Detailed information for compound 320355

Basic information

Technical information
  • TDR Targets ID: 320355
  • Name: 5-methoxy-2-methyl-6-phenylsulfanyl-1,3-benzo selenazole-4,7-dione
  • MW: 364.278 | Formula: C15H11NO3SSe
  • H donors: 0 H acceptors: 2 LogP: 2.4 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC1=C(Sc2ccccc2)C(=O)c2c(C1=O)nc([se]2)C
  • InChi: 1S/C15H11NO3SSe/c1-8-16-10-11(17)13(19-2)14(12(18)15(10)21-8)20-9-6-4-3-5-7-9/h3-7H,1-2H3
  • InChiKey: WBFBUXCEQWGIOA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-methoxy-2-methyl-6-(phenylthio)-1,3-benzoselenazole-4,7-dione
  • 5-methoxy-2-methyl-6-(phenylthio)-1,3-benzoselenazole-4,7-quinone
  • 4,7-Benzoselenazoledione, 5-methoxy-2-methyl-6-(phenylthio)-
  • AIDS-227177
  • AIDS227177

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0168 0.2965 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0202 0.37 1
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0119 0.1916 0.4388
Loa Loa (eye worm) hypothetical protein 0.0202 0.37 0.4203
Brugia malayi tailless protein 0.0095 0.1398 0.1501
Loa Loa (eye worm) hypothetical protein 0.0095 0.1398 0.1538
Brugia malayi photoreceptor-specific nuclear receptor 0.0202 0.37 0.4178
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0119 0.1905 0.4362
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0202 0.37 0.4178
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0202 0.37 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1398 0.1538
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1376 0.353
Onchocerca volvulus 0.0035 0.0108 0.0038
Leishmania major cytochrome p450-like protein 0.0036 0.012 0.0043
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0686 0.161
Loa Loa (eye worm) DR-78 0.0095 0.1398 0.1538
Onchocerca volvulus 0.0095 0.1398 0.1337
Brugia malayi Steroid receptor seven-up type 2 0.0202 0.37 0.4178
Loa Loa (eye worm) glutathione reductase 0.0052 0.0466 0.0458
Echinococcus granulosus dihydrofolate reductase 0.0049 0.0392 0.0792
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1376 0.353
Brugia malayi Pre-SET motif family protein 0.0062 0.0686 0.0673
Onchocerca volvulus 0.0119 0.1916 0.1859
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0202 0.37 1
Onchocerca volvulus 0.0095 0.1398 0.1337
Brugia malayi Nuclear hormone receptor E75 0.0095 0.1398 0.1501
Loa Loa (eye worm) hypothetical protein 0.0035 0.0108 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0202 0.37 0.4178
Brugia malayi Nuclear hormone receptor-like 1 0.0202 0.37 0.4178
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0095 0.1398 0.1501
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0107 0.1645 0.4279
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0095 0.1398 0.3593
Brugia malayi Dihydrofolate reductase 0.0049 0.0392 0.0331
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.1376 0.1511
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0202 0.37 0.4203
Mycobacterium ulcerans thymidylate synthase 0.0119 0.1916 1
Toxoplasma gondii thioredoxin reductase 0.0052 0.0466 0.1255
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0107 0.1645 0.1823
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0095 0.1398 0.3593
Loa Loa (eye worm) nuclear hormone receptor 0.0095 0.1398 0.1538
Schistosoma mansoni chromobox protein 0.0077 0.0998 0.2478
Loa Loa (eye worm) hypothetical protein 0.0095 0.1398 0.1538
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0202 0.37 0.4178
Schistosoma mansoni RAR-like nuclear receptor 0.0202 0.37 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1398 0.1538
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0049 0.0392 0.069
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.0466 0.087
Loa Loa (eye worm) hypothetical protein 0.0202 0.37 0.4203
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0202 0.37 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1398 0.1538
Chlamydia trachomatis dihydrofolate reductase 0.0049 0.0392 0.5
Loa Loa (eye worm) hypothetical protein 0.0107 0.1645 0.1823
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0095 0.1398 0.3593
Brugia malayi steroid hormone receptor 0.0202 0.37 0.4178
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0271 0.0202
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0202 0.37 0.4178
Echinococcus multilocularis nuclear receptor nhr 48 0.0095 0.1398 0.3593
Brugia malayi hypothetical protein 0.0134 0.2235 0.2473
Echinococcus granulosus geminin 0.0169 0.2975 0.7982
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0168 0.2965 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0202 0.37 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1398 0.1538
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0095 0.1398 0.3593
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0686 0.2024
Schistosoma mansoni nuclear hormone receptor 0.0095 0.1398 0.3593
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0132 0.2191 0.5056
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0108 0.0108
Loa Loa (eye worm) thymidylate synthase 0.0119 0.1916 0.2137
Echinococcus multilocularis ecdysone induced protein 78C 0.0202 0.37 1
Onchocerca volvulus 0.0035 0.0108 0.0038
Brugia malayi hypothetical protein 0.0107 0.1645 0.1787
Loa Loa (eye worm) hypothetical protein 0.0095 0.1398 0.1538
Echinococcus multilocularis thymidylate synthase 0.0119 0.1916 0.5033
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0095 0.1398 0.3593
Echinococcus multilocularis chromobox protein 1 0.0077 0.0998 0.2478
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0202 0.37 1
Loa Loa (eye worm) hypothetical protein 0.0202 0.37 0.4203
Loa Loa (eye worm) nuclear receptor NHR-67 0.0095 0.1398 0.1538
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0202 0.37 1
Brugia malayi hypothetical protein 0.0095 0.1398 0.1501
Loa Loa (eye worm) hypothetical protein 0.0095 0.1398 0.1538
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.0466 0.0998
Schistosoma mansoni nuclear receptor 0.0095 0.1398 0.3593
Schistosoma mansoni coup transcription factor 0.0202 0.37 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0119 0.1905 0.4362
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0057 0.0567 0.1608
Echinococcus multilocularis thyroid hormone receptor alpha 0.0202 0.37 1
Schistosoma mansoni dihydrofolate reductase 0.0049 0.0392 0.0792
Echinococcus granulosus chromobox protein 1 0.0077 0.0998 0.2478
Schistosoma mansoni nuclear hormone receptor 0.0202 0.37 1
Echinococcus granulosus chromobox protein 1 0.0077 0.0998 0.2478
Loa Loa (eye worm) hypothetical protein 0.035 0.6879 0.7883
Loa Loa (eye worm) CYP4Cod1 0.0036 0.012 0.0057
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0686 0.161
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0202 0.37 0.4178
Loa Loa (eye worm) hypothetical protein 0.0035 0.0108 0.0043
Schistosoma mansoni hypothetical protein 0.0169 0.2975 0.7982
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0095 0.1398 0.1337
Brugia malayi conserved hypotetical protein 0.0095 0.1398 0.1501
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0202 0.37 0.4203
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0202 0.37 0.4178
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.0466 0.0458
Brugia malayi Heterochromatin protein 1 0.0077 0.0998 0.1035
Brugia malayi nuclear hormone receptor 0.0202 0.37 0.4178
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0107 0.1645 0.4279
Echinococcus multilocularis FTZ F1 alpha 0.0202 0.37 1
Schistosoma mansoni thyroid hormone receptor 0.0202 0.37 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0132 0.2191 1
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0168 0.2965 1
Mycobacterium tuberculosis Probable reductase 0.0119 0.1905 0.4362
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0271 0.0271
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0202 0.37 0.4178
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0119 0.1905 0.4362
Loa Loa (eye worm) hypothetical protein 0.0095 0.1398 0.1538
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0202 0.37 0.4178
Plasmodium vivax SET domain protein, putative 0.0062 0.0686 0.2024
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0709 0.146
Loa Loa (eye worm) hypothetical protein 0.0062 0.0686 0.0713
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0119 0.1905 0.8628
Brugia malayi hypothetical protein 0.0107 0.1645 0.1787
Loa Loa (eye worm) hypothetical protein 0.0202 0.37 0.4203
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0341 0.0341
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0637 0.1473
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1376 0.353
Brugia malayi Thioredoxin reductase 0.0052 0.0466 0.0417
Loa Loa (eye worm) hypothetical protein 0.0202 0.37 0.4203
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.0466 0.0998
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0709 0.1674
Loa Loa (eye worm) hypothetical protein 0.0107 0.1645 0.1823
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.0466 0.1255
Brugia malayi ecdysteroid receptor 0.0202 0.37 0.4178
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0168 0.2965 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0434 0.8706 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0686 0.161
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0075 0.0957 0.2364
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0095 0.1398 0.1538
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0036 0.012 0.0067
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0095 0.1398 0.3593
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0202 0.37 1
Brugia malayi chromobox protein homolog 3 0.0043 0.0271 0.019
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0709 0.3326
Echinococcus granulosus thymidylate synthase 0.0119 0.1916 0.5033
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.012 0.0057
Loa Loa (eye worm) hypothetical protein 0.0035 0.0108 0.0043
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1376 0.353
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0202 0.37 0.4178
Trypanosoma brucei trypanothione reductase 0.0052 0.0466 0.1255
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0567 0.0567
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0202 0.37 0.4203
Brugia malayi Nuclear hormone receptor-like 1 0.0107 0.1645 0.1787
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0709 0.1674
Brugia malayi nuclear hormone receptor 0.0095 0.1398 0.1501
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0049 0.0392 0.1365
Brugia malayi nuclear receptor RXR 0.0107 0.1645 0.1787
Onchocerca volvulus 0.0075 0.0957 0.0893
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1376 0.353
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0095 0.1398 0.1538
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0202 0.37 0.4203
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.0466 0.1255
Loa Loa (eye worm) dihydrofolate reductase 0.0049 0.0392 0.0373
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0095 0.1398 0.3593
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0095 0.1398 0.3593
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0119 0.1916 0.5033
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0271 0.0271
Loa Loa (eye worm) beta-lactamase 0.0035 0.0108 0.0043
Schistosoma mansoni retinoic acid receptor RXR 0.0202 0.37 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0095 0.1398 0.1501
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1376 0.353
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0709 0.1674
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0168 0.2965 1
Onchocerca volvulus 0.0035 0.0108 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0202 0.37 0.4178
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0202 0.37 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0119 0.1905 0.4362
Loa Loa (eye worm) hypothetical protein 0.0107 0.1645 0.1823
Schistosoma mansoni steroid hormone receptor ad4bp 0.0202 0.37 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0709 0.3326
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0119 0.1916 0.8679
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0108 0.0108
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0686 0.161
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0202 0.37 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.0341 0.0273
Schistosoma mansoni thyroid hormone receptor 0.0202 0.37 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0095 0.1398 0.3593
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0202 0.37 1
Brugia malayi Cytochrome P450 family protein 0.0036 0.012 0.0014
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0119 0.1905 0.4362
Loa Loa (eye worm) hypothetical protein 0.0095 0.1398 0.1538
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0709 0.3326
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0202 0.37 1
Echinococcus granulosus ecdysone induced protein 78C 0.0202 0.37 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0108 0.0043
Schistosoma mansoni hypothetical protein 0.0057 0.0572 0.1291
Schistosoma mansoni hypothetical protein 0.0169 0.2975 0.7982
Echinococcus granulosus FTZ F1 alpha 0.0202 0.37 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0202 0.37 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0107 0.1645 0.4279
Loa Loa (eye worm) hypothetical protein 0.0202 0.37 0.4203
Echinococcus granulosus Nuclear hormone receptor HR96 0.0095 0.1398 0.3593
Loa Loa (eye worm) hypothetical protein 0.0035 0.0108 0.0043
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0686 0.161
Brugia malayi nuclear receptor NHR-88 0.0095 0.1398 0.1501
Trypanosoma brucei cytochrome P450, putative 0.0036 0.012 0.0043
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0168 0.2965 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0132 0.2191 0.5056
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0095 0.1398 0.1337
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0202 0.37 0.4178
Loa Loa (eye worm) hypothetical protein 0.0095 0.1398 0.1538
Trichomonas vaginalis set domain proteins, putative 0.0494 1 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0202 0.37 1
Schistosoma mansoni nuclear hormone receptor 0.0095 0.1398 0.3593
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.4228 1
Brugia malayi Nuclear hormone receptor E75 0.0095 0.1398 0.1501
Brugia malayi hypothetical protein 0.0095 0.1398 0.1501
Echinococcus multilocularis chromobox protein 1 0.0077 0.0998 0.2478
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0202 0.37 0.3655
Loa Loa (eye worm) cytochrome P450 family protein 0.0078 0.1024 0.1105
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0108 0.0108
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0202 0.37 1
Brugia malayi nuclear receptor NHR-67 0.0095 0.1398 0.1501
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0095 0.1398 0.3593
Loa Loa (eye worm) hypothetical protein 0.0043 0.0271 0.0232
Brugia malayi glutathione reductase 0.0052 0.0466 0.0417
Brugia malayi Pre-SET motif family protein 0.0434 0.8706 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0095 0.1398 0.3593
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1376 0.353
Schistosoma mansoni chromobox protein 0.0077 0.0998 0.2478
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0202 0.37 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.012 0.0057
Trypanosoma cruzi cytochrome P450, putative 0.0036 0.012 0.0043
Loa Loa (eye worm) hypothetical protein 0.0035 0.0108 0.0043
Echinococcus multilocularis geminin 0.0169 0.2975 0.7982
Loa Loa (eye worm) hypothetical protein 0.0202 0.37 0.4203
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0686 0.161
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0202 0.37 0.4178
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0202 0.37 1
Brugia malayi Cytochrome P450 family protein 0.0078 0.1024 0.1066
Brugia malayi nuclear receptor NHR-88 0.0202 0.37 0.4178
Trypanosoma cruzi cytochrome P450, putative 0.0036 0.012 0.0043
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0202 0.37 0.4203
Mycobacterium tuberculosis Probable oxidoreductase 0.0132 0.2191 0.5056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0202 0.37 0.4203
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0709 0.2105
Echinococcus granulosus nuclear receptor nhr 48 0.0095 0.1398 0.3593
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0202 0.37 0.4178
Plasmodium vivax glutathione reductase, putative 0.0052 0.0466 0.1255
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0709 0.1674
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0108 0.0043
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0709 0.2105
Brugia malayi nuclear receptor RXR 0.0095 0.1398 0.1501
Onchocerca volvulus Bile acid receptor homolog 0.0202 0.37 0.3655
Trichomonas vaginalis chromobox protein, putative 0.0077 0.0998 0.0998
Loa Loa (eye worm) hypothetical protein 0.0107 0.1645 0.1823
Brugia malayi thymidylate synthase 0.0119 0.1916 0.2103
Loa Loa (eye worm) hypothetical protein 0.0095 0.1398 0.1538
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0107 0.1645 0.4279
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0202 0.37 1
Loa Loa (eye worm) steroid hormone receptor 0.0202 0.37 0.4203
Mycobacterium tuberculosis Hypothetical protein 0.0057 0.0567 0.1115
Brugia malayi hypothetical protein 0.0057 0.0567 0.0534
Schistosoma mansoni nuclear receptor nhr-48 0.0095 0.1398 0.3593
Brugia malayi Nuclear hormone receptor-like 1 0.0107 0.1645 0.1787
Trichomonas vaginalis esterase, putative 0.0035 0.0108 0.0108
Loa Loa (eye worm) heterochromatin protein 1 0.0077 0.0998 0.1074
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0341 0.0341
Brugia malayi ecdysone receptor 0.0095 0.1398 0.1501
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0108 0.0108
Echinococcus multilocularis dihydrofolate reductase 0.0049 0.0392 0.0792
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.1376 0.1475
Brugia malayi dihydrofolate reductase family protein 0.0049 0.0392 0.0331
Loa Loa (eye worm) hypothetical protein 0.0202 0.37 0.4203
Trichomonas vaginalis chromobox protein, putative 0.0077 0.0998 0.0998
Brugia malayi nuclear hormone receptor family member odr-7 0.0095 0.1398 0.1501
Loa Loa (eye worm) hypothetical protein 0.0107 0.1645 0.1823
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0202 0.37 1
Schistosoma mansoni nuclear receptor 0.0095 0.1398 0.3593
Brugia malayi orphan nuclear receptor NR2E1 0.0095 0.1398 0.1501
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0049 0.0392 0.1573
Onchocerca volvulus 0.0202 0.37 0.3655
Leishmania major trypanothione reductase 0.0052 0.0466 0.1255
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0202 0.37 0.4203
Onchocerca volvulus Protein ultraspiracle homolog 0.0202 0.37 0.3655
Brugia malayi Cytochrome P450 family protein 0.0036 0.012 0.0014
Schistosoma mansoni zinc finger protein 0.0095 0.1398 0.3593

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 6.3 ug ml-1 Minimum inhibitory concentration of the compound was measured against Candida albicans ATCC 10231 using modified Sabouraud dextrose broth; (a) ChEMBL. 15664836
MIC (functional) = 6.3 ug ml-1 Minimum inhibitory concentration of the compound was measured against Candida tropicalis ATCC 28775 using modified Sabouraud dextrose broth; (a) ChEMBL. 15664836
MIC (functional) = 6.3 ug ml-1 Minimum inhibitory concentration of the compound was measured against Candida krusei ATCC 749 using modified Sabouraud dextrose broth; (a) ChEMBL. 15664836
MIC (functional) = 6.3 ug ml-1 Minimum inhibitory concentration of the compound was measured against Candida albicans ATCC 10231 using modified Sabouraud dextrose broth; (a) ChEMBL. 15664836
MIC (functional) = 12.5 ug ml-1 Minimum inhibitory concentration of the compound was measured against Aspergillus niger KCTC 1231 using modified Sabouraud dextrose broth; (a) ChEMBL. 15664836
MIC (functional) = 12.5 ug ml-1 Minimum inhibitory concentration of the compound was measured against Aspergillus flavus KCCM 11899 using modified Sabouraud dextrose broth; (a) ChEMBL. 15664836

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.