family of potasium channels, alpha subunit 40 0.0087 0.0317 0.0876
Loa Loa (eye worm) hypothetical protein 0.0132 0.0532 0.0532
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0087 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0087 0.0317 0.0317
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0134 0.0541 0.3307
Schistosoma mansoni microtubule-associated protein tau 0.0303 0.1348 0.133
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0026 0.0028 0.0008
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.036 0.1617 0.6367
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0134 0.0541 0.0522
Giardia lamblia Rab geranylgeranyltransferase 0.0516 0.2359 1
Brugia malayi hypothetical protein 0.0087 0.0317 0.0876
Plasmodium falciparum geranylgeranyltransferase, putative 0.0098 0.037 0.0603
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.036 0.1617 0.6367
Giardia lamblia Rab geranylgeranyltransferase 0.0134 0.0541 0.11
Loa Loa (eye worm) hypothetical protein 0.0087 0.0317 0.0317
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.036 0.1617 0.6367
Trypanosoma cruzi cysteine peptidase, putative 0.0028 0.0039 0.0178
Loa Loa (eye worm) carboxylesterase 0.078 0.3616 0.3616
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0098 0.037 0.2097
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 7 0.0087 0.0317 0.0876
Schistosoma mansoni BC026374 protein (S09 family) 0.0132 0.0532 0.0513
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0134 0.0541 0.1414
Toxoplasma gondii hypothetical protein 0.0134 0.0541 0.2022
Echinococcus multilocularis microtubule associated protein 2 0.0303 0.1348 0.133
Echinococcus granulosus potassium channel subfamily K 8 0.0087 0.0317 0.0297
Loa Loa (eye worm) hypothetical protein 0.089 0.4135 0.4135
Loa Loa (eye worm) hypothetical protein 0.0087 0.0317 0.0317
Trypanosoma cruzi lanosterol synthase, putative 0.0098 0.037 0.2237
Loa Loa (eye worm) hypothetical protein 0.0132 0.0532 0.0532
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0382 0.1723 0.6885
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog 0.0087 0.0317 0.0876
Plasmodium vivax potassium channel, putative 0.0087 0.0317 0.0353
Loa Loa (eye worm) hypothetical protein 0.0087 0.0317 0.0317
Schistosoma mansoni neuroligin 3 (S09 family) 0.0132 0.0532 0.0513
Echinococcus multilocularis potassium channel subfamily K 8 0.0087 0.0317 0.0297
Schistosoma mansoni twik family of potassium channels-related 0.0087 0.0317 0.0297
Loa Loa (eye worm) hypothetical protein 0.0087 0.0317 0.0317
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0516 0.2359 1

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 7.44 % Percent inhibition of nitrite release in lipopolysaccharide (LPS) treated J774.A1 macrophage cell lines at concentration of 1E-6M ChEMBL. 15664809
Inhibition (functional) = 7.44 % Percent inhibition of nitrite release in lipopolysaccharide (LPS) treated J774.A1 macrophage cell lines at concentration of 1E-6M ChEMBL. 15664809
Inhibition (functional) = 15.33 % Percent inhibition of nitrite release in lipopolysaccharide (LPS) treated J774.A1 macrophage cell lines at concentration of 1E-5M ChEMBL. 15664809
Inhibition (functional) = 15.33 % Percent inhibition of nitrite release in lipopolysaccharide (LPS) treated J774.A1 macrophage cell lines at concentration of 1E-5M ChEMBL. 15664809
Inhibition (functional) = 65.21 % Percent inhibition of nitrite release in lipopolysaccharide (LPS) treated J774.A1 macrophage cell lines at concentration of 1E-3 M ChEMBL. 15664809
Inhibition (functional) = 65.21 % Percent inhibition of nitrite release in lipopolysaccharide (LPS) treated J774.A1 macrophage cell lines at concentration of 1E-3 M ChEMBL. 15664809

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.